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Select item 101118621.

ALOX5-mediated ferroptosis acts as a distinct cell death pathway upon oxidative stress in Huntington's disease

Shujuan Song, Zhenyi Su, Ning Kon, Bo Chu, Huan Li, Xuejun Jiang, Jianyuan Luo, Brent R. Stockwell, Wei Gu

Genes Dev. 2023 Mar 1; 37(5-6): 204–217. doi: 10.1101/gad.350211.122

PMCID:: PMC10111862

Abstract Article PDF–5.3M

Select item 99458432.

Neonatal imprinting of alveolar macrophages via neutrophil-derived 12-HETE

Erwan Pernet, Sarah Sun, Nicole Sarden, Saideep Gona, Angela Nguyen, Nargis Khan, Martin Mawhinney, Kim A. Tran, Julia Chronopoulos, Dnyandeo Amberkar, Mina Sadeghi, Alexandre Grant, Shradha Wali, Renaud Prevel, Jun Ding, James G. Martin, Ajitha Thanabalasuriar, Bryan G. Yipp, Luis B. Barreiro, Maziar Divangahi

Nature. 2023; 614(7948): 530–538. Published online 2023 Jan 4. doi: 10.1038/s41586-022-05660-7

PMCID:: PMC9945843

Abstract Article PDF–44M

Select item 96729603.

Diminished arachidonate 5-lipoxygenase perturbs phase separation and transcriptional response of Runx2 to reverse pathological ventricular remodeling

Saiyang Xie, Mengya Chen, Wenxi Fang, Shiqiang Liu, Qingqing Wu, Chen Liu, Yun Xing, Wenke Shi, Man Xu, Min Zhang, Si Chen, Xiaofeng Zeng, Shasha Wang, Wei Deng, Qizhu Tang

eBioMedicine. 2022 Dec; 86: 104359. Published online 2022 Nov 14. doi: 10.1016/j.ebiom.2022.104359

PMCID:: PMC9672960

Abstract Article PDF–7.2M

Select item 95765604.

Transcellular biosynthesis of leukotriene B₄ orchestrates neutrophil swarming to fungi

Alex Hopke, Tian Lin, Allison K. Scherer, Ashley E. Shay, Kyle D. Timmer, Brittany Wilson-Mifsud, Michael K. Mansour, Charles N. Serhan, Daniel Irimia, Bryan P. Hurley

iScience. 2022 Oct 21; 25(10): 105226. Published online 2022 Sep 28. doi: 10.1016/j.isci.2022.105226

PMCID:: PMC9576560

Abstract Article PDF–2.7M

Select item 95510345.

Age-linked suppression of lipoxin A4 associates with cognitive deficits in mice and humans

Fabricio A. Pamplona, Gabriela Vitória, Felipe K. Sudo, Felipe C. Ribeiro, Alinny R. Isaac, Carolina A. Moraes, Mariana G. Chauvet, Pitia Flores Ledur, Karina Karmirian, Isis M. Ornelas, Luciana M. Leo, Bruna Paulsen, Gabriel Coutinho, Claudia Drummond, Naima Assunção, Bart Vanderborght, Claudio A. Canetti, Hugo C. Castro-Faria-Neto, Paulo Mattos, Sergio T. Ferreira, Stevens K. Rehen, Fernando A. Bozza, Mychael V. Lourenco, Fernanda Tovar-Moll

Transl Psychiatry. 2022; 12: 439. Published online 2022 Oct 10. doi: 10.1038/s41398-022-02208-1

PMCID:: PMC9551034

Abstract Article PDF–2.5M

Select item 95292656.

Arachidonate 5-lipoxygenase is essential for biosynthesis of specialized pro-resolving mediators and cardiac repair in heart failure

Ganesh V. Halade, Vasundhara Kain, Shahriare Hossain, Vibhu Parcha, Nita A. Limdi, Pankaj Arora

Am J Physiol Heart Circ Physiol. 2022 Oct 1; 323(4): H721–H737. Published online 2022 Aug 26. doi: 10.1152/ajpheart.00115.2022

PMCID:: PMC9529265

Abstract Article

Select item 93021677.

