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Items: 1 to 20 of 85

1.
Genetic determinants of micronucleus formation in vivo
D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus
Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0
PMCID:
PMC10917660
AbstractArticlePDF–4.8M
2.
Loss of CD4+ T cell-intrinsic arginase 1 accelerates Th1 response kinetics and reduces lung pathology during influenza infection
Erin E. West, Nicolas S. Merle, Marcin M. Kamiński, Gustavo Palacios, Dhaneshwar Kumar, Luopin Wang, Jack A. Bibby, Kirsten Overdahl, Alan K. Jarmusch, Simon Freeley, Duck-Yeon Lee, J. Will Thompson, Zu-Xi Yu, Naomi Taylor, Marc Sitbon, Douglas R. Green, Andrea Bohrer, Katrin D. Mayer-Barber, Behdad Afzali, Majid Kazemian, Sabine Scholl-Buergi, Daniela Karall, Martina Huemer, Claudia Kemper
Immunity. Author manuscript; available in PMC 2023 Oct 14.
Published in final edited form as: Immunity. 2023 Sep 12; 56(9): 2036–2053.e12. Published online 2023 Aug 11. doi: 10.1016/j.immuni.2023.07.014
PMCID:
PMC10576612
AbstractArticlePDF–3.1M
3.
Calbindin 2-specific deletion of arginase 2 preserves visual function after optic nerve crush
Syed A. H. Zaidi, Zhimin Xu, Tahira Lemtalsi, Porsche Sandow, Sruthi Athota, Fang Liu, Stephen Haigh, Yuqing Huo, S. Priya Narayanan, David J. R. Fulton, Modesto A. Rojas, Abdelrahman Y. Fouda, Robert W. Caldwell, Ruth B. Caldwell
Cell Death Dis. 2023 Oct; 14(10): 661. Published online 2023 Oct 10. doi: 10.1038/s41419-023-06180-6
PMCID:
PMC10564748
AbstractArticlePDF–8.5M
4.
Elevation of Arginase-II in Podocytes Contributes to Age-Associated Albuminuria in Male Mice
Guillaume Ajalbert, Andrea Brenna, Xiu-Fen Ming, Zhihong Yang, Duilio M. Potenza
Int J Mol Sci. 2023 Jul; 24(13): 11228. Published online 2023 Jul 7. doi: 10.3390/ijms241311228
PMCID:
PMC10342439
AbstractArticlePDF–2.9M
5.
Spermidine from arginine metabolism activates Nrf2 and inhibits kidney fibrosis
Seishi Aihara, Kumiko Torisu, Yushi Uchida, Noriyuki Imazu, Toshiaki Nakano, Takanari Kitazono
Commun Biol. 2023; 6: 676. Published online 2023 Jun 28. doi: 10.1038/s42003-023-05057-w
PMCID:
PMC10307812
AbstractArticlePDF–4.4M
6.
Maf family transcription factors are required for nutrient uptake in the mouse neonatal gut
Anne M. Bara, Lei Chen, Celina Ma, Julie Underwood, Rebecca S. Moreci, Kaelyn Sumigray, Tongyu Sun, Yarui Diao, Michael Verzi, Terry Lechler
Development. 2022 Dec 1; 149(23): dev201251. Published online 2022 Dec 12. doi: 10.1242/dev.201251
PMCID:
PMC10112929
AbstractArticle
7.
Glucose 6-P Dehydrogenase Overexpression Improves Aging-Induced Endothelial Dysfunction in Aorta from Mice: Role of Arginase II
Eva Serna, Maria D Mauricio, Teresa San-Miguel, Sol Guerra-Ojeda, David Verdú, Alicia Valls, Coralie Arc-Chagnaud, Adrián De la Rosa, José Viña
Int J Mol Sci. 2023 Feb; 24(4): 3622. Published online 2023 Feb 11. doi: 10.3390/ijms24043622
PMCID:
PMC9961129
AbstractArticlePDF–2.8M
8.
