PMC Links for GEO Profiles (Select 117392925) - PMC

Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan

Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233

PMCID:: PMC10237422

Abstract Article PDF–23M

Select item 96648184.

PHLPP isoforms differentially regulate Akt isoforms and AS160 affecting neuronal insulin signaling and insulin resistance via Scribble

Medha Sharma, Chinmoy Sankar Dey

Cell Commun Signal. 2022; 20: 179. Published online 2022 Nov 14. doi: 10.1186/s12964-022-00987-0

PMCID:: PMC9664818

Abstract Article PDF–3.9M

Select item 85235185.

Downregulation of PHLPP induced by endoplasmic reticulum stress promotes eIF2α phosphorylation and chemoresistance in colon cancer

Bianqin Guo, Xiaopeng Xiong, Sumati Hasani, Yang-An Wen, Austin T. Li, Rebecca Martinez, Ashley T. Skaggs, Tianyan Gao

Cell Death Dis. 2021 Nov; 12(11): 960. Published online 2021 Oct 18. doi: 10.1038/s41419-021-04251-0

PMCID:: PMC8523518

Abstract Article PDF–2.5M

Select item 85081166.

PMEPA1/TMEPAI Is a Unique Tumorigenic Activator of AKT Promoting Proteasomal Degradation of PHLPP1 in Triple-Negative Breast Cancer Cells

Md. Anwarul Haque, Mohammed Abdelaziz, Meidi Utami Puteri, Thanh Thao Vo Nguyen, Kosei Kudo, Yukihide Watanabe, Mitsuyasu Kato

Cancers (Basel) 2021 Oct; 13(19): 4934. Published online 2021 Sep 30. doi: 10.3390/cancers13194934

PMCID:: PMC8508116

Abstract Article PDF–7.4M

Select item 84210187.

Inhibition of PHLPP1/2 phosphatases rescues pancreatic β-cells in diabetes

Blaz Lupse, Karthika Annamalai, Hazem Ibrahim, Supreet Kaur, Shirin Geravandi, Bhavishya Sarma, Anasua Pal, Sushil Awal, Arundhati Joshi, Sahar Rafizadeh, Murali Krishna Madduri, Mona Khazaei, Huan Liu, Ting Yuan, Wei He, Kanaka Durga Devi Gorrepati, Zahra Azizi, Qi Qi, Keqiang Ye, Jose Oberholzer, Kathrin Maedler, Amin Ardestani

Cell Rep. Author manuscript; available in PMC 2021 Sep 6.

Published in final edited form as: Cell Rep. 2021 Aug 3; 36(5): 109490. doi: 10.1016/j.celrep.2021.109490

PMCID:: PMC8421018

Abstract Article PDF–3.1M

Select item 83145478.

SNX27-driven membrane localisation of OTULIN antagonises linear ubiquitination and NF-κB signalling activation

Ruona Shi, Xue Shi, Dajiang Qin, Shibing Tang, Michiel Vermeulen, Xiaofei Zhang

Cell Biosci. 2021; 11: 146. Published online 2021 Jul 27. doi: 10.1186/s13578-021-00659-5

PMCID:: PMC8314547

Abstract Article PDF–3.7M

Select item 81650309.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 808827410.

The PHLPP1 N-Terminal Extension Is a Mitotic Cdk1 Substrate and Controls an Interactome Switch

Agnieszka T. Kawashima, Cassandra Wong, Gema Lordén, Charles C. King, Pablo Lara-Gonzalez, Arshad Desai, Anne-Claude Gingras, Alexandra C. Newton

Mol Cell Biol. 2021 Mar; 41(3): e00333-20. Prepublished online 2021 Jan 4. Published online 2021 Feb 23. doi: 10.1128/MCB.00333-20

PMCID:: PMC8088274

Abstract Article PDF–3.1M

Select item 756688111.

Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism

Michael Aregger, Keith A. Lawson, Maximillian Billmann, Michael Costanzo, Amy H. Y. Tong, Katherine Chan, Mahfuzur Rahman, Kevin R. Brown, Catherine Ross, Matej Usaj, Lucy Nedyalkova, Olga Sizova, Andrea Habsid, Judy Pawling, Zhen-Yuan Lin, Hala Abdouni, Cassandra J. Wong, Alexander Weiss, Patricia Mero, James W. Dennis, Anne-Claude Gingras, Chad L. Myers, Brenda J. Andrews, Charles Boone, Jason Moffat

Nat Metab. Author manuscript; available in PMC 2020 Dec 1.

Published in final edited form as: Nat Metab. 2020 Jun; 2(6): 499–513. Published online 2020 Jun 1. doi: 10.1038/s42255-020-0211-z

PMCID:: PMC7566881

Abstract Article PDF–4.8M

Select item 753240212.

