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Items: 1 to 20 of 45

1.
Structural basis for the ubiquitination of G protein βγ subunits by KCTD5/Cullin3 E3 ligase
Wentong Jiang, Wei Wang, Yinfei Kong, Sanduo Zheng
Sci Adv. 2023 Jul; 9(28): eadg8369. Published online 2023 Jul 14. doi: 10.1126/sciadv.adg8369
PMCID:
PMC10348674
AbstractArticlePDF–2.3M
2.
OpenCell: proteome-scale endogenous tagging enables the cartography of human cellular organization
Nathan H. Cho, Keith C. Cheveralls, Andreas-David Brunner, Kibeom Kim, André C. Michaelis, Preethi Raghavan, Hirofumi Kobayashi, Laura Savy, Jason Y. Li, Hera Canaj, James Y.S. Kim, Edna M. Stewart, Christian Gnann, Frank McCarthy, Joana P. Cabrera, Rachel M. Brunetti, Bryant B. Chhun, Greg Dingle, Marco Y. Hein, Bo Huang, Shalin B. Mehta, Jonathan S. Weissman, Rafael Gómez-Sjöberg, Daniel N. Itzhak, Loic A. Royer, Matthias Mann, Manuel D. Leonetti
Science. Author manuscript; available in PMC 2022 Sep 11.
Published in final edited form as: Science. 2022 Mar 11; 375(6585): eabi6983. Published online 2022 Mar 11. doi: 10.1126/science.abi6983
PMCID:
PMC9119736
AbstractArticlePDF–3.3M
3.
EZH2 depletion potentiates MYC degradation inhibiting neuroblastoma and small cell carcinoma tumor formation
Liyuan Wang, Chan Chen, Zemin Song, Honghong Wang, Minghui Ye, Donghai Wang, Wenqian Kang, Hudan Liu, Guoliang Qing
Nat Commun. 2022; 13: 12. Published online 2022 Jan 10. doi: 10.1038/s41467-021-27609-6
PMCID:
PMC8748958
AbstractArticlePDF–3.0M
4.
Structural basis for recognition of anti-migraine drug lasmiditan by the serotonin receptor 5-HT1F–G protein complex
Sijie Huang, Peiyu Xu, Yangxia Tan, Chongzhao You, Yumu Zhang, Yi Jiang, H. Eric Xu
Cell Res. 2021 Sep; 31(9): 1036–1038. Published online 2021 Jul 8. doi: 10.1038/s41422-021-00527-4
PMCID:
PMC8410790
ArticlePDF–1.2M
5.
Interference with KCNJ2 inhibits proliferation, migration and EMT progression of apillary thyroid carcinoma cells by upregulating GNG2 expression
Siyuan Chen, Miaoming Huang, Xiarong Hu
Mol Med Rep. 2021 Sep; 24(3): 622. Published online 2021 Jun 30. doi: 10.3892/mmr.2021.12261
PMCID:
PMC8261621
AbstractArticlePDF–11M
6.
Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome
Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi
Cell. Author manuscript; available in PMC 2022 May 27.
Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011
PMCID:
PMC8165030
AbstractArticlePDF–2.2M
7.
Structure of a D2 dopamine receptor-G protein complex in a lipid membrane
Jie Yin, Kuang-Yui M. Chen, Mary J. Clark, Mahdi Hijazi, Punita Kumari, Xiao-chen Bai, Roger K. Sunahara, Patrick Barth, Daniel M. Rosenbaum
Nature. Author manuscript; available in PMC 2020 Dec 11.
Published in final edited form as: Nature. 2020 Aug; 584(7819): 125–129. Published online 2020 Jun 11. doi: 10.1038/s41586-020-2379-5
PMCID:
PMC7415663
AbstractArticlePDF–6.3M
8.
Hepatitis C virus enters liver cells using the CD81 receptor complex proteins calpain-5 and CBLB
Janina Bruening, Lisa Lasswitz, Pia Banse, Sina Kahl, Carine Marinach, Florian W. Vondran, Lars Kaderali, Olivier Silvie, Thomas Pietschmann, Felix Meissner, Gisa Gerold
PLoS Pathog. 2018 Jul; 14(7): e1007111. Published online 2018 Jul 19. doi: 10.1371/journal.ppat.1007111
PMCID:
PMC6053247
AbstractArticlePDF–8.7M
9.
