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Items: 1 to 20 of 46

1.
Genetic determinants of micronucleus formation in vivo
D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus
Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0
PMCID:
PMC10917660
AbstractArticlePDF–4.8M
2.
Gab2 promotes the growth of colorectal cancer by regulating the M2 polarization of tumor-associated macrophages
Xuehan Gao, Runying Long, Ming Qin, Wenfang Zhu, Linna Wei, Pinzhi Dong, Jin Chen, Junmin Luo, Jihong Feng
Int J Mol Med. 2024 Jan; 53(1): 3. Published online 2023 Nov 8. doi: 10.3892/ijmm.2023.5327
PMCID:
PMC10688767
AbstractArticlePDF–5.9M
3.
The Gab2–MALT1 axis regulates thromboinflammation and deep vein thrombosis
Vijay Kondreddy, Shiva Keshava, Kaushik Das, Jhansi Magisetty, L. Vijaya Mohan Rao, Usha R. Pendurthi
Blood. 2022 Sep 29; 140(13): 1549–1564. doi: 10.1182/blood.2022016424
PMCID:
PMC9523376
AbstractArticle
4.
Gab2 deficiency prevents Flt3-ITD driven acute myeloid leukemia in vivo
Corinna Spohr, Teresa Poggio, Geoffroy Andrieux, Katharina Schönberger, Nina Cabezas-Wallscheid, Melanie Boerries, Sebastian Halbach, Anna L. Illert, Tilman Brummer
Leukemia. 2022; 36(4): 970–982. Published online 2021 Dec 13. doi: 10.1038/s41375-021-01490-0
PMCID:
PMC8979819
AbstractArticlePDF–4.7M
5.
Gab2 (Grb2-Associated Binder2) Plays a Crucial Role in Inflammatory Signaling and Endothelial Dysfunction
Vijay Kondreddy, Jhansi Magisetty, Shiva Keshava, L. Vijaya Mohan Rao, Usha R. Pendurthi
Arterioscler Thromb Vasc Biol. 2021 Jun; 41(6): 1987–2005. Published online 2021 Apr 8. doi: 10.1161/ATVBAHA.121.316153
PMCID:
PMC8147699
AbstractArticlePDF–4.9M
6.
Gab2 deficiency suppresses high-fat diet-induced obesity by reducing adipose tissue inflammation and increasing brown adipose function in mice
Xinhui Wang, Yinan Zhao, Dekun Zhou, Yingpu Tian, Gensheng Feng, Zhongxian Lu
Cell Death Dis. 2021 Feb; 12(2): 212. Published online 2021 Feb 26. doi: 10.1038/s41419-021-03519-9
PMCID:
PMC7910586
AbstractArticlePDF–7.5M
7.
Gab1 mediates PDGF signaling and is essential to oligodendrocyte differentiation and CNS myelination
Liang Zhou, Chong-Yu Shao, Ya-Jun Xie, Na Wang, Si-Min Xu, Ben-Yan Luo, Zhi-Ying Wu, Yue Hai Ke, Mengsheng Qiu, Ying Shen
eLife. 2020; 9: e52056. Published online 2020 Jan 16. doi: 10.7554/eLife.52056
PMCID:
PMC6984811
AbstractArticlePDF–7.1M
8.
Grb2-Associated Binder-1 Is Required for Neuregulin-1-Induced Peripheral Nerve Myelination
Yoon Kyung Shin, So Young Jang, So Young Park, Joo Youn Park, Jong Kuk Kim, Jong Phil Kim, Duk Joon Suh, Hye Jeong Lee, Hwan Tae Park
J Neurosci. 2014 May 28; 34(22): 7657–7662. doi: 10.1523/JNEUROSCI.4947-13.2014
PMCID:
PMC6795250
AbstractArticlePDF–2.0M
9.
Gab2 and Gab3 Redundantly Suppress Colitis by Modulating Macrophage and CD8+ T-Cell Activation
Zhengqi Wang, Tamisha Y. Vaughan, Wandi Zhu, Yuhong Chen, Guoping Fu, Magdalena Medrzycki, Hikaru Nishio, Silvia T. Bunting, Pamela A. Hankey-Giblin, Asma Nusrat, Charles A. Parkos, Demin Wang, Renren Wen, Kevin D. Bunting
Front Immunol. 2019; 10: 486. Published online 2019 Mar 18. doi: 10.3389/fimmu.2019.00486
PMCID:
PMC6431666
AbstractArticlePDF–3.7M
10.
USP22 controls multiple signaling pathways that are essential for vasculature formation in the mouse placenta
Evangelia Koutelou, Li Wang, Andria C. Schibler, Hsueh-Ping Chao, Xianghong Kuang, Kevin Lin, Yue Lu, Jianjun Shen, Collene R. Jeter, Andrew Salinger, Marenda Wilson, Yi Chun Chen, Boyko S. Atanassov, Dean G. Tang, Sharon Y. R. Dent
Development. 2019 Feb 15; 146(4): dev174037. Published online 2019 Feb 22. doi: 10.1242/dev.174037
PMCID:
PMC6398448
AbstractArticle
11.
Unique properties of PTEN-L contribute to neuroprotection in response to ischemic-like stress
Magdalena C. E. Jochner, Junfeng An, Gisela Lättig-Tünnemann, Marieluise Kirchner, Alina Dagane, Gunnar Dittmar, Ulrich Dirnagl, Britta J. Eickholt, Christoph Harms
Sci Rep. 2019; 9: 3183. Published online 2019 Feb 28. doi: 10.1038/s41598-019-39438-1
PMCID:
PMC6395706
AbstractArticlePDF–3.5M
12.
