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Select item 109321341.

Inhibition of HDAC8 Reduces the Proliferation of Adult Neural Stem Cells in the Subventricular Zone

Momoko Fukuda, Yuki Fujita, Yuko Hino, Mitsuyoshi Nakao, Katsuhiko Shirahige, Toshihide Yamashita

Int J Mol Sci. 2024 Mar; 25(5): 2540. Published online 2024 Feb 22. doi: 10.3390/ijms25052540

PMCID:: PMC10932134

Abstract Article PDF–5.0M

Select item 109176602.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 105215663.

Hepatocyte-specific HDAC3 ablation promotes hepatocellular carcinoma in females by suppressing Foxa1/2

Yahong Xu, Yongjie Zhu, Zhenru Wu, Shengfu Li, Mingyang Shao, Qing Tao, Qing Xu, Yuwei Chen, Yuke Shu, Menglin Chen, Yongjie Zhou, Yujun Shi

BMC Cancer. 2023; 23: 906. Published online 2023 Sep 26. doi: 10.1186/s12885-023-11393-1

PMCID:: PMC10521566

Abstract Article PDF–11M

Select item 99957944.

Histone deacetylase 8 inhibition prevents the progression of peritoneal fibrosis by counteracting the epithelial-mesenchymal transition and blockade of M2 macrophage polarization

Xun Zhou, Hui Chen, Yingfeng Shi, Jinqing Li, Xiaoyan Ma, Lin Du, Yan Hu, Min Tao, Qin Zhong, Danying Yan, Shougang Zhuang, Na Liu

Front Immunol. 2023; 14: 1137332. Published online 2023 Feb 23. doi: 10.3389/fimmu.2023.1137332

PMCID:: PMC9995794

Abstract Article PDF–17M

Select item 97467755.

Histone deacetylase 8 regulates NF-κB-related inflammation in asthmatic mice through H3K9 acetylation

Yuan Ren, Menglu Li, Shiyao Bai, Xinming Su

Chin Med J (Engl) 2022 Sep 5; 135(17): 2110–2112. Published online 2022 Feb 16. doi: 10.1097/CM9.0000000000001963

PMCID:: PMC9746775

Article PDF–1.5M

Select item 96067226.

O-fucosylation of thrombospondin type 1 repeats is essential for ECM remodeling and signaling during bone development

Sanjiv Neupane, Steven J. Berardinelli, Daniel C. Cameron, Richard C. Grady, David E. Komatsu, Christopher J. Percival, Megumi Takeuchi, Atsuko Ito, Ta-Wei Liu, Alison V. Nairn, Kelley W. Moremen, Robert S. Haltiwanger, Bernadette C. Holdener

Matrix Biol. Author manuscript; available in PMC 2022 Oct 27.

Published in final edited form as: Matrix Biol. 2022 Mar; 107: 77–96. Published online 2022 Feb 12. doi: 10.1016/j.matbio.2022.02.002

PMCID:: PMC9606722

Abstract Article PDF–6.7M

Select item 84571757.

Histone‐deacetylase 8 drives the immune response and the growth of glioma

Alessandro Mormino, Germana Cocozza, Giulia Fontemaggi, Sergio Valente, Vincenzo Esposito, Antonio Santoro, Giovanni Bernardini, Angela Santoni, Francesco Fazi, Antonello Mai, Cristina Limatola, Stefano Garofalo

Glia. 2021 Nov; 69(11): 2682–2698. Published online 2021 Jul 26. doi: 10.1002/glia.24065

PMCID:: PMC8457175

Abstract Article PDF–4.9M

Select item 84431858.

H3 acetylation selectively promotes basal progenitor proliferation and neocortex expansion

Cemil Kerimoglu, Linh Pham, Anton B. Tonchev, M. Sadman Sakib, Yuanbin Xie, Godwin Sokpor, Pauline Antonie Ulmke, Lalit Kaurani, Eman Abbas, Huong Nguyen, Joachim Rosenbusch, Alexandra Michurina, Vincenzo Capece, Meglena Angelova, Nenad Maricic, Beate Brand-Saberi, Miriam Esgleas, Mareike Albert, Radoslav Minkov, Emil Kovachev, Ulrike Teichmann, Rho H. Seong, Wieland B. Huttner, Huu Phuc Nguyen, Anastassia Stoykova, Jochen F. Staiger, Andre Fischer, Tran Tuoc

Sci Adv. 2021 Sep; 7(38): eabc6792. Published online 2021 Sep 15. doi: 10.1126/sciadv.abc6792

PMCID:: PMC8443185

Abstract Article PDF–11M

Select item 83132399.

Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development

Francesco Bedogni, Robert F. Hevner

Front Mol Neurosci. 2021; 14: 686034. Published online 2021 Jul 12. doi: 10.3389/fnmol.2021.686034

PMCID:: PMC8313239

Abstract Article PDF–1.6M

Select item 807213210.

Molecular Profiling Reveals Involvement of ESCO2 in Intermediate Progenitor Cell Maintenance in the Developing Mouse Cortex

Pauline Antonie Ulmke, M. Sadman Sakib, Peter Ditte, Godwin Sokpor, Cemil Kerimoglu, Linh Pham, Yuanbin Xie, Xiaoyi Mao, Joachim Rosenbusch, Ulrike Teichmann, Huu Phuc Nguyen, Andre Fischer, Gregor Eichele, Jochen F. Staiger, Tran Tuoc

Stem Cell Reports. 2021 Apr 13; 16(4): 968–984. Published online 2021 Apr 1. doi: 10.1016/j.stemcr.2021.03.008

PMCID:: PMC8072132

Abstract Article PDF–8.1M

Select item 744547411.

Identification of histone deacetylase 8 as a novel therapeutic target for renal fibrosis

Yunhe Zhang, Jianan Zou, Evelyn Tolbert, Ting C. Zhao, George Bayliss, Shougang Zhuang

FASEB J. Author manuscript; available in PMC 2020 Aug 25.

Published in final edited form as: FASEB J. 2020 Jun; 34(6): 7295–7310. Published online 2020 Apr 12. doi: 10.1096/fj.201903254R

PMCID:: PMC7445474

Abstract Article PDF–2.5M

Select item 667993812.

HDAC3 deficiency promotes liver cancer through a defect in H3K9ac/H3K9me3 transition

Hongjie Ji, Yongjie Zhou, Xiang Zhuang, Yongjie Zhu, Zhenru Wu, Yanrong Lu, Shengfu Li, Yong Zeng, Qing R. Lu, Yanying Huo, Yujun Shi, Hong Bu

Cancer Res. Author manuscript; available in PMC 2019 Aug 4.

Published in final edited form as: Cancer Res. 2019 Jul 15; 79(14): 3676–3688. Published online 2019 May 16. doi: 10.1158/0008-5472.CAN-18-3767

Correction in:: Cancer Res. 2020 Feb 15; 80(4): 923.

PMCID:: PMC6679938

Abstract Article PDF–3.3M

Select item 645951013.

Mouse screen reveals multiple new genes underlying mouse and human hearing loss

Neil J. Ingham, Selina A. Pearson, Valerie E. Vancollie, Victoria Rook, Morag A. Lewis, Jing Chen, Annalisa Buniello, Elisa Martelletti, Lorenzo Preite, Chi Chung Lam, Felix D. Weiss, Zӧe Powis, Pim Suwannarat, Christopher J. Lelliott, Sally J. Dawson, Jacqueline K. White, Karen P. Steel

PLoS Biol. 2019 Apr; 17(4): e3000194. Published online 2019 Apr 11. doi: 10.1371/journal.pbio.3000194

PMCID:: PMC6459510

Abstract Article PDF–5.1M

Select item 573108314.

HDAC8 regulates long-term hematopoietic stem-cell maintenance under stress by modulating p53 activity

Wei-Kai Hua, Jing Qi, Qi Cai, Emily Carnahan, Maria Ayala Ramirez, Ling Li, Guido Marcucci, Ya-Huei Kuo

Blood. 2017 Dec 14; 130(24): 2619–2630. Prepublished online 2017 Oct 30. doi: 10.1182/blood-2017-03-771386

PMCID:: PMC5731083

Abstract Article

Select item 541747015.

