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Items: 1 to 20 of 87

1.
Deletion of ARGLU1 causes global defects in alternative splicing in vivo and mouse cortical malformations primarily via apoptosis
Fenyong Yao, Shisheng Huang, Jiahui Liu, Chunhua Tan, Mengqi Xu, Dengkui Wang, Maoqing Huang, Yiyao Zhu, Xingxu Huang, Shuijin He
Cell Death Dis. 2023 Aug; 14(8): 543. Published online 2023 Aug 23. doi: 10.1038/s41419-023-06071-w
PMCID:
PMC10447433
AbstractArticlePDF–9.2M
2.
Snrpb is required in murine neural crest cells for proper splicing and craniofacial morphogenesis
Sabrina Shameen Alam, Shruti Kumar, Marie-Claude Beauchamp, Eric Bareke, Alexia Boucher, Nadine Nzirorera, Yanchen Dong, Reinnier Padilla, Si Jing Zhang, Jacek Majewski, Loydie A. Jerome-Majewska
Dis Model Mech. 2022 Jun 1; 15(6): dmm049544. Published online 2022 Jun 23. doi: 10.1242/dmm.049544
PMCID:
PMC9235875
AbstractArticle
3.
Loss of TAF8 causes TFIID dysfunction and p53-mediated apoptotic neuronal cell death
Farrah El-Saafin, Maria I. Bergamasco, Yunshun Chen, Rose E. May, Prabagaran Esakky, Soroor Hediyeh-zadeh, Mathew Dixon, Stephen Wilcox, Melissa J. Davis, Andreas Strasser, Gordon K. Smyth, Tim Thomas, Anne K. Voss
Cell Death Differ. 2022 May; 29(5): 1013–1027. Published online 2022 Mar 31. doi: 10.1038/s41418-022-00982-5
PMCID:
PMC9091217
AbstractArticlePDF–7.2M
4.
MDMX acts as a pervasive preleukemic-to-acute myeloid leukemia transition mechanism
Koki Ueda, Rajni Kumari, Emily Schwenger, Justin C. Wheat, Oliver Bohorquez, Swathi-Rao Narayanagari, Samuel J. Taylor, Luis A. Carvajal, Kith Pradhan, Boris Bartholdy, Tihomira I. Todorova, Hiroki Goto, Daqian Sun, Jiahao Chen, Jidong Shan, Yinghui Song, Cristina Montagna, Shunbin Xiong, Guillermina Lozano, Andrea Pellagatti, Jacqueline Boultwood, Amit Verma, Ulrich Steidl
Cancer Cell. Author manuscript; available in PMC 2022 Apr 12.
Published in final edited form as: Cancer Cell. 2021 Apr 12; 39(4): 529–547.e7. Published online 2021 Mar 4. doi: 10.1016/j.ccell.2021.02.006
PMCID:
PMC8575661
AbstractArticlePDF–3.7M
5.
The ion channel TRPM7 regulates zinc-depletion-induced MDMX degradation
Herui Wang, Bin Li, Kulsum Asha, Ryan L. Pangilinan, Asha Thuraisamy, Harman Chopra, Susumu Rokudai, Yong Yu, Carol L. Prives, Yan Zhu
J Biol Chem. 2021 Nov; 297(5): 101292. Published online 2021 Oct 8. doi: 10.1016/j.jbc.2021.101292
PMCID:
PMC8561006
AbstractArticlePDF–3.4M
6.
MDMX is essential for the regulation of p53 protein levels in the absence of a functional MDM2 C-terminal tail
Jack D. Sanford, Jing Yang, Jing Han, Laura A. Tollini, Aiwen Jin, Yanping Zhang
BMC Mol Cell Biol. 2021; 22: 46. Published online 2021 Sep 22. doi: 10.1186/s12860-021-00385-3
PMCID:
PMC8459461
AbstractArticlePDF–1.1M
7.
A p53-dependent translational program directs tissue-selective phenotypes in a model of ribosomopathies
Gerald C. Tiu, Craig H. Kerr, Craig M. Forester, Pallavi S. Krishnarao, Hannah D. Rosenblatt, Nitin Raj, Travis C. Lantz, Olena Zhulyn, Margot E. Bowen, Leila Shokat, Laura D. Attardi, Davide Ruggero, Maria Barna
Dev Cell. Author manuscript; available in PMC 2022 Jul 26.
Published in final edited form as: Dev Cell. 2021 Jul 26; 56(14): 2089–2102.e11. Published online 2021 Jul 8. doi: 10.1016/j.devcel.2021.06.013
PMCID:
PMC8319123
AbstractArticlePDF–2.5M
8.
MDMX recruits UbcH5c to facilitate MDM2 E3 ligase activity and subsequent p53 degradation in vivo
Jing Yang, Aiwen Jin, Jing Han, Xin Chen, Junnian Zheng, Yanping Zhang
Cancer Res. Author manuscript; available in PMC 2021 Aug 15.
Published in final edited form as: Cancer Res. 2021 Feb 15; 81(4): 898–909. Published online 2020 Dec 4. doi: 10.1158/0008-5472.CAN-20-0790
PMCID:
PMC8026549
AbstractArticlePDF–1.7M
9.
