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Items: 1 to 20 of 202

1.
Muscle-building supplement β-hydroxy β-methylbutyrate binds to PPARα to improve hippocampal functions in mice
Ramesh K. Paidi, Sumita Raha, Avik Roy, Kalipada Pahan
Cell Rep. Author manuscript; available in PMC 2023 Aug 20.
Published in final edited form as: Cell Rep. 2023 Jul 25; 42(7): 112717. Published online 2023 Jul 11. doi: 10.1016/j.celrep.2023.112717
PMCID:
PMC10440158
AbstractArticlePDF–4.4M
2.
Treadmill workout activates PPARα in the hippocampus to upregulate ADAM10, decrease plaques and improve cognitive functions in 5XFAD mouse model of Alzheimer’s disease
Suresh B. Rangasamy, Malabendu Jana, Sridevi Dasarathi, Madhuchhanda Kundu, Kalipada Pahan
Brain Behav Immun. Author manuscript; available in PMC 2024 Mar 1.
Published in final edited form as: Brain Behav Immun. 2023 Mar; 109: 204–218. Published online 2023 Jan 19. doi: 10.1016/j.bbi.2023.01.009
Correction in:
Brain Behav Immun. 2024 Oct; 121: 407–409.
PMCID:
PMC10023420
AbstractArticlePDF–3.6M
3.
Transcription factors KLF15 and PPARδ cooperatively orchestrate genome-wide regulation of lipid metabolism in skeletal muscle
Liyan Fan, David R. Sweet, Erica K. Fan, Domenick A. Prosdocimo, Annmarie Madera, Zhen Jiang, Roshan Padmanabhan, Saptarsi M. Haldar, Vinesh Vinayachandran, Mukesh K. Jain
J Biol Chem. 2022 Jun; 298(6): 101926. Published online 2022 Apr 9. doi: 10.1016/j.jbc.2022.101926
PMCID:
PMC9190004
AbstractArticlePDF–1.9M
4.
Rapid acceleration of KRAS-mutant pancreatic carcinogenesis via remodeling of tumor immune microenvironment by PPARδ
Yi Liu, Yasunori Deguchi, Daoyan Wei, Fuyao Liu, Micheline J. Moussalli, Eriko Deguchi, Donghui Li, Huamin Wang, Lovie Ann Valentin, Jennifer K. Colby, Jing Wang, Xiaofeng Zheng, Haoqiang Ying, Mihai Gagea, Baoan Ji, Jiaqi Shi, James C. Yao, Xiangsheng Zuo, Imad Shureiqi
Nat Commun. 2022; 13: 2665. Published online 2022 May 13. doi: 10.1038/s41467-022-30392-7
PMCID:
PMC9106716
AbstractArticlePDF–6.5M
5.
Endothelial PPARδ facilitates the post-ischemic vascular repair through interaction with HIF1α
Yalan Wu, Xiaolong Tang, Sharen Lee, Huiling Hong, Xiaoyun Cao, Chi Wai Lau, Baohua Liu, Ajay Chawla, Ronald Ching Wan Ma, Yu Huang, Kathy O Lui, Xiao Yu Tian
Theranostics. 2022; 12(4): 1855–1869. Published online 2022 Jan 24. doi: 10.7150/thno.69017
PMCID:
PMC8825601
AbstractArticlePDF–3.5M
6.
High-fat diet-activated fatty acid oxidation mediates intestinal stemness and tumorigenicity
Miyeko D. Mana, Amanda M. Hussey, Constantine N. Tzouanas, Shinya Imada, Yesenia Barrera Millan, Dorukhan Bahceci, Dominic R. Saiz, Anna T. Webb, Caroline A. Lewis, Peter Carmeliet, Maria M. Mihaylova, Alex K. Shalek, Ömer H. Yilmaz
Cell Rep. Author manuscript; available in PMC 2021 Jul 6.
Published in final edited form as: Cell Rep. 2021 Jun 8; 35(10): 109212. doi: 10.1016/j.celrep.2021.109212
PMCID:
PMC8258630
AbstractArticlePDF–1.1M
7.
The pharmacodynamic and differential gene expression analysis of PPAR α/δ agonist GFT505 in CDAHFD-induced NASH model
Linfu Liu, Chuang Liu, Manyu Zhao, Qianru Zhang, Ying Lu, Ping Liu, Hua Yang, Jinliang Yang, Xiaoxin Chen, Yuqin Yao
PLoS One. 2020; 15(12): e0243911. Published online 2020 Dec 16. doi: 10.1371/journal.pone.0243911
PMCID:
PMC7743980
AbstractArticlePDF–4.9M
8.
