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Select item 111927371.

Adult microglial TGFβ1 is required for microglia homeostasis via an autocrine mechanism to maintain cognitive function in mice

Alicia Bedolla, Elliot Wegman, Max Weed, Messiyah K. Stevens, Kierra Ware, Aditi Paranjpe, Anastasia Alkhimovitch, Igal Ifergan, Aleksandr Taranov, Joshua D. Peter, Rosa Maria Salazar Gonzalez, J. Elliott Robinson, Lucas McClain, Krishna M. Roskin, Nigel H. Greig, Yu Luo

Nat Commun. 2024; 15: 5306. Published online 2024 Jun 21. doi: 10.1038/s41467-024-49596-0

PMCID:: PMC11192737

Abstract Article PDF–19M

Select item 110175452.

A P2RY12 deficiency results in sex-specific cellular perturbations and sexually dimorphic behavioral anomalies

Ogochukwu J. Uweru, Akhabue K. Okojie, Aparna Trivedi, Jordan Benderoth, Lauren S. Thomas, Georgia Davidson, Kendall Cox, Ukpong B. Eyo

J Neuroinflammation. 2024; 21: 95. Published online 2024 Apr 15. doi: 10.1186/s12974-024-03079-7

PMCID:: PMC11017545

Abstract Article PDF–7.8M

Select item 109292393.

APOE4 genotype and aging impair injury-induced microglial behavior in brain slices, including toward Aβ, through P2RY12

Jordy Sepulveda, Jennifer Yejean Kim, Joseph Binder, Stefano Vicini, G. William Rebeck

Mol Neurodegener. 2024; 19: 24. Published online 2024 Mar 11. doi: 10.1186/s13024-024-00714-y

PMCID:: PMC10929239

Abstract Article PDF–2.4M

Select item 108745874.

A comparative evaluation of the strengths and potential caveats of the microglial inducible CreER mouse models

Alicia M. Bedolla, Gabriel L. McKinsey, Kierra Ware, Nicolas Santander, Thomas D. Arnold, Yu Luo

Cell Rep. Author manuscript; available in PMC 2024 Feb 18.

Published in final edited form as: Cell Rep. 2024 Jan 23; 43(1): 113660. Published online 2024 Jan 12. doi: 10.1016/j.celrep.2023.113660

PMCID:: PMC10874587

Abstract Article PDF–3.5M

Select item 108242755.

Pannexin-1 opening in neuronal edema causes initial cell death but also leads to protection via increased microglia contacts

Nicholas L. Weilinger, Kai Yang, Hyun B. Choi, Christopher J. Groten, Stefan Wendt, Madhuvika Murugan, Leigh E. Wicki-Stordeur, Louis-Philippe Bernier, Prashanth S. Velayudhan, Jiaying Zheng, Jeffrey M. LeDue, Ravi L. Rungta, John R. Tyson, Terrance P. Snutch, Long-Jun Wu, Brian A. MacVicar

Cell Rep. Author manuscript; available in PMC 2024 Jan 29.

Published in final edited form as: Cell Rep. 2023 Oct 31; 42(10): 113128. Published online 2023 Sep 23. doi: 10.1016/j.celrep.2023.113128

PMCID:: PMC10824275

Abstract Article PDF–3.1M

Select item 108242746.

Impaired hemostatic activity of healthy transfused platelets in inherited and acquired platelet disorders: mechanisms and implications

Robert H. Lee, Raymond Piatt, Ankita Dhenge, María L. Lozano, Verónica Palma-Barqueros, José Rivera, Wolfgang Bergmeier

Sci Transl Med. Author manuscript; available in PMC 2024 Jan 29.

Published in final edited form as: Sci Transl Med. 2019 Dec 11; 11(522): eaay0203. doi: 10.1126/scitranslmed.aay0203

PMCID:: PMC10824274

Abstract Article PDF–1.6M

Select item 108215557.

Blood oxygen regulation via P2Y12R expressed in the carotid body

András Iring, Mária Baranyi, Bernadett Iring-Varga, Paula Mut-Arbona, Zsuzsanna T. Gál, Dorina Nagy, László Hricisák, János Varga, Zoltán Benyó, Beáta Sperlágh

Respir Res. 2024; 25: 61. Published online 2024 Jan 27. doi: 10.1186/s12931-024-02680-x

PMCID:: PMC10821555

Abstract Article PDF–8.3M

Select item 107461448.

