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Select item 101971061.

Loss of PI3k activity of inositol polyphosphate multikinase impairs PDK1-mediated AKT activation, cell migration, and intestinal homeostasis

Luke Reilly, Evan R. Semenza, George Koshkaryan, Subrata Mishra, Sujan Chatterjee, Efrat Abramson, Pamela Mishra, Yoshitasu Sei, Stephen A. Wank, Mark Donowitz, Solomon H. Snyder, Prasun Guha

iScience. 2023 May 19; 26(5): 106623. Published online 2023 Apr 11. doi: 10.1016/j.isci.2023.106623

PMCID:: PMC10197106

Abstract Article PDF–5.4M

Select item 99529072.

miRNA-Induced Downregulation of IPMK in Macrophages Mediates Lipopolysaccharide-Triggered TLR4 Signaling

Haein Lee, Eunha Kim, Seyun Kim

Biomolecules. 2023 Feb; 13(2): 332. Published online 2023 Feb 9. doi: 10.3390/biom13020332

PMCID:: PMC9952907

Abstract Article PDF–5.1M

Select item 95793293.

Gut Epithelial Inositol Polyphosphate Multikinase Alleviates Experimental Colitis via Governing Tuft Cell Homeostasis

Seung Eun Park, Dongeun Lee, Jae Woong Jeong, Su-Hyung Lee, Seung Ju Park, Jaeseung Ryu, Se Kyu Oh, Hanseul Yang, Sungsoon Fang, Seyun Kim

Cell Mol Gastroenterol Hepatol. 2022; 14(6): 1235–1256. Published online 2022 Aug 19. doi: 10.1016/j.jcmgh.2022.08.004

PMCID:: PMC9579329

Abstract Article PDF–6.7M

Select item 93286634.

Phytocannabinoid‐dependent mTORC1 regulation is dependent upon inositol polyphosphate multikinase activity

Joseph L. Damstra‐Oddy, Eleanor C. Warren, Christopher J. Perry, Yann Desfougères, John‐Mark K. Fitzpatrick, Judith Schaf, Lisa Costelloe, William Hind, Eric J. Downer, Adolfo Saiardi, Robin S.B. Williams

Br J Pharmacol. 2021 Mar; 178(5): 1149–1163. Published online 2021 Jan 18. doi: 10.1111/bph.15351

PMCID:: PMC9328663

Abstract Article PDF–4.0M

Select item 92711925.

Differentiation and homeostasis of effector Treg cells are regulated by inositol polyphosphates modulating Ca²⁺ influx

Hyungyu Min, Wooseob Kim, Sehoon Hong, Sungkyu Lee, Jinguk Jeong, Seyun Kim, Rho H. Seong

Proc Natl Acad Sci U S A. 2022 Jul 5; 119(27): e2121520119. Published online 2022 Jul 1. doi: 10.1073/pnas.2121520119

PMCID:: PMC9271192

Abstract Article PDF–3.2M

Select item 66009276.

Inositol polyphosphates promote T cell-independent humoral immunity via the regulation of Bruton’s tyrosine kinase

Wooseob Kim, Eunha Kim, Hyungyu Min, Min Gyu Kim, Verena B. Eisenbeis, Amit K. Dutta, Igor Pavlovic, Henning J. Jessen, Seyun Kim, Rho Hyun Seong

Proc Natl Acad Sci U S A. 2019 Jun 25; 116(26): 12952–12957. Published online 2019 Jun 12. doi: 10.1073/pnas.1821552116

PMCID:: PMC6600927

Abstract Article PDF–1.0M

Select item 65849797.

Inositol polyphosphate multikinase deficiency leads to aberrant induction of synaptotagmin-2 in the forebrain

Jina Park, Seung Ju Park, Seyun Kim

Mol Brain. 2019; 12: 58. Published online 2019 Jun 20. doi: 10.1186/s13041-019-0480-1

PMCID:: PMC6584979

Abstract Article PDF–1.8M

Select item 64940838.

IPMK Mediates Activation of ULK Signaling and Transcriptional Regulation of Autophagy Linked to Liver Inflammation and Regeneration

Prasun Guha, Richa Tyagi, Sayan Chowdhury, Luke Reilly, Chenglai Fu, Risheng Xu, Adam C. Resnick, Solomon H. Snyder

Cell Rep. Author manuscript; available in PMC 2019 May 1.

Published in final edited form as: Cell Rep. 2019 Mar 5; 26(10): 2692–2703.e7. doi: 10.1016/j.celrep.2019.02.013

PMCID:: PMC6494083

Abstract Article PDF–2.2M

Select item 63774989.

Inositol polyphosphate multikinase mediates extinction of fear memory

Jina Park, Francesco Longo, Seung Ju Park, Seulgi Lee, Mihyun Bae, Richa Tyagi, Jin-Hee Han, Seyun Kim, Emanuela Santini, Eric Klann, Solomon H. Snyder

Proc Natl Acad Sci U S A. 2019 Feb 12; 116(7): 2707–2712. Published online 2019 Jan 28. doi: 10.1073/pnas.1812771116

PMCID:: PMC6377498

Abstract Article PDF–998K

Select item 580564410.

Inositol Polyphosphate Multikinase Inhibits Angiogenesis via Inositol Pentakisphosphate-Induced HIF-1α Degradation

Chenglai Fu, Richa Tyagi, Alfred C. Chin, Tomas Rojas, Ruo-Jing Li, Prasun Guha, Isaac A. Bernstein, Feng Rao, Risheng Xu, Jiyoung Y. Cha, Jing Xu, Adele M. Snowman, Gregg L. Semenza, Solomon H. Snyder

Circ Res. Author manuscript; available in PMC 2019 Feb 2.

