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Items: 1 to 20 of 159

1.
Phosphatidylinositol 3-kinase-dependent transcriptional silencing of the translational repressor 4E-BP1
R. Azar, S. Najib, H. Lahlou, C. Susini, S. Pyronnet
Cell Mol Life Sci. 2008 Oct; 65(19): 3110–3117. Published online 2008 Sep 23. doi: 10.1007/s00018-008-8418-2
PMCID:
PMC11131698
AbstractArticlePDF–755K
2.
mTORC1 regulates cell survival under glucose starvation through 4EBP1/2-mediated translational reprogramming of fatty acid metabolism
Tal Levy, Kai Voeltzke, Laura Hruby, Khawla Alasad, Zuelal Bas, Marteinn Snaebjörnsson, Ran Marciano, Katerina Scharov, Mélanie Planque, Kim Vriens, Stefan Christen, Cornelius M. Funk, Christina Hassiepen, Alisa Kahler, Beate Heider, Daniel Picard, Jonathan K. M. Lim, Anja Stefanski, Katja Bendrin, Andres Vargas-Toscano, Ulf D. Kahlert, Kai Stühler, Marc Remke, Moshe Elkabets, Thomas G. P. Grünewald, Andreas S. Reichert, Sarah-Maria Fendt, Almut Schulze, Guido Reifenberger, Barak Rotblat, Gabriel Leprivier
Nat Commun. 2024; 15: 4083. Published online 2024 May 14. doi: 10.1038/s41467-024-48386-y
PMCID:
PMC11094136
AbstractArticlePDF–2.0M
3.
eIF4E1b is a non-canonical eIF4E protecting maternal dormant mRNAs
Laura Lorenzo-Orts, Marcus Strobl, Benjamin Steinmetz, Friederike Leesch, Carina Pribitzer, Josef Roehsner, Michael Schutzbier, Gerhard Dürnberger, Andrea Pauli
EMBO Rep. 2024 Jan; 25(1): 404–427. Published online 2023 Dec 14. doi: 10.1038/s44319-023-00006-4
PMCID:
PMC10883267
AbstractArticlePDF–44M
4.
miR-483-5p orchestrates the initiation of protein synthesis by facilitating the decrease in phosphorylated Ser209eIF4E and 4E-BP1 levels
Siranjeevi Nagaraj, Anna Stankiewicz-Drogon, Edward Darzynkiewicz, Urszula Wojda, Renata Grzela
Sci Rep. 2024; 14: 4237. Published online 2024 Feb 20. doi: 10.1038/s41598-024-54154-1
PMCID:
PMC10879198
AbstractArticlePDF–1.8M
5.
4E-BP1 counteracts human mesenchymal stem cell senescence via maintaining mitochondrial homeostasis
Yifang He, Qianzhao Ji, Zeming Wu, Yusheng Cai, Jian Yin, Yiyuan Zhang, Sheng Zhang, Xiaoqian Liu, Weiqi Zhang, Guang-Hui Liu, Si Wang, Moshi Song, Jing Qu
Protein Cell. 2023 Mar; 14(3): 202–216. Published online 2022 Aug 23. doi: 10.1093/procel/pwac037
PMCID:
PMC10098039
AbstractArticlePDF–5.5M
6.
SARS-CoV-2 viral protein Nsp2 stimulates translation under normal and hypoxic conditions
Nadejda Korneeva, Md Imtiaz Khalil, Ishita Ghosh, Ruping Fan, Thomas Arnold, Arrigo De Benedetti
Virol J. 2023; 20: 55. Published online 2023 Mar 30. doi: 10.1186/s12985-023-02021-2
PMCID:
PMC10060939
AbstractArticlePDF–2.7M
7.
4EBP1 senses extracellular glucose deprivation and initiates cell death signaling in lung cancer
Yanan Wang, Jiapeng Lei, Song Zhang, Xiaomei Wang, Jiangbo Jin, Yufeng Liu, Mingxi Gan, Yi Yuan, Longhua Sun, Xiaolei Li, Tianyu Han, Jian-Bin Wang
Cell Death Dis. 2022 Dec; 13(12): 1075. Published online 2022 Dec 27. doi: 10.1038/s41419-022-05466-5
PMCID:
PMC9794714
AbstractArticlePDF–5.7M
8.
Manganese is a physiologically relevant TORC1 activator in yeast and mammals
Raffaele Nicastro, Hélène Gaillard, Laura Zarzuela, Marie-Pierre Péli-Gulli, Elisabet Fernández-García, Mercedes Tomé, Néstor García-Rodríguez, Raúl V Durán, Claudio De Virgilio, Ralf Erik Wellinger
eLife. 2022; 11: e80497. Published online 2022 Jul 29. doi: 10.7554/eLife.80497
PMCID:
PMC9337852
AbstractArticlePDF–3.8M
9.
Overexpression of p-4EBP1 associates with p-eIF4E and predicts poor prognosis for non-small cell lung cancer patients with resection
Yaoxiang Tang, Jiadi Luo, Yang Yang, Sile Liu, Hongmei Zheng, Yuting Zhan, Songqing Fan, Qiuyuan Wen
PLoS One. 2022; 17(6): e0265465. Published online 2022 Jun 23. doi: 10.1371/journal.pone.0265465
PMCID:
PMC9223369
AbstractArticlePDF–1.3M
10.