Cryo-EM structure of the serotonin 5-HT1B receptor coupled to heterotrimeric Go
Javier García-Nafría, Rony Nehmé, Patricia C. Edwards, Christopher G. Tate
Nature. Author manuscript; available in PMC 2018 Dec 20.
Published in final edited form as: Nature. 2018 Jun; 558(7711): 620–623. Published online 2018 Jun 20. doi: 10.1038/s41586-018-0241-9
PMCID:
PMC6027989
ArticlePDF–5.7M
10.
Phase-plate cryo-EM structure of a class B GPCR-G protein complex
Yi-Lynn Liang, Maryam Khoshouei, Mazdak Radjainia, Yan Zhang, Alisa Glukhova, Jeffrey Tarrasch, David M Thal, Sebastian G. B. Furness, George Christopoulos, Thomas Coudrat, Radostin Danev, Wolfgang Baumeister, Laurence J. Miller, Arthur Christopoulos, Brian K Kobilka, Denise Wootten, Georgios Skiniotis, Patrick M. Sexton
Nature. Author manuscript; available in PMC 2018 Mar 1.
Published in final edited form as: Nature. 2017 Jun 1; 546(7656): 118–123. Published online 2017 Apr 24. doi: 10.1038/nature22327
PMCID:
PMC5832441
AbstractArticlePDF–2.4M
11.
Architecture of the human interactome defines protein communities and disease networks
Edward L. Huttlin, Raphael J. Bruckner, Joao A. Paulo, Joe R. Cannon, Lily Ting, Kurt Baltier, Greg Colby, Fana Gebreab, Melanie P. Gygi, Hannah Parzen, John Szpyt, Stanley Tam, Gabriela Zarraga, Laura Pontano-Vaites, Sharan Swarup, Anne E. White, Devin K. Schweppe, Ramin Rad, Brian K. Erickson, Robert A. Obar, K.G. Guruharsha, Kejie Li, Spyros Artavanis-Tsakonas, Steven P. Gygi, J. Wade Harper
Nature. Author manuscript; available in PMC 2017 Nov 17.
Published in final edited form as: Nature. 2017 May 25; 545(7655): 505–509. Published online 2017 May 17. doi: 10.1038/nature22366
PMCID:
PMC5531611
AbstractArticlePDF–2.7M
12.
Hypertension-associated C825T polymorphism impairs the function of Gβ3 to target GRK2 ubiquitination
Zhengyu Zha, Xiao-Ran Han, Matthew D Smith, Qun-Ying Lei, Kun-Liang Guan, Yue Xiong
Cell Discov. 2016; 2: 16005. Published online 2016 Apr 26. doi: 10.1038/celldisc.2016.5
PMCID:
PMC4849471
AbstractArticlePDF–876K
13.
X-ray structure of the mammalian GIRK2 – ß? G protein complex
Matthew R. Whorton, Roderick MacKinnon
Nature. Author manuscript; available in PMC 2015 Nov 20.
Published in final edited form as: Nature. 2013 Jun 13; 498(7453): 190–197. Published online 2013 Jun 5. doi: 10.1038/nature12241
PMCID:
PMC4654628
AbstractArticlePDF–2.1M
14.
The BioPlex Network: A Systematic Exploration of the Human Interactome
Edward L. Huttlin, Lily Ting, Raphael J. Bruckner, Fana Gebreab, Melanie P. Gygi, John Szpyt, Stanley Tam, Gabriela Zarraga, Greg Colby, Kurt Baltier, Rui Dong, Virginia Guarani, Laura Pontano Vaites, Alban Ordureau, Ramin Rad, Brian K. Erickson, Martin Wühr, Joel Chick, Bo Zhai, Deepak Kolippakkam, Julian Mintseris, Robert A. Obar, Tim Harris, Spyros Artavanis-Tsakonas, Mathew E. Sowa, Pietro DeCamilli, Joao A. Paulo, J. Wade Harper, Steven P. Gygi
Cell. Author manuscript; available in PMC 2016 Jul 16.
