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Items: 1 to 20 of 38

1.
Proliferation, migration and phenotypic transformation of VSMC induced via Hcy related to up-expression of WWP2 and p-STAT3
Xiuyu Wang, Na Gui, Xing Ma, Yue Zeng, Tingrun Mo, Minghao Zhang
PLoS One. 2024; 19(1): e0296359. Published online 2024 Jan 2. doi: 10.1371/journal.pone.0296359
PMCID:
PMC10760878
AbstractArticlePDF–2.2M
2.
The E3 ubiquitin ligase WWP2 regulates pro-fibrogenic monocyte infiltration and activity in heart fibrosis
Huimei Chen, Gabriel Chew, Nithya Devapragash, Jui Zhi Loh, Kevin Y. Huang, Jing Guo, Shiyang Liu, Elisabeth Li Sa Tan, Shuang Chen, Nicole Gui Zhen Tee, Masum M. Mia, Manvendra K. Singh, Aihua Zhang, Jacques Behmoaras, Enrico Petretto
Nat Commun. 2022; 13: 7375. Published online 2022 Nov 30. doi: 10.1038/s41467-022-34971-6
PMCID:
PMC9712659
AbstractArticlePDF–4.6M
3.
A WWP2–PTEN–KLF5 signaling axis regulates odontoblast differentiation and dentinogenesis in mice
Jing Fu, Xiaobo Zhang, Huiwen Zheng, Guobin Yang, Zhi Chen, Guohua Yuan
J Biol Chem. 2022 Aug; 298(8): 102220. Published online 2022 Jul 1. doi: 10.1016/j.jbc.2022.102220
PMCID:
PMC9358474
AbstractArticlePDF–3.7M
4.
BraInMap elucidates the macromolecular connectivity landscape of mammalian brain
Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili
Cell Syst. Author manuscript; available in PMC 2021 Apr 22.
Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003
Correction in:
Cell Syst. 2020 Aug 26; 11(2): 208.
PMCID:
PMC7938770
AbstractArticlePDF–2.0M
5.
Selective targeting of ubiquitination and degradation of PARP1 by E3 ubiquitin ligase WWP2 regulates isoproterenol-induced cardiac remodeling
Naijin Zhang, Ying Zhang, Hao Qian, Shaojun Wu, Liu Cao, Yingxian Sun
Cell Death Differ. 2020 Sep; 27(9): 2605–2619. Published online 2020 Mar 5. doi: 10.1038/s41418-020-0523-2
PMCID:
PMC7429876
AbstractArticlePDF–5.5M
6.
WWP2 regulates SIRT1‐STAT3 acetylation and phosphorylation involved in hypertensive angiopathy
Ying Zhang, Shilong You, Yichen Tian, Saien Lu, Liu Cao, Yingxian Sun, Naijin Zhang
J Cell Mol Med. 2020 Aug; 24(16): 9041–9054. Published online 2020 Jul 5. doi: 10.1111/jcmm.15538
PMCID:
PMC7417706
AbstractArticlePDF–2.7M
7.
Optimizing Nervous System-Specific Gene Targeting with Cre Driver Lines: Prevalenceof Germline Recombination and Influencing Factors
Lin Luo, Mateusz C. Ambrozkiewicz, Fritz Benseler, Cui Chen, Emilie Dumontier, Susanne Falkner, Elisabetta Furlanis, Andrea M. Gomez, Naosuke Hoshina, Wei-Hsiang Huang, Mary Anne Hutchison, Yu Itoh-Maruoka, Laura A. Lavery, Wei Li, Tomohiko Maruo, Junko Motohashi, Emily Ling-Lin Pai, Kenneth A. Pelkey, Ariane Pereira, Thomas Philips, Jennifer L. Sinclair, Jeff A. Stogsdill, Lisa Traunmüller, Jiexin Wang, Joke Wortel, Wenjia You, Nashat Abumaria, Kevin T. Beier, Nils Brose, Harold A. Burgess, Constance L. Cepko, Jean-François Cloutier, Cagla Eroglu, Sandra Goebbels, Pascal S. Kaeser, Jeremy N. Kay, Wei Lu, Liqun Luo, Kenji Mandai, Chris J. McBain, Klaus-Armin Nave, Marco A.M. Prado, Vania F. Prado, Jeffrey Rothstein, John L.R. Rubenstein, Gesine Saher, Kenji Sakimura, Joshua R. Sanes, Peter Scheiffele, Yoshimi Takai, Hisashi Umemori, Matthijs Verhage, Michisuke Yuzaki, Huda Yahya Zoghbi, Hiroshi Kawabe, Ann Marie Craig
Neuron. Author manuscript; available in PMC 2021 Apr 8.
