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Items: 1 to 20 of 25

1.
Discovery of Ligands for TRIM58, a Novel Tissue-Selective E3 Ligase
Klemens Hoegenauer, Shaojian An, Jake Axford, Christina Benander, Christian Bergsdorf, Josephine Botsch, Suzanne Chau, César Fernández, Scott Gleim, Ulrich Hassiepen, Juerg Hunziker, Emilie Joly, Aramis Keller, Sandra Lopez Romero, Robert Maher, Anne-Sophie Mangold, Craig Mickanin, Manuel Mihalic, Philippe Neuner, Andrew W. Patterson, Francesca Perruccio, Silvio Roggo, Julien Scesa, Martin Schröder, Dojna Shkoza, Binh Thai, Anna Vulpetti, Martin Renatus, John S. Reece-Hoyes
ACS Med Chem Lett. 2023 Dec 14; 14(12): 1631–1639. Published online 2023 Nov 13. doi: 10.1021/acsmedchemlett.3c00259
PMCID:
PMC10726445
AbstractArticlePDF–4.2M
2.
TRIM58 functions as a tumor suppressor in colorectal cancer by promoting RECQL4 ubiquitination to inhibit the AKT signaling pathway
Naizhi Sun, Jiacheng Shen, Yuhua Shi, Biao Liu, Shengguo Gao, Yichuan Chen, Jinwei Sun
World J Surg Oncol. 2023; 21: 231. Published online 2023 Jul 29. doi: 10.1186/s12957-023-03124-4
PMCID:
PMC10385910
AbstractArticlePDF–5.2M
3.
TRIM58 Interacts with ZEB1 to Suppress NSCLC Tumor Malignancy by Promoting ZEB1 Protein Degradation via UPP
Rongxin Shang, Jiakuan Chen, Yang Gao, Jijun Chen, Guoliang Han
Dis Markers. 2023; 2023: 5899662. Published online 2023 Jan 5. doi: 10.1155/2023/5899662
PMCID:
PMC9836804
AbstractArticlePDF–4.0M
4.
Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome
Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi
Cell. Author manuscript; available in PMC 2022 May 27.
Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011
PMCID:
PMC8165030
AbstractArticlePDF–2.2M
5.
The odorant receptor OR2W3 on airway smooth muscle evokes bronchodilation via a cooperative chemosensory tradeoff between TMEM16A and CFTR
Jessie Huang, Hong Lam, Cynthia Koziol-White, Nathachit Limjunyawong, Donghwa Kim, Nicholas Kim, Nikhil Karmacharya, Premraj Rajkumar, Danielle Firer, Nicholas M. Dalesio, Joseph Jude, Richard C. Kurten, Jennifer L. Pluznick, Deepak A. Deshpande, Raymond B. Penn, Stephen B. Liggett, Reynold A. Panettieri, Jr, Xinzhong Dong, Steven S. An
Proc Natl Acad Sci U S A. 2020 Nov 10; 117(45): 28485–28495. Published online 2020 Oct 23. doi: 10.1073/pnas.2003111117
PMCID:
PMC7668088
AbstractArticlePDF–1.5M
6.
TRIM58 Interacts with Pyruvate Kinase M2 to Inhibit Tumorigenicity in Human Osteosarcoma Cells
Peng Yuan, Yiyi Zhou, Rui Wang, Shayang Chen, Qiqi Wang, Zhujie Xu, Yi Liu, Huilin Yang
Biomed Res Int. 2020; 2020: 8450606. Published online 2020 Mar 7. doi: 10.1155/2020/8450606
PMCID:
PMC7081029
AbstractArticlePDF–1.0M
7.
TRIM58 suppresses the tumor growth in gastric cancer by inactivation of β-catenin signaling via ubiquitination
Xiaowen Liu, Ziwen Long, Hong Cai, Shengjia Yu, Jianghong Wu
Cancer Biol Ther. 2020; 21(3): 203–212. Published online 2019 Nov 21. doi: 10.1080/15384047.2019.1679554
PMCID:
PMC7012179
AbstractArticlePDF–2.9M
8.
