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Select item 116966111.

E4F1 coordinates pyruvate metabolism and the activity of the elongator complex to ensure translation fidelity during brain development

Michela Di Michele, Aurore Attina, Pierre-François Roux, Imène Tabet, Sophie Laguesse, Javier Florido, Morane Houdeville, Armelle Choquet, Betty Encislai, Giuseppe Arena, Carlo De Blasio, Olivia Wendling, François-Xavier Frenois, Laura Papon, Lucille Stuani, Maryse Fuentes, Céline Jahannault Talignani, Mélanie Rousseau, Justine Guégan, Yoan Buscail, Pierrick Dupré, Henri-Alexandre Michaud, Geneviève Rodier, Floriant Bellvert, Hanna Kulyk, Carole Ferraro Peyret, Hugo Mathieu, Pierre Close, Francesca Rapino, Cédric Chaveroux, Nelly Pirot, Lucie Rubio, Adeline Torro, Tania Sorg, Fabrice Ango, Christophe Hirtz, Vincent Compan, Elise Lebigot, Andrea Legati, Daniele Ghezzi, Laurent Nguyen, Alexandre David, Claude Sardet, Matthieu Lacroix, Laurent Le Cam

Nat Commun. 2025; 16: 67. Published online 2025 Jan 2. doi: 10.1038/s41467-024-55444-y

PMCID:: PMC11696611

Article PDF–7.7M

Select item 113385212.

Sestrin2 drives ER-phagy in response to protein misfolding

Chiara De Leonibus, Marianna Maddaluno, Rosa Ferriero, Roberta Besio, Laura Cinque, Pei Jin Lim, Alessandro Palma, Rossella De Cegli, Salvatore Gagliotta, Sandro Montefusco, Maria Iavazzo, Marianne Rohrbach, Cecilia Giunta, Elena Polishchuk, Diego Louis Medina, Diego Di Bernardo, Antonella Forlino, Pasquale Piccolo, Carmine Settembre

Dev Cell. 2024 Aug 19; 59(16): 2035–2052.e10. doi: 10.1016/j.devcel.2024.07.004

PMCID:: PMC11338521

Article

Select item 113101813.

Inhibition of Sesn2 has negative regulatory effects on the myogenic differentiation of C2C12 myoblasts

Zubiao Song, Qing Lin, Jiahui Liang, Weixi Zhang

Mol Biomed. 2024 Dec; 5: 31. Published online 2024 Aug 9. doi: 10.1186/s43556-024-00193-z

PMCID:: PMC11310181

Article PDF–3.8M

Select item 109910444.

Sestrin2 ameliorates diabetic retinopathy by regulating autophagy and ferroptosis

Xiaoting Xi, Qianbo Chen, Jia Ma, Xuewei Wang, Junyan Zhang, Yan Li

J Mol Histol. 2024; 55(2): 169–184. Published online 2024 Jan 2. doi: 10.1007/s10735-023-10180-3

Correction in:: J Mol Histol. 2024; 55(2): 185.

PMCID:: PMC10991044

Article PDF–2.7M

Select item 108321765.

Sestrin1, 2, and 3 are dispensable for female fertility in mice

Mengchen Wang, Wenhui Chen, Xinxin Zeng, Taojun Wang, Yingpu Sun, Qingling Yang

J Ovarian Res. 2024; 17: 28. Published online 2024 Feb 1. doi: 10.1186/s13048-024-01345-z

PMCID:: PMC10832176

Article PDF–4.8M

Select item 108250576.

Sestrin2 maintains hepatic immune homeostasis and redox balance partially via inhibiting RIPK3-mediated necroptosis in metabolic dysfunction-associated steatohepatitis

Jian-Bin Zhang, Qian-Ren Zhang, Qian Jin, Jing Yang, Shuang-Zhe Lin, Jian-Gao Fan

Mol Metab. 2024 Feb; 80: 101865. Published online 2023 Dec 30. doi: 10.1016/j.molmet.2023.101865

PMCID:: PMC10825057

Article PDF–7.2M

Select item 103872377.

