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Items: 1 to 20 of 34

1.
Protein kinase N promotes cardiac fibrosis in heart failure by fibroblast-to-myofibroblast conversion
Satoya Yoshida, Tatsuya Yoshida, Kohei Inukai, Katsuhiro Kato, Yoshimitsu Yura, Tomoki Hattori, Atsushi Enomoto, Koji Ohashi, Takahiro Okumura, Noriyuki Ouchi, Haruya Kawase, Nina Wettschureck, Stefan Offermanns, Toyoaki Murohara, Mikito Takefuji
Nat Commun. 2024; 15: 7638. Published online 2024 Sep 12. doi: 10.1038/s41467-024-52068-0
PMCID:
PMC11392935
AbstractArticlePDF–3.3M
2.
Genetic determinants of micronucleus formation in vivo
D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus
Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0
PMCID:
PMC10917660
AbstractArticlePDF–4.8M
3.
PKN1 Exerts Neurodegenerative Effects in an In Vitro Model of Cerebellar Hypoxic–Ischemic Encephalopathy via Inhibition of AKT/GSK3β Signaling
Stephanie zur Nedden, Motahareh Solina Safari, Friedrich Fresser, Klaus Faserl, Herbert Lindner, Bettina Sarg, Gottfried Baier, Gabriele Baier-Bitterlich
Biomolecules. 2023 Nov; 13(11): 1599. Published online 2023 Oct 31. doi: 10.3390/biom13111599
PMCID:
PMC10669522
AbstractArticlePDF–3.5M
4.
Phosphorylation of KRT8 (keratin 8) by excessive mechanical load-activated PKN (protein kinase N) impairs autophagosome initiation and contributes to disc degeneration
Di Wang, Qiliang Shang, Jianxin Mao, Chu Gao, Jie Wang, Dong Wang, Han Wang, Haoruo Jia, Pandi Peng, Mu Du, Zhuojing Luo, Liu Yang
Autophagy. 2023; 19(9): 2485–2503. Published online 2023 Mar 10. doi: 10.1080/15548627.2023.2186099
PMCID:
PMC10392755
AbstractArticlePDF–9.5M
5.
PKN2 deficiency leads both to prenatal ‘congenital’ cardiomyopathy and defective angiotensin II stress responses
Jacqueline J.T. Marshall, Joshua J. Cull, Hajed O. Alharbi, May Zaw Thin, Susanna T.E. Cooper, Christopher Barrington, Hannah Vanyai, Thomas Snoeks, Bernard Siow, Alejandro Suáarez-Bonnet, Eleanor Herbert, Daniel J. Stuckey, Angus J.M. Cameron, Fabrice Prin, Andrew C. Cook, Simon L. Priestnall, Sonia Chotani, Owen J. L. Rackham, Daniel N. Meijles, Tim Mohun, Angela Clerk, Peter J. Parker
Biochem J. 2022 Jul 15; 479(13): 1467–1486. Prepublished online 2022 Jun 22. Published online 2022 Jul 12. doi: 10.1042/BCJ20220281
PMCID:
PMC9342899
AbstractArticlePDF–30M
6.
Protein kinase N2 mediates flow-induced endothelial NOS activation and vascular tone regulation
Young-June Jin, Ramesh Chennupati, Rui Li, Guozheng Liang, ShengPeng Wang, András Iring, Johannes Graumann, Nina Wettschureck, Stefan Offermanns
J Clin Invest. 2021 Nov 1; 131(21): e145734. Published online 2021 Nov 1. doi: 10.1172/JCI145734
PMCID:
PMC8553558
AbstractArticlePDF–7.7M
7.
BraInMap elucidates the macromolecular connectivity landscape of mammalian brain
Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili
Cell Syst. Author manuscript; available in PMC 2021 Apr 22.
Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003
Correction in:
Cell Syst. 2020 Aug 26; 11(2): 208.
PMCID:
PMC7938770
AbstractArticlePDF–2.0M
8.
PKN1 promotes synapse maturation by inhibiting mGluR-dependent silencing through neuronal glutamate transporter activation
Hiroki Yasuda, Hikaru Yamamoto, Kenji Hanamura, Mona Mehruba, Toshio Kawamata, Hiromi Morisaki, Masaaki Miyamoto, Shinji Takada, Tomoaki Shirao, Yoshitaka Ono, Hideyuki Mukai
Commun Biol. 2020; 3: 710. Published online 2020 Nov 26. doi: 10.1038/s42003-020-01435-w
PMCID:
PMC7691520
AbstractArticlePDF–3.4M
9.
