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Items: 1 to 20 of 117

1.
KRAS Promotes GLI2-Dependent Transcription during Pancreatic Carcinogenesis
Ashley N. Sigafoos, Ezequiel J. Tolosa, Ryan M. Carr, Maite G. Fernandez-Barrena, Luciana L. Almada, David R. Pease, Tara L. Hogenson, Glancis L. Raja Arul, Fatemeh Mousavi, Sandhya Sen, Renzo E. Vera, David L. Marks, Luis F. Flores, Kayla C. LaRue-Nolan, Chen Wu, William R. Bamlet, Anne M. Vrabel, Hugues Sicotte, Erin L. Schenk, Thomas C. Smyrk, Lizhi Zhang, Kari G. Rabe, Ann L. Oberg, Peter G. Zaphiropoulos, Eric Chevet, Rondell P. Graham, Catherine E. Hagen, Marina P. di Magliano, Sherine F. Elsawa, Christopher L. Pin, Junhao Mao, Robert R. McWilliams, Martin E. Fernandez-Zapico
Cancer Res Commun. 2024 Jul; 4(7): 1677–1689. Published online 2024 Jul 9. doi: 10.1158/2767-9764.CRC-23-0464
PMCID:
PMC11232480
AbstractArticlePDF–31M
2.
Heterozygous missense variant in GLI2 impairs human endocrine pancreas development
Laura M. Mueller, Abigail Isaacson, Heather Wilson, Anna Salowka, Isabel Tay, Maolian Gong, Nancy Samir Elbarbary, Klemens Raile, Francesca M. Spagnoli
Nat Commun. 2024; 15: 2483. Published online 2024 Mar 20. doi: 10.1038/s41467-024-46740-8
PMCID:
PMC10954617
AbstractArticlePDF–3.2M
3.
Genetic diagnosis of congenital hypopituitarism in Turkish patients by a target gene panel: novel pathogenic variants in GHRHR, GLI2, LHX4 and POU1F1 genes
Tarık Kırkgöz, Semra Gürsoy, Sezer Acar, Özlem Nalbantoğlu, Beyhan Özkaya, Hüseyin Anıl Korkmaz, Filiz Hazan, Behzat Özkan
Arch Endocrinol Metab. 2024; 68: e220254. Published online 2023 Nov 10. doi: 10.20945/2359-4292-2022-0254
PMCID:
PMC10916835
AbstractArticlePDF–193K
4.
Anoikis regulator GLI2 promotes NC cell immunity escape by TGF-β-mediated non-classic hedgehog signaling in colorectal cancer: based on artificial intelligence and big data analysis
Zhang Shanshan, Ding Fanfei, Sun Xuan, Lu Huina, Zhang Ye, Li Jiayu, Zhao Shuo, Pan Xue, Pu Yingye, Jin Chengjun, Pan Hang, Li Li
Aging (Albany NY) 2023 Dec 31; 15(24): 14733–14748. Published online 2023 Dec 29. doi: 10.18632/aging.205283
PMCID:
PMC10781491
AbstractArticlePDF–2.7M
5.
Increasing Ciliary ARL13B Expression Drives Active and Inhibitor-Resistant Smoothened and GLI into Glioma Primary Cilia
Ping Shi, Jia Tian, Julianne C. Mallinger, Dahao Ling, Loic P. Deleyrolle, Jeremy C. McIntyre, Tamara Caspary, Joshua J. Breunig, Matthew R. Sarkisian
Cells. 2023 Oct; 12(19): 2354. Published online 2023 Sep 26. doi: 10.3390/cells12192354
PMCID:
PMC10571910
AbstractArticlePDF–5.7M
6.
Pulse-SILAC and Interactomics Reveal Distinct DDB1-CUL4–Associated Factors, Cellular Functions, and Protein Substrates
Jennifer Raisch, Marie-Line Dubois, Marika Groleau, Dominique Lévesque, Thomas Burger, Carla-Marie Jurkovic, Romain Brailly, Gwendoline Marbach, Alyson McKenna, Catherine Barrette, Pierre-Étienne Jacques, François-Michel Boisvert
Mol Cell Proteomics. 2023 Oct; 22(10): 100644. Published online 2023 Sep 7. doi: 10.1016/j.mcpro.2023.100644
PMCID:
PMC10565876
AbstractArticlePDF–3.7M
7.