DELE1 is protective for mitochondrial cardiomyopathy

Helen Huynh, Siting Zhu, Sharon Lee, Yutong Bao, Jing Pang, Anh Nguyen, Yusu Gu, Chao Chen, Kunfu Ouyang, Sylvia M. Evans, Xi Fang

J Mol Cell Cardiol. Author manuscript; available in PMC 2023 Jul 30.

Published in final edited form as: J Mol Cell Cardiol. 2023 Feb; 175: 44–48. Published online 2022 Dec 17. doi: 10.1016/j.yjmcc.2022.12.003

PMCID:: PMC10387237

Article PDF–661K

Select item 100602688.

miR-484 mediates oxidative stress-induced ovarian dysfunction and promotes granulosa cell apoptosis via SESN2 downregulation

Xiaofei Wang, Jiahao Yang, Huiying Li, Hongbei Mu, Ling Zeng, Siying Cai, Ping Su, Huaibiao Li, Ling Zhang, Wenpei Xiang

Redox Biol. 2023 Jun; 62: 102684. Published online 2023 Mar 20. doi: 10.1016/j.redox.2023.102684

Correction in:: Redox Biol. 2024 Apr; 70: 103084.

PMCID:: PMC10060268

Article PDF–26M

Select item 100498599.

Zonated leucine sensing by Sestrin-mTORC1 in the liver controls the response to dietary leucine

Andrew L. Cangelosi, Anna M. Puszynska, Justin M. Roberts, Andrea Armani, Thao P. Nguyen, Jessica B. Spinelli, Tenzin Kunchok, Brianna Wang, Sze Ham Chan, Caroline A. Lewis, William C. Comb, George W. Bell, Aharon Helman, David M. Sabatini

Science. Author manuscript; available in PMC 2023 Mar 28.

Published in final edited form as: Science. 2022 Jul; 377(6601): 47–56. Published online 2022 Jun 30. doi: 10.1126/science.abi9547

PMCID:: PMC10049859

Article PDF–1.7M

Select item 990307610.

Sestrin2 provides cerebral protection through activation of Nrf2 signaling in microglia following subarachnoid hemorrhage

Youqing Yang, Han Ding, Chenxing Yang, Jie Wu, Youyuan Bao, Shihai Lan, Lin Zhou, Lu Zhou, Bangliang Liu, Tao Hong, Xichen Wan, Xiao Wu

Front Immunol. 2023; 14: 1089576. Published online 2023 Jan 24. doi: 10.3389/fimmu.2023.1089576

PMCID:: PMC9903076

Article PDF–18M

Select item 983050111.

Sesn2 Serves as a Regulator between Mitochondrial Unfolded Protein Response and Mitophagy in Intervertebral Disc Degeneration

Wen-Ning Xu, Chun Liu, Huo-Liang Zheng, Hai-Xia Xu, Run-Ze Yang, Sheng-Dan Jiang, Li-Xin Zhu

Int J Biol Sci. 2023; 19(2): 571–592. Published online 2023 Jan 1. doi: 10.7150/ijbs.70211

PMCID:: PMC9830501

Article PDF–11M

Select item 965328412.

Conserved and Distinct Functions of the Autism-Related Chromatin Remodeler CHD8 in Embryonic and Adult Forebrain Neurogenesis

Chen Dong, Chuntao Zhao, Xiang Chen, Kalen Berry, Jiajia Wang, Feng Zhang, Yunfei Liao, Rong Han, Sean Ogurek, Lingli Xu, Li Zhang, Yifeng Lin, Wenhao Zhou, Mei Xin, Daniel A. Lim, Kenneth Campbell, Masato Nakafuku, Ronald R. Waclaw, Q. Richard Lu

J Neurosci. 2022 Nov 2; 42(44): 8373–8392. doi: 10.1523/JNEUROSCI.2400-21.2022

PMCID:: PMC9653284

Article PDF–12M

Select item 952349113.

Mitochondrial stress induces an HRI-eIF2α pathway protective for cardiomyopathy

Siting Zhu, Anh Nguyen, Jing Pang, Jun Zhao, Ze’e Chen, Zhengyu Liang, Yusu Gu, Helen Huynh, Yutong Bao, Sharon Lee, Yuval Kluger, Kunfu Ouyang, Sylvia M Evans, Xi Fang

Circulation. Author manuscript; available in PMC 2023 Sep 27.