Mechanistic definition of the cardiovascular mPGES-1/COX-2/ADMA axis
Nicholas S Kirkby, Joan Raouf, Blerina Ahmetaj-Shala, Bin Liu, Sarah I Mazi, Matthew L Edin, Mark Geoffrey Chambers, Marina Korotkova, Xiaomeng Wang, Walter Wahli, Darryl C Zeldin, Rolf Nüsing, Yingbi Zhou, Per-Johan Jakobsson, Jane A Mitchell
Cardiovasc Res. 2020 Oct 1; 116(12): 1972–1980. Published online 2019 Nov 5. doi: 10.1093/cvr/cvz290
PMCID:
PMC7519887
AbstractArticlePDF–928K
9.
Procyanidin B2 mitigates endothelial endoplasmic reticulum stress through a PPARδ-Dependent mechanism
Xin Nie, Weiqi Tang, Zihui Zhang, Chunmiao Yang, Lei Qian, Xinya Xie, Erjiao Qiang, Jingyang Zhao, Wenfei Zhao, Lei Xiao, Nanping Wang
Redox Biol. 2020 Oct; 37: 101728. Published online 2020 Sep 15. doi: 10.1016/j.redox.2020.101728
PMCID:
PMC7509074
AbstractArticlePDF–8.8M
10.
Differential effects of myeloid cell PPARδ and IL10 in regulating macrophage recruitment, phenotype and regeneration following acute muscle injury.
Steven S. Welc, Michelle Wehling-Henricks, Jacqueline Antoun, Tracey T. Ha, Isabella Tous, James G. Tidball
J Immunol. Author manuscript; available in PMC 2021 Sep 15.
Published in final edited form as: J Immunol. 2020 Sep 15; 205(6): 1664–1677. Published online 2020 Aug 19. doi: 10.4049/jimmunol.2000247
PMCID:
PMC7484367
AbstractArticlePDF–2.0M
11.
PPARδ and FOXO1 Mediate Palmitate-Induced Inhibition of Muscle Pyruvate Dehydrogenase Complex and CHO Oxidation, Events Reversed by Electrical Pulse Stimulation
Hung-Che Chien, Paul L. Greenhaff, Dumitru Constantin-Teodosiu
Int J Mol Sci. 2020 Aug; 21(16): 5942. Published online 2020 Aug 18. doi: 10.3390/ijms21165942
PMCID:
PMC7460628
AbstractArticlePDF–2.3M
12.
Deficiency in fibroblast PPARβ/δ reduces nonmelanoma skin cancers in mice
Mark Wei Yi Tan, Ming Keat Sng, Hong Sheng Cheng, Zun Siong Low, Benjamin Jia Juin Leong, Damien Chua, Eddie Han Pin Tan, Jeremy Soon Kiat Chan, Yun Sheng Yip, Yin Hao Lee, Mintu Pal, Xiaomeng Wang, Walter Wahli, Nguan Soon Tan
Cell Death Differ. 2020 Sep; 27(9): 2668–2680. Published online 2020 Apr 20. doi: 10.1038/s41418-020-0535-y
PMCID:
PMC7429869
AbstractArticlePDF–7.9M
13.
Investigating the Role of PPARβ/δ in Retinal Vascular Remodeling Using Pparβ/δ-Deficient Mice
Sze Yuan Ho, Yuet Ping Kwan, Beiying Qiu, Alison Tan, Hannah Louise Murray, Veluchamy Amutha Barathi, Nguan Soon Tan, Chui Ming Gemmy Cheung, Tien Yin Wong, Walter Wahli, Xiaomeng Wang
Int J Mol Sci. 2020 Jun; 21(12): 4403. Published online 2020 Jun 20. doi: 10.3390/ijms21124403
PMCID:
PMC7353058
AbstractArticlePDF–2.7M
14.
PPARβ/δ-dependent MSC metabolism determines their immunoregulatory properties
R. A. Contreras-Lopez, R. Elizondo-Vega, M. J. Torres, A. M. Vega-Letter, N. Luque-Campos, M. J. Paredes-Martinez, C. Pradenas, G. Tejedor, K. Oyarce, M. Salgado, C. Jorgensen, M. Khoury, G. Kronke, M. A. Garcia-Robles, C. Altamirano, P. Luz-Crawford, F. Djouad
Sci Rep. 2020; 10: 11423. Published online 2020 Jul 10. doi: 10.1038/s41598-020-68347-x
PMCID:
PMC7351754
AbstractArticlePDF–1.1M
15.
