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Select item 114472561.

Cell fixation improves performance of in situ crosslinking mass spectrometry while preserving cellular ultrastructure

Andrew R. M. Michael, Bruno C. Amaral, Kallie L. Ball, Kristen H. Eiriksson, David C. Schriemer

Nat Commun. 2024; 15: 8537. Published online 2024 Oct 2. doi: 10.1038/s41467-024-52844-y

PMCID:: PMC11447256

Abstract Article PDF–2.8M

Select item 112969142.

DSBSO-Based XL-MS Analysis of Breast Cancer PDX Tissues to Delineate Protein Interaction Network in Clinical Samples

Fenglong Jiao, Clinton Yu, Andrew Wheat, Lijun Chen, Tung-Shing Mamie Lih, Hui Zhang, Lan Huang

J Proteome Res. Author manuscript; available in PMC 2024 Aug 3.

Published in final edited form as: J Proteome Res. 2024 Aug 2; 23(8): 3269–3279. Published online 2024 Feb 9. doi: 10.1021/acs.jproteome.3c00832

PMCID:: PMC11296914

Abstract Article PDF–1.7M

Select item 112099353.

Antagonistic roles of canonical and alternative-RPA in disease-associated tandem CAG repeat instability

Terence Gall-Duncan, Jennifer Luo, Carla-Marie Jurkovic, Laura A. Fischer, Kyota Fujita, Amit L. Deshmukh, Rachel J. Harding, Stephanie Tran, Mustafa Mehkary, Vanessa Li, David E. Leib, Ran Chen, Hikari Tanaka, Amanda G. Mason, Dominique Lévesque, Mahreen Khan, Mortezaali Razzaghi, Tanya Prasolava, Stella Lanni, Nozomu Sato, Marie-Christine Caron, Gagan B. Panigrahi, Peixiang Wang, Rachel Lau, Arturo López Castel, Jean-Yves Masson, Lynette Tippett, Clinton Turner, Maria Spies, Albert R. La Spada, Eric I. Campos, Maurice A. Curtis, François-Michel Boisvert, Richard L.M. Faull, Beverly L. Davidson, Masayuki Nakamori, Hitoshi Okazawa, Marc S. Wold, Christopher E. Pearson

Cell. Author manuscript; available in PMC 2024 Oct 26.

Published in final edited form as: Cell. 2023 Oct 26; 186(22): 4898–4919.e25. Published online 2023 Oct 11. doi: 10.1016/j.cell.2023.09.008

PMCID:: PMC11209935

Abstract Article PDF–3.0M

Select item 111589274.

Characterization of human NSCLC cell line with innate etoposide‐resistance mediated by cytoplasmic localization of topoisomerase II alpha

Bautista de Lucio, Victor Manuel, Raul Barrera‐Rodríguez

Cancer Sci. 2005 Nov; 96(11): 774–783. Published online 2005 Nov 4. doi: 10.1111/j.1349-7006.2005.00111.x

PMCID:: PMC11158927

Abstract Article PDF–290K

Select item 111334055.

Expression and potential molecular mechanism of TOP2A in metastasis of non-small cell lung cancer

Jiatao Wu, Wenjuan Li, Xueying Zhang, Fan Shi, Qianhao Jia, Yufei Wang, Yuqi Shi, Shiwu Wu, Xiaojing Wang

Sci Rep. 2024; 14: 12228. Published online 2024 May 28. doi: 10.1038/s41598-024-63055-2

PMCID:: PMC11133405

Abstract Article PDF–8.9M

Select item 110455786.

The correlation study between TOP2A gene expression in circulating tumor cells and chemotherapeutic drug resistance of patients with breast cancer

Jin-hui Ye, Jian Yu, Ming-ying Huang, Yue-mei Mo

Breast Cancer. 2024; 31(3): 417–425. Published online 2024 Apr 1. doi: 10.1007/s12282-024-01553-x

PMCID:: PMC11045578

Abstract Article PDF–805K

Select item 110339447.

