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Select item 90748671.

TIPE2 Promotes Tumor Initiation But Inhibits Tumor Progression in Murine Colitis-Associated Colon Cancer

Zienab Etwebi, Jason R Goldsmith, Mayassa Bou-Dargham, Yuhua Tian, Ryan Hood, Nina Spitofsky, Mingyue Li, Honghong Sun, Yunwei Lou, Suxia Liu, Christopher Lengner, Youhai H Chen

Inflamm Bowel Dis. 2022 May; 28(5): 764–774. Published online 2021 Dec 11. doi: 10.1093/ibd/izab306

PMCID:: PMC9074867

Abstract Article PDF–38M

Select item 90720332.

Tumor Necrosis Factor-α-Induced Protein 8-Like 2 Ameliorates Cardiac Hypertrophy by Targeting TLR4 in Macrophages

Rui Yao, Lingyao Kong, Chunlei Yang, Jiaqi Du, Guojun Zhao, Yapeng Li

Oxid Med Cell Longev. 2022; 2022: 9469143. Published online 2022 Apr 26. doi: 10.1155/2022/9469143

PMCID:: PMC9072033

Abstract Article PDF–2.7M

Select item 85572123.

TNF-α-induced protein 8-like 2 negatively regulates the immune function of dendritic cells by suppressing autophagy via the TAK1/JNK pathway in septic mice

Shuang-Qing Liu, Chao Ren, Ren-Qi Yao, Yao Wu, Ying-Yi Luan, Ning Dong, Yong-Ming Yao

Cell Death Dis. 2021 Nov; 12(11): 1032. Published online 2021 Oct 30. doi: 10.1038/s41419-021-04327-x

PMCID:: PMC8557212

Abstract Article PDF–4.9M

Select item 85483914.

The overexpression of Tipe2 in CRC cells suppresses survival while endogenous Tipe2 accelerates AOM/DSS induced-tumor initiation

Yan Li, Na Zhang, Chao Ma, Wenwen Xu, Guiyuan Jin, Yi Zheng, Lei Zhang, Bingyu Liu, Chengjiang Gao, Suxia Liu

Cell Death Dis. 2021 Nov; 12(11): 1001. Published online 2021 Oct 26. doi: 10.1038/s41419-021-04289-0

PMCID:: PMC8548391

Abstract Article PDF–6.8M

Select item 84431875.

TIPE2 is a checkpoint of natural killer cell maturation and antitumor immunity

Jiacheng Bi, Chen Cheng, Chaoyue Zheng, Chen Huang, Xiaohu Zheng, Xiaochun Wan, Youhai H. Chen, Zhigang Tian, Haoyu Sun

Sci Adv. 2021 Sep; 7(38): eabi6515. Published online 2021 Sep 15. doi: 10.1126/sciadv.abi6515

PMCID:: PMC8443187

Abstract Article PDF–1.3M

Select item 83938276.

TIPE2 inhibits PDGF-BB-induced phenotype switching in airway smooth muscle cells through the PI3K/Akt signaling pathway

Huiyuan Wang, Bo Zhong, Yan Geng, Juanjuan Hao, Qiaoyan Jin, Yang Zhang, Lijuan Dong, Dan Gao, Jing Li, Wei Hou

Respir Res. 2021; 22: 238. Published online 2021 Aug 26. doi: 10.1186/s12931-021-01826-5

PMCID:: PMC8393827

Abstract Article PDF–3.3M

Select item 83132397.

Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development

Francesco Bedogni, Robert F. Hevner

Front Mol Neurosci. 2021; 14: 686034. Published online 2021 Jul 12. doi: 10.3389/fnmol.2021.686034

PMCID:: PMC8313239

Abstract Article PDF–1.6M

Select item 82050998.

TNFAIP8L2/TIPE2 impairs autolysosome reformation via modulating the RAC1-MTORC1 axis

Wen Li, Yulan Li, Yetong Guan, Yingxin Du, Mingsheng Zhao, Xiaotong Chen, Faliang Zhu, Chun Guo, Yufeng Jia, Yuan Li, Xiaoyu Wang, Xiaoyan Wang, Yongyu Shi, Qun Wang, Yan Li, Lining Zhang

Autophagy. 2021; 17(6): 1410–1425. Published online 2020 May 28. doi: 10.1080/15548627.2020.1761748

PMCID:: PMC8205099

Abstract Article PDF–19M

Select item 74159919.

BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING)

Kou Motani, Hidetaka Kosako

J Biol Chem. 2020 Aug 7; 295(32): 11174–11183. Published online 2020 Jun 17. doi: 10.1074/jbc.RA120.014323

PMCID:: PMC7415991

Abstract Article PDF–2.0M

Select item 724452910.