Novel roles of PRK1 and PRK2 in cilia and cancer biology
Hitesh Patel, Jun Li, Ana Herrero, Jakob Kroboth, Adam Byron, Alex Von Kriegsheim, Valerie Brunton, Neil Carragher, Toby Hurd, Margaret Frame
Sci Rep. 2020; 10: 3902. Published online 2020 Mar 3. doi: 10.1038/s41598-020-60604-3
PMCID:
PMC7054267
AbstractArticlePDF–3.2M
10.
PKN1 kinase-negative knock-in mice develop splenomegaly and leukopenia at advanced age without obvious autoimmune-like phenotypes
Salman Mahmud Siddique, Koji Kubouchi, Yuka Shinmichi, Nana Sawada, Reiko Sugiura, Yasushi Itoh, Shunsuke Uehara, Kanae Nishimura, Shunsuke Okamura, Hiroyuki Ohsaki, Shingo Kamoshida, Yusuke Yamashita, Shinobu Tamura, Takashi Sonoki, Hiroshi Matsuoka, Tomoo Itoh, Hideyuki Mukai
Sci Rep. 2019; 9: 13977. Published online 2019 Sep 27. doi: 10.1038/s41598-019-50419-2
PMCID:
PMC6764976
AbstractArticlePDF–4.0M
11.
Plasticity in the Glucagon Interactome Reveals Novel Proteins That Regulate Glucagon Secretion in α-TC1-6 Cells
Farzad Asadi, Savita Dhanvantari
Front Endocrinol (Lausanne) 2018; 9: 792. Published online 2019 Jan 18. doi: 10.3389/fendo.2018.00792
PMCID:
PMC6346685
AbstractArticlePDF–3.6M
12.
Protein kinase N1 critically regulates cerebellar development and long-term function
Stephanie zur Nedden, Rafaela Eith, Christoph Schwarzer, Lucia Zanetti, Hartwig Seitter, Friedrich Fresser, Alexandra Koschak, Angus J.M. Cameron, Peter J. Parker, Gottfried Baier, Gabriele Baier-Bitterlich
J Clin Invest. 2018 May 1; 128(5): 2076–2088. Published online 2018 Apr 16. doi: 10.1172/JCI96165
PMCID:
PMC5919825
AbstractArticlePDF–11M
13.
Loss of Protein Kinase Novel 1 (PKN1) is associated with mild systolic and diastolic contractile dysfunction, increased phospholamban Thr17 phosphorylation, and exacerbated ischaemia-reperfusion injury
Asvi A Francois, Kofo Obasanjo-Blackshire, James E Clark, Andrii Boguslavskyi, Mark R Holt, Peter J Parker, Michael S Marber, Richard J Heads
Cardiovasc Res. 2018 Jan 1; 114(1): 138–157. Published online 2017 Oct 16. doi: 10.1093/cvr/cvx206
PMCID:
PMC5815577
AbstractArticlePDF–1.7M
14.
The Protein Kinase C Super-family Member PKN is Regulated by mTOR and Influences Differentiation During Prostate Cancer Progression
Chun-Song Yang, Tiffany A. Melhuish, Adam Spencer, Li Ni, Yi Hao, Kasey Jividen, Thurl Harris, Chelsi Snow, Henry Frierson, David Wotton, Bryce M. Paschal
Prostate. Author manuscript; available in PMC 2018 Nov 1.
Published in final edited form as: Prostate. 2017 Nov; 77(15): 1452–1467. Published online 2017 Sep 6. doi: 10.1002/pros.23400
PMCID:
PMC5669364
AbstractArticlePDF–1.7M
15.
Spatio-temporal profile of postynaptic interactomes integrates components of complex brain disorders
Jing Li, Wangshu Zhang, Hui Yang, Daniel P. Howrigan, Brent Wilkinson, Tade Souaiaia, Oleg V. Evgrafov, Giulio Genovese, Veronica A. Clementel, Jennifer C. Tudor, Ted Abel, James A. Knowles, Benjamin M. Neale, Kai Wang, Fengzhu Sun, Marcelo P. Coba
Nat Neurosci. Author manuscript; available in PMC 2018 Aug 1.
Published in final edited form as: Nat Neurosci. 2017 Aug; 20(8): 1150–1161. Published online 2017 Jun 26. doi: 10.1038/nn.4594
PMCID:
PMC5645082
AbstractArticlePDF–2.3M
16.
