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Select item 109176601.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 96635092.

Inhibiting ACK1-mediated phosphorylation of C-terminal Src kinase counteracts prostate cancer immune checkpoint blockade resistance

Dhivya Sridaran, Surbhi Chouhan, Kiran Mahajan, Arun Renganathan, Cody Weimholt, Shambhavi Bhagwat, Melissa Reimers, Eric H. Kim, Manish K. Thakur, Muhammad A. Saeed, Russell K. Pachynski, Markus A. Seeliger, W. Todd Miller, Felix Y. Feng, Nupam P. Mahajan

Nat Commun. 2022; 13: 6929. Published online 2022 Nov 14. doi: 10.1038/s41467-022-34724-5

PMCID:: PMC9663509

Abstract Article PDF–1.9M

Select item 91641073.

ACK1 Contributes to the Pathogenesis of Inflammation and Autoimmunity by Promoting the Activation of TLR Signaling Pathways

Lina Jing, Xin Zhang, Dong Liu, Yonghong Yang, Huabao Xiong, Guanjun Dong

Front Immunol. 2022; 13: 864995. Published online 2022 May 20. doi: 10.3389/fimmu.2022.864995

PMCID:: PMC9164107

Abstract Article PDF–15M

Select item 81678574.

ACK1 is dispensable for development, skin tumor formation, and breast cancer cell proliferation

Rafael Brandao, Mei Qi Kwa, Yossi Yarden, Cord Brakebusch

FEBS Open Bio. 2021 Jun; 11(6): 1579–1592. Published online 2021 May 2. doi: 10.1002/2211-5463.13149

PMCID:: PMC8167857

Abstract Article PDF–5.1M

Select item 74159915.

BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING)

Kou Motani, Hidetaka Kosako

J Biol Chem. 2020 Aug 7; 295(32): 11174–11183. Published online 2020 Jun 17. doi: 10.1074/jbc.RA120.014323

PMCID:: PMC7415991

Abstract Article PDF–2.0M

Select item 72950336.

Ex vivo Quantitative Proteomic Analysis of Serotonin Transporter Interactome: Network Impact of the SERT Ala56 Coding Variant

Meagan A. Quinlan, Matthew J. Robson, Ran Ye, Kristie L. Rose, Kevin L. Schey, Randy D. Blakely

Front Mol Neurosci. 2020; 13: 89. Published online 2020 Jun 8. doi: 10.3389/fnmol.2020.00089

PMCID:: PMC7295033

Abstract Article PDF–2.7M

Select item 57318627.

Identification of novel Ack1-interacting proteins and Ack1 phosphorylated sites in mouse brain by mass spectrometry

Maria del Mar Masdeu, Beatriz G. Armendáriz, Anna La Torre, Eduardo Soriano, Ferran Burgaya, Jesús Mariano Ureña

Oncotarget. 2017 Nov 24; 8(60): 101146–101157. Published online 2017 Sep 15. doi: 10.18632/oncotarget.20929

PMCID:: PMC5731862

Abstract Article PDF–5.4M

Select item 53917578.

Activated Cdc42-associated kinase 1 (ACK1) binds the sterile α motif (SAM) domain of the adaptor SLP-76 and phosphorylates proximal tyrosines

Youg R. Thaker, Asha Recino, Monika Raab, Asma Jabeen, Maja Wallberg, Nelson Fernandez, Christopher E. Rudd

J Biol Chem. 2017 Apr 14; 292(15): 6281–6290. Published online 2017 Feb 10. doi: 10.1074/jbc.M116.759555

PMCID:: PMC5391757

Abstract Article PDF–2.0M

Select item 46875429.

Ack1 is a dopamine transporter endocytic brake that rescues a trafficking-dysregulated ADHD coding variant

Sijia Wu, Karl D. Bellve, Kevin E. Fogarty, Haley E. Melikian

Proc Natl Acad Sci U S A. 2015 Dec 15; 112(50): 15480–15485. Published online 2015 Nov 30. doi: 10.1073/pnas.1512957112

PMCID:: PMC4687542

Abstract Article PDF–1.2M

Select item 357241010.

A conditional knockout resource for the genome–wide study of mouse gene function

William C. Skarnes, Barry Rosen, Anthony P. West, Manousos Koutsourakis, Wendy Bushell, Vivek Iyer, Alejandro O. Mujica, Mark Thomas, Jennifer Harrow, Tony Cox, David Jackson, Jessica Severin, Patrick Biggs, Jun Fu, Michael Nefedov, Pieter J. de Jong, A. Francis Stewart, Allan Bradley

Nature. Author manuscript; available in PMC 2013 Feb 14.

Published in final edited form as: Nature. 2011 Jun 15; 474(7351): 337–342. Published online 2011 Jun 15. doi: 10.1038/nature10163

PMCID:: PMC3572410

Abstract Article PDF–1.1M

Select item 343137611.

Cortactin Is a Substrate of Activated Cdc42-Associated Kinase 1 (ACK1) during Ligand-induced Epidermal Growth Factor Receptor Downregulation

Laura C. Kelley, Scott A. Weed

PLoS One. 2012; 7(8): e44363. Published online 2012 Aug 30. doi: 10.1371/journal.pone.0044363

PMCID:: PMC3431376

Abstract Article PDF–1.4M

Select item 338116912.

Ack1-mediated Androgen Receptor Phosphorylation Modulates Radiation Resistance in Castration-resistant Prostate Cancer

Kiran Mahajan, Domenico Coppola, Bhupendra Rawal, Y. Ann Chen, Harshani R. Lawrence, Robert W. Engelman, Nicholas J. Lawrence, Nupam P. Mahajan

J Biol Chem. 2012 Jun 22; 287(26): 22112–22122. Published online 2012 May 7. doi: 10.1074/jbc.M112.357384

PMCID:: PMC3381169

Abstract Article PDF–2.6M

Select item 334989513.