Microglia facilitate and stabilize the response to general anesthesia via modulating the neuronal network in a brain region-specific manner

Yang He, Taohui Liu, Quansheng He, Wei Ke, Xiaoyu Li, Jinjin Du, Suixin Deng, Zhenfeng Shu, Jialin Wu, Baozhi Yang, Yuqing Wang, Ying Mao, Yanxia Rao, Yousheng Shu, Bo Peng

eLife. 2023; 12: RP92252. Published online 2023 Dec 22. doi: 10.7554/eLife.92252

PMCID:: PMC10746144

Abstract Article PDF–29M

Select item 107045189.

A thrombus is formed by a gradient of platelet activation and procoagulant endothelium

Estelle Carminita, Julie Tourn, Lydie Crescence, Nicolas Brouilly, Glenn Merrill-Skoloff, Alexandra Mazharian, Christophe Dubois, Laurence Panicot-Dubois

Res Pract Thromb Haemost. 2023 Oct; 7(7): 102209. Published online 2023 Sep 21. doi: 10.1016/j.rpth.2023.102209

PMCID:: PMC10704518

Abstract Article PDF–4.4M

Select item 1059171810.

A comparative analysis of microglial inducible Cre lines

Travis E. Faust, Philip A. Feinberg, Ciara O’Connor, Riki Kawaguchi, Andrew Chan, Hayley Strasburger, Maximilian Frosch, Margaret A. Boyle, Takahiro Masuda, Lukas Amann, Klaus-Peter Knobeloch, Marco Prinz, Anne Schaefer, Dorothy P. Schafer

Cell Rep. Author manuscript; available in PMC 2023 Oct 23.

Published in final edited form as: Cell Rep. 2023 Sep 26; 42(9): 113031. Published online 2023 Aug 26. doi: 10.1016/j.celrep.2023.113031

PMCID:: PMC10591718

Abstract Article PDF–3.9M

Select item 1036754811.

Purinergic receptor P2Y12 boosts autoimmune hepatitis through hexokinase 2-dependent glycolysis in T cells

Wei Zhuang, Xiucheng Liu, Guangyu Liu, Jie Lv, Hao Qin, Chun Wang, Ling Xie, Kaidireya Saimaier, Sanxing Han, Changjie Shi, Qiuhong Hua, Ru Zhang, Changsheng Du

Int J Biol Sci. 2023; 19(11): 3576–3594. Published online 2023 Jul 9. doi: 10.7150/ijbs.85133

PMCID:: PMC10367548

Abstract Article PDF–12M

Select item 1035401612.

Microglial P2Y12 mediates chronic stress-induced synapse loss in the prefrontal cortex and associated behavioral consequences

Justin L. Bollinger, David T. Dadosky, James K. Flurer, Ivanka L. Rainer, Samuel C. Woodburn, Eric S. Wohleb

Neuropsychopharmacology. 2023 Aug; 48(9): 1347–1357. Published online 2022 Dec 14. doi: 10.1038/s41386-022-01519-7

PMCID:: PMC10354016

Abstract Article PDF–5.5M

Select item 959260913.

Microglial debris is cleared by astrocytes via C4b-facilitated phagocytosis and degraded via RUBICON-dependent noncanonical autophagy in mice

Tian Zhou, Yuxin Li, Xiaoyu Li, Fanzhuo Zeng, Yanxia Rao, Yang He, Yafei Wang, Meizhen Liu, Dali Li, Zhen Xu, Xin Zhou, Siling Du, Fugui Niu, Jiyun Peng, Xifan Mei, Sheng-Jian Ji, Yousheng Shu, Wei Lu, Feifan Guo, Tianzhun Wu, Ti-Fei Yuan, Ying Mao, Bo Peng

Nat Commun. 2022; 13: 6233. Published online 2022 Oct 24. doi: 10.1038/s41467-022-33932-3

PMCID:: PMC9592609

Abstract Article PDF–11M

Select item 956943814.

D121 Located within the DRY Motif of P2Y12 Is Essential for P2Y12-Mediated Platelet Function

Carol Dangelmaier, Benjamin Mauri, Akruti Patel, Satya P. Kunapuli, John C Kostyak

Int J Mol Sci. 2022 Oct; 23(19): 11519. Published online 2022 Sep 29. doi: 10.3390/ijms231911519

PMCID:: PMC9569438

Abstract Article PDF–2.2M

Select item 951380615.

