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Items: 1 to 20 of 30

1.
Regulation of meiotic telomere dynamics through membrane fluidity promoted by AdipoR2-ELOVL2
Jingjing Zhang, Mario Ruiz, Per-Olof Bergh, Marcus Henricsson, Nena Stojanović, Ranjan Devkota, Marius Henn, Mohammad Bohlooly-Y, Abrahan Hernández-Hernández, Manfred Alsheimer, Jan Borén, Marc Pilon, Hiroki Shibuya
Nat Commun. 2024; 15: 2315. Published online 2024 Mar 14. doi: 10.1038/s41467-024-46718-6
PMCID:
PMC10940294
AbstractArticlePDF–6.0M
2.
CerS6-dependent ceramide synthesis in hypothalamic neurons promotes ER/mitochondrial stress and impairs glucose homeostasis in obese mice
Philipp Hammerschmidt, Sophie M. Steculorum, Cécile L. Bandet, Almudena Del Río-Martín, Lukas Steuernagel, Vivien Kohlhaas, Marvin Feldmann, Luis Varela, Adam Majcher, Marta Quatorze Correia, Rhena F. U. Klar, Corinna A. Bauder, Ecem Kaya, Marta Porniece, Nasim Biglari, Anna Sieben, Tamas L. Horvath, Thorsten Hornemann, Susanne Brodesser, Jens C. Brüning
Nat Commun. 2023; 14: 7824. Published online 2023 Nov 29. doi: 10.1038/s41467-023-42595-7
PMCID:
PMC10684560
AbstractArticlePDF–5.2M
3.
Ceramide synthase 6 (CerS6) is upregulated in alcohol-associated liver disease and exhibits sex-based differences in the regulation of energy homeostasis and lipid droplet accumulation
Sookyoung Jeon, Eleonora Scorletti, Joseph Dempsey, Delfin Buyco, Chelsea Lin, Yedidya Saiman, Susovon Bayen, Julia Harkin, Jasmin Martin, Royce Hooks, Besim Ogretmen, Josepmaria Argemi, Luma Melo, Ramon Bataller, Rotonya M. Carr
Mol Metab. 2023 Dec; 78: 101804. Published online 2023 Sep 14. doi: 10.1016/j.molmet.2023.101804
PMCID:
PMC10561121
AbstractArticlePDF–3.3M
4.
CERS6-derived ceramides aggravate kidney fibrosis by inhibiting PINK1-mediated mitophagy in diabetic kidney disease
Xiangyu Wang, Minkai Song, Xiaomin Li, Cailin Su, Yanlin Yang, Kai Wang, Cuiting Liu, Zongji Zheng, Yijie Jia, Shijing Ren, Wenhui Dong, Jiaqi Chen, Ting Wang, Lerong Liu, Meiping Guan, Chao Zhang, Yaoming Xue
Am J Physiol Cell Physiol. 2023 Aug 1; 325(2): C538–C549. Published online 2023 Jul 17. doi: 10.1152/ajpcell.00144.2023
PMCID:
PMC10511179
AbstractArticle
5.
Generation of a ceramide synthase 6 mouse lacking the DDRSDIE C-terminal motif
Jiyoon Kim, Yael Pewzner-Jung, Tammar Joseph, Shifra Ben-Dor, Anthony H. Futerman
PLoS One. 2022; 17(7): e0271675. Published online 2022 Jul 18. doi: 10.1371/journal.pone.0271675
PMCID:
PMC9292091
AbstractArticlePDF–1.2M
6.
Ceramide synthase 6 impacts T-cell allogeneic response and graft-versus-host disease through regulating N-RAS/ERK Pathway
M.Hanief Sofi, Linlu Tian, Steven Schutt, Imran Khan, Hee-Jin Choi, Yongxia Wu, David Bastian, Taylor Ticer, Mohamed Faisal Kassir, Firdevs Cansu Atilgan, Jisun Kim, Xiaohui Sui, Aleksandra Zivkovic, Shikhar Mehrotra, John P. O’Bryan, Holger Stark, Paul J. Martin, Besim Ogretmen, Xue-Zhong Yu
Leukemia. Author manuscript; available in PMC 2022 Nov 5.