TRIM58 Restrains Intestinal Mucosal Inflammation by Negatively Regulating TLR2 in Myeloid Cells
Annette Eyking, Frederike Ferber, Stefanie Köhler, Henning Reis, Elke Cario
J Immunol. 2019 Sep 15; 203(6): 1636–1649. Published online 2019 Aug 5. doi: 10.4049/jimmunol.1900413
PMCID:
PMC6731451
AbstractArticlePDF–2.3M
9.
Downregulation of TRIM58 expression is associated with a poor patient outcome and enhances colorectal cancer cell invasion
Min Liu, Xiaowen Zhang, Jian Cai, Yichen Li, Qianxin Luo, Haiyong Wu, Zihuan Yang, Lei Wang, Daici Chen
Oncol Rep. 2018 Sep; 40(3): 1251–1260. Published online 2018 Jun 26. doi: 10.3892/or.2018.6525
PMCID:
PMC6072390
AbstractArticlePDF–1.7M
10.
TRIM58/cg26157385 methylation is associated with eight prognostic genes in lung squamous cell carcinoma
Weimin Zhang, Qichen Cui, Weifeng Qu, Xiaoyun Ding, Donglin Jiang, Hongcheng Liu
Oncol Rep. 2018 Jul; 40(1): 206–216. Published online 2018 May 8. doi: 10.3892/or.2018.6426
PMCID:
PMC6059744
AbstractArticlePDF–1.1M
11.
A Global Analysis of The Receptor Tyrosine Kinase – Protein Phosphatase Interactome
Zhong Yao, Katelyn Darowski, Nicole St-Denis, Victoria Wong, Fabian Offensperger, Annabel Villedieu, Shahreen Amin, Ramy Malty, Hiroyuki Aoki, Hongbo Guo, Yang Xu, Caterina Iorio, Max Kotlyar, Andrew Emili, Igor Jurisica, Benjamin G Neel, Mohan Babu, Anne-Claude Gingras, Igor Stagljar
Mol Cell. Author manuscript; available in PMC 2017 Oct 31.
Published in final edited form as: Mol Cell. 2017 Jan 19; 65(2): 347–360. Published online 2017 Jan 5. doi: 10.1016/j.molcel.2016.12.004
PMCID:
PMC5663465
AbstractArticlePDF–2.1M
12.
Genome-wide association study of post-traumatic stress disorder in two high-risk populations
Whitney E. Melroy-Greif, Kirk C. Wilhelmsen, Rachel Yehuda, Cindy L. Ehlers
Twin Res Hum Genet. Author manuscript; available in PMC 2018 Jun 1.
Published in final edited form as: Twin Res Hum Genet. 2017 Jun; 20(3): 197–207. Published online 2017 Mar 6. doi: 10.1017/thg.2017.12
PMCID:
PMC5479352
AbstractArticlePDF–909K
13.
Frequent silencing of the candidate tumor suppressor TRIM58 by promoter methylation in early-stage lung adenocarcinoma
Koichiro Kajiura, Kiyoshi Masuda, Takuya Naruto, Tomohiro Kohmoto, Miki Watabnabe, Mitsuhiro Tsuboi, Hiromitsu Takizawa, Kazuya Kondo, Akira Tangoku, Issei Imoto
Oncotarget. 2017 Jan 10; 8(2): 2890–2905. Published online 2016 Dec 1. doi: 10.18632/oncotarget.13761
PMCID:
PMC5356850
AbstractArticlePDF–8.7M
14.
Dependence of Human Colorectal Cells Lacking the FBW7 Tumor Suppressor on the Spindle Assembly Checkpoint
Melanie L. Bailey, Tejomayee Singh, Patricia Mero, Jason Moffat, Philip Hieter
Genetics. 2015 Nov; 201(3): 885–895. Published online 2015 Sep 8. doi: 10.1534/genetics.115.180653
PMCID:
PMC4649658
AbstractArticlePDF–1.8M
15.
