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Items: 1 to 20 of 27

1.
Genetic determinants of micronucleus formation in vivo
D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus
Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0
PMCID:
PMC10917660
AbstractArticlePDF–4.8M
2.
PARIS farnesylation prevents neurodegeneration in models of Parkinson’s disease
Areum Jo, Yunjong Lee, Tae-In Kam, Sung-Ung Kang, Stewart Neifert, Senthilkumar S. Karuppagounder, Rin Khang, Hojin Kang, Hyejin Park, Shih-Ching Chou, Sungtaek Oh, Haisong Jiang, Deborah A. Swing, Sangwoo Ham, Sheila Pirooznia, George K. E. Umanah, Xiaobo Mao, Manoj Kumar, Han Seok Ko, Ho Chul Kang, Byoung Dae Lee, Yun-Il Lee, Shaida A. Andrabi, Chi-Hu Park, Ji-Yeong Lee, Hanna Kim, Hyein Kim, Hyojung Kim, Jin Whan Cho, Sun Ha Paek, Chan Hyun Na, Lino Tessarollo, Valina L. Dawson, Ted M. Dawson, Joo-Ho Shin
Sci Transl Med. Author manuscript; available in PMC 2023 Mar 7.
Published in final edited form as: Sci Transl Med. 2021 Jul 28; 13(604): eaax8891. doi: 10.1126/scitranslmed.aax8891
PMCID:
PMC9990146
AbstractArticlePDF–3.4M
3.
Protein farnesylation is upregulated in Alzheimer’s human brains and neuron-specific suppression of farnesyltransferase mitigates pathogenic processes in Alzheimer’s model mice
Angela Jeong, Shaowu Cheng, Rui Zhong, David A. Bennett, Martin O. Bergö, Ling Li
Acta Neuropathol Commun. 2021; 9: 129. Published online 2021 Jul 27. doi: 10.1186/s40478-021-01231-5
PMCID:
PMC8314463
AbstractArticlePDF–2.8M
4.
BraInMap elucidates the macromolecular connectivity landscape of mammalian brain
Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili
Cell Syst. Author manuscript; available in PMC 2021 Apr 22.
Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003
Correction in:
Cell Syst. 2020 Aug 26; 11(2): 208.
PMCID:
PMC7938770
AbstractArticlePDF–2.0M
5.
Protein prenylation drives discrete signaling programs for the differentiation and maintenance of effector Treg cells
Wei Su, Nicole M. Chapman, Jun Wei, Hu Zeng, Yogesh Dhungana, Hao Shi, Jordy Saravia, Peipei Zhou, Lingyun Long, Sherri Rankin, KC Anil, Peter Vogel, Hongbo Chi
Cell Metab. Author manuscript; available in PMC 2021 Dec 1.
Published in final edited form as: Cell Metab. 2020 Dec 1; 32(6): 996–1011.e7. Published online 2020 Nov 17. doi: 10.1016/j.cmet.2020.10.022
PMCID:
PMC7887758
AbstractArticlePDF–2.6M
6.
Mevalonate metabolism–dependent protein geranylgeranylation regulates thymocyte egress
Xingrong Du, Hu Zeng, Shaofeng Liu, Cliff Guy, Yogesh Dhungana, Geoffrey Neale, Martin O. Bergo, Hongbo Chi
J Exp Med. 2020 Feb 3; 217(2): e20190969. Published online 2019 Nov 13. doi: 10.1084/jem.20190969
PMCID:
PMC7041713
AbstractArticlePDF–4.8M
7.
The antiobesity factor WDTC1 suppresses adipogenesis via the CRL4WDTC1 E3 ligase
Beezly S Groh, Feng Yan, Matthew D Smith, Yanbao Yu, Xian Chen, Yue Xiong
EMBO Rep. 2016 May; 17(5): 638–647. Published online 2016 Apr 9. doi: 10.15252/embr.201540500
PMCID:
PMC5341520
AbstractArticlePDF–1.1M
8.