Published in final edited form as: Circulation. 2022 Sep 27; 146(13): 1028–1031. Published online 2022 Sep 26. doi: 10.1161/CIRCULATIONAHA.122.059594

PMCID:: PMC9523491

Article PDF–1016K

Select item 936169114.

SESN2 prevents the slow-to-fast myofiber shift in denervated atrophy via AMPK/PGC-1α pathway

Xiaofan Yang, Pingping Xue, Zhenyu Liu, Wenqing Li, Chuyan Li, Zhenbing Chen

Cell Mol Biol Lett. 2022; 27: 66. Published online 2022 Aug 9. doi: 10.1186/s11658-022-00367-z

PMCID:: PMC9361691

Article PDF–12M

Select item 933894015.

Sestrin2 remedies podocyte injury via orchestrating TSP-1/TGF-β1/Smad3 axis in diabetic kidney disease

Shan Song, Chonglin Shi, Yawei Bian, Zhaohua Yang, Lin Mu, Haijiang Wu, Huijun Duan, Yonghong Shi

Cell Death Dis. 2022 Jul; 13(7): 663. Published online 2022 Jul 30. doi: 10.1038/s41419-022-05120-0

PMCID:: PMC9338940

Article PDF–8.6M

Select item 926269316.

Sestrin2 Regulates Beneficial β3-Adrenergic Receptor-Mediated Effects Observed in Inguinal White Adipose Tissue and Soleus Muscle

Min Jeong Park, Joo Won Kim, Eun Roh, Kyung Mook Choi, Sei Hyun Baik, Hwan-Jin Hwang, Hye Jin Yoo

Endocrinol Metab (Seoul) 2022 Jun; 37(3): 552–557. Published online 2022 Jun 29. doi: 10.3803/EnM.2022.1421

PMCID:: PMC9262693

Article PDF–1.4M

Select item 898000117.

Sestrin2 protects against cholestatic liver injury by inhibiting endoplasmic reticulum stress and NLRP3 inflammasome-mediated pyroptosis

Daewon Han, Haeil Kim, Soojin Kim, Qui Anh Le, Seung Yun Han, Jeongyun Bae, Hye Won Shin, Hyun-Goo Kang, Kyung Ho Han, Jongdae Shin, Hwan-Woo Park

Exp Mol Med. 2022 Mar; 54(3): 239–251. Published online 2022 Mar 8. doi: 10.1038/s12276-022-00737-9

PMCID:: PMC8980001

Article PDF–5.3M

Select item 862989518.

Sestrin2 protects against lethal sepsis by suppressing the pyroptosis of dendritic cells

Li-xue Wang, Chao Ren, Ren-qi Yao, Yi-nan Luo, Yue Yin, Yao Wu, Ning Dong, Xiao-mei Zhu, Yong-ming Yao

Cell Mol Life Sci. 2021 Dec; 78(24): 8209–8227. Published online 2021 Nov 6. doi: 10.1007/s00018-021-03970-z

PMCID:: PMC8629895

Article PDF–11M

Select item 841861419.

Sestrin2 protects dendrite cells against ferroptosis induced by sepsis

Jing-yan Li, Chao Ren, Li-Xue Wang, Ren-qi Yao, Ning Dong, Yao Wu, Ying-ping Tian, Yong-ming Yao

Cell Death Dis. 2021 Sep; 12(9): 834. Published online 2021 Sep 4. doi: 10.1038/s41419-021-04122-8

PMCID:: PMC8418614

Article PDF–4.6M

Select item 831912320.

A p53-dependent translational program directs tissue-selective phenotypes in a model of ribosomopathies

Gerald C. Tiu, Craig H. Kerr, Craig M. Forester, Pallavi S. Krishnarao, Hannah D. Rosenblatt, Nitin Raj, Travis C. Lantz, Olena Zhulyn, Margot E. Bowen, Leila Shokat, Laura D. Attardi, Davide Ruggero, Maria Barna

Dev Cell. Author manuscript; available in PMC 2022 Jul 26.

Published in final edited form as: Dev Cell. 2021 Jul 26; 56(14): 2089–2102.e11. Published online 2021 Jul 8. doi: 10.1016/j.devcel.2021.06.013

PMCID:: PMC8319123

Article PDF–2.5M

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