Increased levels of Gab1 and Gab2 adaptor proteins skew interleukin-4 (IL-4) signaling toward M2 macrophage-driven pulmonary fibrosis in mice
Xiaohong Guo, Tingting Li, Yun Xu, Xiayan Xu, Zhengyi Zhu, Yun Zhang, Jiaqi Xu, Kaihong Xu, Hongqiang Cheng, Xue Zhang, Yuehai Ke
J Biol Chem. 2017 Aug 25; 292(34): 14003–14015. Published online 2017 Jul 7. doi: 10.1074/jbc.M117.802066
PMCID:
PMC5572909
AbstractArticlePDF–3.4M
13.
Inhibition of the Gab2/PI3K/mTOR signaling ameliorates myeloid malignancy caused by Ptpn11 (Shp2) gain-of-function mutations
Wei Liu, Wen-Mei Yu, Jing Zhang, Rebecca J. Chan, Mignon L. Loh, Zheng Zhang, Kevin D. Bunting, Cheng-Kui Qu
Leukemia. Author manuscript; available in PMC 2017 Jun 8.
Published in final edited form as: Leukemia. 2017 Jun; 31(6): 1415–1422. Published online 2016 Nov 14. doi: 10.1038/leu.2016.326
PMCID:
PMC5462847
AbstractArticlePDF–911K
14.
The Proximal Signaling Network of the BCR-ABL1 Oncogene Shows a Modular Organization
Björn Titz, Tracey Low, Evangelia Komisopoulou, Sharon S Chen, Liudmilla Rubbi, Thomas G Graeber
Oncogene. Author manuscript; available in PMC 2017 Feb 14.
Published in final edited form as: Oncogene. 2010 Nov 4; 29(44): 5895–5910. Published online 2010 Aug 9. doi: 10.1038/onc.2010.331
PMCID:
PMC5308218
AbstractArticlePDF–3.8M
15.
Transcriptome of the inner circular smooth muscle of the developing mouse intestine: evidence for regulation of visceral smooth muscle genes by the Hedgehog target gene, cJun
Katherine Gurdziel, Kyle R. Vogt, Katherine D. Walton, Gary K. Schneider, Deborah L. Gumucio
Dev Dyn. Author manuscript; available in PMC 2017 May 1.
Published in final edited form as: Dev Dyn. 2016 May; 245(5): 614–626. Published online 2016 Mar 17. doi: 10.1002/dvdy.24399
PMCID:
PMC4844863
AbstractArticlePDF–2.1M
16.
Distinct GAB2 signaling pathways are essential for myeloid and lymphoid transformation and leukemogenesis by BCR-ABL1
Shengqing Gu, Wayne W. Chan, Golam Mohi, Joel Rosenbaum, Azin Sayad, Zhibin Lu, Carl Virtanen, Shaoguang Li, Benjamin G. Neel, Richard A. Van Etten
Blood. 2016 Apr 7; 127(14): 1803–1813. Prepublished online 2016 Jan 15. doi: 10.1182/blood-2015-06-653006
PMCID:
PMC4825414
AbstractArticle
17.
Frs2α and Shp2 signal independently of Gab to mediate FGF signaling in lens development
Hongge Li, Chenqi Tao, Zhigang Cai, Kristina Hertzler-Schaefer, Tamica N. Collins, Fen Wang, Gen-Sheng Feng, Noriko Gotoh, Xin Zhang
J Cell Sci. 2014 Feb 1; 127(3): 571–582. doi: 10.1242/jcs.134478
PMCID:
PMC4007765
AbstractArticle
18.
Gab2 Phosphorylation by RSK Inhibits Shp2 Recruitment and Cell Motility
Xiaocui Zhang, Genevieve Lavoie, Loic Fort, Edward L. Huttlin, Joseph Tcherkezian, Jacob A. Galan, Haihua Gu, Steven P. Gygi, Sebastien Carreno, Philippe P. Roux
Mol Cell Biol. 2013 Apr; 33(8): 1657–1670. doi: 10.1128/MCB.01353-12
PMCID:
PMC3624252
AbstractArticlePDF–3.6M
19.
Early estrogen-induced gene 1, a novel RANK signaling component, is essential for osteoclastogenesis
Han Kyoung Choi, Hye Ri Kang, Eutteum Jung, Tae Eon Kim, Jing Jing Lin, Soo Young Lee
Cell Res. 2013 Apr; 23(4): 524–536. Published online 2013 Mar 12. doi: 10.1038/cr.2013.33
PMCID:
PMC3616434
AbstractArticlePDF–6.0M
20.
A conditional knockout resource for the genome–wide study of mouse gene function
William C. Skarnes, Barry Rosen, Anthony P. West, Manousos Koutsourakis, Wendy Bushell, Vivek Iyer, Alejandro O. Mujica, Mark Thomas, Jennifer Harrow, Tony Cox, David Jackson, Jessica Severin, Patrick Biggs, Jun Fu, Michael Nefedov, Pieter J. de Jong, A. Francis Stewart, Allan Bradley
Nature. Author manuscript; available in PMC 2013 Feb 14.
Published in final edited form as: Nature. 2011 Jun 15; 474(7351): 337–342. Published online 2011 Jun 15. doi: 10.1038/nature10163
PMCID:
PMC3572410
AbstractArticlePDF–1.1M

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