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Select item 115877671.

Human hepatocyte PNPLA3 148M exacerbates rapid non-alcoholic fatty liver disease development in chimeric mice

Mohammad Kabbani, Eleftherios Michailidis, Sandra Steensels, Clifton G. Fulmer, Joseph M. Luna, Jérémie Le Pen, Matteo Tardelli, Brandon Razooky, Inna Ricardo-Lax, Chenhui Zou, Briana Zeck, Ansgar F. Stenzel, Corrine Quirk, Lander Foquet, Alison W. Ashbrook, William M. Schneider, Serkan Belkaya, Gadi Lalazar, Yupu Liang, Meredith Pittman, Lindsey Devisscher, Hiroshi Suemizu, Neil D. Theise, Luis Chiriboga, David E. Cohen, Robert Copenhaver, Markus Grompe, Philip Meuleman, Baran A. Ersoy, Charles M. Rice, Ype P. de Jong

Cell Rep. Author manuscript; available in PMC 2024 Nov 25.

Published in final edited form as: Cell Rep. 2022 Sep 13; 40(11): 111321. doi: 10.1016/j.celrep.2022.111321

PMCID:: PMC11587767

Abstract Article PDF–5.2M

Select item 115782862.

Ambient air pollution exposure is associated with liver fat and stiffness in Latino youth with a more pronounced effect in those with PNPLA3 genotype and more advanced liver disease

Rachel B. Schenker, Christopher J. Machle, Hooman Allayee, Fredrick Lurmann, William B. Patterson, Rohit Kohli, Michael I. Goran, Tanya L. Alderete

Ecotoxicol Environ Saf. Author manuscript; available in PMC 2024 Nov 20.

Published in final edited form as: Ecotoxicol Environ Saf. 2024 Nov 1; 286: 117234. Published online 2024 Oct 24. doi: 10.1016/j.ecoenv.2024.117234

PMCID:: PMC11578286

Abstract Article PDF–730K

Select item 114972573.

Modeling PNPLA3‐Associated NAFLD Using Human‐Induced Pluripotent Stem Cells

Samantha G. Tilson, Carola M. Morell, An‐Sofie Lenaerts, Seung Bum Park, Zongyi Hu, Benjamin Jenkins, Albert Koulman, T. Jake Liang, Ludovic Vallier

Hepatology. 2021 Dec; 74(6): 2998–3017. Published online 2021 Sep 27. doi: 10.1002/hep.32063

PMCID:: PMC11497257

Abstract Article PDF–1.7M

Select item 114309404.

Epidemiological Study on the Interaction between the PNPLA3 (rs738409) and Gut Microbiota in Metabolic Dysfunction-Associated Steatotic Liver Disease

Satoshi Sato, Chikara Iino, Takafumi Sasada, Go Soma, Keisuke Furusawa, Kenta Yoshida, Kaori Sawada, Tatsuya Mikami, Shigeyuki Nakaji, Hirotake Sakuraba, Shinsaku Fukuda

Genes (Basel) 2024 Sep; 15(9): 1172. Published online 2024 Sep 6. doi: 10.3390/genes15091172

PMCID:: PMC11430940

Abstract Article PDF–3.9M

Select item 112425445.

A PNPLA3-Deficient iPSC-Derived Hepatocyte Screen Identifies Pathways to Potentially Reduce Steatosis in Metabolic Dysfunction-Associated Fatty Liver Disease

Caren Doueiry, Christiana S. Kappler, Carla Martinez-Morant, Stephen A. Duncan

Int J Mol Sci. 2024 Jul; 25(13): 7277. Published online 2024 Jul 2. doi: 10.3390/ijms25137277

PMCID:: PMC11242544

Abstract Article PDF–5.8M

Select item 111247116.

PNPLA3 risk allele is associated with risk of hepatocellular carcinoma but not decompensation in compensated cirrhosis

Esteban Urias, Nicholas R. Tedesco, Daniel A. Burkholder, Isabel J. Moran, Matthew J. Miller, Venkata Sai J. Jasty, Snehal Patil, Sebastian Zoellner, Karn Wijarnpreecha, Vincent L. Chen

Hepatol Commun. 2024 Jun; 8(6): e0441. Published online 2024 May 22. doi: 10.1097/HC9.0000000000000441

PMCID:: PMC11124711

Abstract Article PDF–211K

Select item 111247007.