An Acetylation Switch Modulates the Transcriptional Activity of Estrogen-Related Receptor α

Brian J. Wilson, Annie M. Tremblay, Geneviève Deblois, Guillaume Sylvain-Drolet, Vincent Giguère

Mol Endocrinol. July 1, 2010; 24(7): 1349–1358. doi: 10.1210/me.2009-0441

PMCID:: PMC5417470

Abstract Article

Select item 486144316.

Inhibition of Interleukin 1β (IL-1β) Expression by Anthrax Lethal Toxin (LeTx) Is Reversed by Histone Deacetylase 8 (HDAC8) Inhibition in Murine Macrophages

Soon-Duck Ha, Chantelle Reid, Shahab Meshkibaf, Sung Ouk Kim

J Biol Chem. 2016 Apr 15; 291(16): 8745–8755. Published online 2016 Feb 24. doi: 10.1074/jbc.M115.695809

Correction in:: J Biol Chem. 2016 Oct 28; 291(44): 23363.

PMCID:: PMC4861443

Abstract Article PDF–2.6M

Select item 475005117.

Hdac3 Interaction with p300 Histone Acetyltransferase Regulates the Oligodendrocyte and Astrocyte Lineage Fate Switch

Liguo Zhang, Xuelian He, Lei Liu, Minqing Jiang, Chuntao Zhao, Haibo Wang, Danyang He, Tao Zheng, Xianyao Zhou, Aishlin Hassan, Zhixing Ma, Mei Xin, Zheng Sun, Mitchell A. Lazar, Steven A. Goldman, Eric N. Olson, Q. Richard Lu

Dev Cell. Author manuscript; available in PMC 2017 Feb 8.

Published in final edited form as: Dev Cell. 2016 Feb 8; 36(3): 316–330. doi: 10.1016/j.devcel.2016.01.002

PMCID:: PMC4750051

Abstract Article PDF–3.1M

Select item 463696118.

HDAC8 Inhibition Specifically Targets Inv(16) Acute Myeloid Leukemic Stem Cells by Restoring p53 Acetylation

Jing Qi, Sandeep Singh, Wei-Kai Hua, Qi Cai, Shi-Wei Chao, Ling Li, Hongjun Liu, Yinwei Ho, Tinisha McDonald, Allen Lin, Guido Marcucci, Ravi Bhatia, Wei-Jan Huang, Chung-I Chang, Ya-Huei Kuo

Cell Stem Cell. Author manuscript; available in PMC 2016 Nov 5.

Published in final edited form as: Cell Stem Cell. 2015 Nov 5; 17(5): 597–610. Published online 2015 Sep 18. doi: 10.1016/j.stem.2015.08.004

PMCID:: PMC4636961

Abstract Article PDF–2.7M

Select item 451172019.

HDAC8, A Potential Therapeutic Target for the Treatment of Malignant Peripheral Nerve Sheath Tumors (MPNST)

Gonzalo Lopez, Kate Lynn J. Bill, Hemant Kumar Bid, Danielle Braggio, Dylan Constantino, Bethany Prudner, Abeba Zewdu, Kara Batte, Dina Lev, Raphael E. Pollock

PLoS One. 2015; 10(7): e0133302. Published online 2015 Jul 22. doi: 10.1371/journal.pone.0133302

PMCID:: PMC4511720

Abstract Article PDF–4.3M

Select item 430368720.

Specific Inhibition of Histone Deacetylase 8 Reduces Gene Expression and Production of Proinflammatory Cytokines in Vitro and in Vivo

Suzhao Li, Gianluca Fossati, Carlo Marchetti, Daniela Modena, Pietro Pozzi, Leonid L. Reznikov, Maria Luisa Moras, Tania Azam, Antonio Abbate, Paolo Mascagni, Charles A. Dinarello

J Biol Chem. 2015 Jan 23; 290(4): 2368–2378. Published online 2014 Dec 1. doi: 10.1074/jbc.M114.618454

PMCID:: PMC4303687

Abstract Article PDF–1.5M

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