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Select item 99522051.

Fatal Epileptic Seizures in Mice Having Compromised Glutathione and Ascorbic Acid Biosynthesis

Ying Chen, Katherine D. Holland, Howard G. Shertzer, Daniel W. Nebert, Timothy P. Dalton

Antioxidants (Basel) 2023 Feb; 12(2): 448. Published online 2023 Feb 10. doi: 10.3390/antiox12020448

PMCID:: PMC9952205

Abstract Article PDF–4.2M

Select item 95375122.

Vitamin C epigenetically controls osteogenesis and bone mineralization

Roman Thaler, Farzaneh Khani, Ines Sturmlechner, Sharareh S. Dehghani, Janet M. Denbeigh, Xianhu Zhou, Oksana Pichurin, Amel Dudakovic, Sofia S. Jerez, Jian Zhong, Jeong-Heon Lee, Ramesh Natarajan, Ivo Kalajzic, Yong-hui Jiang, David R. Deyle, Eleftherios P. Paschalis, Barbara M. Misof, Tamas Ordog, Andre J. van Wijnen

Nat Commun. 2022; 13: 5883. Published online 2022 Oct 6. doi: 10.1038/s41467-022-32915-8

PMCID:: PMC9537512

Abstract Article PDF–4.4M

Select item 95202803.

Vitamin C modulates the levels of several proteins of the mitochondrial complex III and its activity in the mouse liver

Lucie Aumailley, Sylvie Bourassa, Clarisse Gotti, Arnaud Droit, Michel Lebel

Redox Biol. 2022 Nov; 57: 102491. Published online 2022 Sep 24. doi: 10.1016/j.redox.2022.102491

PMCID:: PMC9520280

Abstract Article PDF–7.0M

Select item 89750624.

Vitamin C Deficiency Causes Cell Type–Specific Epigenetic Reprogramming and Acute Tubular Necrosis in a Mouse Model

Zihui Yu, Ziying Xu, Yuan Liang, Pengbin Yin, Yue Shi, Jiayi Yu, Junfeng Hao, Ting Wang, Weimin Ci

J Am Soc Nephrol. 2022 Mar; 33(3): 531–546. Published online 2022 Mar. doi: 10.1681/ASN.2021070881

PMCID:: PMC8975062

Abstract Article

Select item 89390535.

SDHB knockout and succinate accumulation are insufficient for tumorigenesis but dual SDHB/NF1 loss yields SDHx-like pheochromocytomas

Neali Armstrong, Claire M. Storey, Sarah E. Noll, Katherine Margulis, Myat Han Soe, Haixia Xu, Benjamin Yeh, Lauren Fishbein, Electron Kebebew, Brooke E. Howitt, Richard N. Zare, Julien Sage, Justin P. Annes

Cell Rep. Author manuscript; available in PMC 2022 Mar 22.

Published in final edited form as: Cell Rep. 2022 Mar 1; 38(9): 110453. doi: 10.1016/j.celrep.2022.110453

PMCID:: PMC8939053

Abstract Article PDF–3.1M

Select item 87753456.

The Roles of IL-22 and Its Receptor in the Regulation of Inflammatory Responses in the Brain

Dahae Lee, Hyejung Jo, Cheolhyeon Go, Yoojin Jang, Naghyung Chu, Suhyun Bae, Dongmin Kang, Yejin Kim, Jae Seung Kang

Int J Mol Sci. 2022 Jan; 23(2): 757. Published online 2022 Jan 11. doi: 10.3390/ijms23020757

PMCID:: PMC8775345

Abstract Article PDF–2.6M

Select item 84233477.

Maternal Vitamin C regulates reprogramming of DNA methylation and germline development

Stephanie P DiTroia, Michelle Percharde, Marie-Justine Guerquin, Estelle Wall, Evelyne Collignon, Kevin T Ebata, Kathryn Mesh, Swetha Mahesula, Michalis Agathocleous, Diana J Laird, Gabriel Livera, Miguel Ramalho-Santos

Nature. Author manuscript; available in PMC 2021 Sep 7.

Published in final edited form as: Nature. 2019 Sep; 573(7773): 271–275. Published online 2019 Sep 4. doi: 10.1038/s41586-019-1536-1

Correction in:: Nature. 2019 Nov 13

PMCID:: PMC8423347

Abstract Article PDF–4.2M

Select item 83949798.

Vitamin C Enhances Antiviral Functions of Lung Epithelial Cells

Trevor Teafatiller, Sudhanshu Agrawal, Gabriela De Robles, Farah Rahmatpanah, Veedamali S. Subramanian, Anshu Agrawal

Biomolecules. 2021 Aug; 11(8): 1148. Published online 2021 Aug 3. doi: 10.3390/biom11081148

PMCID:: PMC8394979

Abstract Article PDF–2.1M

Select item 78820089.

Ascorbate deficiency decreases dopamine release in gulo^–/– and APP/PSEN1 mice

David C. Consoli, Lillian J. Brady, Aaron B. Bowman, Erin S. Calipari, Fiona E. Harrison

J Neurochem. Author manuscript; available in PMC 2022 May 1.

Published in final edited form as: J Neurochem. 2021 May; 157(3): 656–665. Published online 2020 Sep 21. doi: 10.1111/jnc.15151

PMCID:: PMC7882008

Abstract Article PDF–1.2M

Select item 768102610.

Ascorbic acid enhances low-density lipoprotein receptor expression by suppressing proprotein convertase subtilisin/kexin 9 expression

Dandan Wang, Xiaoxiao Yang, Yuanli Chen, Ke Gong, Maoyun Yu, Yongyao Gao, Ximei Wu, Huaqing Hu, Chenzhong Liao, Jihong Han, Yajun Duan

J Biol Chem. 2020 Nov 20; 295(47): 15870–15882. Published online 2020 Sep 10. doi: 10.1074/jbc.RA120.015623

PMCID:: PMC7681026

Abstract Article PDF–3.4M

Select item 753006311.

