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Select item 112370141.

Caspase-8 promotes scramblase-mediated phosphatidylserine exposure and fusion of osteoclast precursors

Brenda Krishnacoumar, Martin Stenzel, Hilal Garibagaoglu, Yasunori Omata, Rachel L. Sworn, Thea Hofmann, Natacha Ipseiz, Magdalena A. Czubala, Ulrike Steffen, Antonio Maccataio, Cornelia Stoll, Christina Böhm, Martin Herrmann, Stefan Uderhardt, Robert H. Jenkins, Philip R. Taylor, Anika Grüneboom, Mario M. Zaiss, Georg Schett, Gerhard Krönke, Carina Scholtysek

Bone Res. 2024; 12: 40. Published online 2024 Jul 11. doi: 10.1038/s41413-024-00338-4

PMCID:: PMC11237014

Abstract Article PDF–2.5M

Select item 111468882.

The modular nature of apoptotic signaling proteins

K. Hofmann

Cell Mol Life Sci. 1999 Jul; 55(8-9): 1113–1128. doi: 10.1007/s000180050361

PMCID:: PMC11146888

Abstract Article PDF–923K

Select item 111320953.

LAMP3 induces lysosome-dependent cell death by impairing autophagic caspase-8 degradation in Sjögren’s salivary glands

Hiroyuki Nakamura, Tsutomu Tanaka, Changyu Zheng, Sandra A Afione, Blake M. Warner, Masayuki Noguchi, Tatsuya Atsumi, John A. Chiorini

Arthritis Rheumatol. Author manuscript; available in PMC 2024 Sep 1.

Published in final edited form as: Arthritis Rheumatol. 2023 Sep; 75(9): 1586–1598. Published online 2023 Jul 27. doi: 10.1002/art.42540

PMCID:: PMC11132095

Abstract Article PDF–1.2M

Select item 110939694.

ZBP1 and TRIF trigger lethal necroptosis in mice lacking caspase-8 and TNFR1

Margaret Solon, Nianfeng Ge, Shannon Hambro, Susan Haller, Jian Jiang, Miriam Baca, Jessica Preston, Allie Maltzman, Katherine E. Wickliffe, Yuxin Liang, Rohit Reja, Dorothee Nickles, Kim Newton, Joshua D. Webster

Cell Death Differ. 2024 May; 31(5): 672–682. Published online 2024 Mar 28. doi: 10.1038/s41418-024-01286-6

PMCID:: PMC11093969

Abstract Article PDF–5.5M

Select item 110398375.

Interferon alpha promotes caspase-8 dependent ultraviolet light-mediated keratinocyte apoptosis via interferon regulatory factor 1

Shannon N. Loftus, Mehrnaz Gharaee-Kermani, Bin Xu, Tyson M. Moore, Andrew Hannoudi, Mischa J. Mallbris, Benjamin Klein, Johann E. Gudjonsson, J. Michelle Kahlenberg

Front Immunol. 2024; 15: 1384606. Published online 2024 Apr 10. doi: 10.3389/fimmu.2024.1384606

PMCID:: PMC11039837

Abstract Article PDF–4.1M

Select item 110265256.

Caspase 8 deletion causes infection/inflammation-induced bone marrow failure and MDS-like disease in mice

Shanhui Liu, Kanak Joshi, Lei Zhang, Wenyan Li, Ryan Mack, Austin Runde, Patrick A. Hagen, Kevin Barton, Peter Breslin, Hong-Long Ji, Ameet R. Kini, Zhiping Wang, Jiwang Zhang

Cell Death Dis. 2024 Apr; 15(4): 278. Published online 2024 Apr 18. doi: 10.1038/s41419-024-06660-3

PMCID:: PMC11026525

Abstract Article PDF–3.0M

Select item 108605487.

Study on pyroptosis-related genes Casp8, Gsdmd and Trem2 in mice with cerebral infarction

Shunli Liang, Linsheng Xu, Xilin Xin, Rongbo Zhang, You Wu

PeerJ. 2024; 12: e16818. Published online 2024 Feb 9. doi: 10.7717/peerj.16818

PMCID:: PMC10860548

Abstract Article PDF–6.5M

Select item 105492048.

