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Select item 112115351.

The F-box protein FBXL-5 governs vitellogenesis and lipid homeostasis in C. elegans

Peter C. Breen, Kendall G. Kanakanui, Martin A. Newman, Robert H. Dowen

Front Cell Dev Biol. 2024; 12: 1389077. Published online 2024 Jun 14. doi: 10.3389/fcell.2024.1389077

PMCID:: PMC11211535

Abstract Article PDF–3.0M

Select item 110199322.

LPD-3 as a megaprotein brake for aging and insulin-mTOR signaling in C. elegans

Taruna Pandey, Bingying Wang, Changnan Wang, Jenny Zu, Huichao Deng, Kang Shen, Goncalo Dias do Vale, Jeffrey G. McDonald, Dengke K. Ma

Cell Rep. Author manuscript; available in PMC 2024 Apr 16.

Published in final edited form as: Cell Rep. 2024 Mar 26; 43(3): 113899. Published online 2024 Mar 5. doi: 10.1016/j.celrep.2024.113899

PMCID:: PMC11019932

Abstract Article PDF–1.8M

Select item 108351293.

Amino acid and protein specificity of protein fatty acylation in C. elegans

Bingsen Zhang, Yan Yu, Bennett W. Fox, Yinong Liu, Venkatesh P. Thirumalaikumar, Aleksandra Skirycz, Hening Lin, Frank C. Schroeder

Proc Natl Acad Sci U S A. 2024 Jan 30; 121(5): e2307515121. Published online 2024 Jan 22. doi: 10.1073/pnas.2307515121

PMCID:: PMC10835129

Abstract Article PDF–1.4M

Select item 107535864.

GRD-1/PTR-11, the C. elegans hedgehog/patched-like morphogen-receptor pair, modulates developmental rate

Sinclair W. Emans, Armen Yerevanian, Fasih M. Ahsan, Jen F. Rotti, Yifei Zhou, Lucydalila Cedillo, Alexander A. Soukas

Development. 2023 Dec 15; 150(24): dev201974. Published online 2023 Dec 11. doi: 10.1242/dev.201974

PMCID:: PMC10753586

Abstract Article

Select item 107028235.

Metabolic plasticity sustains the robustness of Caenorhabditis elegans embryogenesis

Siyu Chen, Xing Su, Jinglin Zhu, Long Xiao, Yulin Cong, Leilei Yang, Zhuo Du, Xun Huang

EMBO Rep. 2023 Dec; 24(12): e57440. Published online 2023 Oct 27. doi: 10.15252/embr.202357440

PMCID:: PMC10702823

Abstract Article PDF–9.5M

Select item 99920956.

A BORC-dependent molecular pathway for vesiculation of cell corpse phagolysosomes

Gholamreza Fazeli, Roni Levin-Konigsberg, Michael C. Bassik, Christian Stigloher, Ann M. Wehman

Curr Biol. Author manuscript; available in PMC 2024 Feb 27.

Published in final edited form as: Curr Biol. 2023 Feb 27; 33(4): 607–621.e7. Published online 2023 Jan 17. doi: 10.1016/j.cub.2022.12.041

PMCID:: PMC9992095

Abstract Article PDF–2.5M

Select item 98854407.

Intracellular lipid surveillance by small G protein geranylgeranylation

Abigail Watterson, Lexus Tatge, Naureen Wajahat, Sonja L. B. Arneaud, Rene Solano Fonseca, Shaghayegh T. Beheshti, Patrick Metang, Melina Mihelakis, Kielen R. Zuurbier, Chase D. Corley, Ishmael Dehghan, Jeffrey G. McDonald, Peter M. Douglas

Nature. Author manuscript; available in PMC 2023 Jan 30.

Published in final edited form as: Nature. 2022 May; 605(7911): 736–740. Published online 2022 May 18. doi: 10.1038/s41586-022-04729-7

PMCID:: PMC9885440

Abstract Article PDF–4.2M

Select item 90361188.

The TORC1 phosphoproteome in C. elegans reveals roles in transcription and autophagy

Aileen K. Sewell, Zachary C. Poss, Christopher C. Ebmeier, Jeremy R. Jacobsen, William M. Old, Min Han

iScience. 2022 May 20; 25(5): 104186. Published online 2022 Mar 31. doi: 10.1016/j.isci.2022.104186

PMCID:: PMC9036118

Abstract Article PDF–2.4M

Select item 89537239.

Anabolic Function Downstream of TOR Controls Trade-offs Between Longevity and Reproduction at the Level of Specific Tissues in C. elegans

Amber C. Howard, Dilawar Mir, Santina Snow, Jordan Horrocks, Hussein Sayed, Zhengxin Ma, Aric N. Rogers

Front Aging. 2021; 2: 725068. Published online 2021 Sep 10. doi: 10.3389/fragi.2021.725068

PMCID:: PMC8953723

Abstract Article PDF–2.1M

Select item 885722610.

