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Items: 1 to 20 of 65

1.
CRISPR editing of anti-anemia drug target rescues independent preclinical models of retinitis pigmentosa
Nicholas D. Nolan, Xuan Cui, Brian M. Robbings, Aykut Demirkol, Kriti Pandey, Wen-Hsuan Wu, Hannah F. Hu, Laura A. Jenny, Chyuan-Sheng Lin, Daniel T. Hass, Jianhai Du, James B. Hurley, Stephen H. Tsang
Cell Rep Med. 2024 Apr 16; 5(4): 101459. Published online 2024 Mar 21. doi: 10.1016/j.xcrm.2024.101459
PMCID:
PMC11031380
AbstractArticlePDF–6.3M
2.
Prolonged hypoxia alleviates prolyl hydroxylation-mediated suppression of RIPK1 to promote necroptosis and inflammation
Tao Zhang, Daichao Xu, Jianping Liu, Min Wang, Li-Juan Duan, Min Liu, Huyan Meng, Yuan Zhuang, Huibing Wang, Yingnan Wang, Mingming Lv, Zhengyi Zhang, Jia Hu, Linyu Shi, Rui Guo, Xingxing Xie, Hui Liu, Emily Erickson, Yaru Wang, Wenyu Yu, Fabin Dang, Dongxian Guan, Cong Jiang, Xiaoming Dai, Hiroyuki Inuzuka, Peiqiang Yan, Jingchao Wang, Mrigya Babuta, Gewei Lian, Zhenbo Tu, Ji Miao, Gyongyi Szabo, Guo-Hua Fong, Antoine E. Karnoub, Yu-Ru Lee, Lifeng Pan, William G. Kaelin, Jr., Junying Yuan, Wenyi Wei
Nat Cell Biol. Author manuscript; available in PMC 2023 Oct 31.
Published in final edited form as: Nat Cell Biol. 2023 Jul; 25(7): 950–962. Published online 2023 Jul 3. doi: 10.1038/s41556-023-01170-4
PMCID:
PMC10617019
AbstractArticlePDF–8.3M
3.
The HIF-prolyl hydroxylases have distinct and nonredundant roles in colitis-associated cancer
Kilian B. Kennel, Julius Burmeister, Praveen Radhakrishnan, Nathalia A. Giese, Thomas Giese, Martin Salfenmoser, Jasper M. Gebhardt, Moritz J. Strowitzki, Cormac T. Taylor, Ben Wielockx, Martin Schneider, Jonathan M. Harnoss
JCI Insight. 2022 Nov 22; 7(22): e153337. Published online 2022 Nov 22. doi: 10.1172/jci.insight.153337
PMCID:
PMC9746807
AbstractArticlePDF–4.9M
4.
Deletion of hypoxia-inducible factor prolyl 4-hydroxylase 2 in FoxD1-lineage mesenchymal cells leads to congenital truncal alopecia
Ann-Helen Rosendahl, Mia Monnius, Anu Laitala, Antti Railo, Ilkka Miinalainen, Ritva Heljasvaara, Joni M. Mäki, Johanna Myllyharju
J Biol Chem. 2022 Apr; 298(4): 101787. Published online 2022 Mar 2. doi: 10.1016/j.jbc.2022.101787
PMCID:
PMC8988008
AbstractArticlePDF–6.1M
5.
Adaptation of the Oxygen Sensing System during Lung Development
Karin M. Kirschner, Simon Kelterborn, Herrmann Stehr, Johanna L. T. Penzlin, Charlotte L. J. Jacobi, Stefanie Endesfelder, Miriam Sieg, Jochen Kruppa, Christof Dame, Lina K. Sciesielski
Oxid Med Cell Longev. 2022; 2022: 9714669. Published online 2022 Feb 18. doi: 10.1155/2022/9714669
PMCID:
PMC8886745
AbstractArticlePDF–2.8M
6.
Isoform-specific Roles of Prolyl Hydroxylases in the Regulation of Pancreatic β-Cell Function
Monica Hoang, Emelien Jentz, Sarah M Janssen, Daniela Nasteska, Federica Cuozzo, David J Hodson, A Russell Tupling, Guo-Hua Fong, Jamie W Joseph
Endocrinology. 2022 Jan; 163(1): bqab226. Published online 2021 Oct 28. doi: 10.1210/endocr/bqab226
PMCID:
PMC8643417
AbstractArticle
7.