Autophagy critically controls skin inflammation and apoptosis-induced stem cell activation

Lisette Van Hove, Annagiada Toniolo, Mohammad Ghiasloo, Kim Lecomte, Fleur Boone, Maarten Ciers, Kris Raaijmakers, Niels Vandamme, Jana Roels, Sophia Maschalidi, Kodi S Ravichandran, Maria Kasper, Geert van Loo, Esther Hoste

Autophagy. 2023; 19(11): 2958–2971. Published online 2023 Sep 1. doi: 10.1080/15548627.2023.2247742

PMCID:: PMC10549204

Abstract Article PDF–3.9M

Select item 105473009.

Crk and Crkl Are Required in the Endocardial Lineage for Heart Valve Development

Bingruo Wu, Brian Wu, Sonia Benkaci, Lijie Shi, Pengfei Lu, Taeju Park, Bernice E. Morrow, Yidong Wang, Bin Zhou

J Am Heart Assoc. 2023 Sep 19; 12(18): e029683. Published online 2023 Sep 13. doi: 10.1161/JAHA.123.029683

PMCID:: PMC10547300

Abstract Article PDF–41M

Select item 1041698410.

Differential Modulation of miR-122 Transcription by TGFβ1/BMP6: Implications for Nonresolving Inflammation and Hepatocarcinogenesis

Martha Paluschinski, Claus Kordes, Mihael Vucur, Veronika Buettner, Christoph Roderburg, Haifeng C. Xu, Prashant V. Shinte, Philipp A. Lang, Tom Luedde, Mirco Castoldi

Cells. 2023 Aug; 12(15): 1955. Published online 2023 Jul 27. doi: 10.3390/cells12151955

PMCID:: PMC10416984

Abstract Article PDF–4.8M

Select item 1040980011.

SNIP1 and PRC2 coordinate cell fates of neural progenitors during brain development

Yurika Matsui, Mohamed Nadhir Djekidel, Katherine Lindsay, Parimal Samir, Nina Connolly, Gang Wu, Xiaoyang Yang, Yiping Fan, Beisi Xu, Jamy C. Peng

Nat Commun. 2023; 14: 4754. Published online 2023 Aug 8. doi: 10.1038/s41467-023-40487-4

PMCID:: PMC10409800

Abstract Article PDF–5.3M

Select item 1039417112.

Caspase-8 inhibition improves the outcome of bacterial infections in mice by promoting neutrophil activation

Germana Lentini, Agata Famà, Giuseppe Valerio De Gaetano, Francesco Coppolino, Ahlem Khachroub Mahjoub, Liv Ryan, Egil Lien, Terje Espevik, Concetta Beninati, Giuseppe Teti

Cell Rep Med. 2023 Jul 18; 4(7): 101098. Published online 2023 Jun 29. doi: 10.1016/j.xcrm.2023.101098

PMCID:: PMC10394171

Abstract Article PDF–6.8M

Select item 1029412113.

Regulation of distinct caspase-8 functions in retinal ganglion cells and astroglia in experimental glaucoma

Xiangjun Yang, Qun Zeng, Gülgün Tezel

Neurobiol Dis. Author manuscript; available in PMC 2023 Jun 27.

Published in final edited form as: Neurobiol Dis. 2021 Mar; 150: 105258. Published online 2021 Jan 9. doi: 10.1016/j.nbd.2021.105258

PMCID:: PMC10294121

Abstract Article PDF–3.1M

Select item 1026756314.

Oxidation of caspase-8 by hypothiocyanous acid enables TNF-mediated necroptosis

Stephanie M. Bozonet, Nicholas J. Magon, Abigail J. Schwartfeger, Andreas Konigstorfer, Sarah G. Heath, Margreet C.M. Vissers, Vanessa K. Morris, Christoph Göbl, James M. Murphy, Guy S. Salvesen, Mark B. Hampton

J Biol Chem. 2023 Jun; 299(6): 104792. Published online 2023 May 6. doi: 10.1016/j.jbc.2023.104792

PMCID:: PMC10267563

Abstract Article PDF–2.2M

Select item 1019144115.

