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Select item 105848181.

mRNA trans-splicing dual AAV vectors for (epi)genome editing and gene therapy

Lisa Maria Riedmayr, Klara Sonnie Hinrichsmeyer, Stefan Bernhard Thalhammer, David Manuel Mittas, Nina Karguth, Dina Yehia Otify, Sybille Böhm, Valentin Johannes Weber, Michael David Bartoschek, Victoria Splith, Manuela Brümmer, Raphael Ferreira, Nanda Boon, Gabriele Maria Wögenstein, Christian Grimm, Jan Wijnholds, Verena Mehlfeld, Stylianos Michalakis, Stefanie Fenske, Martin Biel, Elvir Becirovic

Nat Commun. 2023; 14: 6578. Published online 2023 Oct 18. doi: 10.1038/s41467-023-42386-0

PMCID:: PMC10584818

Abstract Article PDF–2.9M

Select item 105683492.

Development of novel cytoprotective small compounds inhibiting mitochondria-dependent cell death

Mieko Matsuyama, Joseph T. Ortega, Yuri Fedorov, Jonah Scott-McKean, Jeannie Muller-Greven, Matthias Buck, Drew Adams, Beata Jastrzebska, William Greenlee, Shigemi Matsuyama

iScience. 2023 Oct 20; 26(10): 107916. Published online 2023 Sep 17. doi: 10.1016/j.isci.2023.107916

PMCID:: PMC10568349

Abstract Article PDF–4.4M

Select item 99187193.

Galanin receptor 3 - a new pharmacological target in retina degeneration

Joseph T. Ortega, Tanu Parmar, Beata Jastrzebska

Pharmacol Res. Author manuscript; available in PMC 2024 Feb 1.

Published in final edited form as: Pharmacol Res. 2023 Jan 21; 188: 106675. Published online 2023 Jan 21. doi: 10.1016/j.phrs.2023.106675

PMCID:: PMC9918719

Abstract Article PDF–2.8M

Select item 97783624.

Retinal Photoreceptor Protection in an AMD-Related Mouse Model by Selective Sigma-1 or Sigma-2 Receptor Modulation

Timur A. Mavlyutov, Jing Li, Xinying Liu, Hongtao Shen, Huan Yang, Christopher R. McCurdy, Bikash Pattnaik, Lian-Wang Guo

Genes (Basel) 2022 Dec; 13(12): 2386. Published online 2022 Dec 16. doi: 10.3390/genes13122386

PMCID:: PMC9778362

Abstract Article PDF–1.6M

Select item 95588425.

Chromenone derivatives as novel pharmacological chaperones for retinitis pigmentosa-linked rod opsin mutants

Joseph T Ortega, Andrew G McKee, Francis J Roushar, Wesley D Penn, Jonathan P Schlebach, Beata Jastrzebska

Hum Mol Genet. 2022 Oct 15; 31(20): 3439–3457. Published online 2022 Jun 1. doi: 10.1093/hmg/ddac125

PMCID:: PMC9558842

Abstract Article PDF–2.2M

Select item 87597956.

In vivo imaging of the human eye using a 2-photon-excited fluorescence scanning laser ophthalmoscope

Jakub Boguslawski, Grazyna Palczewska, Slawomir Tomczewski, Jadwiga Milkiewicz, Piotr Kasprzycki, Dorota Stachowiak, Katarzyna Komar, Marcin J. Marzejon, Bartosz L. Sikorski, Arkadiusz Hudzikowski, Aleksander Głuszek, Zbigniew Łaszczych, Karol Karnowski, Grzegorz Soboń, Krzysztof Palczewski, Maciej Wojtkowski

J Clin Invest. 2022 Jan 18; 132(2): e154218. Published online 2022 Jan 18. doi: 10.1172/JCI154218

PMCID:: PMC8759795

Abstract Article PDF–1.7M

Select item 84870607.