The health care experience of adults with metabolic dysfunction–associated steatohepatitis and influence of PNPLA3: A qualitative study

Jonathan G. Stine, Nenad Medic, Billie Pettersson, Meredith Venerus, Jenny E. Blau

Hepatol Commun. 2024 Jun; 8(6): e0451. Published online 2024 May 22. doi: 10.1097/HC9.0000000000000451

PMCID:: PMC11124700

Abstract Article PDF–314K

Select item 110670378.

The fatty liver disease–causing protein PNPLA3-I148M alters lipid droplet–Golgi dynamics

David J. Sherman, Lei Liu, Jennifer L. Mamrosh, Jiansong Xie, John Ferbas, Brett Lomenick, Mark S. Ladinsky, Rati Verma, Ingrid C. Rulifson, Raymond J. Deshaies

Proc Natl Acad Sci U S A. 2024 Apr 30; 121(18): e2318619121. Published online 2024 Apr 24. doi: 10.1073/pnas.2318619121

PMCID:: PMC11067037

Abstract Article PDF–6.4M

Select item 110549639.

The Role of PNPLA3_rs738409 Gene Variant, Lifestyle Factors, and Bioactive Compounds in Nonalcoholic Fatty Liver Disease: A Population-Based and Molecular Approach towards Healthy Nutrition

Meiling Liu, Sunmin Park

Nutrients. 2024 Apr; 16(8): 1239. Published online 2024 Apr 21. doi: 10.3390/nu16081239

PMCID:: PMC11054963

Abstract Article PDF–2.7M

Select item 1085961410.

Association of liver fibrosis with extrahepatic cancer in steatotic liver disease patients with PNPLA3 I148M GG genotype

Jennifer Tai, Chao‐Wei Hsu, Wei‐Ting Chen, Sien‐Sing Yang, Cheng‐Hsun Chiu, Rong‐Nan Chien, Ming‐Ling Chang

Cancer Sci. 2024 Feb; 115(2): 564–574. Published online 2023 Dec 11. doi: 10.1111/cas.16042

PMCID:: PMC10859614

Abstract Article PDF–820K

Select item 1057909911.

Interaction between estrogen receptor-α and PNPLA3 p.I148M variant drives fatty liver disease susceptibility in women

Alessandro Cherubini, Mahnoosh Ostadreza, Oveis Jamialahmadi, Serena Pelusi, Eniada Rrapaj, Elia Casirati, Giulia Passignani, Marjan Norouziesfahani, Elena Sinopoli, Guido Baselli, Clara Meda, Paola Dongiovanni, Daniele Dondossola, Neil Youngson, Aikaterini Tourna, Shilpa Chokshi, Elisabetta Bugianesi, EPIDEMIC Study Investigators, Sara Della Torre, Daniele Prati, Stefano Romeo, Luca Valenti

Nat Med. 2023; 29(10): 2643–2655. Published online 2023 Sep 25. doi: 10.1038/s41591-023-02553-8

Correction in:: Nat Med. 2024; 30(4): 1212.

PMCID:: PMC10579099

Abstract Article PDF–7.8M

Select item 1055020612.

PNPLA3 genotype and diabetes identify patients with non-alcoholic fatty liver disease at high risk of incident cirrhosis

Vincent L. Chen, Antonino Oliveri, Matthew J. Miller, Karn Wijarnpreecha, Xiaomeng Du, Yanhua Chen, Kelly C. Cushing, Anna S. Lok, Elizabeth K. Speliotes

Gastroenterology. Author manuscript; available in PMC 2024 May 1.

Published in final edited form as: Gastroenterology. 2023 May; 164(6): 966–977.e17. Published online 2023 Feb 7. doi: 10.1053/j.gastro.2023.01.040

PMCID:: PMC10550206

Abstract Article PDF–860K

Select item 1043173813.

The variability of PNPLA3 gene as a potential marker of cold adaptation in Yakuts

Nadezhda Ivanovna Pavlova, Alexey Alexeevich Bochurov, Vladislav Amirovich Alekseev, Lyubov Akhmedovna Sydykova, Vladimir Vladimirovich Dodokhov, Khariton Alekseevich Kurtanov, Alexey Vasilievich Krylov

Int J Circumpolar Health. 2023; 82(1): 2246647. Published online 2023 Aug 15. doi: 10.1080/22423982.2023.2246647

PMCID:: PMC10431738

Abstract Article PDF–1.0M

Select item 1031656314.

