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Items: 1 to 20 of 29

1.
Genetic determinants of micronucleus formation in vivo
D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus
Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0
PMCID:
PMC10917660
AbstractArticlePDF–4.8M
2.
Lung dendritic-cell metabolism underlies susceptibility to viral infection in diabetes
Samuel Philip Nobs, Aleksandra A. Kolodziejczyk, Lital Adler, Nir Horesh, Christine Botscharnikow, Ella Herzog, Gayatree Mohapatra, Sophia Hejndorf, Ryan-James Hodgetts, Igor Spivak, Lena Schorr, Leviel Fluhr, Denise Kviatcovsky, Anish Zacharia, Suzanne Njuki, Dinorah Barasch, Noa Stettner, Mally Dori-Bachash, Alon Harmelin, Alexander Brandis, Tevie Mehlman, Ayelet Erez, Yiming He, Sara Ferrini, Jens Puschhof, Hagit Shapiro, Manfred Kopf, Arieh Moussaieff, Suhaib K. Abdeen, Eran Elinav
Nature. 2023; 624(7992): 645–652. Published online 2023 Dec 13. doi: 10.1038/s41586-023-06803-0
PMCID:
PMC10733144
AbstractArticlePDF–13M
3.
Genome-wide analysis of sex-specific differences in the mother–child PELAGIE cohort exposed to organophosphate metabolites
Martina Capriati, Chunxiang Hao, Shereen Cynthia D’Cruz, Christine Monfort, Cecile Chevrier, Charline Warembourg, Fatima Smagulova
Sci Rep. 2023; 13: 8003. Published online 2023 May 17. doi: 10.1038/s41598-023-35113-8
PMCID:
PMC10192208
AbstractArticlePDF–3.0M
4.
Pyruvate dehydrogenase kinase 1 and 2 deficiency reduces high-fat diet-induced hypertrophic obesity and inhibits the differentiation of preadipocytes into mature adipocytes
Hyeon-Ji Kang, Byong-Keol Min, Won-Il Choi, Jae-Han Jeon, Dong Wook Kim, Sungmi Park, Yun-Kyung Lee, Hwa-jin Kim, Ju-Eun Byeon, Younghoon Go, Hye Jin Ham, Yong Hyun Jeon, Mi-Jin Kim, Jung Yi Lee, Adam R. Wende, Sung Hee Choi, Robert A. Harris, In-Kyu Lee
Exp Mol Med. 2021 Sep; 53(9): 1390–1401. Published online 2021 Sep 22. doi: 10.1038/s12276-021-00672-1
PMCID:
PMC8492875
AbstractArticlePDF–5.5M
5.
Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development
Francesco Bedogni, Robert F. Hevner
Front Mol Neurosci. 2021; 14: 686034. Published online 2021 Jul 12. doi: 10.3389/fnmol.2021.686034
PMCID:
PMC8313239
AbstractArticlePDF–1.6M
6.
BraInMap elucidates the macromolecular connectivity landscape of mammalian brain
Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili
Cell Syst. Author manuscript; available in PMC 2021 Apr 22.
Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003
Correction in:
Cell Syst. 2020 Aug 26; 11(2): 208.
PMCID:
PMC7938770
AbstractArticlePDF–2.0M
7.
GGPP depletion initiates metaflammation through disequilibrating CYB5R3-dependent eicosanoid metabolism
Lisha Wei, Yan-Yan Zheng, Jie Sun, Pei Wang, Tao Tao, Yeqiong Li, Xin Chen, Yongjuan Sang, Danyang Chong, Wei Zhao, Yuwei Zhou, Ye Wang, Zhihui Jiang, Tiantian Qiu, Chao-Jun Li, Min-Sheng Zhu, Xuena Zhang
J Biol Chem. 2020 Nov 20; 295(47): 15988–16001. Published online 2020 Sep 10. doi: 10.1074/jbc.RA120.015020
PMCID:
PMC7681012
AbstractArticlePDF–3.6M
8.
