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Items: 1 to 20 of 39

1.
Genetic determinants of micronucleus formation in vivo
D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus
Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0
PMCID:
PMC10917660
AbstractArticlePDF–4.8M
2.
Identification of Arhgef12 and Prkci as genetic modifiers of retinal dysplasia in the Crb1rd8 mouse model
Sonia M. Weatherly, Gayle B. Collin, Jeremy R. Charette, Lisa Stone, Nattaya Damkham, Lillian F. Hyde, James G. Peterson, Wanda Hicks, Gregory W. Carter, Jürgen K. Naggert, Mark P. Krebs, Patsy M. Nishina
PLoS Genet. 2022 Jun; 18(6): e1009798. Published online 2022 Jun 8. doi: 10.1371/journal.pgen.1009798
PMCID:
PMC9212170
AbstractArticlePDF–6.4M
3.
BraInMap elucidates the macromolecular connectivity landscape of mammalian brain
Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili
Cell Syst. Author manuscript; available in PMC 2021 Apr 22.
Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003
Correction in:
Cell Syst. 2020 Aug 26; 11(2): 208.
PMCID:
PMC7938770
AbstractArticlePDF–2.0M
4.
ARHGEF12 regulates erythropoiesis and is involved in erythroid regeneration after chemotherapy in acute lymphoblastic leukemia patients
Yangyang Xie, Li Gao, Chunhui Xu, Liming Chu, Lei Gao, Ruichi Wu, Yu Liu, Ting Liu, Xiao-jian Sun, Ruibao Ren, Jingyan Tang, Yi Zheng, Yong Zhou, Shuhong Shen
Haematologica. 2020 Apr; 105(4): 925–936. Prepublished online 2019 Aug 29. doi: 10.3324/haematol.2018.210286
PMCID:
PMC7109745
AbstractArticlePDF–2.7M
5.
Myogenic vasoconstriction requires G12/G13 and LARG to maintain local and systemic vascular resistance
Ramesh Chennupati, Angela Wirth, Julie Favre, Rui Li, Rémy Bonnavion, Young-June Jin, Astrid Wietelmann, Frank Schweda, Nina Wettschureck, Daniel Henrion, Stefan Offermanns
eLife. 2019; 8: e49374. Published online 2019 Sep 24. doi: 10.7554/eLife.49374
PMCID:
PMC6777979
AbstractArticlePDF–4.6M
6.
Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics
Joel D. Federspiel, Todd M. Greco, Krystal K. Lum, Ileana M. Cristea
Mol Cell Proteomics. 2019 Aug 9; 18(8 Suppl 1): S92–S113. Published online 2019 Apr 30. doi: 10.1074/mcp.RA118.001253
PMCID:
PMC6692770
AbstractArticlePDF–7.7M
7.
A CRISPR-based screen for Hedgehog signaling provides insights into ciliary function and ciliopathies
David K. Breslow, Sascha Hoogendoorn, Adam R. Kopp, David W. Morgens, Brandon K. Vu, Margaret C. Kennedy, Kyuho Han, Amy Li, Gaelen T. Hess, Michael C. Bassik, James K. Chen, Maxence V. Nachury
Nat Genet. Author manuscript; available in PMC 2018 Aug 19.
Published in final edited form as: Nat Genet. 2018 Mar; 50(3): 460–471. Published online 2018 Feb 19. doi: 10.1038/s41588-018-0054-7
PMCID:
PMC5862771
AbstractArticlePDF–2.5M
8.
Leukemia-associated Rho guanine nucleotide exchange factor (LARG) plays an agonist specific role in platelet function through RhoA activation
Siying Zou, Alexandra M. Teixeira, Mingzhu Yin, Yaozu Xiang, Juliana Xavier-Ferruccio, Ping-xia Zhang, John Hwa, Wang Min, Diane S. Krause
Thromb Haemost. Author manuscript; available in PMC 2018 Mar 12.