Susceptibility to male infertility: replication study in Japanese men looking for an association with four GWAS-derived loci identified in European men
Makoto Chihara, Kosuke Yoshihara, Tatsuya Ishiguro, Yuki Yokota, Sosuke Adachi, Hiroyuki Okada, Katsunori Kashima, Takaaki Sato, Atsushi Tanaka, Kenichi Tanaka, Takayuki Enomoto
J Assist Reprod Genet. 2015 Jun; 32(6): 903–908. Published online 2015 Apr 7. doi: 10.1007/s10815-015-0468-4
PMCID:
PMC4491079
AbstractArticlePDF–132K
16.
Whole-exome sequencing identifies OR2W3 mutation as a cause of autosomal dominant retinitis pigmentosa
Xiangyu Ma, Liping Guan, Wei Wu, Yao Zhang, Wei Zheng, Yu-Tang Gao, Jirong Long, Na Wu, Long Wu, Ying Xiang, Bin Xu, Miaozhong Shen, Yanhua Chen, Yuewen Wang, Ye Yin, Yingrui Li, Haiwei Xu, Xun Xu, Yafei Li
Sci Rep. 2015; 5: 9236. Published online 2015 Mar 18. doi: 10.1038/srep09236
PMCID:
PMC4363838
AbstractArticlePDF–545K
17.
Association of single nucleotide polymorphisms in the USF1, GTF2A1L and OR2W3 genes with non-obstructive azoospermia in the Chinese population
Yan Zhang, Xiao-Jin He, Bing Song, Lei Ye, Xu-Shi Xie, Jian Ruan, Fu-Sheng Zhou, Xian-Bo Zuo, Yun-Xia Cao, Wei-Dong Du
J Assist Reprod Genet. 2015 Jan; 32(1): 95–101. Published online 2014 Nov 6. doi: 10.1007/s10815-014-0369-y
PMCID:
PMC4294865
AbstractArticlePDF–170K
18.
Trim58 degrades dynein and regulates terminal erythropoiesis
Christopher S Thom, Elizabeth A Traxler, Eugene Khandros, Jenna M Nickas, Olivia Y Zhou, Jacob E Lazarus, Ana PG Silva, Dolly Prabhu, Yu Yao, Chiaka Aribeana, Serge Y Fuchs, Joel P Mackay, Erika LF Holzbaur, Mitchell J Weiss
Dev Cell. Author manuscript; available in PMC 2015 Sep 29.
Published in final edited form as: Dev Cell. 2014 Sep 29; 30(6): 688–700. Published online 2014 Sep 18. doi: 10.1016/j.devcel.2014.07.021
PMCID:
PMC4203341
AbstractArticlePDF–1.9M
19.
EVI1 oncoprotein interacts with a large and complex network of proteins and integrates signals through protein phosphorylation
Emilie A. Bard-Chapeau, Jayantha Gunaratne, Pankaj Kumar, Belinda Q. Chua, Julius Muller, Frederic A. Bard, Walter Blackstock, Neal G. Copeland, Nancy A. Jenkins
Proc Natl Acad Sci U S A. 2013 Jul 30; 110(31): E2885–E2894. Published online 2013 Jul 15. doi: 10.1073/pnas.1309310110
PMCID:
PMC3732971
AbstractArticlePDF–1.9M
20.