TNFAIP8 controls murine intestinal stem cell homeostasis and regeneration by regulating microbiome-induced Akt signaling

Jason R. Goldsmith, Nina Spitofsky, Ali Zamani, Ryan Hood, Amanda Boggs, Xinyuan Li, Mingyue Li, Elizabeth Reiner, Arshad Ayyaz, Zienab Etwebi, Ling Lu, Javier Rivera Guzman, Mayassa J. Bou-Dargham, Terry Cathoupolis, Hakon Hakonarson, Honghong Sun, Jeffrey L. Wrana, Michael V. Gonzalez, Youhai H. Chen

Nat Commun. 2020; 11: 2591. Published online 2020 May 22. doi: 10.1038/s41467-020-16379-2

PMCID:: PMC7244529

Abstract Article PDF–14M

Select item 717086111.

The TIPE Molecular Pilot That Directs Lymphocyte Migration in Health and Inflammation

Honghong Sun, Mei Lin, Ali Zamani, Jason R. Goldsmith, Amanda E. Boggs, Mingyue Li, Chin-Nien Lee, Xu Chen, Xinyuan Li, Ting Li, Brigid L. Dorrity, Ning Li, Yunwei Lou, Songlin Shi, Wei Wang, Youhai H. Chen

Sci Rep. 2020; 10: 6617. Published online 2020 Apr 20. doi: 10.1038/s41598-020-63629-w

PMCID:: PMC7170861

Abstract Article PDF–4.0M

Select item 709917312.

Protective Effect of Dexmedetomidine on Acute Lung Injury via the Upregulation of Tumour Necrosis Factor-α-Induced Protein-8-like 2 in Septic Mice

Qian Kong, Xiaojing Wu, Zhen Qiu, Qin Huang, Zhongyuan Xia, Xuemin Song

Inflammation. 2020; 43(3): 833–846. Published online 2020 Jan 11. doi: 10.1007/s10753-019-01169-w

PMCID:: PMC7099173

Abstract Article PDF–4.8M

Select item 709606113.

TIPE2 ameliorates lipopolysaccharide-induced apoptosis and inflammation in acute lung injury

Xiaojing Wu, Qian Kong, Liying Zhan, Zhen Qiu, Qin Huang, Xuemin Song

Inflamm Res. 2019; 68(11): 981–992. Published online 2019 Sep 5. doi: 10.1007/s00011-019-01280-6

PMCID:: PMC7096061

Abstract Article PDF–1.8M

Select item 704170514.

TIPE2 specifies the functional polarization of myeloid-derived suppressor cells during tumorigenesis

Dehong Yan, Jinghui Wang, Honghong Sun, Ali Zamani, Honglin Zhang, Weihong Chen, Aifa Tang, Qingguo Ruan, Xiaolu Yang, Youhai H. Chen, Xiaochun Wan

J Exp Med. 2020 Feb 3; 217(2): e20182005. Published online 2019 Oct 29. doi: 10.1084/jem.20182005

PMCID:: PMC7041705

Abstract Article PDF–3.0M

Select item 679510515.

Tumor Necrosis Factor-α-Induced Protein 8-like 2 Downregulation Reduces CD4⁺ T Lymphocyte Apoptosis in Mice with Thermal Injury

He Huang, Yunliang Cui, Zhaotao Tian, Tanshi Li, Yongming Yao

Med Sci Monit. 2019; 25: 7547–7556. Published online 2019 Oct 8. doi: 10.12659/MSM.917229

PMCID:: PMC6795105

Abstract Article PDF–2.1M

Select item 676904216.

Loss of TIPE2 Has Opposing Effects on the Pathogenesis of Autoimmune Diseases

Ruiling Liu, Xiaozhen He, Wenwen Geng, Ting Wang, Qingguo Ruan

Front Immunol. 2019; 10: 2284. Published online 2019 Sep 24. doi: 10.3389/fimmu.2019.02284

PMCID:: PMC6769042

Abstract Article PDF–1.2M

Select item 578017617.

TIPE2 governs macrophage polarization via negative regulation of mTORC1

Yuan Jiang, Qiang Li, Yuanyuan Zhang, Yuzhi Gao, Libing Jiang, Zhimin Chen

Mol Med Rep. 2018 Jan; 17(1): 952–960. Published online 2017 Nov 6. doi: 10.3892/mmr.2017.7991

PMCID:: PMC5780176

Abstract Article PDF–1.5M

Select item 569082118.

Directing leukocyte polarization and migration by the phosphoinositide transfer protein TIPE2

Svetlana A. Fayngerts, Zhaojun Wang, Ali Zamani, Honghong Sun, Amanda E. Boggs, Thomas P. Porturas, Weidong Xie, Mei Lin, Terry Cathopoulis, Jason R. Goldsmith, Anastassios Vourekas, Youhai H. Chen

Nat Immunol. Author manuscript; available in PMC 2018 Apr 23.

Published in final edited form as: Nat Immunol. 2017 Dec; 18(12): 1353–1360. Published online 2017 Oct 23. doi: 10.1038/ni.3866