The Novel C-terminal Truncated 90-kDa Isoform of Topoisomerase IIα (TOP2α/90) Is a Determinant of Etoposide Resistance in K562 Leukemia Cells via Heterodimerization with the TOP2α/170 Isoform

Ragu Kanagasabai, Soumendrakrishna Karmahapatra, Corey A. Kientz, Yang Yu, Victor A. Hernandez, Evan E. Kania, Jack C. Yalowich, Terry S. Elton

Mol Pharmacol. 2018 May; 93(5): 515–525. Published online 2018 May. doi: 10.1124/mol.117.111567

PMCID:: PMC11033944

Abstract Article PDF–949K

Select item 109366598.

TOP2A modulates signaling via the AKT/mTOR pathway to promote ovarian cancer cell proliferation

Kaiwen Zhang, Xingyu Zheng, Yiqing Sun, Xinyu Feng, Xirong Wu, Wenlu Liu, Chao Gao, Ye Yan, Wenyan Tian, Yingmei Wang

Cancer Biol Ther. 2024; 25(1): 2325126. Published online 2024 Mar 6. doi: 10.1080/15384047.2024.2325126

PMCID:: PMC10936659

Abstract Article PDF–7.9M

Select item 109332679.

Interaction network of human early embryonic transcription factors

Lisa Gawriyski, Zenglai Tan, Xiaonan Liu, Iftekhar Chowdhury, Dicle Malaymar Pinar, Qin Zhang, Jere Weltner, Eeva-Mari Jouhilahti, Gong-Hong Wei, Juha Kere, Markku Varjosalo

EMBO Rep. 2024 Mar; 25(3): 1589–1622. Published online 2024 Jan 31. doi: 10.1038/s44319-024-00074-0

PMCID:: PMC10933267

Abstract Article PDF–2.9M

Select item 1092387610.

Deubiquitinase USP7 stabilizes KDM5B and promotes tumor progression and cisplatin resistance in nasopharyngeal carcinoma through the ZBTB16/TOP2A axis

Bin Zhang, Jie Li, Yijun Wang, Xixi Liu, Xiao Yang, Zhiyun Liao, Suke Deng, Yue Deng, Zhiyuan Zhou, Yu Tian, Wenwen Wei, Jingshu Meng, Yan Hu, Chao Wan, Zhanjie Zhang, Fang Huang, Lu Wen, Bian Wu, Yajie Sun, Yan Li, Kunyu Yang

Cell Death Differ. 2024 Mar; 31(3): 309–321. Published online 2024 Jan 29. doi: 10.1038/s41418-024-01257-x

PMCID:: PMC10923876

Abstract Article PDF–8.3M

Select item 1090533611.

HPV16 E6 promoting cervical cancer progression through down‐regulation of miR‐320a to increase TOP2A expression

Jianing Zhang, Xiaohui Yu, Yi Guo, Daqing Wang

Cancer Med. 2024 Feb; 13(3): e6875. Published online 2024 Jan 11. doi: 10.1002/cam4.6875

PMCID:: PMC10905336

Abstract Article PDF–43M

Select item 1085081812.

Cancer‐associated FBXW7 loss is synthetic lethal with pharmacological targeting of CDC7

Joseph S. Baxter, Rachel Brough, Dragomir B. Krastev, Feifei Song, Sandhya Sridhar, Aditi Gulati, John Alexander, Theodoros I. Roumeliotis, Zuza Kozik, Jyoti S. Choudhary, Syed Haider, Stephen J. Pettitt, Andrew N. J. Tutt, Christopher J. Lord

Mol Oncol. 2024 Feb; 18(2): 369–385. Published online 2023 Oct 22. doi: 10.1002/1878-0261.13537

PMCID:: PMC10850818

Abstract Article PDF–2.7M

Select item 1076495813.

TRIM28-mediated nucleocapsid protein SUMOylation enhances SARS-CoV-2 virulence

Jiang Ren, Shuai Wang, Zhi Zong, Ting Pan, Sijia Liu, Wei Mao, Huizhe Huang, Xiaohua Yan, Bing Yang, Xin He, Fangfang Zhou, Long Zhang

Nat Commun. 2024; 15: 244. Published online 2024 Jan 4. doi: 10.1038/s41467-023-44502-6

PMCID:: PMC10764958

Abstract Article PDF–4.4M

Select item 1073046614.