Toxoplasma gondii Infection Decreases Intestinal 5-Lipoxygenase Expression, while Exogenous LTB₄ Controls Parasite Growth

Ester Cristina Borges Araujo, Marisol Patricia Pallete Briceño, Yusmaris Cariaco, Mário Cézar Oliveira, Marcos Paulo Oliveira Almeida, Natália Carnevalli de Miranda, Neide Maria Silva

Infect Immun. 2022 Jul; 90(7): e00029-22. Published online 2022 Jun 6. doi: 10.1128/iai.00029-22

PMCID:: PMC9302167

Abstract Article PDF–3.1M

Select item 88908678.

5-Lipoxygenase Inhibition Protects Retinal Pigment Epithelium from Sodium Iodate-Induced Ferroptosis and Prevents Retinal Degeneration

Jong-Jer Lee, Guo-Ping Chang-Chien, Sufan Lin, Yu-Ting Hsiao, Mu-Chan Ke, Alexander Chen, Tsu-Kung Lin

Oxid Med Cell Longev. 2022; 2022: 1792894. Published online 2022 Feb 23. doi: 10.1155/2022/1792894

PMCID:: PMC8890867

Abstract Article PDF–3.9M

Select item 85673159.

Proteomic and lipidomic profiling of demyelinating lesions identifies fatty acids as modulators in lesion recovery

Horst Penkert, Alix Bertrand, Vini Tiwari, Stephan Breimann, Stephan A. Müller, Paul M. Jordan, Mathias J. Gerl, Christian Klose, Ludovico Cantuti-Castelvetri, Mar Bosch-Queralt, Ilya Levental, Stefan F. Lichtenthaler, Oliver Werz, Mikael Simons

Cell Rep. 2021 Oct 26; 37(4): 109898. Published online 2021 Oct 26. doi: 10.1016/j.celrep.2021.109898

PMCID:: PMC8567315

Abstract Article

Select item 848674910.

Alveolar socket healing in 5-lipoxygenase knockout aged female mice treated or not with high dose of zoledronic acid

Ramez H. Mahmoud, Claudia C. Biguetti, Gustavo B. Simionato, Isabela C. Custódio, Raquel B. P. Silva, Marco A. H. Duarte, Leonardo P. Faverani, Edilson Ervolino, Walid D. Fakhouri, Mariza A. Matsumoto

Sci Rep. 2021; 11: 19535. Published online 2021 Oct 1. doi: 10.1038/s41598-021-98713-2

PMCID:: PMC8486749

Abstract Article PDF–3.6M

Select item 793877011.

BraInMap elucidates the macromolecular connectivity landscape of mammalian brain

Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili

Cell Syst. Author manuscript; available in PMC 2021 Apr 22.

Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003

Correction in:: Cell Syst. 2020 Aug 26; 11(2): 208.

PMCID:: PMC7938770

Abstract Article PDF–2.0M

Select item 787801512.

A Basophil-Neuronal Axis Promotes Itch

Fang Wang, Anna M. Trier, Fengxian Li, Seonyoung Kim, Zhen Chen, Jiani N. Chai, Madison R. Mack, Stephanie A. Morrison, Jennifer D. Hamilton, Jinok Baek, Ting-Lin B. Yang, Aaron M. Ver Heul, Amy Z. Xu, Zili Xie, Xintong Dong, Masato Kubo, Hongzhen Hu, Chyi-Song Hsieh, Xinzhong Dong, Qin Liu, David J. Margolis, Marius Ardeleanu, Mark J. Miller, Brian S. Kim

Cell. Author manuscript; available in PMC 2022 Jan 21.

Published in final edited form as: Cell. 2021 Jan 21; 184(2): 422–440.e17. Published online 2021 Jan 14. doi: 10.1016/j.cell.2020.12.033

PMCID:: PMC7878015

Abstract Article PDF–2.6M

Select item 765972913.

The LTB₄–BLT1 axis regulates actomyosin and β₂-integrin dynamics during neutrophil extravasation

Bhagawat C. Subramanian, Nicolas Melis, Desu Chen, Weiye Wang, Devorah Gallardo, Roberto Weigert, Carole A. Parent

J Cell Biol. 2020 Oct 5; 219(10): e201910215. Published online 2020 Aug 26. doi: 10.1083/jcb.201910215

PMCID:: PMC7659729

Abstract Article PDF–5.1M

Select item 764416714.

COX inhibition increases Alternaria-induced pulmonary ILC2 responses and IL-33 release in mice

Weisong Zhou, Jian Zhang, Shinji Toki, Kasia Goleniewska, Allison E. Norlander, Dawn C. Newcomb, Pingsheng Wu, Kelli L. Boyd, Hirohito Kita, R. Stokes Peebles, Jr.