ATF-4 and hydrogen sulfide signalling mediate longevity in response to inhibition of translation or mTORC1

Cyril Statzer, Jin Meng, Richard Venz, Monet Bland, Stacey Robida-Stubbs, Krina Patel, Dunja Petrovic, Raffaella Emsley, Pengpeng Liu, Ianessa Morantte, Cole Haynes, William B. Mair, Alban Longchamp, Milos R. Filipovic, T. Keith Blackwell, Collin Y. Ewald

Nat Commun. 2022; 13: 967. Published online 2022 Feb 18. doi: 10.1038/s41467-022-28599-9

PMCID:: PMC8857226

Abstract Article PDF–2.5M

Select item 852071311.

Increased mitochondrial calcium uptake and concomitant mitochondrial activity by presenilin loss promotes mTORC1 signaling to drive neurodegeneration

Kerry C. Ryan, Zahra Ashkavand, Shaarika Sarasija, Jocelyn T. Laboy, Rohan Samarakoon, Kenneth R. Norman

Aging Cell. 2021 Oct; 20(10): e13472. Published online 2021 Sep 9. doi: 10.1111/acel.13472

PMCID:: PMC8520713

Abstract Article PDF–1.6M

Select item 844257512.

Insulin/IGF-1 signaling and heat stress differentially regulate HSF1 activities in germline development

Stacey L. Edwards, Purevsuren Erdenebat, Allison C. Morphis, Lalit Kumar, Lai Wang, Tomasz Chamera, Constantin Georgescu, Jonathan D. Wren, Jian Li

Cell Rep. Author manuscript; available in PMC 2021 Sep 15.

Published in final edited form as: Cell Rep. 2021 Aug 31; 36(9): 109623. doi: 10.1016/j.celrep.2021.109623

PMCID:: PMC8442575

Abstract Article PDF–1.5M

Select item 621659013.

OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes

Woojin Kim, Ryan S. Underwood, Iva Greenwald, Daniel D. Shaye

Genetics. 2018 Oct; 210(2): 445–461. Published online 2018 Aug 17. doi: 10.1534/genetics.118.301307

PMCID:: PMC6216590

Abstract Article PDF–1.4M

Select item 581983214.

Rictor/TORC2 mediates gut-to-brain signaling in the regulation of phenotypic plasticity in C. elegans

Michael P. O’Donnell, Pin-Hao Chao, Jan E. Kammenga, Piali Sengupta

PLoS Genet. 2018 Feb; 14(2): e1007213. Published online 2018 Feb 7. doi: 10.1371/journal.pgen.1007213

PMCID:: PMC5819832

Abstract Article PDF–11M

Select item 544463215.

The intestinal TORC2 signaling pathway contributes to associative learning in Caenorhabditis elegans

Naoko Sakai, Hayao Ohno, Masahiro Tomioka, Yuichi Iino

PLoS One. 2017; 12(5): e0177900. Published online 2017 May 25. doi: 10.1371/journal.pone.0177900

PMCID:: PMC5444632

Abstract Article PDF–2.8M

Select item 476915216.

Angiotensin Converting Enzyme (ACE) Inhibitor Extends Caenorhabditis elegans Life Span

Sandeep Kumar, Nicholas Dietrich, Kerry Kornfeld

PLoS Genet. 2016 Feb; 12(2): e1005866. Published online 2016 Feb 26. doi: 10.1371/journal.pgen.1005866

PMCID:: PMC4769152

Abstract Article PDF–5.0M

Select item 418043717.

Prohibitin-Mediated Lifespan and Mitochondrial Stress Implicate SGK-1, Insulin/IGF and mTORC2 in C. elegans

Roxani Gatsi, Bettina Schulze, María Jesús Rodríguez-Palero, Blanca Hernando-Rodríguez, Ralf Baumeister, Marta Artal-Sanz

PLoS One. 2014; 9(9): e107671. Published online 2014 Sep 29. doi: 10.1371/journal.pone.0107671

PMCID:: PMC4180437

Abstract Article PDF–1.4M

Select item 417265618.

mTORC2-SGK-1 acts in two environmentally responsive pathways with opposing effects on longevity

Masaki Mizunuma, Elke Neumann-Haefelin, Natalie Moroz, Yujie Li, T Keith Blackwell

Aging Cell. 2014 Oct; 13(5): 869–878. Published online 2014 Jul 9. doi: 10.1111/acel.12248

PMCID:: PMC4172656

Abstract Article PDF–390K

Select item 387777119.

TORC2 signaling antagonizes SKN-1 to induce C. elegans mesendodermal embryonic development

Vanessa Ruf, Christina Holzem, Tobias Peyman, Gerd Walz, T. Keith Blackwell, Elke Neumann-Haefelin

Dev Biol. Author manuscript; available in PMC 2014 Dec 15.

Published in final edited form as: Dev Biol. 2013 Dec 15; 384(2): 10.1016/j.ydbio.2013.08.011. Published online 2013 Aug 20. doi: 10.1016/j.ydbio.2013.08.011