Published in final edited form as: Leukemia. 2022 Jul; 36(7): 1907–1915. Published online 2022 May 5. doi: 10.1038/s41375-022-01581-6
PMCID:
PMC9256768
AbstractArticlePDF–1.4M
7.
BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING)
Kou Motani, Hidetaka Kosako
J Biol Chem. 2020 Aug 7; 295(32): 11174–11183. Published online 2020 Jun 17. doi: 10.1074/jbc.RA120.014323
PMCID:
PMC7415991
AbstractArticlePDF–2.0M
8.
Ceramide Synthase 6 Deficiency Enhances Inflammation in the DSS model of Colitis
Kristi Helke, Peggi Angel, Ping Lu, Elizabeth Garrett-Mayer, Besim Ogretmen, Richard Drake, Christina Voelkel-Johnson
Sci Rep. 2018; 8: 1627. Published online 2018 Jan 26. doi: 10.1038/s41598-018-20102-z
PMCID:
PMC5786068
AbstractArticlePDF–2.2M
9.
A novel role for ceramide synthase 6 in mouse and human alcoholic steatosis
Bianca Williams, Jason Correnti, Amanke Oranu, Annie Lin, Victoria Scott, Maxine Annoh, James Beck, Emma Furth, Victoria Mitchell, Can E. Senkal, Lina Obeid, Rotonya M. Carr
FASEB J. 2018 Jan; 32(1): 130–142. Published online 2017 Sep 1. doi: 10.1096/fj.201601142R
PMCID:
PMC5731793
AbstractArticle
10.
Adoptive Transfer of Ceramide Synthase 6 Deficient Splenocytes Reduces the Development of Colitis
Matthew J. Scheffel, Kristi Helke, Ping Lu, Jacob S. Bowers, Besim Ogretmen, Elizabeth Garrett-Mayer, Chrystal M. Paulos, Christina Voelkel-Johnson
Sci Rep. 2017; 7: 15552. Published online 2017 Nov 14. doi: 10.1038/s41598-017-15791-x
PMCID:
PMC5686186
AbstractArticlePDF–2.5M
11.
Transcription Factor CTIP1/ BCL11A Regulates Epidermal Differentiation and Lipid Metabolism During Skin Development
Shan Li, Amy Teegarden, Emily M. Bauer, Jaewoo Choi, Nadia Messaddeq, David A. Hendrix, Gitali Ganguli-Indra, Mark Leid, Arup K. Indra
Sci Rep. 2017; 7: 13427. Published online 2017 Oct 18. doi: 10.1038/s41598-017-13347-7
PMCID:
PMC5647389
AbstractArticlePDF–5.2M
12.
Ceramide synthesis regulates T cell activity and GVHD development
M. Hanief Sofi, Jessica Heinrichs, Mohammed Dany, Hung Nguyen, Min Dai, David Bastian, Steven Schutt, Yongxia Wu, Anusara Daenthanasanmak, Salih Gencer, Aleksandra Zivkovic, Zdzislaw Szulc, Holger Stark, Chen Liu, Ying-Jun Chang, Besim Ogretmen, Xue-Zhong Yu
JCI Insight. 2017 May 18; 2(10): e91701. Published online 2017 May 18. doi: 10.1172/jci.insight.91701
PMCID:
PMC5436544
AbstractArticlePDF–2.4M
13.
Enzyme Activities of the Ceramide Synthases CERS2–6 Are Regulated by Phosphorylation in the C-terminal Region
Takayuki Sassa, Taisuke Hirayama, Akio Kihara
J Biol Chem. 2016 Apr 1; 291(14): 7477–7487. Published online 2016 Feb 17. doi: 10.1074/jbc.M115.695858
PMCID:
PMC4817178
AbstractArticlePDF–1.8M
14.