Role of Arginase-II in Podocyte Injury under Hypoxic Conditions
Zhilong Ren, Duilio Michele Potenza, Yiqiong Ma, Guillaume Ajalbert, David Hoogewijs, Xiu-Fen Ming, Zhihong Yang
Biomolecules. 2022 Sep; 12(9): 1213. Published online 2022 Aug 31. doi: 10.3390/biom12091213
PMCID:
PMC9496188
AbstractArticlePDF–5.6M
9.
OxLDL Triggers Retrograde Translocation of Arginase 2 in Aortic Endothelial Cells via ROCK and Mitochondrial Processing Peptidase
Deepesh Pandey, Anil Bhunia, Young Jun Oh, Fumin Chang, Yehudit Bergman, Jae Hyung Kim, Janna Serbo, Tatiana N. Boronina, Robert N. Cole, Jennifer Van Eyk, Alan T. Remaley, Dan E. Berkowitz, Lewis Romer
Circ Res. Author manuscript; available in PMC 2022 Jan 15.
Published in final edited form as: Circ Res. 2014 Aug 1; 115(4): 450–459. Published online 2014 Jun 5. doi: 10.1161/CIRCRESAHA.115.304262
PMCID:
PMC8760889
AbstractArticlePDF–2.3M
10.
Metabolomic Analysis of Diverse Mice Reveals Hepatic Arginase-1 as Source of Plasma Arginase in Plasmodium chabaudi Infection
Nicole M. Davis, Michelle M. Lissner, Crystal L. Richards, Victoria Chevée, Avni S. Gupta, Frank C. Gherardini, David S. Schneider
mBio. 2021 Sep-Oct; 12(5): e02424-21. Published online 2021 Oct 5. doi: 10.1128/mBio.02424-21
PMCID:
PMC8546868
AbstractArticlePDF–3.8M
11.
Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development
Francesco Bedogni, Robert F. Hevner
Front Mol Neurosci. 2021; 14: 686034. Published online 2021 Jul 12. doi: 10.3389/fnmol.2021.686034
PMCID:
PMC8313239
AbstractArticlePDF–1.6M
12.
Endothelial arginase 2 mediates retinal ischemia/reperfusion injury by inducing mitochondrial dysfunction
Esraa Shosha, Abdelrahman Y. Fouda, Tahira Lemtalsi, Stephen Haigh, David Fulton, Ahmed Ibrahim, Mohamed Al-Shabrawey, R. William Caldwell, Ruth B. Caldwell
Mol Metab. 2021 Nov; 53: 101273. Published online 2021 Jun 15. doi: 10.1016/j.molmet.2021.101273
PMCID:
PMC8274341
AbstractArticlePDF–3.8M
13.
Deletion of arginase 2 attenuates neuroinflammation in an experimental model of optic neuritis
Amritha A. Candadai, Fang Liu, Abdelrahman Y. Fouda, Moaddey Alfarhan, Chithra D. Palani, Zhimin Xu, Ruth B. Caldwell, S. Priya Narayanan
PLoS One. 2021; 16(3): e0247901. Published online 2021 Mar 18. doi: 10.1371/journal.pone.0247901
PMCID:
PMC7971528
AbstractArticlePDF–1.6M
14.
Mitochondrial arginase-2 is essential for IL-10 metabolic reprogramming of inflammatory macrophages
Jennifer K. Dowling, Remsha Afzal, Linden J. Gearing, Mariana P. Cervantes-Silva, Stephanie Annett, Gavin M. Davis, Chiara De Santi, Nadine Assmann, Katja Dettmer, Daniel J. Gough, Glenn R. Bantug, Fidinny I. Hamid, Frances K. Nally, Conor P. Duffy, Aoife L. Gorman, Alex M. Liddicoat, Ed C. Lavelle, Christoph Hess, Peter J. Oefner, David K. Finlay, Gavin P. Davey, Tracy Robson, Annie M. Curtis, Paul J. Hertzog, Bryan R. G. Williams, Claire E. McCoy
Nat Commun. 2021; 12: 1460. Published online 2021 Mar 5. doi: 10.1038/s41467-021-21617-2
PMCID:
PMC7936006
AbstractArticlePDF–3.0M
15.