Circular RNA circ‐FIRRE interacts with HNRNPC to promote esophageal squamous cell carcinoma progression by stabilizing GLI2 mRNA
Yongjia Zhou, Xia Xue, Junwen Luo, Peiwei Li, Zhaohua Xiao, Wenhao Zhang, Jie Zhou, Peichao Li, Jiangfeng Zhao, Haibo Ge, Zhongxian Tian, Xiaogang Zhao
Cancer Sci. 2023 Sep; 114(9): 3608–3622. Published online 2023 Jul 7. doi: 10.1111/cas.15899
PMCID:
PMC10475760
AbstractArticlePDF–16M
8.
Comparative genomic analysis of human GLI2 locus using slowly evolving fish revealed the ancestral gnathostome set of early developmental enhancers
Shahid Ali, Irum Arif, Ayesha Iqbal, Irfan Hussain, Muhammad Abrar, Muhammad Ramzan Khan, Neil Shubin, Amir Ali Abbasi
Dev Dyn. 2021 May; 250(5): 669–683. Published online 2021 Jan 7. doi: 10.1002/dvdy.291
PMCID:
PMC9292287
AbstractArticlePDF–2.7M
9.
A Critical Function for the Transcription Factors GLI1 and GLI2 in the Proliferation and Survival of Human Mast Cells
Guido Hernan Falduto, Annika Pfeiffer, Qunshu Zhang, Yuzhi Yin, Dean Darrel Metcalfe, Ana Olivera
Front Immunol. 2022; 13: 841045. Published online 2022 Feb 16. doi: 10.3389/fimmu.2022.841045
PMCID:
PMC8888842
AbstractArticlePDF–4.1M
10.
Human transcription factor protein interaction networks
Helka Göös, Matias Kinnunen, Kari Salokas, Zenglai Tan, Xiaonan Liu, Leena Yadav, Qin Zhang, Gong-Hong Wei, Markku Varjosalo
Nat Commun. 2022; 13: 766. Published online 2022 Feb 9. doi: 10.1038/s41467-022-28341-5
PMCID:
PMC8828895
AbstractArticlePDF–1.7M
11.
Proteome‐scale mapping of binding sites in the unstructured regions of the human proteome
Caroline Benz, Muhammad Ali, Izabella Krystkowiak, Leandro Simonetti, Ahmed Sayadi, Filip Mihalic, Johanna Kliche, Eva Andersson, Per Jemth, Norman E Davey, Ylva Ivarsson
Mol Syst Biol. 2022 Jan; 18(1): e10584. Published online 2022 Jan 19. doi: 10.15252/msb.202110584
PMCID:
PMC8769072
AbstractArticlePDF–2.9M
12.
MiR-144-3p inhibits gastric cancer progression and stemness via directly targeting GLI2 involved in hedgehog pathway
Yixun Lu, Benlong Zhang, Baohua Wang, Di Wu, Chuang Wang, Yunhe Gao, Wenquan Liang, Hongqing Xi, Xinxin Wang, Lin Chen
J Transl Med. 2021; 19: 432. Published online 2021 Oct 17. doi: 10.1186/s12967-021-03093-w
PMCID:
PMC8521984
AbstractArticlePDF–4.8M
13.
Constitutive Hedgehog/GLI2 signaling drives extracutaneous basaloid squamous cell carcinoma development and bone remodeling
Marina Grachtchouk, Jianhong Liu, Mark E Hutchin, Paul W Harms, Dafydd Thomas, Lebing Wei, Aiqin Wang, Donelle Cummings, Lori Lowe, Jonathan Garlick, James Sciubba, Arul M Chinnaiyan, Monique E Verhaegen, Andrzej A Dlugosz
Carcinogenesis. 2021 Aug; 42(8): 1100–1109. Published online 2021 Jun 12. doi: 10.1093/carcin/bgab050
PMCID:
PMC8374060
AbstractArticlePDF–1.3M
14.
circCD151 promotes GLI2 expression by regulating miR-30d-5p and enhancing proliferation, invasion and stemness of lung cancer
Lihong Zhao, Hong Zheng, Ping Jiang
Mol Med Rep. 2021 Oct; 24(4): 699. Published online 2021 Aug 4. doi: 10.3892/mmr.2021.12338
PMCID:
PMC8365425
AbstractArticlePDF–2.2M
15.