Metabolic disorders induced by PNPLA3 and TM6SF2 gene variants affect chronic kidney disease in patients infected with non-genotype 3 hepatitis C virus

Jia Liu, Wenqian Qi, Song Wang, Yonggui Zhang, Xu Wang, Derong Sun, Yanhui Xu, Jingyi Shi, Honglei Duan, Qian Zhang, Hongguang Wang, Jiangbin Wang

Lipids Health Dis. 2023; 22: 91. Published online 2023 Jul 3. doi: 10.1186/s12944-023-01858-4

PMCID:: PMC10316563

Abstract Article PDF–1.7M

Select item 1025326315.

PNPLA3-I148M Variant Promotes the Progression of Liver Fibrosis by Inducing Mitochondrial Dysfunction

Yusong Gou, Lifei Wang, Jinhan Zhao, Xiaoyi Xu, Hangfei Xu, Fang Xie, Yanjun Wang, Yingmei Feng, Jing Zhang, Yang Zhang

Int J Mol Sci. 2023 Jun; 24(11): 9681. Published online 2023 Jun 2. doi: 10.3390/ijms24119681

PMCID:: PMC10253263

Abstract Article PDF–3.7M

Select item 1003196016.

PNPLA3 rs738409 risk genotype decouples TyG index from HOMA2-IR and intrahepatic lipid content

Ákos Nádasdi, Viktor Gál, Tamás Masszi, Anikó Somogyi, Gábor Firneisz

Cardiovasc Diabetol. 2023; 22: 64. Published online 2023 Mar 21. doi: 10.1186/s12933-023-01792-w

PMCID:: PMC10031960

Abstract Article PDF–1.0M

Select item 1002666417.

Association of PNPLA3 SNP With the Development of HBV-related Hepatocellular Carcinoma

HIRAYUKI ENOMOTO, NOBUHIRO AIZAWA, NAOTO IKEDA, TOMOYUKI TAKASHIMA, YUKIHISA YURI, MAMIKO OKAMOTO, RYOTA YOSHIOKA, SHOKI KAWATA, KOHEI YOSHIHARA, SHOGO OTA, RYOTA NAKANO, HIDEYUKI SHIOMI, TAKASHI NISHIMURA, HIROKO IIJIMA

In Vivo. 2023 Mar-Apr; 37(2): 763–770. Published online 2023 Mar 3. doi: 10.21873/invivo.13139

PMCID:: PMC10026664

Abstract Article PDF–660K

Select item 999776718.

Patatin-like phospholipase domain-containing 3 gene (PNPLA3) polymorphic (rs738409) single nucleotide polymorphisms and susceptibility to nonalcoholic fatty liver disease: A meta-analysis of twenty studies

Yan Zhao, Wenli Zhao, Jingchao Ma, Maeda Toshiyoshi, Ye Zhao

Medicine (Baltimore) 2023 Mar 10; 102(10): e33110. Published online 2023 Mar 10. doi: 10.1097/MD.0000000000033110

PMCID:: PMC9997767

Abstract Article PDF–3.1M

Select item 997567919.

Association of PNPLA3 (rs738409) & TM6SF2 (rs58542926) and ATG16L1 (rs2241880) genetic variants with susceptibility to hepatocellular carcinoma in a group of Egyptian patients with HCV-induced liver cirrhosis

Asmaa Mohamed Fteah, Ali Abdel Rahim, Afaf Ahmed AbdelHady, Hanan Shawky, Mohamed A Elrefaiy, Doaa Mamdouh Aly

Tumour Virus Res. 2023 Jun; 15: 200256. Published online 2023 Feb 16. doi: 10.1016/j.tvr.2023.200256

PMCID:: PMC9975679

Article PDF–493K

Select item 989195120.

Different effects of low muscle mass on the risk of non‐alcoholic fatty liver disease and hepatic fibrosis in a prospective cohort

Hun Jee Choe, Hyunsuk Lee, DongHo Lee, Soo‐Heon Kwak, Bo Kyung Koo

J Cachexia Sarcopenia Muscle. 2023 Feb; 14(1): 260–269. Published online 2022 Nov 20. doi: 10.1002/jcsm.13125

PMCID:: PMC9891951

Abstract Article PDF–501K

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