Glucose Metabolism Drives Histone Acetylation Landscape Transitions that Dictate Muscle Stem Cell Function
Nora Yucel, Yu Xin Wang, Thach Mai, Ermelinda Porpiglia, Peder J. Lund, Glenn Markov, Benjamin A. Garcia, Sean C. Bendall, Michael Angelo, Helen M. Blau
Cell Rep. Author manuscript; available in PMC 2019 Oct 11.
Published in final edited form as: Cell Rep. 2019 Jun 25; 27(13): 3939–3955.e6. doi: 10.1016/j.celrep.2019.05.092
PMCID:
PMC6788807
AbstractArticlePDF–2.3M
9.
Metabolic Connection of Inflammatory Pain: Pivotal Role of a Pyruvate Dehydrogenase Kinase-Pyruvate Dehydrogenase-Lactic Acid Axis
Mithilesh Kumar Jha, Gyun Jee Song, Maan Gee Lee, Nam Ho Jeoung, Younghoon Go, Robert A. Harris, Dong Ho Park, Hyun Kook, In-Kyu Lee, Kyoungho Suk
J Neurosci. 2015 Oct 21; 35(42): 14353–14369. doi: 10.1523/JNEUROSCI.1910-15.2015
PMCID:
PMC6605420
AbstractArticlePDF–5.5M
10.
Regulation of Glycolysis by Pdk Functions as a Metabolic Checkpoint for Cell Cycle Quiescence in Hematopoietic Stem Cells
Keiyo Takubo, Go Nagamatsu, Chiharu I. Kobayashi, Ayako Nakamura-Ishizu, Hiroshi Kobayashi, Eiji Ikeda, Nobuhito Goda, Yasmeen Rahimi, Randall S. Johnson, Tomoyoshi Soga, Atsushi Hirao, Makoto Suematsu, Toshio Suda
Cell Stem Cell. Author manuscript; available in PMC 2019 Jun 25.
Published in final edited form as: Cell Stem Cell. 2013 Jan 3; 12(1): 49–61. doi: 10.1016/j.stem.2012.10.011
PMCID:
PMC6592822
AbstractArticlePDF–2.5M
11.
Pyruvate Dehydrogenase Kinase Is a Metabolic Checkpoint for Polarization of Macrophages to the M1 Phenotype
Byong-Keol Min, Sungmi Park, Hyeon-Ji Kang, Dong Wook Kim, Hye Jin Ham, Chae-Myeong Ha, Byung-Jun Choi, Jung Yi Lee, Chang Joo Oh, Eun Kyung Yoo, Hui Eon Kim, Byung-Gyu Kim, Jae-Han Jeon, Do Young Hyeon, Daehee Hwang, Yong-Hoon Kim, Chul-Ho Lee, Taeho Lee, Jung-whan Kim, Yeon-Kyung Choi, Keun-Gyu Park, Ajay Chawla, Jongsoon Lee, Robert A. Harris, In-Kyu Lee
Front Immunol. 2019; 10: 944. Published online 2019 May 7. doi: 10.3389/fimmu.2019.00944
PMCID:
PMC6514528
AbstractArticlePDF–9.8M
12.
Tissue-specific kinase expression and activity regulate flux through the pyruvate dehydrogenase complex
Alla Klyuyeva, Alina Tuganova, Natalia Kedishvili, Kirill M. Popov
J Biol Chem. 2019 Jan 18; 294(3): 838–851. Published online 2018 Nov 27. doi: 10.1074/jbc.RA118.006433
PMCID:
PMC6341403
AbstractArticlePDF–2.7M
13.
PEG3 binds to H19-ICR as a transcriptional repressor
An Ye, Hongzhi He, Joomyeong Kim
Epigenetics. 2016; 11(12): 889–900. Published online 2016 Nov 8. doi: 10.1080/15592294.2016.1255385
PMCID:
PMC5193492
AbstractArticlePDF–1.2M
14.