ADAM17 mediates ectodomain shedding of the soluble VLDL receptor fragment in the retinal epithelium

Xiang Ma, Yusuke Takahashi, Wenjing Wu, Wentao Liang, Jianglei Chen, Dibyendu Chakraborty, Yangxiong Li, Yanhong Du, Siribhinya Benyajati, Jian-Xing Ma

J Biol Chem. 2021 Oct; 297(4): 101185. Published online 2021 Sep 10. doi: 10.1016/j.jbc.2021.101185

PMCID:: PMC8487060

Abstract Article PDF–3.9M

Select item 78627338.

Relative Contributions of All-Trans and 11-Cis Retinal to Formation of Lipofuscin and A2E Accumulating in Mouse Retinal Pigment Epithelium

Nicholas P. Boyer, Debra A. Thompson, Yiannis Koutalos

Invest Ophthalmol Vis Sci. 2021 Feb; 62(2): 1. Published online 2021 Feb 1. doi: 10.1167/iovs.62.2.1

PMCID:: PMC7862733

Abstract Article PDF–757K

Select item 77368349.

Protective Effects of Flavonoids in Acute Models of Light-Induced Retinal Degeneration

Joseph T. Ortega, Tanu Parmar, Marcin Golczak, Beata Jastrzebska

Mol Pharmacol. 2021 Jan; 99(1): 60–77. Published online 2021 Jan. doi: 10.1124/molpharm.120.000072

PMCID:: PMC7736834

Abstract Article PDF–2.8M

Select item 724270010.

Activation of JNK signaling promotes all-trans-retinal–induced photoreceptor apoptosis in mice

Chunyan Liao, Binxiang Cai, Yufeng Feng, Jingmeng Chen, Yiping Wu, Jingbin Zhuang, Zuguo Liu, Yalin Wu

J Biol Chem. 2020 May 15; 295(20): 6958–6971. Published online 2020 Apr 7. doi: 10.1074/jbc.RA120.013189

PMCID:: PMC7242700

Abstract Article PDF–3.8M

Select item 657948011.

The selective estrogen receptor modulator raloxifene mitigates the effect of all-trans-retinal toxicity in photoreceptor degeneration

Tamar Getter, Susie Suh, Thanh Hoang, James T. Handa, Zhiqian Dong, Xiuli Ma, Yuanyuan Chen, Seth Blackshaw, Krzysztof Palczewski

J Biol Chem. 2019 Jun 14; 294(24): 9461–9475. Published online 2019 May 9. doi: 10.1074/jbc.RA119.008697

PMCID:: PMC6579480

Abstract Article PDF–3.9M

Select item 617181312.

Two-photon imaging of the mammalian retina with ultrafast pulsing laser

Grazyna Palczewska, Patrycjusz Stremplewski, Susie Suh, Nathan Alexander, David Salom, Zhiqian Dong, Daniel Ruminski, Elliot H. Choi, Avery E. Sears, Timothy S. Kern, Maciej Wojtkowski, Krzysztof Palczewski

JCI Insight. 2018 Sep 6; 3(17): e121555. Published online 2018 Sep 6. doi: 10.1172/jci.insight.121555

PMCID:: PMC6171813

Abstract Article PDF–4.0M

Select item 610857513.

Protective Effect of a Locked Retinal Chromophore Analog against Light-Induced Retinal Degeneration

Songqi Gao, Tanu Parmar, Grazyna Palczewska, Zhiqian Dong, Marcin Golczak, Krzysztof Palczewski, Beata Jastrzebska

Mol Pharmacol. 2018 Oct; 94(4): 1132–1144. Published online 2018 Oct. doi: 10.1124/mol.118.112581

PMCID:: PMC6108575

Abstract Article PDF–2.0M

Select item 605486714.