SIRT3 Deacetylates Ceramide Synthases: IMPLICATIONS FOR MITOCHONDRIAL DYSFUNCTION AND BRAIN INJURY
Sergei A. Novgorodov, Christopher L. Riley, Jarryd A. Keffler, Jin Yu, Mark S. Kindy, Wendy B. Macklin, David B. Lombard, Tatyana I. Gudz
J Biol Chem. 2016 Jan 22; 291(4): 1957–1973. Published online 2015 Nov 30. doi: 10.1074/jbc.M115.668228
PMCID:
PMC4722471
AbstractArticlePDF–2.0M
15.
Venus trap in the mouse embryo reveals distinct molecular dynamics underlying specification of first embryonic lineages
Jens-Erik Dietrich, Laura Panavaite, Stefan Gunther, Sebastian Wennekamp, Anna C Groner, Anton Pigge, Stefanie Salvenmoser, Didier Trono, Lars Hufnagel, Takashi Hiiragi
EMBO Rep. 2015 Aug; 16(8): 1005–1021. Published online 2015 Jul 3. doi: 10.15252/embr.201540162
PMCID:
PMC4552493
AbstractArticlePDF–2.7M
16.
Inactivation of Ceramide Synthase 6 in Mice Results in an Altered Sphingolipid Metabolism and Behavioral Abnormalities
Philipp Ebel, Katharina vom Dorp, Elisabeth Petrasch-Parwez, Armin Zlomuzica, Kiyoka Kinugawa, Jean Mariani, David Minich, Christina Ginkel, Jochen Welcker, Joachim Degen, Matthias Eckhardt, Ekrem Dere, Peter Dörmann, Klaus Willecke
J Biol Chem. 2013 Jul 19; 288(29): 21433–21447. Published online 2013 Jun 12. doi: 10.1074/jbc.M113.479907
PMCID:
PMC3774410
AbstractArticlePDF–3.3M
17.
Oxidized Phospholipids Induce Ceramide Accumulation in RAW 264.7 Macrophages: Role of Ceramide Synthases
Lingaraju M. Halasiddappa, Harald Koefeler, Anthony H. Futerman, Albin Hermetter
PLoS One. 2013; 8(7): e70002. Published online 2013 Jul 31. doi: 10.1371/journal.pone.0070002
PMCID:
PMC3729465
AbstractArticlePDF–729K
18.
Transcription factor Ctip2 controls epidermal lipid metabolism and regulates expression of genes involved in sphingolipid biosynthesis during skin development
Zhixing Wang, Jay S. Kirkwood, Alan W. Taylor, Jan F. Stevens, Mark Leid, Gitali Ganguli-Indra, Arup K. Indra
J Invest Dermatol. Author manuscript; available in PMC 2013 Sep 1.
Published in final edited form as: J Invest Dermatol. 2013 Mar; 133(3): 668–676. Published online 2012 Oct 25. doi: 10.1038/jid.2012.358
PMCID:
PMC3556343
AbstractArticlePDF–608K
19.
Alteration of Ceramide Synthase 6/C16-Ceramide Induces Activating Transcription Factor 6-mediated Endoplasmic Reticulum (ER) Stress and Apoptosis via Perturbation of Cellular Ca2+ and ER/Golgi Membrane Network
Can E. Senkal, Suriyan Ponnusamy, Yefim Manevich, Marisa Meyers-Needham, Sahar A. Saddoughi, Archana Mukhopadyay, Paul Dent, Jacek Bielawski, Besim Ogretmen
J Biol Chem. 2011 Dec 9; 286(49): 42446–42458. Published online 2011 Oct 19. doi: 10.1074/jbc.M111.287383
PMCID:
PMC3234959
AbstractArticlePDF–3.9M
20.
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas
Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042
PMCID:
PMC3178059
AbstractArticlePDF–1.0M

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