Requirement for the Mitochondrial Pyruvate Carrier in Mammalian Development Revealed by a Hypomorphic Allelic Series
Caitlyn E. Bowman, Liang Zhao, Thomas Hartung, Michael J. Wolfgang
Mol Cell Biol. 2016 Aug 1; 36(15): 2089–2104. Prepublished online 2016 May 23. Published online 2016 Jul 14. doi: 10.1128/MCB.00166-16
PMCID:
PMC4946427
AbstractArticlePDF–3.4M
15.
Pyruvate Dehydrogenase Kinase-mediated Glycolytic Metabolic Shift in the Dorsal Root Ganglion Drives Painful Diabetic Neuropathy
Md Habibur Rahman, Mithilesh Kumar Jha, Jong-Heon Kim, Youngpyo Nam, Maan Gee Lee, Younghoon Go, Robert A. Harris, Dong Ho Park, Hyun Kook, In-Kyu Lee, Kyoungho Suk
J Biol Chem. 2016 Mar 11; 291(11): 6011–6025. Published online 2016 Jan 14. doi: 10.1074/jbc.M115.699215
PMCID:
PMC4786733
AbstractArticlePDF–3.1M
16.
Differing roles of pyruvate dehydrogenase kinases during mouse oocyte maturation
Xiaojing Hou, Liang Zhang, Longsen Han, Juan Ge, Rujun Ma, Xuesen Zhang, Kelle Moley, Tim Schedl, Qiang Wang
J Cell Sci. 2015 Jul 1; 128(13): 2319–2329. doi: 10.1242/jcs.167049
PMCID:
PMC4510846
AbstractArticle
17.
Fasting induces ketoacidosis and hypothermia in PDHK2/PDHK4-double-knockout mice
Nam Ho Jeoung, Yasmeen Rahimi, Pengfei Wu, W. N. Paul Lee, Robert A. Harris
Biochem J. Author manuscript; available in PMC 2015 Feb 10.
Published in final edited form as: Biochem J. 2012 May 1; 443(3): 829–839. doi: 10.1042/BJ20112197
PMCID:
PMC4323161
AbstractArticlePDF–437K
18.
Genetic activation of pyruvate dehydrogenase alters oxidative substrate selection to induce skeletal muscle insulin resistance
Yasmeen Rahimi, João-Paulo G. Camporez, Max C. Petersen, Dominik Pesta, Rachel J. Perry, Michael J. Jurczak, Gary W. Cline, Gerald I. Shulman
Proc Natl Acad Sci U S A. 2014 Nov 18; 111(46): 16508–16513. Published online 2014 Nov 3. doi: 10.1073/pnas.1419104111
PMCID:
PMC4246337
AbstractArticlePDF–814K
19.
Genetic mechanisms and signaling pathways in autosomal dominant polycystic kidney disease
Peter C. Harris, Vicente E. Torres
J Clin Invest. 2014 Jun 2; 124(6): 2315–2324. Published online 2014 Jun 2. doi: 10.1172/JCI72272
PMCID:
PMC4089452
AbstractArticlePDF–1.5M
20.
Structure-guided Development of Specific Pyruvate Dehydrogenase Kinase Inhibitors Targeting the ATP-binding Pocket
Shih-Chia Tso, Xiangbing Qi, Wen-Jun Gui, Cheng-Yang Wu, Jacinta L. Chuang, Ingrid Wernstedt-Asterholm, Lorraine K. Morlock, Kyle R. Owens, Philipp E. Scherer, Noelle S. Williams, Uttam K. Tambar, R. Max Wynn, David T. Chuang
J Biol Chem. 2014 Feb 14; 289(7): 4432–4443. Published online 2013 Dec 19. doi: 10.1074/jbc.M113.533885
PMCID:
PMC3924305
AbstractArticlePDF–2.8M

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