A Critical Role for Estrogen-Related Receptor Signaling in Cardiac Maturation
Tomoya Sakamoto, Timothy R. Matsuura, Shibiao Wan, David M. Ryba, Junil Kim, Kyoung Jae Won, Ling Lai, Christopher Petucci, Nataliya Petrenko, Kiran Musunuru, Rick B. Vega, Daniel P. Kelly
Circ Res. Author manuscript; available in PMC 2021 Jun 5.
Published in final edited form as: Circ Res. 2020 Jun 5; 126(12): 1685–1702. Published online 2020 Mar 26. doi: 10.1161/CIRCRESAHA.119.316100
PMCID:
PMC7274895
AbstractArticlePDF–2.7M
16.
Upregulation of BDNF and hippocampal functions by a hippocampal ligand of PPARα
Dhruv Patel, Avik Roy, Sumita Raha, Madhuchhanda Kundu, Frank J. Gonzalez, Kalipada Pahan
JCI Insight. 2020 May 21; 5(10): e136654. Published online 2020 May 21. doi: 10.1172/jci.insight.136654
PMCID:
PMC7259538
AbstractArticlePDF–18M
17.
PPARδ-mediated mitochondrial rewiring of osteoblasts determines bone mass
Dorothea I. H. Müller, Cornelia Stoll, Katrin Palumbo-Zerr, Christina Böhm, Brenda Krishnacoumar, Natacha Ipseiz, Jule Taubmann, Max Zimmermann, Martin Böttcher, Dimitrios Mougiakakos, Jan Tuckermann, Farida Djouad, Georg Schett, Carina Scholtysek, Gerhard Krönke
Sci Rep. 2020; 10: 8428. Published online 2020 May 21. doi: 10.1038/s41598-020-65305-5
PMCID:
PMC7242479
AbstractArticlePDF–2.9M
18.
Mature myelin maintenance requires Qki to coactivate PPARβ-RXRα–mediated lipid metabolism
Xin Zhou, Chenxi He, Jiangong Ren, Congxin Dai, Sharon R. Stevens, Qianghu Wang, Daniel Zamler, Takashi Shingu, Liang Yuan, Chythra R. Chandregowda, Yunfei Wang, Visweswaran Ravikumar, Arvind U.K. Rao, Feng Zhou, Hongwu Zheng, Matthew N. Rasband, Yiwen Chen, Fei Lan, Amy B. Heimberger, Benjamin M. Segal, Jian Hu
J Clin Invest. 2020 May 1; 130(5): 2220–2236. Published online 2020 Mar 23. doi: 10.1172/JCI131800
PMCID:
PMC7191000
AbstractArticlePDF–16M
19.
PPARβ/δ Agonism Upregulates Forkhead Box A2 to Reduce Inflammation in C2C12 Myoblasts and in Skeletal Muscle
Wendy Wen Ting Phua, Wei Ren Tan, Yun Sheng Yip, Ivan Dongzheng Hew, Jonathan Wei Kiat Wee, Hong Sheng Cheng, Melvin Khee Shing Leow, Walter Wahli, Nguan Soon Tan
Int J Mol Sci. 2020 Mar; 21(5): 1747. Published online 2020 Mar 4. doi: 10.3390/ijms21051747
PMCID:
PMC7084392
AbstractArticlePDF–4.1M
20.
CD36-mediated metabolic adaptation supports regulatory T cell survival and function in tumors
Haiping Wang, Fabien Franco, Yao-Chen Tsui, Xin Xie, Marcel P. Trefny, Roberta Zappasodi, Syed Raza Mohmood, Juan Fernández-García, Chin-Hsien Tsai, Isabell Schulze, Florence Picard, Etienne Meylan, Roy Silverstein, Ira Goldberg, Sarah-Maria Fendt, Jedd D. Wolchok, Taha Merghoub, Camilla Jandus, Alfred Zippelius, Ping-Chih Ho
Nat Immunol. Author manuscript; available in PMC 2020 Aug 17.
Published in final edited form as: Nat Immunol. 2020 Mar; 21(3): 298–308. Published online 2020 Feb 17. doi: 10.1038/s41590-019-0589-5
PMCID:
PMC7043937
AbstractArticlePDF–5.3M

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