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Select item 109176601.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 106964672.

Reduction of oligomer size modulates the competition between cluster formation and phase separation of the tumor suppressor SPOP

Nafiseh Sabri, Matthew J. Cuneo, Melissa R. Marzahn, Jihun Lee, Jill J. Bouchard, Ömer Güllülü, Sivaraja Vaithiyalingam, Madeleine B. Borgia, Jeremy Schmit, Tanja Mittag

J Biol Chem. 2023 Dec; 299(12): 105427. Published online 2023 Nov 4. doi: 10.1016/j.jbc.2023.105427

PMCID:: PMC10696467

Abstract Article PDF–5.1M

Select item 99923473.

Higher-order SPOP assembly reveals a basis for cancer mutant dysregulation

Matthew J. Cuneo, Brian G. O’Flynn, Yu-Hua Lo, Nafiseh Sabri, Tanja Mittag

Mol Cell. Author manuscript; available in PMC 2024 Mar 2.

Published in final edited form as: Mol Cell. 2023 Mar 2; 83(5): 731–745.e4. Published online 2023 Jan 23. doi: 10.1016/j.molcel.2022.12.033

PMCID:: PMC9992347

Abstract Article PDF–4.6M

Select item 96180524.

Sufu- and Spop-mediated regulation of Gli2 is essential for the control of mammalian cochlear hair cell differentiation

Tianli Qin, Chin Chung Ho, Boshi Wang, Chi-Chung Hui, Mai Har Sham

Proc Natl Acad Sci U S A. 2022 Oct 25; 119(43): e2206571119. Published online 2022 Oct 17. doi: 10.1073/pnas.2206571119

PMCID:: PMC9618052

Abstract Article PDF–1.9M

Select item 92698855.

A phospho-tyrosine–based signaling module using SPOP, CSK, and LYN controls TLR-induced IRF activity

Kazuki Tawaratsumida, Vanessa Redecke, Ruiqiong Wu, Jeeba Kuriakose, Jill J. Bouchard, Tanja Mittag, Brian K. Lohman, Ashutosh Mishra, Anthony A. High, Hans Häcker

Sci Adv. 2022 Jul; 8(27): eabq0084. Published online 2022 Jul 8. doi: 10.1126/sciadv.abq0084

PMCID:: PMC9269885

Abstract Article PDF–6.3M

Select item 90912176.

Loss of TAF8 causes TFIID dysfunction and p53-mediated apoptotic neuronal cell death

Farrah El-Saafin, Maria I. Bergamasco, Yunshun Chen, Rose E. May, Prabagaran Esakky, Soroor Hediyeh-zadeh, Mathew Dixon, Stephen Wilcox, Melissa J. Davis, Andreas Strasser, Gordon K. Smyth, Tim Thomas, Anne K. Voss

Cell Death Differ. 2022 May; 29(5): 1013–1027. Published online 2022 Mar 31. doi: 10.1038/s41418-022-00982-5

PMCID:: PMC9091217

Abstract Article PDF–7.2M

Select item 90145597.

Functional genomic landscape of cancer-intrinsic evasion of killing by T cells

Keith A. Lawson, Cristovão M. Sousa, Xiaoyu Zhang, Eiru Kim, Rummy Akthar, Joseph J. Caumanns, Yuxi Yao, Nicholas Mikolajewicz, Catherine Ross, Kevin R. Brown, Abdelrahman Abou Zid, Zi Peng Fan, Shirley Hui, Jordan A. Krall, Donald M. Simons, Chloe J. Slater, Victor De Jesus, Lujia Tang, Richa Singh, Joshua E. Goldford, Sarah Martin, Qian Huang, Elizabeth A. Francis, Andrea Habsid, Ryan Climie, David Tieu, Jiarun Wei, Ren Li, Amy Hin Yan Tong, Michael Aregger, Katherine S. Chan, Hong Han, Xiaowei Wang, Patricia Mero, John H. Brumell, Antonio Finelli, Laurie Ailles, Gary Bader, Gromoslaw A. Smolen, Gillian A. Kingsbury, Traver Hart, Charles Kung, Jason Moffat

Nature. Author manuscript; available in PMC 2022 Apr 18.

Published in final edited form as: Nature. 2020 Oct; 586(7827): 120–126. Published online 2020 Sep 23. doi: 10.1038/s41586-020-2746-2

PMCID:: PMC9014559

Abstract Article PDF–6.6M

Select item 83132398.

Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development

Francesco Bedogni, Robert F. Hevner

Front Mol Neurosci. 2021; 14: 686034. Published online 2021 Jul 12. doi: 10.3389/fnmol.2021.686034

PMCID:: PMC8313239

Abstract Article PDF–1.6M

Select item 78547329.

Dual functions of SPOP and ERG dictate androgen therapy responses in prostate cancer

Tiziano Bernasocchi, Geniver El Tekle, Marco Bolis, Azzurra Mutti, Arianna Vallerga, Laura P. Brandt, Filippo Spriano, Tanya Svinkina, Marita Zoma, Valentina Ceserani, Anna Rinaldi, Hana Janouskova, Daniela Bossi, Manuela Cavalli, Simone Mosole, Roger Geiger, Ze Dong, Cai-Guang Yang, Domenico Albino, Andrea Rinaldi, Peter Schraml, Simon Linder, Giuseppina M. Carbone, Andrea Alimonti, Francesco Bertoni, Holger Moch, Steven A. Carr, Wilbert Zwart, Marianna Kruithof-de Julio, Mark A. Rubin, Namrata D. Udeshi, Jean-Philippe P. Theurillat

Nat Commun. 2021; 12: 734. Published online 2021 Feb 2. doi: 10.1038/s41467-020-20820-x

PMCID:: PMC7854732

Abstract Article PDF–4.5M

Select item 752318810.

AMPK promotes SPOP-mediated NANOG degradation to regulate prostate cancer cell stemness

Xinbo Wang, Jiali Jin, Fangning Wan, Linlin Zhao, Hongshang Chu, Cong Chen, Guanghong Liao, Jian Liu, Yue Yu, Hongqi Teng, Lan Fang, Cong Jiang, Weijuan Pan, Xin Xie, Jia Li, Xiaolin Lu, Xuejun Jiang, Xin Ge, Dingwei Ye, Ping Wang

Dev Cell. Author manuscript; available in PMC 2020 Sep 29.

Published in final edited form as: Dev Cell. 2019 Feb 11; 48(3): 345–360.e7. Published online 2018 Dec 27. doi: 10.1016/j.devcel.2018.11.033

PMCID:: PMC7523188

Abstract Article PDF–2.9M

Select item 737638511.

The E3 ubiquitin ligase SPOP controls resolution of systemic inflammation by triggering MYD88 degradation

Maria Guillamot, Dahmane Ouazia, Igor Dolgalev, Stephen T. Yeung, Nikos Kourtis, Yuling Dai, Kate Corrigan, Luna Zea-Redondo, Anita Saraf, Laurence Florens, Michael P. Washburn, Anastasia N. Tikhonova, Marina Malumbres, Yixiao Gong, Aristotelis Tsirigos, Christopher Park, Christopher Barbieri, Kamal M. Khanna, Luca Busino, Iannis Aifantis

Nat Immunol. Author manuscript; available in PMC 2020 Jul 23.

Published in final edited form as: Nat Immunol. 2019 Sep; 20(9): 1196–1207. Published online 2019 Aug 12. doi: 10.1038/s41590-019-0454-6

PMCID:: PMC7376385

Abstract Article PDF–3.1M

Select item 722456712.

SPOP promotes ubiquitination and degradation of MyD88 to suppress the innate immune response

Qinghe Li, Fei Wang, Qiao Wang, Na Zhang, Jumei Zheng, Maiqing Zheng, Ranran Liu, Huanxian Cui, Jie Wen, Guiping Zhao

PLoS Pathog. 2020 May; 16(5): e1008188. Published online 2020 May 4. doi: 10.1371/journal.ppat.1008188

PMCID:: PMC7224567

Abstract Article PDF–1.8M

Select item 713690913.

SPOP and cancer: a systematic review

Alison Clark, Marieke Burleson

Am J Cancer Res. 2020; 10(3): 704–726. Published online 2020 Mar 1.

PMCID:: PMC7136909

Abstract Article PDF–944K

Select item 696905214.

Single cell and genetic analyses reveal conserved populations and signaling mechanisms of gastrointestinal stromal niches

Ji-Eun Kim, Lijiang Fei, Wen-Chi Yin, Sabrina Coquenlorge, Abilasha Rao-Bhatia, Xiaoyun Zhang, Sammy Shun Wai Shi, Ju Hee Lee, Noah A. Hahn, Wasi Rizvi, Kyoung-Han Kim, Hoon-Ki Sung, Chi-chung Hui, Guoji Guo, Tae-Hee Kim

Nat Commun. 2020; 11: 334. Published online 2020 Jan 17. doi: 10.1038/s41467-019-14058-5