Published in final edited form as: Neuron. 2020 Apr 8; 106(1): 37–65.e5. Published online 2020 Feb 5. doi: 10.1016/j.neuron.2020.01.008
PMCID:
PMC7377387
AbstractArticlePDF–2.3M
8.
WWP1 knockout in mice exacerbates obesity‐related phenotypes in white adipose tissue but improves whole‐body glucose metabolism
Shunsuke Hoshino, Masaki Kobayashi, Ryoma Tagawa, Ryutaro Konno, Takuro Abe, Kazuhiro Furuya, Kumi Miura, Hiroki Wakasawa, Naoyuki Okita, Yuka Sudo, Yuhei Mizunoe, Yoshimi Nakagawa, Takeshi Nakamura, Hiroshi Kawabe, Yoshikazu Higami
FEBS Open Bio. 2020 Mar; 10(3): 306–315. Published online 2020 Feb 3. doi: 10.1002/2211-5463.12795
PMCID:
PMC7050250
AbstractArticlePDF–1.2M
9.
Transmembrane adaptor protein WBP1L regulates CXCR4 signalling and murine haematopoiesis
Simon Borna, Ales Drobek, Jarmila Kralova, Daniela Glatzova, Iva Splichalova, Matej Fabisik, Jana Pokorna, Tereza Skopcova, Pavla Angelisova, Veronika Kanderova, Julia Starkova, Petr Stanek, Orest V. Matveichuk, Nataliia Pavliuchenko, Katarzyna Kwiatkowska, Majd B. Protty, Michael G. Tomlinson, Meritxell Alberich‐Jorda, Vladimir Korinek, Tomas Brdicka
J Cell Mol Med. 2020 Jan; 24(2): 1980–1992. Published online 2019 Dec 17. doi: 10.1111/jcmm.14895
PMCID:
PMC6991692
AbstractArticlePDF–1.8M
10.
WWP2 regulates pathological cardiac fibrosis by modulating SMAD2 signaling
Huimei Chen, Aida Moreno-Moral, Francesco Pesce, Nithya Devapragash, Massimiliano Mancini, Ee Ling Heng, Maxime Rotival, Prashant K. Srivastava, Nathan Harmston, Kirill Shkura, Owen J. L. Rackham, Wei-Ping Yu, Xi-Ming Sun, Nicole Gui Zhen Tee, Elisabeth Li Sa Tan, Paul J. R. Barton, Leanne E. Felkin, Enrique Lara-Pezzi, Gianni Angelini, Cristina Beltrami, Michal Pravenec, Sebastian Schafer, Leonardo Bottolo, Norbert Hubner, Costanza Emanueli, Stuart A. Cook, Enrico Petretto
Nat Commun. 2019; 10: 3616. Published online 2019 Aug 9. doi: 10.1038/s41467-019-11551-9
Correction in:
Nat Commun. 2019; 10: 4085.
PMCID:
PMC6689010
AbstractArticlePDF–4.1M
11.
Wwp2 maintains cartilage homeostasis through regulation of Adamts5
Sho Mokuda, Ryo Nakamichi, Tokio Matsuzaki, Yoshiaki Ito, Tempei Sato, Kohei Miyata, Masafumi Inui, Merissa Olmer, Eiji Sugiyama, Martin Lotz, Hiroshi Asahara
Nat Commun. 2019; 10: 2429. Published online 2019 Jun 3. doi: 10.1038/s41467-019-10177-1
PMCID:
PMC6546747
AbstractArticlePDF–2.8M
12.
Dissecting the roles of miR-140 and its host gene.
Masafumi Inui, Sho Mokuda, Tempei Sato, Moe Tamano, Shuji Takada, Hiroshi Asahara
Nat Cell Biol. Author manuscript; available in PMC 2019 May 1.
Published in final edited form as: Nat Cell Biol. 2018 May; 20(5): 516–518. doi: 10.1038/s41556-018-0077-4
PMCID:
PMC6373877
ArticlePDF–880K
13.