Ultrastructural alterations in the retinal pigment epithelium and photoreceptors of a Stargardt patient and three Stargardt mouse models: indication for the central role of RPE melanin in oxidative stress

Tatjana Taubitz, Alexander V. Tschulakow, Marina Tikhonovich, Barbara Illing, Yuan Fang, Antje Biesemeier, Sylvie Julien-Schraermeyer, Ulrich Schraermeyer

PeerJ. 2018; 6: e5215. Published online 2018 Jul 19. doi: 10.7717/peerj.5215

PMCID:: PMC6054867

Abstract Article PDF–30M

Select item 595811515.

A novel small molecule chaperone of rod opsin and its potential therapy for retinal degeneration

Yuanyuan Chen, Yu Chen, Beata Jastrzebska, Marcin Golczak, Sahil Gulati, Hong Tang, William Seibel, Xiaoyu Li, Hui Jin, Yong Han, Songqi Gao, Jianye Zhang, Xujie Liu, Hossein Heidari-Torkabadi, Phoebe L. Stewart, William E. Harte, Gregory P. Tochtrop, Krzysztof Palczewski

Nat Commun. 2018; 9: 1976. Published online 2018 May 17. doi: 10.1038/s41467-018-04261-1

PMCID:: PMC5958115

Abstract Article PDF–4.7M

Select item 595624516.

New GABA modulators protect photoreceptor cells from light-induced degeneration in mouse models

Rebecca M. Schur, Songqi Gao, Guanping Yu, Yu Chen, Akiko Maeda, Krzysztof Palczewski, Zheng-Rong Lu

FASEB J. 2018 Jun; 32(6): 3289–3300. Published online 2018 Jan 24. doi: 10.1096/fj.201701250R

PMCID:: PMC5956245

Abstract Article

Select item 591603817.

Lipocalin 2 plays an important role in regulating inflammation in retinal degeneration

Tanu Parmar, Vipul M Parmar, Lindsay Perusek, Anouk Georges, Masayo Takahashi, John W Crabb, Akiko Maeda

J Immunol. Author manuscript; available in PMC 2019 May 1.

Published in final edited form as: J Immunol. 2018 May 1; 200(9): 3128–3141. Published online 2018 Mar 30. doi: 10.4049/jimmunol.1701573

PMCID:: PMC5916038

Abstract Article PDF–1.8M

Select item 577131418.

A Combination of G Protein–Coupled Receptor Modulators Protects Photoreceptors from Degeneration

Tivadar Orban, Henri Leinonen, Tamar Getter, Zhiqian Dong, Wenyu Sun, Songqi Gao, Alexander Veenstra, Hossein Heidari-Torkabadi, Timothy S. Kern, Philip D. Kiser, Krzysztof Palczewski

J Pharmacol Exp Ther. 2018 Feb; 364(2): 207–220. Published online 2018 Feb. doi: 10.1124/jpet.117.245167

PMCID:: PMC5771314

Abstract Article PDF–1.0M

Select item 570267419.

Interphotoreceptor retinoid–binding protein removes all-trans-retinol and retinal from rod outer segments, preventing lipofuscin precursor formation

Chunhe Chen, Leopold Adler, IV, Patrice Goletz, Federico Gonzalez-Fernandez, Debra A. Thompson, Yiannis Koutalos

J Biol Chem. 2017 Nov 24; 292(47): 19356–19365. Published online 2017 Sep 28. doi: 10.1074/jbc.M117.795187

PMCID:: PMC5702674

Abstract Article PDF–1.3M

Select item 520720120.

Receptor MER Tyrosine Kinase Proto-oncogene (MERTK) Is Not Required for Transfer of Bis-retinoids to the Retinal Pigmented Epithelium

Grazyna Palczewska, Akiko Maeda, Marcin Golczak, Eisuke Arai, Zhiqian Dong, Lindsay Perusek, Brian Kevany, Krzysztof Palczewski

J Biol Chem. 2016 Dec 23; 291(52): 26937–26949. Published online 2016 Nov 14. doi: 10.1074/jbc.M116.764563

PMCID:: PMC5207201

Abstract Article PDF–3.5M

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