Seventy-five genetic loci influencing the human red blood cell
Pim van der Harst, Weihua Zhang, Irene Mateo Leach, Augusto Rendon, Niek Verweij, Joban Sehmi, Dirk S. Paul, Ulrich Elling, Hooman Allayee, Xinzhong Li, Aparna Radhakrishnan, Sian-Tsung Tan, Katrin Voss, Christian X. Weichenberger, Cornelis A. Albers, Abtehale Al-Hussani, Folkert W. Asselbergs, Marina Ciullo, Fabrice Danjou, Christian Dina, Tõnu Esko, David M. Evans, Lude Franke, Martin Gögele, Jaana Hartiala, Micha Hersch, Hilma Holm, Jouke-Jan Hottenga, Stavroula Kanoni, Marcus E. Kleber, Vasiliki Lagou, Claudia Langenberg, Lorna M. Lopez, Leo-Pekka Lyytikäinen, Olle Melander, Federico Murgia, Ilja M. Nolte, Paul F. O’Reilly, Sandosh Padmanabhan, Afshin Parsa, Nicola Pirastu, Eleonora Porcu, Laura Portas, Inga Prokopenko, Janina S. Ried, So-Youn Shin, Clara S. Tang, Alexander Teumer, Michela Traglia, Sheila Ulivi, Harm-Jan Westra, Jian Yang, Jing Hua Zhao, Franco Anni, Abdel Abdellaoui, Antony Attwood, Beverley Balkau, Stefania Bandinelli, François Bastardot, Beben Benyamin, Bernhard O. Boehm, William O. Cookson, Debashish Das, Paul I. W. de Bakker, Rudolf A. de Boer, Eco J. C. de Geus, Marleen H. de Moor, Maria Dimitriou, Francisco S. Domingues, Angela Döring, Gunnar Engström, Gudmundur Ingi Eyjolfsson, Luigi Ferrucci, Krista Fischer, Renzo Galanello, Stephen F. Garner, Bernd Genser, Quince D. Gibson, Giorgia Girotto, Daniel Fannar Gudbjartsson, Sarah E. Harris, Anna-Liisa Hartikainen, Claire E. Hastie, Bo Hedblad, Thomas Illig, Jennifer Jolley, Mika Kähönen, Ido P. Kema, John P. Kemp, Liming Liang, Heather Lloyd-Jones, Ruth J. F. Loos, Stuart Meacham, Sarah E. Medland, Christa Meisinger, Yasin Memari, Evelin Mihailov, Kathy Miller, Miriam F. Moffatt, Matthias Nauck, Maria Novatchkova, Teresa Nutile, Isleifur Olafsson, Pall T. Onundarson, Debora Parracciani, Brenda W. Penninx, Lucia Perseu, Antonio Piga, Giorgio Pistis, Anneli Pouta, Ursula Puc, Olli Raitakari, Susan M. Ring, Antonietta Robino, Daniela Ruggiero, Aimo Ruokonen, Aude Saint-Pierre, Cinzia Sala, Andres Salumets, Jennifer Sambrook, Hein Schepers, Carsten Oliver Schmidt, Herman H. W. Silljé, Rob Sladek, Johannes H. Smit, John M. Starr, Jonathan Stephens, Patrick Sulem, Toshiko Tanaka, Unnur Thorsteinsdottir, Vinicius Tragante, Wiek H. van Gilst, L. Joost van Pelt, Dirk J. van Veldhuisen, Uwe Völker, John B. Whitfield, Gonneke Willemsen, Bernhard R. Winkelmann, Gerald Wirnsberger, Ale Algra, Francesco Cucca, Adamo Pio d’Adamo, John Danesh, Ian J. Deary, Anna F. Dominiczak, Paul Elliott, Paolo Fortina, Philippe Froguel, Paolo Gasparini, Andreas Greinacher, Stanley L. Hazen, Marjo-Riitta Jarvelin, Kay Tee Khaw, Terho Lehtimäki, Winfried Maerz, Nicholas G. Martin, Andres Metspalu, Braxton D. Mitchell, Grant W. Montgomery, Carmel Moore, Gerjan Navis, Mario Pirastu, Peter P. Pramstaller, Ramiro Ramirez-Solis, Eric Schadt, James Scott, Alan R. Shuldiner, George Davey Smith, J. Gustav Smith, Harold Snieder, Rossella Sorice, Tim D. Spector, Kari Stefansson, Michael Stumvoll, W. H. Wilson Tang, Daniela Toniolo, Anke Tönjes, Peter M. Visscher, Peter Vollenweider, Nicholas J. Wareham, Bruce H. R. Wolffenbuttel, Dorret I. Boomsma, Jacques S. Beckmann, George V. Dedoussis, Panos Deloukas, Manuel A. Ferreira, Serena Sanna, Manuela Uda, Andrew A. Hicks, Josef Martin Penninger, Christian Gieger, Jaspal S. Kooner, Willem H. Ouwehand, Nicole Soranzo, John C Chambers
Nature. Author manuscript; available in PMC 2013 Apr 11.
Published in final edited form as: Nature. 2012 Dec 20; 492(7429): 369–375. Published online 2012 Dec 5. doi: 10.1038/nature11677
PMCID:
PMC3623669
AbstractArticlePDF–1.7M

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