Association of TOP2A and ADH1B with lipid levels and prognosis in patients with lung adenocarcinoma and squamous cell carcinoma

Dongdong Yin, Yinci Zhang, Hui Li, Longqiang Cheng

Clin Respir J. 2023 Dec; 17(12): 1301–1315. Published online 2023 Nov 20. doi: 10.1111/crj.13717

PMCID:: PMC10730466

Abstract Article PDF–3.8M

Select item 1072184315.

ERK2-topoisomerase II regulatory axis is important for gene activation in immediate early genes

Heeyoun Bunch, Deukyeong Kim, Masahiro Naganuma, Reiko Nakagawa, Anh Cong, Jaehyeon Jeong, Haruhiko Ehara, Hongha Vu, Jeong Ho Chang, Matthew J. Schellenberg, Shun-ichi Sekine

Nat Commun. 2023; 14: 8341. Published online 2023 Dec 14. doi: 10.1038/s41467-023-44089-y

PMCID:: PMC10721843

Abstract Article PDF–2.7M

Select item 1068022016.

EZH2-H3K27me3-mediated silencing of mir-139-5p inhibits cellular senescence in hepatocellular carcinoma by activating TOP2A

Ke Wang, Xunliang Jiang, Yu Jiang, Jun Liu, Yongtao Du, Zecheng Zhang, Yunlong Li, Xinhui Zhao, Jipeng Li, Rui Zhang

J Exp Clin Cancer Res. 2023; 42: 320. Published online 2023 Nov 27. doi: 10.1186/s13046-023-02855-2

PMCID:: PMC10680220

Abstract Article PDF–11M

Select item 1061767317.

The midnolin-proteasome pathway catches proteins for ubiquitination-independent degradation

Xin Gu, Christopher Nardone, Nolan Kamitaki, Aoyue Mao, Stephen J. Elledge, Michael E. Greenberg

Science. Author manuscript; available in PMC 2023 Oct 31.

Published in final edited form as: Science. 2023 Aug 25; 381(6660): eadh5021. Published online 2023 Aug 25. doi: 10.1126/science.adh5021

PMCID:: PMC10617673

Abstract Article PDF–3.6M

Select item 1058954718.

Role of TOP2A and CDC6 in liver cancer

Wei Jia, Xiang Liu, Zhilei Zhang

Medicine (Baltimore) 2023 Oct 20; 102(42): e35604. Published online 2023 Oct 20. doi: 10.1097/MD.0000000000035604

PMCID:: PMC10589547

Abstract Article PDF–3.8M

Select item 1056587619.

Pulse-SILAC and Interactomics Reveal Distinct DDB1-CUL4–Associated Factors, Cellular Functions, and Protein Substrates

Jennifer Raisch, Marie-Line Dubois, Marika Groleau, Dominique Lévesque, Thomas Burger, Carla-Marie Jurkovic, Romain Brailly, Gwendoline Marbach, Alyson McKenna, Catherine Barrette, Pierre-Étienne Jacques, François-Michel Boisvert

Mol Cell Proteomics. 2023 Oct; 22(10): 100644. Published online 2023 Sep 7. doi: 10.1016/j.mcpro.2023.100644

PMCID:: PMC10565876

Abstract Article PDF–3.7M

Select item 1053569520.

cDCBLD2 mediates sorafenib resistance in hepatocellular carcinoma by sponging miR-345-5p binding to the TOP2A coding sequence

YeLing Ruan, TianYi Chen, LongBo Zheng, JingWei Cai, Hu Zhao, YaLi Wang, LiYe Tao, JunJie Xu, Lin Ji, XiuJun Cai

Int J Biol Sci. 2023; 19(14): 4608–4626. Published online 2023 Aug 28. doi: 10.7150/ijbs.86227

PMCID:: PMC10535695

Abstract Article PDF–10M

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