Microglial control of neuronal development via somatic purinergic junctions

Csaba Cserép, Anett D. Schwarcz, Balázs Pósfai, Zsófia I. László, Anna Kellermayer, Zsuzsanna Környei, Máté Kisfali, Miklós Nyerges, Zsolt Lele, István Katona, Ádám Dénes

Cell Rep. 2022 Sep 20; 40(12): 111369. Published online 2022 Sep 20. doi: 10.1016/j.celrep.2022.111369

PMCID:: PMC9513806

Abstract Article

Select item 947460516.

Platelets control liver tumor growth through P2Y12-dependent CD40L release in NAFLD

Chi Ma, Qiong Fu, Laurence P. Diggs, John C. McVey, Justin McCallen, Simon Wabitsch, Benjamin Ruf, Zachary Brown, Bernd Heinrich, Qianfei Zhang, Umberto Rosato, Sophie Wang, Linda Cui, Jay A. Berzofsky, David E. Kleiner, Dale B. Bosco, Long-Jun Wu, Chunwei Walter Lai, Yaron Rotman, Changqing Xie, Firouzeh Korangy, Tim F. Greten

Cancer Cell. Author manuscript; available in PMC 2023 Sep 12.

Published in final edited form as: Cancer Cell. 2022 Sep 12; 40(9): 986–998.e5. Published online 2022 Sep 1. doi: 10.1016/j.ccell.2022.08.004

PMCID:: PMC9474605

Abstract Article PDF–2.3M

Select item 927663917.

The zinc finger transcription factor Sall1 is required for the early developmental transition of microglia in mouse embryos

Earl Parker Scott, Emma Breyak, Ryuichi Nishinakamura, Yasushi Nakagawa

Glia. 2022 Sep; 70(9): 1720–1733. Published online 2022 May 14. doi: 10.1002/glia.24192

PMCID:: PMC9276639

Abstract Article PDF–9.7M

Select item 898004218.

Astrocyte plasticity in mice ensures continued endfoot coverage of cerebral blood vessels following injury and declines with age

William A. Mills, III, AnnaLin M. Woo, Shan Jiang, Joelle Martin, Dayana Surendran, Matthew Bergstresser, Ian F. Kimbrough, Ukpong B. Eyo, Michael V. Sofroniew, Harald Sontheimer

Nat Commun. 2022; 13: 1794. Published online 2022 Apr 4. doi: 10.1038/s41467-022-29475-2

PMCID:: PMC8980042

Abstract Article PDF–5.6M

Select item 893253419.

Microglia modulate blood flow, neurovascular coupling, and hypoperfusion via purinergic actions

Eszter Császár, Nikolett Lénárt, Csaba Cserép, Zsuzsanna Környei, Rebeka Fekete, Balázs Pósfai, Diána Balázsfi, Balázs Hangya, Anett D. Schwarcz, Eszter Szabadits, Dávid Szöllősi, Krisztián Szigeti, Domokos Máthé, Brian L. West, Katalin Sviatkó, Ana Rita Brás, Jean-Charles Mariani, Andrea Kliewer, Zsolt Lenkei, László Hricisák, Zoltán Benyó, Mária Baranyi, Beáta Sperlágh, Ákos Menyhárt, Eszter Farkas, Ádám Dénes

J Exp Med. 2022 Mar 7; 219(3): e20211071. Published online 2022 Feb 24. doi: 10.1084/jem.20211071

PMCID:: PMC8932534

Abstract Article PDF–9.0M

Select item 869976120.

P2Y₁₂ Inhibition in Murine Myocarditis Results in Reduced Platelet Infiltration and Preserved Ejection Fraction

Sarah Nasreen Schmidt, Wilfried Reichardt, Beat A. Kaufmann, Carolin Wadle, Dominik von Elverfeldt, Peter Stachon, Ingo Hilgendorf, Dennis Wolf, Timo Heidt, Daniel Duerschmied, Karlheinz Peter, Christoph Bode, Constantin von zur Mühlen, Alexander Maier

Cells. 2021 Dec; 10(12): 3414. Published online 2021 Dec 4. doi: 10.3390/cells10123414

PMCID:: PMC8699761

Abstract Article PDF–1.5M

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