High-throughput discovery of novel developmental phenotypes
Mary E. Dickinson, Ann M. Flenniken, Xiao Ji, Lydia Teboul, Michael D. Wong, Jacqueline K. White, Terrence F. Meehan, Wolfgang J. Weninger, Henrik Westerberg, Hibret Adissu, Candice N. Baker, Lynette Bower, James M. Brown, L. Brianna Caddle, Francesco Chiani, Dave Clary, James Cleak, Mark J. Daly, James M. Denegre, Brendan Doe, Mary E. Dolan, Sarah M. Edie, Helmut Fuchs, Valerie Gailus-Durner, Antonella Galli, Alessia Gambadoro, Juan Gallegos, Shiying Guo, Neil R. Horner, Chih-wei Hsu, Sara J. Johnson, Sowmya Kalaga, Lance C. Keith, Louise Lanoue, Thomas N. Lawson, Monkol Lek, Manuel Mark, Susan Marschall, Jeremy Mason, Melissa L. McElwee, Susan Newbigging, Lauryl M.J. Nutter, Kevin A. Peterson, Ramiro Ramirez-Solis, Douglas J. Rowland, Edward Ryder, Kaitlin E. Samocha, John R. Seavitt, Mohammed Selloum, Zsombor Szoke-Kovacs, Masaru Tamura, Amanda G Trainor, Ilinca Tudose, Shigeharu Wakana, Jonathan Warren, Olivia Wendling, David B. West, Leeyean Wong, Atsushi Yoshiki, The International Mouse Phenotyping Consortium, Daniel G. MacArthur, Glauco P. Tocchini-Valentini, Xiang Gao, Paul Flicek, Allan Bradley, William C. Skarnes, Monica J. Justice, Helen E. Parkinson, Mark Moore, Sara Wells, Robert E. Braun, Karen L. Svenson, Martin Hrabe de Angelis, Yann Herault, Tim Mohun, Ann-Marie Mallon, R. Mark Henkelman, Steve D.M. Brown, David J. Adams, K.C. Kent Lloyd, Colin McKerlie, Arthur L. Beaudet, Maja Bucan, Stephen A. Murray
Nature. Author manuscript; available in PMC 2017 Mar 14.
Published in final edited form as: Nature. 2016 Sep 22; 537(7621): 508–514. Published online 2016 Sep 14. doi: 10.1038/nature19356
Correction in:
Nature. 2017 Nov 16; 551(7680): 398.
PMCID:
PMC5295821
AbstractArticlePDF–3.0M
9.
Lonafarnib Is a Potential Inhibitor for Neovascularization
Linlin Sun, Songbo Xie, Guoyuan Peng, Jian Wang, Yuanyuan Li, Juan Qin, Diansheng Zhong
PLoS One. 2015; 10(4): e0122830. Published online 2015 Apr 8. doi: 10.1371/journal.pone.0122830
PMCID:
PMC4390146
AbstractArticlePDF–3.4M
10.
Targeting Isoprenylcysteine Methylation Ameliorates Disease in a Mouse Model of Progeria
Mohamed X. Ibrahim, Volkan I. Sayin, Murali K. Akula, Meng Liu, Loren G. Fong, Stephen G. Young, Martin O. Bergo
Science. Author manuscript; available in PMC 2015 Jan 15.
Published in final edited form as: Science. 2013 Jun 14; 340(6138): 1330–1333. Published online 2013 May 16. doi: 10.1126/science.1238880
PMCID:
PMC4295631
AbstractArticlePDF–1.2M
11.
Farnesyltransferase Haplodeficiency Reduces Neuropathology and Rescues Cognitive Function in a Mouse Model of Alzheimer Disease
Shaowu Cheng, Dongfeng Cao, David A. Hottman, LiLian Yuan, Martin O. Bergo, Ling Li
J Biol Chem. 2013 Dec 13; 288(50): 35952–35960. Published online 2013 Oct 17. doi: 10.1074/jbc.M113.503904
PMCID:
PMC3861644
AbstractArticlePDF–1.9M
12.
Severe hepatocellular disease in mice lacking one or both CaaX prenyltransferases
Shao H. Yang, Sandy Y. Chang, Yiping Tu, Gregory W. Lawson, Martin O. Bergo, Loren G. Fong, Stephen G. Young
J Lipid Res. 2012 Jan; 53(1): 77–86. doi: 10.1194/jlr.M021220
PMCID:
PMC3243483
AbstractArticlePDF–2.8M
13.
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas
Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042
PMCID:
PMC3178059
AbstractArticlePDF–1.0M
14.
Geranylgeranyltransferase type I (GGTase-I) deficiency hyperactivates macrophages and induces erosive arthritis in mice
Omar M. Khan, Mohamed X. Ibrahim, Ing-Marie Jonsson, Christin Karlsson, Meng Liu, Anna-Karin M. Sjogren, Frida J. Olofsson, Mikael Brisslert, Sofia Andersson, Claes Ohlsson, Lillemor Mattsson Hultén, Maria Bokarewa, Martin O. Bergo
J Clin Invest. 2011 Feb 1; 121(2): 628–639. Published online 2011 Jan 25. doi: 10.1172/JCI43758
PMCID:
PMC3026725
AbstractArticlePDF–1.0M
15.