Published in final edited form as: Thromb Haemost. 2016 Aug 30; 116(3): 506–516. Published online 2016 Jun 23. doi: 10.1160/TH15-11-0848
PMCID:
PMC5845781
AbstractArticlePDF–846K
9.
LARG GEF and ARHGAP18 Orchestrate RhoA Activity to Control Mesenchymal Stem Cell Lineage
William R. Thompson, Sherwin S. Yen, Gunes Uzer, Zhihui Xie, Buer Sen, Maya Styner, Keith Burridge, Janet Rubin
Bone. Author manuscript; available in PMC 2019 Feb 1.
Published in final edited form as: Bone. 2018 Feb; 107: 172–180. Published online 2017 Dec 5. doi: 10.1016/j.bone.2017.12.001
PMCID:
PMC5743610
AbstractArticlePDF–1.1M
10.
Spatio-temporal profile of postynaptic interactomes integrates components of complex brain disorders
Jing Li, Wangshu Zhang, Hui Yang, Daniel P. Howrigan, Brent Wilkinson, Tade Souaiaia, Oleg V. Evgrafov, Giulio Genovese, Veronica A. Clementel, Jennifer C. Tudor, Ted Abel, James A. Knowles, Benjamin M. Neale, Kai Wang, Fengzhu Sun, Marcelo P. Coba
Nat Neurosci. Author manuscript; available in PMC 2018 Aug 1.
Published in final edited form as: Nat Neurosci. 2017 Aug; 20(8): 1150–1161. Published online 2017 Jun 26. doi: 10.1038/nn.4594
PMCID:
PMC5645082
AbstractArticlePDF–2.3M
11.
Potentiation of receptor responses induced by prolonged binding of Gα13 and leukemia-associated RhoGEF
Eva-Lisa Bodmann, Anna-Lena Krett, Moritz Bünemann
FASEB J. 2017 Aug; 31(8): 3663–3676. Published online 2017 May 2. doi: 10.1096/fj.201700026R
PMCID:
PMC5503709
AbstractArticle
12.
Leukemia‐associated Rho guanine‐nucleotide exchange factor is not critical for RhoA regulation, yet is important for platelet activation and thrombosis in mice
C. M. Williams, M. T. Harper, R. Goggs, T. G. Walsh, S. Offermanns, A. W. Poole
J Thromb Haemost. 2015 Nov; 13(11): 2102–2107. Published online 2015 Oct 20. doi: 10.1111/jth.13129
PMCID:
PMC4755168
AbstractArticlePDF–407K
13.
RhoA and ROCK mediate histamine-induced vascular leakage and anaphylactic shock
Constantinos M. Mikelis, May Simaan, Koji Ando, Shigetomo Fukuhara, Atsuko Sakurai, Panomwat Amornphimoltham, Andrius Masedunskas, Roberto Weigert, Triantafyllos Chavakis, Ralf Adams, Stefan Offermanns, Naoki Mochizuki, Yi Zheng, J. Silvio Gutkind
Nat Commun. Author manuscript; available in PMC 2015 Oct 10.
Published in final edited form as: Nat Commun. 2015; 6: 6725. Published online 2015 Apr 10. doi: 10.1038/ncomms7725
PMCID:
PMC4394241
AbstractArticlePDF–2.6M
14.
Jun kinase-induced overexpression of leukemia-associated Rho GEF (LARG) mediates sustained hypercontraction of longitudinal smooth muscle in inflammation
Othman Al-Shboul, Ancy D. Nalli, Divya P. Kumar, Ruizhe Zhou, Sunila Mahavadi, John F. Kuemmerle, John R. Grider, Karnam S. Murthy
Am J Physiol Cell Physiol. 2014 Jun 15; 306(12): C1129–C1141. Published online 2014 Apr 16. doi: 10.1152/ajpcell.00021.2014
PMCID:
PMC4060000
AbstractArticle
15.