Published in final edited form as: Circ Res. 2018 Feb 2; 122(3): 457–472. Published online 2017 Dec 26. doi: 10.1161/CIRCRESAHA.117.311983

PMCID:: PMC5805644

Abstract Article PDF–2.6M

Select item 540042911.

Inositol polyphosphate multikinase promotes Toll-like receptor–induced inflammation by stabilizing TRAF6

Eunha Kim, Jiyoon Beon, Seulgi Lee, Seung Ju Park, Hyoungjoon Ahn, Min Gyu Kim, Jeong Eun Park, Wooseob Kim, Jae-Min Yuk, Suk-Jo Kang, Seung-Hyo Lee, Eun-Kyeong Jo, Rho Hyun Seong, Seyun Kim

Sci Adv. 2017 Apr; 3(4): e1602296. Published online 2017 Apr 21. doi: 10.1126/sciadv.1602296

PMCID:: PMC5400429

Abstract Article PDF–959K

Select item 535664812.

IPMK and β-catenin mediate PLC-β1-dependent signaling in myogenic differentiation

Giulia Ramazzotti, Anna Maria Billi, Lucia Manzoli, Cristina Mazzetti, Alessandra Ruggeri, Christophe Erneux, Seyun Kim, Pann-Ghill Suh, Lucio Cocco, Irene Faenza

Oncotarget. 2016 Dec 20; 7(51): 84118–84127. Published online 2016 Aug 23. doi: 10.18632/oncotarget.11527

PMCID:: PMC5356648

Abstract Article PDF–6.9M

Select item 453427813.

Huntington’s disease: Neural dysfunction linked to inositol polyphosphate multikinase

Ishrat Ahmed, Juan I. Sbodio, Maged M. Harraz, Richa Tyagi, Jonathan C. Grima, Lauren K. Albacarys, Maimon E. Hubbi, Risheng Xu, Seyun Kim, Bindu D. Paul, Solomon H. Snyder

Proc Natl Acad Sci U S A. 2015 Aug 4; 112(31): 9751–9756. Published online 2015 Jul 20. doi: 10.1073/pnas.1511810112

PMCID:: PMC4534278

Abstract Article PDF–1.0M

Select item 410819614.

Inositol Polyphosphate Multikinase Is a Coactivator of p53-Mediated Transcription and Cell Death

Risheng Xu, Nilkantha Sen, Bindu D. Paul, Adele M. Snowman, Feng Rao, M. Scott Vandiver, Jing Xu, Solomon H. Snyder

Sci Signal. Author manuscript; available in PMC 2014 Jul 23.

Published in final edited form as: Sci Signal. 2013 Apr 2; 6(269): ra22. Published online 2013 Apr 2. doi: 10.1126/scisignal.2003405

Correction in:: volume 6 on page er1

PMCID:: PMC4108196

Abstract Article PDF–1.5M

Select item 407515815.

Convergence of IPMK and LKB1-AMPK Signaling Pathways on Metformin Action

Sookhee Bang, Yong Chen, Rexford S. Ahima, Sangwon F. Kim

Mol Endocrinol. 2014 Jul; 28(7): 1186–1193. Published online 2014 May 30. doi: 10.1210/me.2014-1134

PMCID:: PMC4075158

Abstract Article

Select item 385679216.

Inositol polyphosphate multikinase is a coactivator for serum response factor-dependent induction of immediate early genes

Eunha Kim, Richa Tyagi, Joo-Young Lee, Jina Park, Young-ran Kim, Jiyoon Beon, Po Yu Chen, Jiyoung Y. Cha, Solomon H. Snyder, Seyun Kim

Proc Natl Acad Sci U S A. 2013 Dec 3; 110(49): 19938–19943. Published online 2013 Nov 18. doi: 10.1073/pnas.1320171110

PMCID:: PMC3856792

Abstract Article PDF–749K

Select item 379172717.

Inositol polyphosphate multikinase is a transcriptional coactivator required for immediate early gene induction

Risheng Xu, Bindu D. Paul, Dani R. Smith, Richa Tyagi, Feng Rao, A. Basit Khan, Daniel J. Blech, M. Scott Vandiver, Maged M. Harraz, Prasun Guha, Ishrat Ahmed, Nilkantha Sen, Michela Gallagher, Solomon H. Snyder

Proc Natl Acad Sci U S A. 2013 Oct 1; 110(40): 16181–16186. Published online 2013 Sep 16. doi: 10.1073/pnas.1315551110

PMCID:: PMC3791727

Abstract Article PDF–851K

Select item 365733018.

The Regulation of Runx2 by FGF2 and Connexin43 Requires the Inositol Polyphosphate/Protein Kinase Cδ Cascade

Corinne Niger, Maria A. Luciotti, Atum M. Buo, Carla Hebert, Vy Ma, Joseph P. Stains

J Bone Miner Res. Author manuscript; available in PMC 2014 Jun 1.

Published in final edited form as: J Bone Miner Res. 2013 Jun; 28(6): 1468–1477. doi: 10.1002/jbmr.1867

PMCID:: PMC3657330

Abstract Article PDF–1.3M

Select item 357241019.

A conditional knockout resource for the genome–wide study of mouse gene function

William C. Skarnes, Barry Rosen, Anthony P. West, Manousos Koutsourakis, Wendy Bushell, Vivek Iyer, Alejandro O. Mujica, Mark Thomas, Jennifer Harrow, Tony Cox, David Jackson, Jessica Severin, Patrick Biggs, Jun Fu, Michael Nefedov, Pieter J. de Jong, A. Francis Stewart, Allan Bradley

Nature. Author manuscript; available in PMC 2013 Feb 14.

Published in final edited form as: Nature. 2011 Jun 15; 474(7351): 337–342. Published online 2011 Jun 15. doi: 10.1038/nature10163