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Select item 109176601.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 90345492.

Genome-wide CRISPR screen identified Rad18 as a determinant of doxorubicin sensitivity in osteosarcoma

Mingrui Du, Jintao Gu, Chenlin Liu, Nannan Liu, Zhe Yu, Chengpei Zhou, Wei Heng, Zhengcong Cao, Feilong Wei, Kailong Zhu, Yingwen Wang, Wei Zhang, Xiaochang Xue, Yong Zhang, Jixian Qian

J Exp Clin Cancer Res. 2022; 41: 154. Published online 2022 Apr 23. doi: 10.1186/s13046-022-02344-y

PMCID:: PMC9034549

Abstract Article PDF–5.6M

Select item 64595103.

Mouse screen reveals multiple new genes underlying mouse and human hearing loss

Neil J. Ingham, Selina A. Pearson, Valerie E. Vancollie, Victoria Rook, Morag A. Lewis, Jing Chen, Annalisa Buniello, Elisa Martelletti, Lorenzo Preite, Chi Chung Lam, Felix D. Weiss, Zӧe Powis, Pim Suwannarat, Christopher J. Lelliott, Sally J. Dawson, Jacqueline K. White, Karen P. Steel

PLoS Biol. 2019 Apr; 17(4): e3000194. Published online 2019 Apr 11. doi: 10.1371/journal.pbio.3000194

PMCID:: PMC6459510

Abstract Article PDF–5.1M

Select item 48720844.

Rad18 confers hematopoietic progenitor cell DNA damage tolerance independently of the Fanconi Anemia pathway in vivo

Yang Yang, Jonathan C. Poe, Lisong Yang, Andrew Fedoriw, Siddhi Desai, Terry Magnuson, Zhiguo Li, Yuri Fedoriw, Kimi Araki, Yanzhe Gao, Satoshi Tateishi, Stefanie Sarantopoulos, Cyrus Vaziri

Nucleic Acids Res. 2016 May 19; 44(9): 4174–4188. Published online 2016 Feb 15. doi: 10.1093/nar/gkw072

PMCID:: PMC4872084

Abstract Article PDF–9.0M

Select item 43262755.

RAD18 Activates the G2/M Checkpoint through DNA Damage Signaling to Maintain Genome Integrity after Ionizing Radiation Exposure

Megumi Sasatani, Yanbin Xu, Hidehiko Kawai, Lili Cao, Satoshi Tateishi, Tsutomu Shimura, Jianxiang Li, Daisuke Iizuka, Asao Noda, Kanya Hamasaki, Yoichiro Kusunoki, Kenji Kamiya

PLoS One. 2015; 10(2): e0117845. Published online 2015 Feb 12. doi: 10.1371/journal.pone.0117845

PMCID:: PMC4326275

Abstract Article PDF–885K

Select item 42076186.

Identification of Genes Important for Cutaneous Function Revealed by a Large Scale Reverse Genetic Screen in the Mouse

Tia DiTommaso, Lynelle K. Jones, Denny L. Cottle, The WTSI Mouse Genetics Program, Anna-Karin Gerdin, Valerie E. Vancollie, Fiona M. Watt, Ramiro Ramirez-Solis, Allan Bradley, Karen P. Steel, John P. Sundberg, Jacqueline K. White, Ian M. Smyth

PLoS Genet. 2014 Oct; 10(10): e1004705. Published online 2014 Oct 23. doi: 10.1371/journal.pgen.1004705

PMCID:: PMC4207618

Abstract Article PDF–1.8M

Select item 41077947.

DNA damage-specific deubiquitination regulates Rad18 functions to suppress mutagenesis

Michelle K. Zeman, Jia-Ren Lin, Raimundo Freire, Karlene A. Cimprich

J Cell Biol. 2014 Jul 21; 206(2): 183–197. doi: 10.1083/jcb.201311063

PMCID:: PMC4107794

Abstract Article PDF–3.2M

Select item 40074038.