Ack1 Tyrosine Kinase Activation Correlates with Pancreatic Cancer Progression

Kiran Mahajan, Domenico Coppola, Y. Ann Chen, Weiwei Zhu, Harshani R. Lawrence, Nicholas J. Lawrence, Nupam P. Mahajan

Am J Pathol. 2012 Apr; 180(4): 1386–1393. doi: 10.1016/j.ajpath.2011.12.028

PMCID:: PMC3349895

Abstract Article PDF–1.3M

Select item 317805914.

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas

Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042

PMCID:: PMC3178059

Abstract Article PDF–1.0M

Select item 303864715.

Constitutive activated Cdc42-associated kinase (Ack) phosphorylation at arrested endocytic clathrin-coated pits of cells that lack dynamin

Hongying Shen, Shawn M. Ferguson, Noah Dephoure, Ryan Park, Yan Yang, Laura Volpicelli-Daley, Steven Gygi, Joseph Schlessinger, Pietro De Camilli

Mol Biol Cell. 2011 Feb 15; 22(4): 493–502. doi: 10.1091/mbc.E10-07-0637

PMCID:: PMC3038647

Abstract Article PDF–2.3M

Select item 302253416.

A High-Resolution Anatomical Atlas of the Transcriptome in the Mouse Embryo

Graciana Diez-Roux, Sandro Banfi, Marc Sultan, Lars Geffers, Santosh Anand, David Rozado, Alon Magen, Elena Canidio, Massimiliano Pagani, Ivana Peluso, Nathalie Lin-Marq, Muriel Koch, Marchesa Bilio, Immacolata Cantiello, Roberta Verde, Cristian De Masi, Salvatore A. Bianchi, Juliette Cicchini, Elodie Perroud, Shprese Mehmeti, Emilie Dagand, Sabine Schrinner, Asja Nürnberger, Katja Schmidt, Katja Metz, Christina Zwingmann, Norbert Brieske, Cindy Springer, Ana Martinez Hernandez, Sarah Herzog, Frauke Grabbe, Cornelia Sieverding, Barbara Fischer, Kathrin Schrader, Maren Brockmeyer, Sarah Dettmer, Christin Helbig, Violaine Alunni, Marie-Annick Battaini, Carole Mura, Charlotte N. Henrichsen, Raquel Garcia-Lopez, Diego Echevarria, Eduardo Puelles, Elena Garcia-Calero, Stefan Kruse, Markus Uhr, Christine Kauck, Guangjie Feng, Nestor Milyaev, Chuang Kee Ong, Lalit Kumar, MeiSze Lam, Colin A. Semple, Attila Gyenesei, Stefan Mundlos, Uwe Radelof, Hans Lehrach, Paolo Sarmientos, Alexandre Reymond, Duncan R. Davidson, Pascal Dollé, Stylianos E. Antonarakis, Marie-Laure Yaspo, Salvador Martinez, Richard A. Baldock, Gregor Eichele, Andrea Ballabio

PLoS Biol. 2011 Jan; 9(1): e1000582. Published online 2011 Jan 18. doi: 10.1371/journal.pbio.1000582

PMCID:: PMC3022534

Abstract Article PDF–3.8M

Select item 284163517.

Ack1 Mediated AKT/PKB Tyrosine 176 Phosphorylation Regulates Its Activation

Kiran Mahajan, Domenico Coppola, Sridevi Challa, Bin Fang, Y. Ann Chen, Weiwei Zhu, Alexis S. Lopez, John Koomen, Robert W. Engelman, Charlene Rivera, Rebecca S. Muraoka-Cook, Jin Q. Cheng, Ernst Schönbrunn, Said M. Sebti, H. Shelton Earp, Nupam P. Mahajan

PLoS One. 2010; 5(3): e9646. Published online 2010 Mar 19. doi: 10.1371/journal.pone.0009646

PMCID:: PMC2841635

Abstract Article PDF–1.8M

Select item 283249418.

HECT E3 Ubiquitin Ligase Nedd4-1 Ubiquitinates ACK and Regulates Epidermal Growth Factor (EGF)-Induced Degradation of EGF Receptor and ACK

Qiong Lin, Jian Wang, Chandra Childress, Marius Sudol, David J. Carey, Wannian Yang

Mol Cell Biol. 2010 Mar; 30(6): 1541–1554. Published online 2010 Jan 19. doi: 10.1128/MCB.00013-10

PMCID:: PMC2832494

Abstract Article PDF–2.6M

Select item 282877519.

Dynamin-1 co-associates with native mouse brain BK_Ca channels: Proteomics analysis of synaptic protein complexes

Giorgio Gorini, Olga Ponomareva, Kevin S. Shores, Maria D. Person, R. Adron Harris, R. Dayne Mayfield

FEBS Lett. Author manuscript; available in PMC 2011 Mar 5.

Published in final edited form as: FEBS Lett. 2010 Mar 5; 584(5): 845–851. Published online 2010 Jan 29. doi: 10.1016/j.febslet.2009.12.061

PMCID:: PMC2828775

Abstract Article PDF–918K

Select item 259068020.

FGD2, a CDC42-specific Exchange Factor Expressed by Antigen-presenting Cells, Localizes to Early Endosomes and Active Membrane Ruffles

Christoph Huber, Annica Mårtensson, Gary M. Bokoch, David Nemazee, Amanda L. Gavin

J Biol Chem. 2008 Dec 5; 283(49): 34002–34012. doi: 10.1074/jbc.M803957200

PMCID:: PMC2590680

Abstract Article PDF–771K

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