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Select item 112635931.

mtDNA release promotes cGAS-STING activation and accelerated aging of postmitotic muscle cells

Ying Li, Jie Cui, Lei Liu, William S. Hambright, Yutai Gan, Yajun Zhang, Shifeng Ren, Xianlin Yue, Liwei Shao, Yan Cui, Johnny Huard, Yanling Mu, Qingqiang Yao, Xiaodong Mu

Cell Death Dis. 2024 Jul; 15(7): 523. Published online 2024 Jul 23. doi: 10.1038/s41419-024-06863-8

PMCID:: PMC11263593

Abstract Article PDF–7.1M

Select item 102031172.

Accelerated aging in articular cartilage by ZMPSTE24 deficiency leads to osteoarthritis with impaired metabolic signaling and epigenetic regulation

Jinlong Suo, Rui Shao, Ruici Yang, Jinghui Wang, Zhong Zhang, Duo Wang, Ningning Niu, Xianyou Zheng, Weiguo Zou

Cell Death Dis. 2023 May; 14(5): 336. Published online 2023 May 22. doi: 10.1038/s41419-023-05856-3

PMCID:: PMC10203117

Abstract Article PDF–6.0M

Select item 101921983.

Nuclear softening mediated by Sun2 suppression delays mechanical stress-induced cellular senescence

Xianlin Yue, Jie Cui, Zewei Sun, Lei Liu, Ying Li, Liwei Shao, Qi Feng, Ziyue Wang, William S. Hambright, Yan Cui, Johnny Huard, Yanling Mu, Xiaodong Mu

Cell Death Discov. 2023; 9: 167. Published online 2023 May 17. doi: 10.1038/s41420-023-01467-1

PMCID:: PMC10192198

Abstract Article PDF–3.5M

Select item 96011214.

The Integral Membrane Protein ZMPSTE24 Protects Cells from SARS-CoV-2 Spike-Mediated Pseudovirus Infection and Syncytia Formation

Khurts Shilagardi, Eric D. Spear, Rachy Abraham, Diane E. Griffin, Susan Michaelis

mBio. 2022 Sep-Oct; 13(5): e02543-22. Published online 2022 Oct 5. doi: 10.1128/mbio.02543-22

PMCID:: PMC9601121

Abstract Article PDF–1.4M

Select item 88925265.

Abolishing the prelamin A ZMPSTE24 cleavage site leads to progeroid phenotypes with near-normal longevity in mice

Yuexia Wang, Khurts Shilagardi, Trunee Hsu, Kamsi O. Odinammadu, Takamitsu Maruyama, Wei Wu, Chyuan-Sheng Lin, Christopher B. Damoci, Eric D. Spear, Ji-Yeon Shin, Wei Hsu, Susan Michaelis, Howard J. Worman

Proc Natl Acad Sci U S A. 2022 Mar 1; 119(9): e2118695119. Published online 2022 Feb 23. doi: 10.1073/pnas.2118695119

PMCID:: PMC8892526

Abstract Article PDF–1.7M

Select item 86727816.

Novel small molecule inhibition of IKK/NF‐κB activation reduces markers of senescence and improves healthspan in mouse models of aging

Lei Zhang, Jing Zhao, Xiaodong Mu, Sara J. McGowan, Luise Angelini, Ryan D. O'Kelly, Matthew J. Yousefzadeh, Ayumi Sakamoto, Zaira Aversa, Nathan K. LeBrasseur, Yousin Suh, Johnny Huard, Theodore M. Kamenecka, Laura J. Niedernhofer, Paul D. Robbins

Aging Cell. 2021 Dec; 20(12): e13486. Published online 2021 Nov 3. doi: 10.1111/acel.13486

PMCID:: PMC8672781

Abstract Article PDF–2.2M

Select item 77395627.

Diminished canonical β-catenin signaling during osteoblast differentiation contributes to osteopenia in progeria

Ji Young Choi, Jim K Lai, Zheng-Mei Xiong, Margaret Ren, Megan C Moorer, Joseph P Stains, Kan Cao

J Bone Miner Res. Author manuscript; available in PMC 2020 Dec 16.