USP46 Inhibits Cell Proliferation in Lung Cancer through PHLPP1/AKT Pathway

Wei Wang, Meng Chen, Hailing Xu, Dongqing Lv, Suna Zhou, Haihua Yang

Biomed Res Int. 2020; 2020: 2509529. Published online 2020 Sep 23. doi: 10.1155/2020/2509529

PMCID:: PMC7532402

Abstract Article PDF–1.0M

Select item 730946313.

Heat shock protein 47 promotes tumor survival and therapy resistance by modulating AKT signaling via PHLPP1 in colorectal cancer

Yijye Chern, Peter Zhang, Hyelim Ju, Isabella T. Tai

Cancer Biol Med. 2020 May 15; 17(2): 343–356. Published online 2020 May 15. doi: 10.20892/j.issn.2095-3941.2019.0261

PMCID:: PMC7309463

Abstract Article PDF–1.2M

Select item 677655314.

Phlpp1 is associated with human intervertebral disc degeneration and its deficiency promotes healing after needle puncture injury in mice

Changli Zhang, Madeline P. Smith, George K. Zhou, Alon Lai, Robert C. Hoy, Victoria Mroz, Olivia M. Torre, Damien M. Laudier, Elizabeth W. Bradley, Jennifer J. Westendorf, James C. Iatridis, Svenja Illien-Jünger

Cell Death Dis. 2019 Oct; 10(10): 754. Published online 2019 Oct 3. doi: 10.1038/s41419-019-1985-3

PMCID:: PMC6776553

Abstract Article PDF–3.9M

Select item 650454915.

Protein Kinase C Quality Control by Phosphatase PHLPP1 Unveils Loss-of-Function Mechanism in Cancer

Timothy R. Baffi, An-Angela N. Van, Wei Zhao, Gordon B. Mills, Alexandra C. Newton

Mol Cell. Author manuscript; available in PMC 2020 Apr 18.

Published in final edited form as: Mol Cell. 2019 Apr 18; 74(2): 378–392.e5. Published online 2019 Mar 20. doi: 10.1016/j.molcel.2019.02.018

PMCID:: PMC6504549

Article PDF–2.8M

Select item 645054616.

PHLPP1 mediates melanoma metastasis suppression through repressing AKT2 activation

Yanlin Yu, Meng Dai, Andrew Lu, Ellen Yu, Glenn Merlino

Oncogene. Author manuscript; available in PMC 2019 Apr 5.

Published in final edited form as: Oncogene. 2018 Apr; 37(17): 2225–2236. Published online 2018 Feb 2. doi: 10.1038/s41388-017-0061-7

PMCID:: PMC6450546

Abstract Article PDF–985K

Select item 620092317.

The tuberous sclerosis complex subunit TBC1D7 is stabilized by Akt phosphorylation–mediated 14-3-3 binding

James P. Madigan, Feng Hou, Linlei Ye, Jicheng Hu, Aiping Dong, Wolfram Tempel, Marielle E. Yohe, Paul A. Randazzo, Lisa M. Miller Jenkins, Michael M. Gottesman, Yufeng Tong

J Biol Chem. 2018 Oct 19; 293(42): 16142–16159. Published online 2018 Aug 24. doi: 10.1074/jbc.RA118.003525

PMCID:: PMC6200923

Abstract Article PDF–3.4M

Select item 616668218.

Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei

Domenico Fasci, Hugo van Ingen, Richard A. Scheltema, Albert J. R. Heck

Mol Cell Proteomics. 2018 Oct; 17(10): 2018–2033. Published online 2018 Jul 18. doi: 10.1074/mcp.RA118.000924

PMCID:: PMC6166682

Abstract Article PDF–3.8M

Select item 582692619.

VIRMA mediates preferential m⁶A mRNA methylation in 3′UTR and near stop codon and associates with alternative polyadenylation

Yanan Yue, Jun Liu, Xiaolong Cui, Jie Cao, Guanzheng Luo, Zezhou Zhang, Tao Cheng, Minsong Gao, Xiao Shu, Honghui Ma, Fengqin Wang, Xinxia Wang, Bin Shen, Yizhen Wang, Xinhua Feng, Chuan He, Jianzhao Liu

Cell Discov. 2018; 4: 10. Published online 2018 Feb 27. doi: 10.1038/s41421-018-0019-0

PMCID:: PMC5826926

Abstract Article PDF–2.3M

Select item 578357220.

PHLPPing through History: A Decade in the Life of PHLPP Phosphatases

Agnieszka T. Grzechnik, Alexandra C. Newton

Biochem Soc Trans. Author manuscript; available in PMC 2018 Jan 24.

Published in final edited form as: Biochem Soc Trans. 2016 Dec 15; 44(6): 1675–1682. doi: 10.1042/BST20160170

PMCID:: PMC5783572

Abstract Article PDF–503K

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