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Select item 110013221.

MicroRNA-192-5p downregulates Fat Mass and Obesity-associated Protein to aggravate renal ischemia/reperfusion injury

Chengjun Zhang, Ge Guan, Jiantao Wang, Haijian Wei, Jinzhen Cai

Ren Fail. 2023; 45(2): 2285869. Published online 2023 Dec 4. doi: 10.1080/0886022X.2023.2285869

PMCID:: PMC11001322

Abstract Article PDF–3.8M

Select item 109176602.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 109083553.

Fat mass and obesity associated protein inhibits neuronal ferroptosis via the FYN/Drp1 axis and alleviate cerebral ischemia/reperfusion injury

Yi Zhang, Xin Gong

CNS Neurosci Ther. 2024 Mar; 30(3): e14636. Published online 2024 Mar 2. doi: 10.1111/cns.14636

PMCID:: PMC10908355

Abstract Article PDF–35M

Select item 108973044.

Lactylation-driven FTO targets CDK2 to aggravate microvascular anomalies in diabetic retinopathy

Xue Chen, Ying Wang, Jia-Nan Wang, Yi-Chen Zhang, Ye-Ran Zhang, Ru-Xu Sun, Bing Qin, Yuan-Xin Dai, Hong-Jing Zhu, Jin-Xiang Zhao, Wei-Wei Zhang, Jiang-Dong Ji, Song-Tao Yuan, Qun-Dong Shen, Qing-Huai Liu

EMBO Mol Med. 2024 Feb; 16(2): 294–318. Published online 2024 Jan 31. doi: 10.1038/s44321-024-00025-1

PMCID:: PMC10897304

Abstract Article PDF–6.8M

Select item 106345695.

Cell Differentiation and Aging Lead To Up-Regulation of FTO, While the ALKBH5 Protein Level Was Stable During Aging but Up-Regulated During in vitro-Induced Cardiomyogenesis

Jana KREJČÍ, Orazio Angelo ARCIDIACONO, Radim ČEGAN, Katarzyna RADASZKIEWICZ, Jiří PACHERNÍK, Jan PIRK, Martin PEŠL, Petr FILA, Eva BÁRTOVÁ

Physiol Res. 2023 Aug; 72(4): 425–444. Published online 2023 Aug 31. doi: 10.33549/physiolres.935078

PMCID:: PMC10634569

Abstract Article PDF–3.8M

Select item 105436436.

Mettl14-mediated m⁶A modification ensures the cell-cycle progression of late-born retinal progenitor cells

Liang Li, Yue Sun, Alexander E. Davis, Sahil H. Shah, Lobna K. Hamed, Man-Ru Wu, Cheng-Hui Lin, Jun B. Ding, Sui Wang

Cell Rep. Author manuscript; available in PMC 2023 Oct 2.

Published in final edited form as: Cell Rep. 2023 Jun 27; 42(6): 112596. Published online 2023 Jun 1. doi: 10.1016/j.celrep.2023.112596

PMCID:: PMC10543643

Abstract Article PDF–3.9M

Select item 105412047.

FTO fuels diabetes-induced vascular endothelial dysfunction associated with inflammation by erasing m⁶A methylation of TNIP1

Chuandi Zhou, Xinping She, Chufeng Gu, Yanan Hu, Mingming Ma, Qinghua Qiu, Tao Sun, Xun Xu, Haibing Chen, Zhi Zheng

J Clin Invest. 2023 Oct 2; 133(19): e160517. Published online 2023 Oct 2. doi: 10.1172/JCI160517

PMCID:: PMC10541204

Abstract Article PDF–19M

Select item 104272078.

A lncRNA from the FTO locus acts as a suppressor of the m⁶A writer complex and p53 tumor suppression signaling

Jianong Zhang, Jiangbo Wei, Rui Sun, Haoyue Sheng, Kai Yin, Yunqian Pan, Rafael Jimenez, Sujun Chen, Xiao-long Cui, Zhongyu Zou, Zhiying Yue, Michael J. Emch, John R. Hawse, Liguo Wang, Housheng Hansen He, Shujie Xia, Bangmin Han, Chuan He, Haojie Huang

Mol Cell. Author manuscript; available in PMC 2024 Aug 3.

