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Items: 1 to 20 of 54

1.
LACK OF EMBRYONIC HOMOZYGOUS OR ADULT HETEROZYGOUS LYMPHATIC PHENOTYPES FOR A Sos1 MUTATION AND LACK OF LYMPHATIC EMBRYONIC PHENOTYPES FOR A HOMOZYGOUS Cx47 MUTATION IN MICE
X. Geng, L. Chen, R.S. Srinivasan, R.J. Kylat, M.H. Witte, R.P. Erickson
Lymphology. Author manuscript; available in PMC 2023 Oct 18.
Published in final edited form as: Lymphology. 2022; 55(3): 129–134.
PMCID:
PMC10583265
AbstractArticlePDF–1.5M
2.
Critical requirement of SOS1 for tumor development and microenvironment modulation in KRASG12D-driven lung adenocarcinoma
Fernando C. Baltanás, Rósula García-Navas, Pablo Rodríguez-Ramos, Nuria Calzada, Cristina Cuesta, Javier Borrajo, Rocío Fuentes-Mateos, Andrea Olarte-San Juan, Nerea Vidaña, Esther Castellano, Eugenio Santos
Nat Commun. 2023; 14: 5856. Published online 2023 Sep 20. doi: 10.1038/s41467-023-41583-1
PMCID:
PMC10511506
AbstractArticlePDF–4.3M
3.
PPDPF Promotes the Development of Mutant KRAS‐Driven Pancreatic Ductal Adenocarcinoma by Regulating the GEF Activity of SOS1
Qian‐Zhi Ni, Bing Zhu, Yan Ji, Qian‐Wen Zheng, Xin Liang, Ning Ma, Hao Jiang, Feng‐Kun Zhang, Yu‐Rong Shang, Yi‐Kang Wang, Sheng Xu, Er‐Bin Zhang, Yan‐Mei Yuan, Tian‐Wei Chen, Fen‐Fen Yin, Hui‐Jun Cao, Jing‐Yi Huang, Ji Xia, Xu‐Fen Ding, Xiao‐Song Qiu, Kai Ding, Chao Song, Wen‐Tao Zhou, Meng Wu, Kang Wang, Rui Lui, Qiu Lin, Wei Chen, Zhi‐Gang Li, Shu‐Qun Cheng, Xiao‐Fan Wang, Dong Xie, Jing‐Jing Li
Adv Sci (Weinh) 2023 Jan; 10(2): 2202448. Published online 2022 Dec 1. doi: 10.1002/advs.202202448
PMCID:
PMC9839844
AbstractArticlePDF–5.7M
4.
Critical Requirement of SOS1 for Development of BCR/ABL-Driven Chronic Myelogenous Leukemia
Carmela Gómez, Rósula Garcia-Navas, Fernando C. Baltanás, Rocío Fuentes-Mateos, Alberto Fernández-Medarde, Nuria Calzada, Eugenio Santos
Cancers (Basel) 2022 Aug; 14(16): 3893. Published online 2022 Aug 11. doi: 10.3390/cancers14163893
PMCID:
PMC9406065
AbstractArticlePDF–3.6M
5.
Critical requirement of SOS1 RAS-GEF function for mitochondrial dynamics, metabolism, and redox homeostasis
Rósula García-Navas, Pilar Liceras-Boillos, Carmela Gómez, Fernando C. Baltanás, Nuria Calzada, Cristina Nuevo-Tapioles, José M. Cuezva, Eugenio Santos
Oncogene. 2021; 40(27): 4538–4551. Published online 2021 Jun 12. doi: 10.1038/s41388-021-01886-3
PMCID:
PMC8266680
AbstractArticlePDF–6.6M
6.
SOS2 Comes to the Fore: Differential Functionalities in Physiology and Pathology
Fernando C. Baltanás, Rósula García-Navas, Eugenio Santos
Int J Mol Sci. 2021 Jun; 22(12): 6613. Published online 2021 Jun 21. doi: 10.3390/ijms22126613
PMCID:
PMC8234257
AbstractArticlePDF–643K
7.