Arginine metabolic control of airway inflammation
Kewal Asosingh, Chris D. Lauruschkat, Mario Alemagno, Matthew Frimel, Nicholas Wanner, Kelly Weiss, Sean Kessler, Deborah A. Meyers, Carole Bennett, Weiling Xu, Serpil Erzurum
JCI Insight. 2020 Jan 30; 5(2): e127801. Published online 2020 Jan 30. doi: 10.1172/jci.insight.127801
PMCID:
PMC7098726
AbstractArticlePDF–6.9M
16.
Regulatory T cells use arginase 2 to enhance their metabolic fitness in tissues
Margaret M. Lowe, Ian Boothby, Sean Clancy, Richard S. Ahn, Wilson Liao, David N. Nguyen, Kathrin Schumann, Alexander Marson, Kelly M. Mahuron, Gillian A. Kingsbury, Zheng Liu, Priscila Munoz Sandoval, Robert Sanchez Rodriguez, Mariela L. Pauli, Keyon Taravati, Sarah T. Arron, Isaac M. Neuhaus, Hobart W. Harris, Esther A. Kim, Uk Sok Shin, Matthew F. Krummel, Adil Daud, Tiffany C. Scharschmidt, Michael D. Rosenblum
JCI Insight. 2019 Dec 19; 4(24): e129756. Published online 2019 Dec 19. doi: 10.1172/jci.insight.129756
PMCID:
PMC6975275
AbstractArticlePDF–5.0M
17.
Mitochondrial arginase-2 is a cell‑autonomous regulator of CD8+ T cell function and antitumor efficacy
Adrià-Arnau Martí i Líndez, Isabelle Dunand-Sauthier, Mark Conti, Florian Gobet, Nicolás Núñez, J. Thomas Hannich, Howard Riezman, Roger Geiger, Alessandra Piersigilli, Kerstin Hahn, Sylvain Lemeille, Burkhard Becher, Thibaut De Smedt, Stéphanie Hugues, Walter Reith
JCI Insight. 2019 Dec 19; 4(24): e132975. Published online 2019 Dec 19. doi: 10.1172/jci.insight.132975
PMCID:
PMC6975264
AbstractArticlePDF–7.0M
18.
Deletion of Arginase 2 Ameliorates Retinal Neurodegeneration in a Mouse Model of Multiple Sclerosis
Chithra D. Palani, Abdelrahman Y. Fouda, Fang Liu, Zhimin Xu, Eslam Mohamed, Shailedra Giri, Sylvia B. Smith, Ruth B. Caldwell, S. Priya Narayanan
Mol Neurobiol. Author manuscript; available in PMC 2020 Dec 1.
Published in final edited form as: Mol Neurobiol. 2019 Dec; 56(12): 8589–8602. Published online 2019 Jul 6. doi: 10.1007/s12035-019-01691-w
PMCID:
PMC6857799
AbstractArticlePDF–2.1M
19.
Arginase II activity regulates cytosolic Ca2+ level in a p32-dependent manner that contributes to Ca2+-dependent vasoconstriction in native low-density lipoprotein-stimulated vascular smooth muscle cells
Bon-hyeock Koo, Dongeui Hong, Hyeon Don Hong, Hyun Kyo Lim, Kwang Lae Hoe, Moo-Ho Won, Young Myeong Kim, Dan E. Berkowitz, Sungwoo Ryoo
Exp Mol Med. 2019 Jun; 51(6): 60. Published online 2019 Jun 3. doi: 10.1038/s12276-019-0262-y
PMCID:
PMC6545325
AbstractArticlePDF–2.2M
20.
Hepatic arginase 2 (Arg2) is sufficient to convey the therapeutic metabolic effects of fasting
Yiming Zhang, Cassandra B. Higgins, Hannah M. Fortune, Phillip Chen, Alicyn I. Stothard, Allyson L. Mayer, Benjamin M. Swarts, Brian J. DeBosch
Nat Commun. 2019; 10: 1587. Published online 2019 Apr 8. doi: 10.1038/s41467-019-09642-8
PMCID:
PMC6453920
AbstractArticlePDF–2.1M

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