Published in final edited form as: J Bone Miner Res. 2018 Nov; 33(11): 2059–2070. Published online 2018 Aug 1. doi: 10.1002/jbmr.3549

PMCID:: PMC7739562

Abstract Article PDF–1.9M

Select item 74325988.

Satellite cell‐specific ablation of Cdon impairs integrin activation, FGF signalling, and muscle regeneration

Ju‐Hyeon Bae, Mingi Hong, Hyeon‐Ju Jeong, Hyebeen Kim, Sang‐Jin Lee, Dongryeol Ryu, Gyu‐Un Bae, Sung Chun Cho, Young‐Sam Lee, Robert S. Krauss, Jong‐Sun Kang

J Cachexia Sarcopenia Muscle. 2020 Aug; 11(4): 1089–1103. Published online 2020 Feb 27. doi: 10.1002/jcsm.12563

Correction in:: J Cachexia Sarcopenia Muscle. 2020 Oct; 11(5): 1381.

PMCID:: PMC7432598

Abstract Article PDF–1.0M

Select item 74318319.

Cytoskeleton stiffness regulates cellular senescence and innate immune response in Hutchinson–Gilford Progeria Syndrome

Xiaodong Mu, Chieh Tseng, William S. Hambright, Polina Matre, Chih‐Yi Lin, Palas Chanda, Wanqun Chen, Jianhua Gu, Sudheer Ravuri, Yan Cui, Ling Zhong, John P. Cooke, Laura J. Niedernhofer, Paul D. Robbins, Johnny Huard

Aging Cell. 2020 Aug; 19(8): e13152. Published online 2020 Jul 25. doi: 10.1111/acel.13152

PMCID:: PMC7431831

Abstract Article PDF–1.6M

Select item 743182110.

Targeting RAS‐converting enzyme 1 overcomes senescence and improves progeria‐like phenotypes of ZMPSTE24 deficiency

Haidong Yao, Xue Chen, Muhammad Kashif, Ting Wang, Mohamed X. Ibrahim, Elin Tüksammel, Gwladys Revêchon, Maria Eriksson, Clotilde Wiel, Martin O. Bergo

Aging Cell. 2020 Aug; 19(8): e13200. Published online 2020 Jul 24. doi: 10.1111/acel.13200

PMCID:: PMC7431821

Abstract Article PDF–928K

Select item 718999111.

The JAK1/2 inhibitor ruxolitinib delays premature aging phenotypes

Audrey Griveau, Clotilde Wiel, Dorian V. Ziegler, Martin O. Bergo, David Bernard

Aging Cell. 2020 Apr; 19(4): e13122. Published online 2020 Mar 20. doi: 10.1111/acel.13122

PMCID:: PMC7189991

Abstract Article PDF–529K

Select item 705384512.

Deficiency in ZMPSTE24 and resulting farnesyl–prelamin A accumulation only modestly affect mouse adipose tissue stores

Patrick J. Heizer, Ye Yang, Yiping Tu, Paul H. Kim, Natalie Y. Chen, Yan Hu, Yuko Yoshinaga, Pieter J. de Jong, Laurent Vergnes, Jazmin E. Morales, Robert L. Li, Nicholas Jackson, Karen Reue, Stephen G. Young, Loren G. Fong

J Lipid Res. 2020 Mar; 61(3): 413–421. Published online 2020 Jan 15. doi: 10.1194/jlr.RA119000593

PMCID:: PMC7053845

Abstract Article PDF–1.5M

Select item 661263513.

Ca_v1.2 regulates osteogenesis of bone marrow‐derived mesenchymal stem cells via canonical Wnt pathway in age‐related osteoporosis

Dongdong Fei, Yang Zhang, Junjie Wu, Hui Zhang, Anqi Liu, Xiaoning He, Jinjin Wang, Bei Li, Qintao Wang, Yan Jin

Aging Cell. 2019 Aug; 18(4): e12967. Published online 2019 May 23. doi: 10.1111/acel.12967

PMCID:: PMC6612635

Abstract Article PDF–2.3M

Select item 642646814.

Lamin A buffers CK2 kinase activity to modulate aging in a progeria mouse model.