USP7 represses lineage differentiation genes in mouse embryonic stem cells by both catalytic and noncatalytic activities

Chao Liu, Lingang Sun, Yijun Tan, Qi Wang, Tao Luo, Chenlu Li, Nan Yao, Yuting Xie, Xiao Yi, Yi Zhu, Tiannan Guo, Junfeng Ji

Sci Adv. 2023 May; 9(20): eade3888. Published online 2023 May 17. doi: 10.1126/sciadv.ade3888

PMCID:: PMC10191441

Abstract Article PDF–2.4M

Select item 1011932316.

Gasdermin D independent canonical inflammasome responses cooperate with caspase-8 to establish host defense against gastrointestinal Citrobacter rodentium infection

Elien Eeckhout, Lisa Hamerlinck, Veronique Jonckheere, Petra Van Damme, Geert van Loo, Andy Wullaert

Cell Death Dis. 2023 Apr; 14(4): 282. Published online 2023 Apr 21. doi: 10.1038/s41419-023-05801-4

PMCID:: PMC10119323

Abstract Article PDF–7.1M

Select item 997742517.

Role of the caspase-8/RIPK3 axis in Alzheimer’s disease pathogenesis and Aβ-induced NLRP3 inflammasome activation

Sushanth Kumar, Sakar Budhathoki, Christopher B. Oliveira, August D. Kahle, O. Yipkin Calhan, John R. Lukens, Christopher D. Deppmann

JCI Insight. 2023 Feb 8; 8(3): e157433. Published online 2023 Feb 8. doi: 10.1172/jci.insight.157433

PMCID:: PMC9977425

Abstract Article PDF–11M

Select item 996425418.

Caspase Inhibition Modulates Monocyte-Derived Macrophage Polarization in Damaged Tissues

Stéphanie Solier, Michele Mondini, Lydia Meziani, Arnaud Jacquel, Catherine Lacout, Tom Vanden Berghe, Yvon Julé, Jean-Claude Martinou, Gérard Pierron, Julie Rivière, Marc Deloger, Corinne Dupuy, Anny Slama-Schwok, Nathalie Droin, Peter Vandenabeele, Patrick Auberger, Eric Deutsch, Jamel El-Benna, Pham My-Chan Dang, Eric Solary

Int J Mol Sci. 2023 Feb; 24(4): 4151. Published online 2023 Feb 19. doi: 10.3390/ijms24044151

PMCID:: PMC9964254

Abstract Article PDF–7.5M

Select item 992231919.

RIPK3 controls MAIT cell accumulation during development but not during infection

Timothy Patton, Zhe Zhao, Xin Yi Lim, Eleanor Eddy, Huimeng Wang, Adam G. Nelson, Bronte Ennis, Sidonia B. G. Eckle, Michael N. T. Souter, Troi J. Pediongco, Hui-Fern Koay, Jian-Guo Zhang, Tirta M. Djajawi, Cynthia Louis, Najoua Lalaoui, Nicolas Jacquelot, Andrew M. Lew, Daniel G. Pellicci, James McCluskey, Yifan Zhan, Zhenjun Chen, Kate E. Lawlor, Alexandra J. Corbett

Cell Death Dis. 2023 Feb; 14(2): 111. Published online 2023 Feb 11. doi: 10.1038/s41419-023-05619-0

PMCID:: PMC9922319

Abstract Article PDF–2.2M

Select item 988352320.

Endothelial Caspase-8 prevents fatal necroptotic hemorrhage caused by commensal bacteria

Stefanie M. Bader, Simon P. Preston, Katie Saliba, Adam Lipszyc, Zoe L. Grant, Liana Mackiewicz, Andrew Baldi, Anne Hempel, Michelle P. Clark, Thanushi Peiris, William Clow, Jan Bjelic, Michael D. Stutz, Philip Arandjelovic, Jack Teale, Fashuo Du, Leigh Coultas, James M. Murphy, Cody C. Allison, Marc Pellegrini, Andre L. Samson

Cell Death Differ. 2023 Jan; 30(1): 27–36. Published online 2022 Jul 23. doi: 10.1038/s41418-022-01042-8