The E3 ligases Itch and WWP2 cooperate to limit TH2 differentiation by enhancing signaling through the TCR
Daisuke Aki, Hui Li, Wen Zhang, Mingke Zheng, Chris Elly, Jee H. Lee, Weiguo Zou, Yun-Cai Liu
Nat Immunol. Author manuscript; available in PMC 2019 Jan 28.
Published in final edited form as: Nat Immunol. 2018 Jul; 19(7): 766–775. Published online 2018 Jun 20. doi: 10.1038/s41590-018-0137-8
PMCID:
PMC6348860
AbstractArticlePDF–2.0M
14.
WWP2 is a physiological ubiquitin ligase for phosphatase and tensin homolog (PTEN) in mice
Hongchang Li, Pengfei Zhang, Qiuyue Zhang, Chaonan Li, Weiguo Zou, Zhijie Chang, Chun-Ping Cui, Lingqiang Zhang
J Biol Chem. 2018 Jun 8; 293(23): 8886–8899. Published online 2018 Apr 23. doi: 10.1074/jbc.RA117.001060
PMCID:
PMC5995496
AbstractArticlePDF–6.0M
15.
Synergistic co-regulation and competition by a SOX9-GLI-FOXA phasic transcriptional network coordinate chondrocyte differentiation transitions
Zhijia Tan, Ben Niu, Kwok Yeung Tsang, Ian G. Melhado, Shinsuke Ohba, Xinjun He, Yongheng Huang, Cheng Wang, Andrew P. McMahon, Ralf Jauch, Danny Chan, Michael Q. Zhang, Kathryn S. E. Cheah
PLoS Genet. 2018 Apr; 14(4): e1007346. Published online 2018 Apr 16. doi: 10.1371/journal.pgen.1007346
PMCID:
PMC5919691
AbstractArticlePDF–4.0M
16.
The E3 ubiquitin ligase WWP2 facilitates RUNX2 protein transactivation in a mono-ubiquitination manner during osteogenic differentiation
Wei Zhu, Xinyu He, Yue Hua, Qian Li, Jiyong Wang, Xiaoqing Gan
J Biol Chem. 2017 Jul 7; 292(27): 11178–11188. Published online 2017 May 12. doi: 10.1074/jbc.M116.772277
PMCID:
PMC5500787
AbstractArticlePDF–2.3M
17.
DIDO as a Switchboard that Regulates Self-Renewal and Differentiation in Embryonic Stem Cells
Agnes Fütterer, Jésus de Celis, Rosana Navajas, Luis Almonacid, Julio Gutiérrez, Amaia Talavera-Gutiérrez, Cristina Pacios-Bras, Ilenia Bernascone, Fernando Martin-Belmonte, Carlos Martinéz-A
Stem Cell Reports. 2017 Apr 11; 8(4): 1062–1075. Published online 2017 Mar 16. doi: 10.1016/j.stemcr.2017.02.013
PMCID:
PMC5390109
AbstractArticlePDF–3.5M
18.
A developmental transcriptomic analysis of Pax1 and Pax9 in embryonic intervertebral disc development
V. Sivakamasundari, Petra Kraus, Wenjie Sun, Xiaoming Hu, Siew Lan Lim, Shyam Prabhakar, Thomas Lufkin
Biol Open. 2017 Feb 15; 6(2): 187–199. Published online 2016 Dec 23. doi: 10.1242/bio.023218
PMCID:
PMC5312110
AbstractArticlePDF–4.2M
19.
Cdh1 regulates craniofacial development via APC-dependent ubiquitination and activation of Goosecoid
Rui Shao, Jia Liu, Guang Yan, Jinfang Zhang, Yujiao Han, Jianfeng Guo, Zhan Xu, Zhu Yuan, Jiankang Liu, Marcos Malumbres, Lixin Wan, Wenyi Wei, Weiguo Zou
Cell Res. 2016 Jun; 26(6): 699–712. Published online 2016 Apr 29. doi: 10.1038/cr.2016.51
PMCID:
PMC4897181
AbstractArticlePDF–6.3M
20.
HECT E3 Ubiquitin Ligase Itch Functions as a Novel Negative Regulator of Gli-Similar 3 (Glis3) Transcriptional Activity
Gary T. ZeRuth, Jason G. Williams, Yasemin C. Cole, Anton M. Jetten
PLoS One. 2015; 10(7): e0131303. Published online 2015 Jul 6. doi: 10.1371/journal.pone.0131303
PMCID:
PMC4493090
AbstractArticlePDF–2.2M

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