PHD3 loss promotes exercise capacity and fat oxidation in skeletal muscle
Haejin Yoon, Jessica B. Spinelli, Elma Zaganjor, Samantha J. Wong, Natalie J. German, Elizabeth C. Randall, Afsah Dean, Allen Clermont, Joao A. Paulo, Daniel Garcia, Hao Li, Olivia Rombold, Nathalie Y. R. Agar, Laurie J. Goodyear, Reuben J. Shaw, Steven P. Gygi, Johan Auwerx, Marcia C. Haigis
Cell Metab. Author manuscript; available in PMC 2021 Apr 24.
Published in final edited form as: Cell Metab. 2020 Aug 4; 32(2): 215–228.e7. Published online 2020 Jul 13. doi: 10.1016/j.cmet.2020.06.017
PMCID:
PMC8065255
AbstractArticlePDF–1.3M
8.
Hypoxia-inducible factor prolyl hydroxylase domain (PHD) inhibition after contusive spinal cord injury does not improve locomotor recovery
George Z. Wei, Sujata Saraswat Ohri, Nicolas K. Khattar, Adam W. Listerman, Catherine H. Doyle, Kariena R. Andres, Saravanan S. Karuppagounder, Rajiv R. Ratan, Scott R. Whittemore, Michal Hetman
PLoS One. 2021; 16(4): e0249591. Published online 2021 Apr 5. doi: 10.1371/journal.pone.0249591
PMCID:
PMC8021188
AbstractArticlePDF–820K
9.
BraInMap elucidates the macromolecular connectivity landscape of mammalian brain
Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili
Cell Syst. Author manuscript; available in PMC 2021 Apr 22.
Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003
Correction in:
Cell Syst. 2020 Aug 26; 11(2): 208.
PMCID:
PMC7938770
AbstractArticlePDF–2.0M
10.
Transmembrane Prolyl 4-Hydroxylase is a Novel Regulator of Calcium Signaling in Astrocytes
Nadiya Byts, Subodh Sharma, Jenny Laurila, Prodeep Paudel, Ilkka Miinalainen, Veli-Pekka Ronkainen, Reetta Hinttala, Kid Törnquist, Peppi Koivunen, Johanna Myllyharju
eNeuro. 2021 Jan-Feb; 8(1): ENEURO.0253-20.2020. Prepublished online 2020 Dec 8. Published online 2021 Jan 5. doi: 10.1523/ENEURO.0253-20.2020
PMCID:
PMC7814479
AbstractArticlePDF–4.9M
11.
Loss of the oxygen sensor PHD3 augments macrophage-mediated systemic inflammatory responses in mice
Judit Kiss, Martin Mollenhauer, Sarah R. Walmsley, Johanna Kirchberg, Praveen Radhakrishnan, Thomas Niemietz, Gunnar Steinert, Moira K.B. Whyte, Peter Carmeliet, Massimiliano Mazzone, Jürgen Weitz, Martin Schneider
J Immunol. Author manuscript; available in PMC 2021 Sep 8.
Published in final edited form as: J Immunol. 2012 Aug 15; 189(4): 1955–65. Published online 2012 Jul 11. doi: 10.4049/jimmunol.1103471
PMCID:
PMC7611627
AbstractArticlePDF–2.5M
12.
Endothelial prolyl hydroxylase 2 is necessary for angiotensin II-mediated renal fibrosis and injury
Yongzhen Zhao, Heng Zeng, Bo Liu, Xiaochen He, Jian-Xiong Chen
Am J Physiol Renal Physiol. 2020 Aug 1; 319(2): F345–F357. Published online 2020 Jul 27. doi: 10.1152/ajprenal.00032.2020
PMCID:
PMC7473903
AbstractArticle
13.
PHD1 controls muscle mTORC1 in a hydroxylation-independent manner by stabilizing leucyl tRNA synthetase
Gommaar D’Hulst, Inés Soro-Arnaiz, Evi Masschelein, Koen Veys, Gillian Fitzgerald, Benoit Smeuninx, Sunghoon Kim, Louise Deldicque, Bert Blaauw, Peter Carmeliet, Leigh Breen, Peppi Koivunen, Shi-Min Zhao, Katrien De Bock
Nat Commun. 2020; 11: 174. Published online 2020 Jan 10. doi: 10.1038/s41467-019-13889-6
PMCID:
PMC6954236
AbstractArticlePDF–2.4M
14.