Vitamin C regulates Schwann cell myelination by promoting DNA demethylation of pro-myelinating genes

Tyler C. Huff, David W. Sant, Vladimir Camarena, Derek Van Booven, Nadja S. Andrade, Sushmita Mustafi, Paula V. Monje, Gaofeng Wang

J Neurochem. Author manuscript; available in PMC 2021 Jun 24.

Published in final edited form as: J Neurochem. 2021 Jun; 157(6): 1759–1773. Published online 2020 Apr 14. doi: 10.1111/jnc.15015

PMCID:: PMC7530063

Abstract Article PDF–2.4M

Select item 747758212.

Context dependent effects of ascorbic acid treatment in TET2 mutant myeloid neoplasia

Yihong Guan, Edward F. Greenberg, Metis Hasipek, Shi Chen, Xiaochen Liu, Cassandra M. Kerr, Daniel Gackowski, Ewelina Zarakowska, Tomas Radivoyevitch, Xiaorong Gu, Belinda Willard, Valeria Visconte, Hideki Makishima, Aziz Nazha, Mridul Mukherji, Mikkael A. Sekeres, Yogen Saunthararajah, Ryszard Oliński, Mingjiang Xu, Jaroslaw P. Maciejewski, Babal K. Jha

Commun Biol. 2020; 3: 493. Published online 2020 Sep 7. doi: 10.1038/s42003-020-01220-9

PMCID:: PMC7477582

Abstract Article PDF–2.4M

Select item 668562413.

Vitamin C effects on 5-hydroxymethylcytosine and gene expression in osteoblasts and chondrocytes: Potential involvement of PHD2

Richard C. Lindsey, Shaohong Cheng, Subburaman Mohan

PLoS One. 2019; 14(8): e0220653. Published online 2019 Aug 7. doi: 10.1371/journal.pone.0220653

PMCID:: PMC6685624

Abstract Article PDF–3.3M

Select item 616215214.

Altered glutamate clearance in ascorbate deficient mice increases seizure susceptibility and contributes to cognitive impairment in APP/PSEN1 mice

Deborah J Mi, Shilpy Dixit, Timothy A Warner, John A Kennard, Daniel A Scharf, Eric S Kessler, Lisa M Moore, David C Consoli, Corey W Bown, Angeline J Eugene, Jing-Qiong Kang, Fiona E Harrison

Neurobiol Aging. Author manuscript; available in PMC 2019 Nov 1.

Published in final edited form as: Neurobiol Aging. 2018 Nov; 71: 241–254. Published online 2018 Aug 7. doi: 10.1016/j.neurobiolaging.2018.08.002

PMCID:: PMC6162152

Abstract Article PDF–938K

Select item 607332015.

Oxidative Stress Levels in the Brain Are Determined by Post-Mortem Interval and Ante-Mortem Vitamin C State but Not Alzheimer’s Disease Status

Jared Eckman, Shilpy Dixit, Alex Nackenoff, Matthew Schrag, Fiona E. Harrison

Nutrients. 2018 Jul; 10(7): 883. Published online 2018 Jul 9. doi: 10.3390/nu10070883

PMCID:: PMC6073320

Abstract Article PDF–1.2M

Select item 604998716.

Ascorbate Suppresses VEGF Expression in Retinal Pigment Epithelial Cells

David W. Sant, Vladimir Camarena, Sushmita Mustafi, Yiwen Li, Zachary Wilkes, Derek Van Booven, Rong Wen, Gaofeng Wang

Invest Ophthalmol Vis Sci. 2018 Jul; 59(8): 3608–3618. doi: 10.1167/iovs.18-24101

PMCID:: PMC6049987

Abstract Article PDF–1.2M

Select item 599897017.

Serum vitamin C levels modulate the lifespan and endoplasmic reticulum stress response pathways in mice synthesizing a nonfunctional mutant WRN protein

Lucie Aumailley, Marie Julie Dubois, Tracy A. Brennan, Chantal Garand, Eric R. Paquet, Robert J. Pignolo, André Marette, Michel Lebel

FASEB J. 2018 Jul; 32(7): 3623–3640. Published online 2018 Feb 8. doi: 10.1096/fj.201701176R

PMCID:: PMC5998970

Abstract Article

Select item 591006318.

Ascorbate regulates haematopoietic stem cell function and leukaemogenesis

Michalis Agathocleous, Corbin E. Meacham, Rebecca J. Burgess, Elena Piskounova, Zhiyu Zhao, Genevieve M. Crane, Brianna L. Cowin, Emily Bruner, Malea M. Murphy, Weina Chen, Gerald J. Spangrude, Zeping Hu, Ralph J. DeBerardinis, Sean J. Morrison

Nature. Author manuscript; available in PMC 2018 Apr 20.

Published in final edited form as: Nature. 2017 Sep 28; 549(7673): 476–481. Published online 2017 Aug 21. doi: 10.1038/nature23876

PMCID:: PMC5910063

Abstract Article PDF–2.8M

Select item 577198119.

Vitamin C sensitizes melanoma to BET inhibitors

Sushmita Mustafi, Vladimir Camarena, Claude-Henry Volmar, Tyler C. Huff, David W. Sant, Shaun P. Brothers, Zhao-Jun Liu, Claes Wahlestedt, Gaofeng Wang

Cancer Res. Author manuscript; available in PMC 2019 Jan 15.

Published in final edited form as: Cancer Res. 2018 Jan 15; 78(2): 572–583. Published online 2017 Nov 27. doi: 10.1158/0008-5472.CAN-17-2040