Published in final edited form as: Cell. 2015 Jul 16; 162(2): 425–440. doi: 10.1016/j.cell.2015.06.043
PMCID:
PMC4617211
AbstractArticlePDF–2.2M
15.
A non-canonical function of Gβ as a subunit of E3 ligase in targeting GRK2 ubiquitylation
Zhengyu Zha, Xiaoran Han, Matthew D. Smith, Yang Liu, Patrick M. Giguère, Dragana Kopanja, Pradip Raychaudhuri, David P. Siderovski, Kun-Liang Guan, Qun-Ying Lei, Yue Xiong
Mol Cell. Author manuscript; available in PMC 2016 Jun 4.
Published in final edited form as: Mol Cell. 2015 Jun 4; 58(5): 794–803. Published online 2015 May 14. doi: 10.1016/j.molcel.2015.04.017
PMCID:
PMC4458238
AbstractArticlePDF–4.0M
16.
G-protein βγ subunits are positive regulators of Kv7.4 and native vascular Kv7 channel activity
Jennifer B. Stott, Oleksandr V. Povstyan, Georgina Carr, Vincenzo Barrese, Iain A. Greenwood
Proc Natl Acad Sci U S A. 2015 May 19; 112(20): 6497–6502. Published online 2015 May 4. doi: 10.1073/pnas.1418605112
PMCID:
PMC4443360
AbstractArticlePDF–1.2M
17.
A genome-wide gene–environment interaction analysis for tobacco smoke and lung cancer susceptibility
Ruyang Zhang, Minjie Chu, Yang Zhao, Chen Wu, Huan Guo, Yongyong Shi, Juncheng Dai, Yongyue Wei, Guangfu Jin, Hongxia Ma, Jing Dong, Honggang Yi, Jianling Bai, Jianhang Gong, Chongqi Sun, Meng Zhu, Tangchun Wu, Zhibin Hu, Dongxin Lin, Hongbing Shen, Feng Chen
Carcinogenesis. 2014 Jul; 35(7): 1528–1535. Published online 2014 Mar 22. doi: 10.1093/carcin/bgu076
PMCID:
PMC4076813
AbstractArticlePDF–1.2M
18.
The Gβ3 splice variant associated with the C825T gene polymorphism is an unstable and functionally inactive protein
Zhizeng Sun, Caitlin Runne, Xiaoyun Tang, Fang Lin, Songhai Chen
Cell Signal. Author manuscript; available in PMC 2013 Dec 1.
Published in final edited form as: Cell Signal. 2012 Dec; 24(12): 2349–2359. Published online 2012 Aug 30. doi: 10.1016/j.cellsig.2012.08.011
PMCID:
PMC3771542
AbstractArticlePDF–3.3M
19.
Genome-wide association studies identify several new loci associated with pigmentation traits and skin cancer risk in European Americans
Mingfeng Zhang, Fengju Song, Liming Liang, Hongmei Nan, Jiangwen Zhang, Hongliang Liu, Li-E. Wang, Qingyi Wei, Jeffrey E. Lee, Christopher I. Amos, Peter Kraft, Abrar A. Qureshi, Jiali Han
Hum Mol Genet. 2013 Jul 15; 22(14): 2948–2959. Published online 2013 Apr 1. doi: 10.1093/hmg/ddt142
PMCID:
PMC3690971
AbstractArticlePDF–208K
20.
Topography of Gng2- and NetrinG2-Expression Suggests an Insular Origin of the Human Claustrum
Andrea Pirone, Bruno Cozzi, Larry Edelstein, Antonella Peruffo, Carla Lenzi, Francesca Quilici, Rita Antonini, Maura Castagna
PLoS One. 2012; 7(9): e44745. Published online 2012 Sep 5. doi: 10.1371/journal.pone.0044745
PMCID:
PMC3434180
AbstractArticlePDF–518K

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