Bioactive peptide inhibits acute myeloid leukemia cell proliferation by downregulating ALKBH5-mediated m6A demethylation of EIF4EBP1 and MLST8 mRNA
Le Zhang, Xiulan Su
Cell Oncol (Dordr) 2022; 45(3): 355–365. Published online 2022 May 17. doi: 10.1007/s13402-022-00666-9
PMCID:
PMC9187541
AbstractArticlePDF–2.6M
11.
Physical and functional interactome atlas of human receptor tyrosine kinases
Kari Salokas, Xiaonan Liu, Tiina Öhman, Iftekhar Chowdhury, Lisa Gawriyski, Salla Keskitalo, Markku Varjosalo
EMBO Rep. 2022 Jun; 23(6): e54041. Published online 2022 Apr 5. doi: 10.15252/embr.202154041
PMCID:
PMC9171411
AbstractArticlePDF–1.9M
12.
Proteome‐scale mapping of binding sites in the unstructured regions of the human proteome
Caroline Benz, Muhammad Ali, Izabella Krystkowiak, Leandro Simonetti, Ahmed Sayadi, Filip Mihalic, Johanna Kliche, Eva Andersson, Per Jemth, Norman E Davey, Ylva Ivarsson
Mol Syst Biol. 2022 Jan; 18(1): e10584. Published online 2022 Jan 19. doi: 10.15252/msb.202110584
PMCID:
PMC8769072
AbstractArticlePDF–2.9M
13.
circCHST15 is a novel prognostic biomarker that promotes clear cell renal cell carcinoma cell proliferation and metastasis through the miR-125a-5p/EIF4EBP1 axis
Cheng-Peng Gui, Bing Liao, Cheng-Gong Luo, Yu-Hang Chen, Lei Tan, Yi-Ming Tang, Jia-Ying Li, Yi Hou, Hong-De Song, Hai-Shan Lin, Quan-Hui Xu, Gao-Sheng Yao, Hao-Hua Yao, Xi-Liu, Jun-Hang Luo, Jia-Zheng Cao, Jin-Huan Wei
Mol Cancer. 2021; 20: 169. Published online 2021 Dec 18. doi: 10.1186/s12943-021-01449-w
PMCID:
PMC8684108
AbstractArticlePDF–7.5M
14.
Targeting of EIF4EBP1 by miR‐99a‐3p affects the functions of B lymphocytes via autophagy and aggravates SLE disease progression
Meng Yang, Binbin Yang, Danqi Deng
J Cell Mol Med. 2021 Nov; 25(21): 10291–10305. Published online 2021 Oct 20. doi: 10.1111/jcmm.16991
PMCID:
PMC8572797
AbstractArticlePDF–2.5M
15.
The proximal proteome of 17 SARS-CoV-2 proteins links to disrupted antiviral signaling and host translation
Jordan M. Meyers, Muthukumar Ramanathan, Ronald L. Shanderson, Aimee Beck, Laura Donohue, Ian Ferguson, Margaret G. Guo, Deepti S. Rao, Weili Miao, David Reynolds, Xue Yang, Yang Zhao, Yen-Yu Yang, Catherine Blish, Yinsheng Wang, Paul A. Khavari
PLoS Pathog. 2021 Oct; 17(10): e1009412. Published online 2021 Oct 1. doi: 10.1371/journal.ppat.1009412
PMCID:
PMC8513853
AbstractArticlePDF–4.1M
16.
Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome
Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi
Cell. Author manuscript; available in PMC 2022 May 27.
Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011
PMCID:
PMC8165030
AbstractArticlePDF–2.2M
17.
BAD regulates mammary gland morphogenesis by 4E-BP1-mediated control of localized translation in mouse and human models
John Maringa Githaka, Namita Tripathi, Raven Kirschenman, Namrata Patel, Vrajesh Pandya, David A. Kramer, Rachel Montpetit, Lin Fu Zhu, Nahum Sonenberg, Richard P. Fahlman, Nika N. Danial, D. Alan Underhill, Ing Swie Goping
Nat Commun. 2021; 12: 2939. Published online 2021 May 19. doi: 10.1038/s41467-021-23269-8
PMCID:
PMC8134504
AbstractArticlePDF–14M
18.
The translational repressor 4E-BP1regulates RRM2 levels and functions as a tumor suppressor in Ewing Sarcoma Tumors
Kelli L. Goss, Stacia L. Koppenhafer, Torin Waters, William W. Terry, Kuo-Kuang Wen, Meng Wu, Jason Ostergaard, Peter M. Gordon, David J. Gordon
Oncogene. Author manuscript; available in PMC 2021 May 15.
Published in final edited form as: Oncogene. 2021 Jan; 40(3): 564–577. Published online 2020 Nov 15. doi: 10.1038/s41388-020-01552-0
PMCID:
PMC7856031
AbstractArticlePDF–896K
19.
4EBP1/2 are active under standard cell culture conditions to regulate the translation of specific mRNAs
Khawla Alasad, Kai Voeltzke, Liron Levin, Guido Reifenberger, Gabriel Leprivier, Barak Rotblat
Cell Death Dis. 2020 Nov; 11(11): 968. Published online 2020 Nov 11. doi: 10.1038/s41419-020-03182-6
PMCID:
PMC7659004
ArticlePDF–542K
20.
BRDT is a novel regulator of eIF4EBP1 in renal cell carcinoma
Pei Wan, Zhilin Chen, Weifeng Zhong, Huiming Jiang, Zhicheng Huang, Dong Peng, Qiang He, Nanhui Chen
Oncol Rep. 2020 Dec; 44(6): 2475–2486. Published online 2020 Oct 8. doi: 10.3892/or.2020.7796
PMCID:
PMC7610328
AbstractArticlePDF–982K

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