J Immunol. Author manuscript; available in PMC 2020 Nov 5.

Published in final edited form as: J Immunol. 2020 Aug 15; 205(4): 1157–1166. Published online 2020 Jul 20. doi: 10.4049/jimmunol.1901544

PMCID:: PMC7644167

Abstract Article PDF–1.5M

Select item 746947415.

Tuft cell-derived leukotrienes drive rapid anti-helminth immunity in the small intestine but are dispensable for anti-protist immunity

John W. McGinty, Hung-An Ting, Tyler E. Billipp, Marija S. Nadjsombati, Danish M. Khan, Nora A. Barrett, Hong-Erh Liang, Ichiro Matsumoto, Jakob von Moltke

Immunity. Author manuscript; available in PMC 2020 Sep 17.

Published in final edited form as: Immunity. 2020 Mar 17; 52(3): 528–541.e7. Published online 2020 Mar 10. doi: 10.1016/j.immuni.2020.02.005

PMCID:: PMC7469474

Abstract Article PDF–1.1M

Select item 743161016.

New Surgical Model for Bone–Muscle Injury Reveals Age and Gender-Related Healing Patterns in the 5 Lipoxygenase (5LO) Knockout Mouse

Claudia Cristina Biguetti, Maira Cristina Rondina Couto, Ana Claudia Rodrigues Silva, João Vitor Tadashi Cosin Shindo, Vinicius Mateus Rosa, André Luis Shinohara, Jesus Carlos Andreo, Marco Antonio Hungaro Duarte, Zhiying Wang, Marco Brotto, Mariza Akemi Matsumoto

Front Endocrinol (Lausanne) 2020; 11: 484. Published online 2020 Aug 11. doi: 10.3389/fendo.2020.00484

PMCID:: PMC7431610

Abstract Article PDF–8.0M

Select item 706434417.

A novel role for lipoxin A₄ in driving a lymph node–eye axis that controls autoimmunity to the neuroretina

Jessica Wei, Mary J Mattapallil, Reiko Horai, Yingyos Jittayasothorn, Arnav P Modi, H Nida Sen, Karsten Gronert, Rachel R Caspi

eLife. 2020; 9: e51102. Published online 2020 Mar 2. doi: 10.7554/eLife.51102

PMCID:: PMC7064344

Abstract Article PDF–1.6M

Select item 682554318.

Leukotriene synthesis is critical for medulloblastoma progression

Fang Du, Larra Yuelling, Eric H. Lee, Yuan Wang, Shengyou Liao, Yan Cheng, Li Zhang, Chaonan Zheng, Suraj Peri, Kathy Q. Cai, Jessica M. Y. Ng, Tom Curran, Peng Li, Zeng-jie Yang

Clin Cancer Res. Author manuscript; available in PMC 2020 May 1.

Published in final edited form as: Clin Cancer Res. 2019 Nov 1; 25(21): 6475–6486. Published online 2019 Jul 12. doi: 10.1158/1078-0432.CCR-18-3549

PMCID:: PMC6825543

Abstract Article PDF–2.5M

Select item 660559319.

Identification of 12/15-Lipoxygenase as a Regulator of Axon Degeneration through High-Content Screening

York Rudhard, Arundhati Sengupta Ghosh, Beatrix Lippert, Alexander Böcker, Mehdi Pedaran, Joachim Krämer, Hai Ngu, Oded Foreman, Yichin Liu, Joseph W. Lewcock

J Neurosci. 2015 Feb 18; 35(7): 2927–2941. doi: 10.1523/JNEUROSCI.2936-14.2015

PMCID:: PMC6605593

Abstract Article PDF–8.5M

Select item 647708520.

Paradoxical Effect of LTB₄ on the Regulation of Stress-Induced Corticosterone Production

Gisele A. Locachevic, Morgana K. B. Prado, Karina F. Zoccal, Priscilla A. T. Pereira, Carlos A. Sorgi, Mariza Bortolanza, Ana Paula F. Peti, Manoela V. Fogaça, Francisco S. Guimarães, Elaine Del Bel, Lúcia H. Faccioli

Front Behav Neurosci. 2019; 13: 73. Published online 2019 Apr 16. doi: 10.3389/fnbeh.2019.00073

PMCID:: PMC6477085

Abstract Article PDF–2.3M

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