Ying Ao, Jie Zhang, Zuojun Liu, Minxian Qian, Yao Li, Zhuping Wu, Pengfei Sun, Jie Wu, Weixin Bei, Junqu Wen, Xuli Wu, Feng Li, Zhongjun Zhou, Wei-Guo Zhu, Baohua Liu, Zimei Wang

Sci Adv. 2019 Mar; 5(3): eaav5078. Published online 2019 Mar 20. doi: 10.1126/sciadv.aav5078

PMCID:: PMC6426468

Abstract Article PDF–2.3M

Select item 632665215.

Accelerated aging induced by deficiency of Zmpste24 protects old mice to develop bleomycin-induced pulmonary fibrosis

Jazmín Calyeca, Yalbi I. Balderas-Martínez, Raúl Olmos, Rogelio Jasso, Vilma Maldonado, Quetzali Rivera, Moisés Selman, Annie Pardo

Aging (Albany NY) 2018 Dec; 10(12): 3881–3896. Published online 2018 Dec 10. doi: 10.18632/aging.101679

PMCID:: PMC6326652

Abstract Article PDF–4.7M

Select item 626092216.

Targeting the phospholipase A2 receptor ameliorates premature aging phenotypes

Audrey Griveau, Clotilde Wiel, Benjamin Le Calvé, Dorian V. Ziegler, Sophia Djebali, Marine Warnier, Nadine Martin, Jacqueline Marvel, David Vindrieux, Martin O. Bergo, David Bernard

Aging Cell. 2018 Dec; 17(6): e12835. Published online 2018 Sep 14. doi: 10.1111/acel.12835

PMCID:: PMC6260922

Abstract Article PDF–1.9M

Select item 623746917.

Prelamin A causes aberrant myonuclear arrangement and results in muscle fiber weakness

Yotam Levy, Jacob A. Ross, Marili Niglas, Vladimir A. Snetkov, Steven Lynham, Chen-Yu Liao, Megan J. Puckelwartz, Yueh-Mei Hsu, Elizabeth M. McNally, Manfred Alsheimer, Stephen D.R. Harridge, Stephen G. Young, Loren G. Fong, Yaiza Español, Carlos Lopez-Otin, Brian K. Kennedy, Dawn A. Lowe, Julien Ochala

JCI Insight. 2018 Oct 4; 3(19): e120920. Published online 2018 Oct 4. doi: 10.1172/jci.insight.120920

PMCID:: PMC6237469

Abstract Article PDF–2.2M

Select item 620941618.

Next-Generation Sequencing and Quantitative Proteomics of Hutchinson-Gilford progeria syndrome-derived cells point to a role of nucleotide metabolism in premature aging

Jesús Mateos, Juan Fafián-Labora, Miriam Morente-López, Iván Lesende-Rodriguez, Lorenzo Monserrat, María A. Ódena, Eliandre de Oliveira, Javier de Toro, María C. Arufe

PLoS One. 2018; 13(10): e0205878. Published online 2018 Oct 31. doi: 10.1371/journal.pone.0205878

PMCID:: PMC6209416

Abstract Article PDF–2.7M

Select item 616647219.

Disrupting the LINC Complex in Smooth Muscle Cells Reduces Aortic Disease in a Mouse Model of HGPS

Paul Kim, Jennings Luu, Patrick Heizer, Yiping Tu, Thomas A. Weston, Natalie Chen, Christopher Lim, Robert L. Li, Po-Yu Lin, James C. Y. Dunn, Didier Hodzic, Stephen G. Young, Loren G. Fong

Sci Transl Med. Author manuscript; available in PMC 2018 Oct 1.

Published in final edited form as: Sci Transl Med. 2018 Sep 26; 10(460): eaat7163. doi: 10.1126/scitranslmed.aat7163

PMCID:: PMC6166472

Abstract Article PDF–2.5M

Select item 613005120.

Methionine Restriction Extends Lifespan in Progeroid Mice and Alters Lipid and Bile Acid Metabolism

Clea Bárcena, Pedro M. Quirós, Sylvère Durand, Pablo Mayoral, Francisco Rodríguez, Xurde M. Caravia, Guillermo Mariño, Cecilia Garabaya, María Teresa Fernández-García, Guido Kroemer, José M.P. Freije, Carlos López-Otín

Cell Rep. 2018 Aug 28; 24(9): 2392–2403. Published online 2018 Aug 28. doi: 10.1016/j.celrep.2018.07.089