Published in final edited form as: Mol Cell. 2023 Aug 3; 83(15): 2692–2708.e7. Published online 2023 Jul 20. doi: 10.1016/j.molcel.2023.06.024

PMCID:: PMC10427207

Abstract Article PDF–3.6M

Select item 103209669.

FTO-dependent m⁶A regulates muscle fiber remodeling in an NFATC1–YTHDF2 dependent manner

Wengang Wang, Xueming Du, Ming Luo, Ningning Yang

Clin Epigenetics. 2023; 15: 109. Published online 2023 Jul 5. doi: 10.1186/s13148-023-01526-5

PMCID:: PMC10320966

Abstract Article PDF–13M

Select item 1025000810.

Cerebroprotective role of m⁶A demethylase FTO after experimental stroke

Anil K Chokkalla, Soomin Jeong, Suresh L Mehta, Charles K Davis, Kahlilia C Morris-Blanco, Saivenkateshkomal Bathula, Simran S Qureshi, Raghu Vemuganti

Stroke. Author manuscript; available in PMC 2024 Jan 1.

Published in final edited form as: Stroke. 2023 Jan; 54(1): 245–254. Published online 2022 Nov 2. doi: 10.1161/STROKEAHA.122.040401

PMCID:: PMC10250008

Abstract Article PDF–676K

Select item 989748611.

Recruitment of CTCF to an Fto enhancer is responsible for transgenerational inheritance of BPA-induced obesity

Yoon Hee Jung, Hsiao-Lin V. Wang, Daniel Ruiz, Brianna J. Bixler, Hannah Linsenbaum, Jian-Feng Xiang, Samantha Forestier, Andrew M. Shafik, Peng Jin, Victor G. Corces

Proc Natl Acad Sci U S A. 2022 Dec 13; 119(50): e2214988119. Published online 2022 Dec 5. doi: 10.1073/pnas.2214988119

PMCID:: PMC9897486

Abstract Article PDF–5.5M

Select item 988693912.

FTO-dependent m⁶A modification of Plpp3 in circSCMH1-regulated vascular repair and functional recovery following stroke

Bin Li, Wen Xi, Ying Bai, Xue Liu, Yuan Zhang, Lu Li, Liang Bian, Chenchen Liu, Ying Tang, Ling Shen, Li Yang, Xiaochun Gu, Jian Xie, Zhongqiu Zhou, Yu Wang, Xiaoyu Yu, Jianhong Wang, Jie Chao, Bing Han, Honghong Yao

Nat Commun. 2023; 14: 489. Published online 2023 Jan 30. doi: 10.1038/s41467-023-36008-y

PMCID:: PMC9886939

Abstract Article PDF–4.2M

Select item 974648913.

FTO mediates LINE1 m⁶A demethylation and chromatin regulation in mESCs and mouse development

Jiangbo Wei, Xianbin Yu, Lei Yang, Xuelian Liu, Boyang Gao, Boxian Huang, Xiaoyang Dou, Jun Liu, Zhongyu Zou, Xiao-Long Cui, Li-Sheng Zhang, Xingsen Zhao, Qinzhe Liu, P. Cody He, Caraline Sepich-Poore, Nicole Zhong, Wenqiang Liu, Yanhe Li, Xiaochen Kou, Yanhong Zhao, You Wu, Xuejun Cheng, Chuan Chen, Yiming An, Xueyang Dong, Huanyu Wang, Qiang Shu, Ziyang Hao, Tao Duan, Yu-Ying He, Xuekun Li, Shaorong Gao, Yawei Gao, Chuan He

Science. Author manuscript; available in PMC 2023 May 27.

Published in final edited form as: Science. 2022 May 27; 376(6596): 968–973. Published online 2022 May 5. doi: 10.1126/science.abe9582

PMCID:: PMC9746489

Abstract Article PDF–1.3M

Select item 971275914.

Jian Zhang, Jing Chen, Yufei Lu, Yan Yang, Weize Chen, Bo Shen, Jiachang Hu, Ping Jia, Sujuan Xu, Yiqin Shi, Yichun Ning, Jialin Wang, Yi Fang, Shuan Zhao, Yang Li, Yan Dai, Xiaoyan Zhang, Meng Xiang, Yang Tian, Zhichao Liu, Nana Song, Xiaoqiang Ding

iScience. 2022 Dec 22; 25(12): 105620. Published online 2022 Nov 17. doi: 10.1016/j.isci.2022.105620