A High-Resolution Anatomical Atlas of the Transcriptome in the Mouse Embryo
Graciana Diez-Roux, Sandro Banfi, Marc Sultan, Lars Geffers, Santosh Anand, David Rozado, Alon Magen, Elena Canidio, Massimiliano Pagani, Ivana Peluso, Nathalie Lin-Marq, Muriel Koch, Marchesa Bilio, Immacolata Cantiello, Roberta Verde, Cristian De Masi, Salvatore A. Bianchi, Juliette Cicchini, Elodie Perroud, Shprese Mehmeti, Emilie Dagand, Sabine Schrinner, Asja Nürnberger, Katja Schmidt, Katja Metz, Christina Zwingmann, Norbert Brieske, Cindy Springer, Ana Martinez Hernandez, Sarah Herzog, Frauke Grabbe, Cornelia Sieverding, Barbara Fischer, Kathrin Schrader, Maren Brockmeyer, Sarah Dettmer, Christin Helbig, Violaine Alunni, Marie-Annick Battaini, Carole Mura, Charlotte N. Henrichsen, Raquel Garcia-Lopez, Diego Echevarria, Eduardo Puelles, Elena Garcia-Calero, Stefan Kruse, Markus Uhr, Christine Kauck, Guangjie Feng, Nestor Milyaev, Chuang Kee Ong, Lalit Kumar, MeiSze Lam, Colin A. Semple, Attila Gyenesei, Stefan Mundlos, Uwe Radelof, Hans Lehrach, Paolo Sarmientos, Alexandre Reymond, Duncan R. Davidson, Pascal Dollé, Stylianos E. Antonarakis, Marie-Laure Yaspo, Salvador Martinez, Richard A. Baldock, Gregor Eichele, Andrea Ballabio
PLoS Biol. 2011 Jan; 9(1): e1000582. Published online 2011 Jan 18. doi: 10.1371/journal.pbio.1000582
PMCID:
PMC3022534
AbstractArticlePDF–3.8M
16.
Targeting the protein prenyltransferases efficiently reduces tumor development in mice with K-RAS-induced lung cancer
Meng Liu, Anna-Karin M. Sjogren, Christin Karlsson, Mohamed X. Ibrahim, Karin M. E. Andersson, Frida J. Olofsson, Annika M. Wahlstrom, Martin Dalin, Huiming Yu, Zhenggang Chen, Shao H. Yang, Stephen G. Young, Martin O. Bergo
Proc Natl Acad Sci U S A. 2010 Apr 6; 107(14): 6471–6476. Published online 2010 Mar 22. doi: 10.1073/pnas.0908396107
PMCID:
PMC2852017
AbstractArticlePDF–984K
17.
Genetic studies on the functional relevance of the protein prenyltransferases in skin keratinocytes
Roger Lee, Sandy Y. Chang, Hung Trinh, Yiping Tu, Andrew C. White, Brandon S.J. Davies, Martin O. Bergo, Loren G. Fong, William E. Lowry, Stephen G. Young
Hum Mol Genet. 2010 Apr 15; 19(8): 1603–1617. Published online 2010 Jan 27. doi: 10.1093/hmg/ddq036
PMCID:
PMC2846164
AbstractArticlePDF–1.3M
18.
Lack of periostin leads to suppression of Notch1 signaling and calcific aortic valve disease
Tatiana V. Tkatchenko, Ricardo A. Moreno-Rodriguez, Simon J. Conway, Jeffery D. Molkentin, Roger R. Markwald, Andrei V. Tkatchenko
Physiol Genomics. 2009 Nov; 39(3): 160–168. Published online 2009 Sep 1. doi: 10.1152/physiolgenomics.00078.2009
PMCID:
PMC2789674
AbstractArticle
19.
Caution! Analyze transcripts from conditional knockout alleles
Shao H. Yang, Martin O. Bergo, Emily Farber, Xin Qiao, Loren G. Fong, Stephen G. Young
Transgenic Res. Author manuscript; available in PMC 2009 Jun 1.
Published in final edited form as: Transgenic Res. 2009 Jun; 18(3): 483–489. Published online 2008 Dec 18. doi: 10.1007/s11248-008-9237-9
PMCID:
PMC2679093
AbstractArticlePDF–645K
20.
Large-scale gene trapping in C57BL/6N mouse embryonic stem cells
Gwenn M. Hansen, Diane C. Markesich, Michael B. Burnett, Qichao Zhu, Karen M. Dionne, Lizabeth J. Richter, Richard H. Finnell, Arthur T. Sands, Brian P. Zambrowicz, Alejandro Abuin
Genome Res. 2008 Oct; 18(10): 1670–1679. doi: 10.1101/gr.078352.108
PMCID:
PMC2556270
AbstractArticlePDF–493K

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