Prenatal correction of IGF2 to rescue the growth phenotypes in mouse models of Beckwith-Wiedemann and Silver-Russell syndromes
Ji Liao, Tie-Bo Zeng, Nicholas Pierce, Diana A. Tran, Purnima Singh, Jeffrey R. Mann, Piroska E. Szabó
Cell Rep. Author manuscript; available in PMC 2021 Mar 17.
Published in final edited form as: Cell Rep. 2021 Feb 9; 34(6): 108729. doi: 10.1016/j.celrep.2021.108729
PMCID:
PMC7968144
AbstractArticlePDF–1.7M
8.
BraInMap elucidates the macromolecular connectivity landscape of mammalian brain
Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili
Cell Syst. Author manuscript; available in PMC 2021 Apr 22.
Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003
Correction in:
Cell Syst. 2020 Aug 26; 11(2): 208.
PMCID:
PMC7938770
AbstractArticlePDF–2.0M
9.
Alternative ZAP70-p38 signals prime a classical p38 pathway through LAT and SOS to support regulatory T cell differentiation
Jesse E. Jun, Kayla R. Kulhanek, Hang Chen, Arup Chakraborty, Jeroen P. Roose
Sci Signal. Author manuscript; available in PMC 2020 Jul 7.
Published in final edited form as: Sci Signal. 2019 Jul 23; 12(591): eaao0736. Published online 2019 Jul 23. doi: 10.1126/scisignal.aao0736
PMCID:
PMC7340343
AbstractArticlePDF–2.4M
10.
Frontline Science: TNF‐α and GM‐CSF1 priming augments the role of SOS1/2 in driving activation of Ras, PI3K‐γ, and neutrophil proinflammatory responses
Sabine Suire, Fernando C. Baltanas, Anne Segonds‐Pichon, Keith Davidson, Eugenio Santos, Phillip T. Hawkins, Len R. Stephens
J Leukoc Biol. 2019 Oct; 106(4): 815–822. Published online 2019 Feb 5. doi: 10.1002/JLB.2HI0918-359RR
PMCID:
PMC6977543
AbstractArticlePDF–1.0M
11.
Telencephalic Embryonic Subtractive Sequences: A Unique Collection of Neurodevelopmental Genes
Alessandro Bulfone, Pietro Carotenuto, Andrea Faedo, Veruska Aglio, Livia Garzia, Anna Maria Bello, Andrea Basile, Alessandra Andrè, Massimo Cocchia, Ombretta Guardiola, Andrea Ballabio, John L. R. Rubenstein, Massimo Zollo
J Neurosci. 2005 Aug 17; 25(33): 7586–7600. doi: 10.1523/JNEUROSCI.0522-05.2005
PMCID:
PMC6725394
AbstractArticlePDF–682K
12.
The CSN3 subunit of the COP9 signalosome interacts with the HD region of Sos1 regulating stability of this GEF protein
Natasha Zarich, Begoña Anta, Alberto Fernández-Medarde, Alicia Ballester, María Pilar de Lucas, Ana Belén Cámara, Berta Anta, José Luís Oliva, José M. Rojas-Cabañeros, Eugenio Santos
Oncogenesis. 2019 Jan; 8(1): 2. Published online 2019 Jan 4. doi: 10.1038/s41389-018-0111-1
PMCID:
PMC6328564
AbstractArticlePDF–1.3M
13.
Unique dependence on Sos1 in KrasG12D-induced leukemogenesis
Xiaona You, Guangyao Kong, Erik A. Ranheim, David Yang, Yun Zhou, Jing Zhang
Blood. 2018 Dec 13; 132(24): 2575–2579. Prepublished online 2018 Oct 30. doi: 10.1182/blood-2018-09-874107
PMCID:
PMC6293870
AbstractArticle
14.
Differential Role of the RasGEFs Sos1 and Sos2 in Mouse Skin Homeostasis and Carcinogenesis
Pilar Liceras-Boillos, David Jimeno, Rósula García-Navas, L. Francisco Lorenzo-Martín, Mauricio Menacho-Marquez, Carmen Segrelles, Carmela Gómez, Nuria Calzada, Rocío Fuentes-Mateos, Jesús M. Paramio, Xosé R. Bustelo, Fernando C. Baltanás, Eugenio Santos
Mol Cell Biol. 2018 Aug 15; 38(16): e00049-18. Prepublished online 2018 May 29. Published online 2018 Jul 30. doi: 10.1128/MCB.00049-18
PMCID:
PMC6066753
AbstractArticlePDF–7.8M
15.