The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data
Gautier Koscielny, Gagarine Yaikhom, Vivek Iyer, Terrence F. Meehan, Hugh Morgan, Julian Atienza-Herrero, Andrew Blake, Chao-Kung Chen, Richard Easty, Armida Di Fenza, Tanja Fiegel, Mark Grifiths, Alan Horne, Natasha A. Karp, Natalja Kurbatova, Jeremy C. Mason, Peter Matthews, Darren J. Oakley, Asfand Qazi, Jack Regnart, Ahmad Retha, Luis A. Santos, Duncan J. Sneddon, Jonathan Warren, Henrik Westerberg, Robert J. Wilson, David G. Melvin, Damian Smedley, Steve D. M. Brown, Paul Flicek, William C. Skarnes, Ann-Marie Mallon, Helen Parkinson
Nucleic Acids Res. 2014 Jan 1; 42(Database issue): D802–D809. Published online 2013 Nov 3. doi: 10.1093/nar/gkt977
PMCID:
PMC3964955
AbstractArticlePDF–5.7M
16.
Genetic dissection of plexin signaling in vivo
Thomas Worzfeld, Jakub M. Swiercz, Aycan Sentürk, Berit Genz, Alexander Korostylev, Suhua Deng, Jingjing Xia, Mikio Hoshino, Jonathan A. Epstein, Andrew M. Chan, Brigitte Vollmar, Amparo Acker-Palmer, Rohini Kuner, Stefan Offermanns
Proc Natl Acad Sci U S A. 2014 Feb 11; 111(6): 2194–2199. Published online 2014 Jan 27. doi: 10.1073/pnas.1308418111
PMCID:
PMC3926053
AbstractArticlePDF–1.3M
17.
The splicing regulator PTBP2 controls a program of embryonic splicing required for neuronal maturation
Qin Li, Sika Zheng, Areum Han, Chia-Ho Lin, Peter Stoilov, Xiang-Dong Fu, Douglas L Black
eLife. 2014; 3: e01201. Published online 2014 Jan 21. doi: 10.7554/eLife.01201
Correction in:
eLife. 2017; 6: e31550.
PMCID:
PMC3896118
AbstractArticlePDF–12M
18.
Agonist-induced Ca2+ Sensitization in Smooth Muscle: REDUNDANCY OF RHO GUANINE NUCLEOTIDE EXCHANGE FACTORS (RhoGEFs) AND RESPONSE KINETICS, A CAGED COMPOUND STUDY
Mykhaylo V. Artamonov, Ko Momotani, Andra Stevenson, David R. Trentham, Urszula Derewenda, Zygmunt S. Derewenda, Paul W. Read, J. Silvio Gutkind, Avril V. Somlyo
J Biol Chem. 2013 Nov 22; 288(47): 34030–34040. Published online 2013 Oct 8. doi: 10.1074/jbc.M113.514596
PMCID:
PMC3837142
AbstractArticlePDF–1.8M
19.
PDZ-RhoGEF and LARG Are Essential for Embryonic Development and Provide a Link between Thrombin and LPA Receptors and Rho Activation
Constantinos M. Mikelis, Todd R. Palmby, May Simaan, Wenling Li, Roman Szabo, Ruth Lyons, Daniel Martin, Hiroshi Yagi, Shigetomo Fukuhara, Hiroki Chikumi, Rebeca Galisteo, Yoh-suke Mukouyama, Thomas H. Bugge, J. Silvio Gutkind
J Biol Chem. 2013 Apr 26; 288(17): 12232–12243. Published online 2013 Mar 6. doi: 10.1074/jbc.M112.428599
PMCID:
PMC3636907
AbstractArticlePDF–3.7M
20.
RhoGEF12 controls cardiac remodeling by integrating G protein– and integrin-dependent signaling cascades
Mikito Takefuji, Marcus Krüger, Kishor K. Sivaraj, Kozo Kaibuchi, Stefan Offermanns, Nina Wettschureck
J Exp Med. 2013 Apr 8; 210(4): 665–673. doi: 10.1084/jem.20122126
PMCID:
PMC3620351
AbstractArticlePDF–2.2M

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