Regulation of ATP13A2 via PHD2-HIF1α Signaling Is Critical for Cellular Iron Homeostasis: Implications for Parkinson's Disease
Subramanian Rajagopalan, Anand Rane, Shankar J. Chinta, Julie K. Andersen
J Neurosci. 2016 Jan 27; 36(4): 1086–1095. doi: 10.1523/JNEUROSCI.3117-15.2016
PMCID:
PMC6404282
AbstractArticlePDF–2.7M
15.
Hypoxia-inducible factor prolyl-4-hydroxylase-1 is a convergent point in the reciprocal negative regulation of NF-κB and p53 signaling pathways
Karim Ullah, Ann-Helen Rosendahl, Valerio Izzi, Ulrich Bergmann, Taina Pihlajaniemi, Joni M. Mäki, Johanna Myllyharju
Sci Rep. 2017; 7: 17220. Published online 2017 Dec 8. doi: 10.1038/s41598-017-17376-0
PMCID:
PMC5722952
AbstractArticlePDF–7.2M
16.
Hypoxia inducible factor prolyl-4-hydroxylation in FOXD1 lineage cells is essential for normal kidney development
Hanako Kobayashi, Jiao Liu, Andres A. Urrutia, Mikhail Burmakin, Ken Ishii, Malini Rajan, Olena Davidoff, Zubaida Saifudeen, Volker H. Haase
Kidney Int. Author manuscript; available in PMC 2018 Dec 1.
Published in final edited form as: Kidney Int. 2017 Dec; 92(6): 1370–1383. Published online 2017 Aug 26. doi: 10.1016/j.kint.2017.06.015
PMCID:
PMC5696043
AbstractArticlePDF–1.3M
17.
T cell oxygen-sensing proteins establish an immunologically tolerant metastatic niche
David Clever, Rahul Roychoudhuri, Michael G Constantinides, Michael H Askenase, Madhusudhanan Sukumar, Christopher A Klebanoff, Robert L Eil, Heather D Hickman, Zhiya Yu, Jenny H Pan, Douglas C Palmer, Anthony T Phan, John Goulding, Luca Gattinoni, Ananda W Goldrath, Yasmine Belkaid, Nicholas P Restifo
Cell. Author manuscript; available in PMC 2017 Aug 25.
Published in final edited form as: Cell. 2016 Aug 25; 166(5): 1117–1131.e14. doi: 10.1016/j.cell.2016.07.032
PMCID:
PMC5548538
AbstractArticlePDF–1.4M
18.
Hypoxia‐inducible factor 1‐alpha does not regulate osteoclastogenesis but enhances bone resorption activity via prolyl‐4‐hydroxylase 2
Philippa A Hulley, Tammie Bishop, Aude Vernet, Jurgen E Schneider, James R Edwards, Nick A Athanasou, Helen J Knowles
J Pathol. 2017 Jul; 242(3): 322–333. Published online 2017 May 29. doi: 10.1002/path.4906
Correction in:
J Pathol. 2017 Aug; 242(4): 513.
PMCID:
PMC5518186
AbstractArticlePDF–1.1M
19.
Chapter 21: Hyperplasia of Pulmonary Neuroepithelial Bodies (NEB) in Lungs of Prolyl Hydroxylase –1(PHD-1) Deficient Mice
Jie Pan, Herman Yeger, Peter Ratcliffe, Tammie Bishop, Ernest Cutz
Adv Exp Med Biol. Author manuscript; available in PMC 2017 Apr 12.
Published in final edited form as: Adv Exp Med Biol. 2012; 758: 149–155. doi: 10.1007/978-94-007-4584-1_21
PMCID:
PMC5389447
AbstractArticlePDF–1.3M
20.
EglN2 contributes to triple negative breast tumorigenesis by functioning as a substrate for the FBW7 tumor suppressor
Mamoru Takada, Ming Zhuang, Hiroyuki Inuzuka, Jing Zhang, Giada Zurlo, Jinfang Zhang, Qing Zhang
Oncotarget. 2017 Jan 24; 8(4): 6787–6795. Published online 2016 Dec 27. doi: 10.18632/oncotarget.14290
PMCID:
PMC5351669
AbstractArticlePDF–3.3M

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