Protein interaction landscapes revealed by advanced in vivo cross-linking–mass spectrometry
Andrew Wheat, Clinton Yu, Xiaorong Wang, Anthony M. Burke, Ilan E. Chemmama, Robyn M. Kaake, Peter Baker, Scott D. Rychnovsky, Jing Yang, Lan Huang
Proc Natl Acad Sci U S A. 2021 Aug 10; 118(32): e2023360118. Published online 2021 Aug 4. doi: 10.1073/pnas.2023360118
PMCID:
PMC8364181
AbstractArticlePDF–3.0M
16.
PGE2-JNK signaling axis non-canonically promotes Gli activation by protecting Gli2 from ubiquitin-proteasomal degradation
Jun Yang, Juan Wang, Yuan Liu, Yu Zhang, Wenjing Huang, Yu Zou, Yanyan Qiu, Weiyang Cai, Jing Gao, Hu Zhou, Yingli Wu, Weijun Liu, Qingqing Ding, Yanjie Zhang, Pei-hao Yin, Wenfu Tan
Cell Death Dis. 2021 Jul; 12(7): 707. Published online 2021 Jul 15. doi: 10.1038/s41419-021-03995-z
PMCID:
PMC8282835
AbstractArticlePDF–3.4M
17.
Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome
Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi
Cell. Author manuscript; available in PMC 2022 May 27.
Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011
PMCID:
PMC8165030
AbstractArticlePDF–2.2M
18.
sEVs from tonsil-derived mesenchymal stromal cells alleviate activation of hepatic stellate cells and liver fibrosis through miR-486-5p
Jieun Kim, Chanbin Lee, Yongbo Shin, Sihyung Wang, Jinsol Han, Minju Kim, Ji Min Kim, Sung-Chan Shin, Byung-Joo Lee, Tae-Jin Kim, Youngmi Jung
Mol Ther. 2021 Apr 7; 29(4): 1471–1486. Published online 2020 Dec 19. doi: 10.1016/j.ymthe.2020.12.025
PMCID:
PMC8058446
AbstractArticlePDF–5.4M
19.
Impact of cytosine methylation on DNA binding specificities of human transcription factors
Yimeng Yin, Ekaterina Morgunova, Arttu Jolma, Eevi Kaasinen, Biswajyoti Sahu, Syed Khund-Sayeed, Pratyush K. Das, Teemu Kivioja, Kashyap Dave, Fan Zhong, Kazuhiro R. Nitta, Minna Taipale, Alexander Popov, Paul A. Ginno, Silvia Domcke, Jian Yan, Dirk Schübeler, Charles Vinson, Jussi Taipale
Science. Author manuscript; available in PMC 2021 Mar 30.
Published in final edited form as: Science. 2017 May 5; 356(6337): eaaj2239. doi: 10.1126/science.aaj2239
PMCID:
PMC8009048
AbstractArticlePDF–2.6M
20.
GLI2 but not GLI1/GLI3 plays a central role in the induction of malignant phenotype of gallbladder cancer
Shu Ichimiya, Hideya Onishi, Shinjiro Nagao, Satoko Koga, Kukiko Sakihama, Kazunori Nakayama, Akiko Fujimura, Yasuhiro Oyama, Akira Imaizumi, Yoshinao Oda, Masafumi Nakamura
Oncol Rep. 2021 Mar; 45(3): 997–1010. Published online 2021 Jan 22. doi: 10.3892/or.2021.7947
PMCID:
PMC7860001
AbstractArticlePDF–1.5M

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