Histopathology reveals correlative and unique phenotypes in a high-throughput mouse phenotyping screen

Hibret A. Adissu, Jeanne Estabel, David Sunter, Elizabeth Tuck, Yvette Hooks, Damian M. Carragher, Kay Clarke, Natasha A. Karp, Sanger Mouse Genetics Project, Susan Newbigging, Nora Jones, Lily Morikawa, Jacqueline K. White, Colin McKerlie

Dis Model Mech. 2014 May; 7(5): 515–524. Published online 2014 Mar 20. doi: 10.1242/dmm.015263

PMCID:: PMC4007403

Abstract Article

Select item 39965429.

Novel skin phenotypes revealed by a genome-wide mouse reverse genetic screen

Kifayathullah Liakath-Ali, Valerie E. Vancollie, Emma Heath, Damian P. Smedley, Jeanne Estabel, David Sunter, Tia DiTommaso, Jacqueline K. White, Ramiro Ramirez-Solis, Ian Smyth, Karen P. Steel, Fiona M. Watt

Nat Commun. 2014 Apr 11; 5: 3540. Published online 2014 Apr 11. doi: 10.1038/ncomms4540

PMCID:: PMC3996542

Abstract Article PDF–4.0M

Select item 357241010.

A conditional knockout resource for the genome–wide study of mouse gene function

William C. Skarnes, Barry Rosen, Anthony P. West, Manousos Koutsourakis, Wendy Bushell, Vivek Iyer, Alejandro O. Mujica, Mark Thomas, Jennifer Harrow, Tony Cox, David Jackson, Jessica Severin, Patrick Biggs, Jun Fu, Michael Nefedov, Pieter J. de Jong, A. Francis Stewart, Allan Bradley

Nature. Author manuscript; available in PMC 2013 Feb 14.

Published in final edited form as: Nature. 2011 Jun 15; 474(7351): 337–342. Published online 2011 Jun 15. doi: 10.1038/nature10163

PMCID:: PMC3572410

Abstract Article PDF–1.1M

Select item 321322911.

Meiotic functions of RAD18

Akiko Inagaki, Esther Sleddens-Linkels, Evelyne Wassenaar, Marja Ooms, Wiggert A. van Cappellen, Jan H. J. Hoeijmakers, Jost Seibler, Thomas F. Vogt, Myung K. Shin, J. Anton Grootegoed, Willy M. Baarends

J Cell Sci. 2011 Aug 15; 124(16): 2837–2850. doi: 10.1242/jcs.081968

PMCID:: PMC3213229

Abstract Article

Select item 317805912.

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas

Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042

PMCID:: PMC3178059

Abstract Article PDF–1.0M

Select item 302253413.

A High-Resolution Anatomical Atlas of the Transcriptome in the Mouse Embryo

Graciana Diez-Roux, Sandro Banfi, Marc Sultan, Lars Geffers, Santosh Anand, David Rozado, Alon Magen, Elena Canidio, Massimiliano Pagani, Ivana Peluso, Nathalie Lin-Marq, Muriel Koch, Marchesa Bilio, Immacolata Cantiello, Roberta Verde, Cristian De Masi, Salvatore A. Bianchi, Juliette Cicchini, Elodie Perroud, Shprese Mehmeti, Emilie Dagand, Sabine Schrinner, Asja Nürnberger, Katja Schmidt, Katja Metz, Christina Zwingmann, Norbert Brieske, Cindy Springer, Ana Martinez Hernandez, Sarah Herzog, Frauke Grabbe, Cornelia Sieverding, Barbara Fischer, Kathrin Schrader, Maren Brockmeyer, Sarah Dettmer, Christin Helbig, Violaine Alunni, Marie-Annick Battaini, Carole Mura, Charlotte N. Henrichsen, Raquel Garcia-Lopez, Diego Echevarria, Eduardo Puelles, Elena Garcia-Calero, Stefan Kruse, Markus Uhr, Christine Kauck, Guangjie Feng, Nestor Milyaev, Chuang Kee Ong, Lalit Kumar, MeiSze Lam, Colin A. Semple, Attila Gyenesei, Stefan Mundlos, Uwe Radelof, Hans Lehrach, Paolo Sarmientos, Alexandre Reymond, Duncan R. Davidson, Pascal Dollé, Stylianos E. Antonarakis, Marie-Laure Yaspo, Salvador Martinez, Richard A. Baldock, Gregor Eichele, Andrea Ballabio

PLoS Biol. 2011 Jan; 9(1): e1000582. Published online 2011 Jan 18. doi: 10.1371/journal.pbio.1000582

PMCID:: PMC3022534

Abstract Article PDF–3.8M

Select item 268980814.