Impaired lymphocyte trafficking in mice deficient in the kinase activity of PKN1
Rana Mashud, Akira Nomachi, Akihide Hayakawa, Koji Kubouchi, Sally Danno, Takako Hirata, Kazuhiko Matsuo, Takashi Nakayama, Ryosuke Satoh, Reiko Sugiura, Manabu Abe, Kenji Sakimura, Shigeharu Wakana, Hiroyuki Ohsaki, Shingo Kamoshida, Hideyuki Mukai
Sci Rep. 2017; 7: 7663. Published online 2017 Aug 9. doi: 10.1038/s41598-017-07936-9
PMCID:
PMC5550459
AbstractArticlePDF–3.5M
17.
PKN1 directs polarized RAB21 vesicle trafficking via phosphorylation of RPH3A and is important for neutrophil adhesion and ischemia-reperfusion injury
Qianying Yuan, Chunguang Ren, Wenwen Xu, Björn Petri, Jiasheng Zhang, Yong Zhang, Paul Kubes, Dianqing Wu, Wenwen Tang
Cell Rep. Author manuscript; available in PMC 2017 Aug 8.
Published in final edited form as: Cell Rep. 2017 Jun 20; 19(12): 2586–2597. doi: 10.1016/j.celrep.2017.05.080
PMCID:
PMC5548392
AbstractArticlePDF–2.3M
18.
Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function
Tingting Zhang, Wei Du, Andrew F. Wilson, Satoshi H. Namekawa, Paul R. Andreassen, Amom Ruhikanta Meetei, Qishen Pang
Sci Rep. 2017; 7: 45626. Published online 2017 Apr 5. doi: 10.1038/srep45626
PMCID:
PMC5381226
AbstractArticlePDF–1.4M
19.
High-throughput discovery of novel developmental phenotypes
Mary E. Dickinson, Ann M. Flenniken, Xiao Ji, Lydia Teboul, Michael D. Wong, Jacqueline K. White, Terrence F. Meehan, Wolfgang J. Weninger, Henrik Westerberg, Hibret Adissu, Candice N. Baker, Lynette Bower, James M. Brown, L. Brianna Caddle, Francesco Chiani, Dave Clary, James Cleak, Mark J. Daly, James M. Denegre, Brendan Doe, Mary E. Dolan, Sarah M. Edie, Helmut Fuchs, Valerie Gailus-Durner, Antonella Galli, Alessia Gambadoro, Juan Gallegos, Shiying Guo, Neil R. Horner, Chih-wei Hsu, Sara J. Johnson, Sowmya Kalaga, Lance C. Keith, Louise Lanoue, Thomas N. Lawson, Monkol Lek, Manuel Mark, Susan Marschall, Jeremy Mason, Melissa L. McElwee, Susan Newbigging, Lauryl M.J. Nutter, Kevin A. Peterson, Ramiro Ramirez-Solis, Douglas J. Rowland, Edward Ryder, Kaitlin E. Samocha, John R. Seavitt, Mohammed Selloum, Zsombor Szoke-Kovacs, Masaru Tamura, Amanda G Trainor, Ilinca Tudose, Shigeharu Wakana, Jonathan Warren, Olivia Wendling, David B. West, Leeyean Wong, Atsushi Yoshiki, The International Mouse Phenotyping Consortium, Daniel G. MacArthur, Glauco P. Tocchini-Valentini, Xiang Gao, Paul Flicek, Allan Bradley, William C. Skarnes, Monica J. Justice, Helen E. Parkinson, Mark Moore, Sara Wells, Robert E. Braun, Karen L. Svenson, Martin Hrabe de Angelis, Yann Herault, Tim Mohun, Ann-Marie Mallon, R. Mark Henkelman, Steve D.M. Brown, David J. Adams, K.C. Kent Lloyd, Colin McKerlie, Arthur L. Beaudet, Maja Bucan, Stephen A. Murray
Nature. Author manuscript; available in PMC 2017 Mar 14.
Published in final edited form as: Nature. 2016 Sep 22; 537(7621): 508–514. Published online 2016 Sep 14. doi: 10.1038/nature19356
Correction in:
Nature. 2017 Nov 16; 551(7680): 398.
PMCID:
PMC5295821
AbstractArticlePDF–3.0M
20.
The Yersinia Virulence Factor YopM Hijacks Host Kinases to Inhibit Type III Effector-Triggered Activation of the Pyrin Inflammasome
Lawton K. Chung, Yong Hwan Park, Yueting Zheng, Igor E. Brodsky, Patrick Hearing, Daniel L. Kastner, Jae Jin Chae, James B. Bliska
Cell Host Microbe. Author manuscript; available in PMC 2017 Sep 14.
Published in final edited form as: Cell Host Microbe. 2016 Sep 14; 20(3): 296–306. Published online 2016 Aug 25. doi: 10.1016/j.chom.2016.07.018
PMCID:
PMC5025386
AbstractArticlePDF–1.1M

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