Absence of both Sos-1 and Sos-2 in peripheral CD4+ T cells leads to PI3K pathway activation and defects in migration
Geoffrey Guittard, Robert L Kortum, Lakshmi Balagopalan, Nicolas Çuburu, Phan Nguyen, Connie L Sommers, Lawrence E Samelson
Eur J Immunol. Author manuscript; available in PMC 2016 Aug 1.
Published in final edited form as: Eur J Immunol. 2015 Aug; 45(8): 2389–2395. Published online 2015 Jun 5. doi: 10.1002/eji.201445226
PMCID:
PMC4536155
AbstractArticlePDF–1.1M
16.
The Ability of Sos1 to Oligomerize the Adaptor Protein LAT Is Separable from its Guanine Nucleotide Exchange Activity In Vivo
Robert L. Kortum, Lakshmi Balagopalan, Clayton P. Alexander, Julie Garcia, John M. Pinski, Robert K. Merrill, Phan H. Nguyen, Wenmei Li, Isha Agarwal, Itoro O. Akpan, Connie L. Sommers, Lawrence E. Samelson
Sci Signal. Author manuscript; available in PMC 2014 Dec 8.
Published in final edited form as: Sci Signal. 2013 Nov 12; 6(301): ra99. Published online 2013 Nov 12. doi: 10.1126/scisignal.2004494
PMCID:
PMC4259567
AbstractArticlePDF–2.3M
17.
ROS1 Signaling Regulates Epithelial Differentiation in the Epididymis
Hyun Jung Jun, Jeremy Roy, Tegan B. Smith, Levi B. Wood, Keara Lane, Steve Woolfenden, Diana Punko, Roderick T. Bronson, Kevin M. Haigis, Sylvie Breton, Al Charest
Endocrinology. 2014 Sep; 155(9): 3661–3673. Published online 2014 Jun 27. doi: 10.1210/en.2014-1341
PMCID:
PMC4138574
AbstractArticle
18.
SUMOylation of Grb2 enhances the ERK activity by increasing its binding with Sos1
Yingying Qu, Qin Chen, Xueping Lai, Changhong Zhu, Cheng Chen, Xian Zhao, Rong Deng, Ming Xu, Haihua Yuan, Yanli Wang, Jianxiu Yu, Jian Huang
Mol Cancer. 2014; 13: 95. Published online 2014 Apr 29. doi: 10.1186/1476-4598-13-95
PMCID:
PMC4021559
AbstractArticlePDF–1.5M
19.
Regulation of Son of sevenless by the membrane-actin linker protein ezrin
Katja J. Geißler, M. Juliane Jung, Lars Björn Riecken, Tobias Sperka, Yan Cui, Stephan Schacke, Ulrike Merkel, Robby Markwart, Ignacio Rubio, Manuel E. Than, Constanze Breithaupt, Sebastian Peuker, Reinhard Seifert, Ulrich Benjamin Kaupp, Peter Herrlich, Helen Morrison
Proc Natl Acad Sci U S A. 2013 Dec 17; 110(51): 20587–20592. Published online 2013 Dec 2. doi: 10.1073/pnas.1222078110
PMCID:
PMC3870676
AbstractArticlePDF–1.7M
20.
Functional Redundancy of Sos1 and Sos2 for Lymphopoiesis and Organismal Homeostasis and Survival
Fernando C. Baltanás, Martín Pérez-Andrés, Alicia Ginel-Picardo, David Diaz, David Jimeno, Pilar Liceras-Boillos, Robert L. Kortum, Lawrence E. Samelson, Alberto Orfao, Eugenio Santos
Mol Cell Biol. 2013 Nov; 33(22): 4562–4578. doi: 10.1128/MCB.01026-13
PMCID:
PMC3838185
AbstractArticlePDF–3.2M

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