Diminished Pancreatic β-Cell Mass in Securin-Null Mice Is Caused by β-Cell Apoptosis and Senescence

Vera Chesnokova, Chris Wong, Svetlana Zonis, Anna Gruszka, Kolja Wawrowsky, Song-Guang Ren, Anat BenShlomo, Run Yu

Endocrinology. 2009 Jun; 150(6): 2603–2610. Published online 2009 Feb 12. doi: 10.1210/en.2008-0972

PMCID:: PMC2689808

Abstract Article

Select item 267342815.

RAD18 promotes DNA double-strand break repair during G1 phase through chromatin retention of 53BP1

Kenji Watanabe, Kuniyoshi Iwabuchi, Jinghua Sun, Yuri Tsuji, Tokio Tani, Kazuaki Tokunaga, Takayasu Date, Mitsumasa Hashimoto, Masaru Yamaizumi, Satoshi Tateishi

Nucleic Acids Res. 2009 Apr; 37(7): 2176–2193. Published online 2009 Feb 19. doi: 10.1093/nar/gkp082

PMCID:: PMC2673428

Abstract Article PDF–13M

Select item 255627016.

Large-scale gene trapping in C57BL/6N mouse embryonic stem cells

Gwenn M. Hansen, Diane C. Markesich, Michael B. Burnett, Qichao Zhu, Karen M. Dionne, Lizabeth J. Richter, Richard H. Finnell, Arthur T. Sands, Brian P. Zambrowicz, Alejandro Abuin

Genome Res. 2008 Oct; 18(10): 1670–1679. doi: 10.1101/gr.078352.108

PMCID:: PMC2556270

Abstract Article PDF–493K

Select item 203448517.

Functional characterization of Rad18 domains for Rad6, ubiquitin, DNA binding and PCNA modification

Valerie Notenboom, Richard G. Hibbert, Sarah E. van Rossum-Fikkert, Jesper V. Olsen, Matthias Mann, Titia K. Sixma

Nucleic Acids Res. 2007 Sep; 35(17): 5819–5830. Published online 2007 Aug 24. doi: 10.1093/nar/gkm615

PMCID:: PMC2034485

Abstract Article PDF–8.8M

Select item 146301718.

Effect of DNA Repair Protein Rad18 on Viral Infection

Aliza G Lloyd, Satoshi Tateishi, Paul D Bieniasz, Mark A Muesing, Masaru Yamaizumi, Lubbertus C. F Mulder

PLoS Pathog. 2006 May; 2(5): e40. Published online 2006 May 19. doi: 10.1371/journal.ppat.0020040

PMCID:: PMC1463017

Abstract Article PDF–120K

Select item 144742119.

Rad18 Regulates DNA Polymerase κ and Is Required for Recovery from S-Phase Checkpoint-Mediated Arrest

Xiaohui Bi, Laura R. Barkley, Damien M. Slater, Satoshi Tateishi, Masaru Yamaizumi, Haruo Ohmori, Cyrus Vaziri

Mol Cell Biol. 2006 May; 26(9): 3527–3540. doi: 10.1128/MCB.26.9.3527-3540.2006

PMCID:: PMC1447421

Abstract Article PDF–586K

Select item 54399720.

Silencing of Unpaired Chromatin and Histone H2A Ubiquitination in Mammalian Meiosis

Willy M. Baarends, Evelyne Wassenaar, Roald van der Laan, Jos Hoogerbrugge, Esther Sleddens-Linkels, Jan H. J. Hoeijmakers, Peter de Boer, J. Anton Grootegoed

Mol Cell Biol. 2005 Feb; 25(3): 1041–1053. doi: 10.1128/MCB.25.3.1041-1053.2005

PMCID:: PMC543997

Abstract Article PDF–1.6M

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