Targeting mechanosensitive MDM4 promotes lung fibrosis resolution in aged mice
Jing Qu, Shan-Zhong Yang, Yi Zhu, Ting Guo, Victor J. Thannickal, Yong Zhou
J Exp Med. 2021 May 3; 218(5): e20202033. Published online 2021 Mar 10. doi: 10.1084/jem.20202033
PMCID:
PMC7953267
AbstractArticlePDF–6.4M
10.
MDMX phosphorylation-dependent p53 downregulation contributes to an immunosuppressive tumor microenvironment
Bing Wang, Chuan-Bian Lim, Jiawei Yan, Lizhen Li, Jufang Wang, John B Little, Zhi-Min Yuan
J Mol Cell Biol. 2020 Sep; 12(9): 713–722. Published online 2020 Jul 24. doi: 10.1093/jmcb/mjaa038
PMCID:
PMC7749742
AbstractArticlePDF–1.0M
11.
Mdm4 supports DNA replication in a p53-independent fashion
Kai Wohlberedt, Ina Klusmann, Polina K. Derevyanko, Kester Henningsen, Josephine Ann Mun Yee Choo, Valentina Manzini, Anna Magerhans, Celeste Giansanti, Christine M. Eischen, Aart G. Jochemsen, Matthias Dobbelstein
Oncogene. Author manuscript; available in PMC 2021 Jun 1.
Published in final edited form as: Oncogene. 2020 Jun; 39(25): 4828–4843. Published online 2020 May 19. doi: 10.1038/s41388-020-1325-1
PMCID:
PMC7521021
AbstractArticlePDF–2.2M
12.
CDK9 activity is critical for maintaining MDM4 overexpression in tumor cells
Monika Štětková, Kateřina Growková, Petr Fojtík, Barbora Valčíková, Veronika Palušová, Amandine Verlande, Radek Jorda, Vladimír Kryštof, Václav Hejret, Panagiotis Alexiou, Vladimír Rotrekl, Stjepan Uldrijan
Cell Death Dis. 2020 Sep; 11(9): 754. Published online 2020 Sep 15. doi: 10.1038/s41419-020-02971-3
PMCID:
PMC7494941
AbstractArticlePDF–2.2M
13.
Mdm4 controls ureteric bud branching via regulation of p53 activity
Sylvia A. Hilliard, Yuwen Li, Angelina Dixon, Samir S. El-Dahr
Mech Dev. Author manuscript; available in PMC 2021 Sep 1.
Published in final edited form as: Mech Dev. 2020 Sep; 163: 103616. Published online 2020 May 25. doi: 10.1016/j.mod.2020.103616
PMCID:
PMC7487065
AbstractArticlePDF–4.3M
14.
The sperm associated antigen 6 interactome and its role in spermatogenesis
Yunhao Liu, Ling Zhang, Wei Li, Yuhong Li, Junpin Liu, Shiyang Zhang, Guanglun Pin, Shizhen Song, Pierre F Ray, Christophe Arnoult, Chunghee Cho, Balbina Garcia-Reyes, Uwe Knippschild, Jerome F. Strauss, III, Zhibing Zhang
Reproduction. Author manuscript; available in PMC 2020 Jul 18.
Published in final edited form as: Reproduction. 2019 Aug; 158(2): 181–197. doi: 10.1530/REP-18-0522
PMCID:
PMC7368494
AbstractArticlePDF–1.8M
15.
MDMX inhibits casein kinase 1α activity and stimulates Wnt signaling
Qingling Huang, Lihong Chen, Ernst Schonbrunn, Jiandong Chen
EMBO J. 2020 Jul 15; 39(14): e104410. Published online 2020 Jun 8. doi: 10.15252/embj.2020104410
PMCID:
PMC7361285
AbstractArticlePDF–3.7M
16.
The spatiotemporal pattern and intensity of p53 activation during embryogenesis dictates phenotypic diversity in p53-driven developmental syndromes
Margot E. Bowen, Jacob McClendon, Hannah K. Long, Aryo Sorayya, Jeanine L. Van Nostrand, Joanna Wysocka, Laura D. Attardi
Dev Cell. Author manuscript; available in PMC 2020 Jul 22.
Published in final edited form as: Dev Cell. 2019 Jul 22; 50(2): 212–228.e6. Published online 2019 Jun 6. doi: 10.1016/j.devcel.2019.05.015
PMCID:
PMC6650355
AbstractArticlePDF–4.1M
17.
Role of smooth muscle cell p53 in pulmonary arterial hypertension
Takayuki Wakasugi, Ippei Shimizu, Yohko Yoshida, Yuka Hayashi, Ryutaro Ikegami, Masayoshi Suda, Goro Katsuumi, Masaaki Nakao, Makoto Hoyano, Takeshi Kashimura, Kazufumi Nakamura, Hiroshi Ito, Takashi Nojiri, Tomoyoshi Soga, Tohru Minamino
PLoS One. 2019; 14(2): e0212889. Published online 2019 Feb 26. doi: 10.1371/journal.pone.0212889
PMCID:
PMC6391010
AbstractArticlePDF–1.5M
18.
Dysregulation of Mdm2 and Mdm4 alternative splicing underlies motor neuron death in spinal muscular atrophy
Meaghan Van Alstyne, Christian M. Simon, S. Pablo Sardi, Lamya S. Shihabuddin, George Z. Mentis, Livio Pellizzoni
Genes Dev. 2018 Aug 1; 32(15-16): 1045–1059. doi: 10.1101/gad.316059.118
PMCID:
PMC6075148
AbstractArticlePDF–15M
19.
MDMX acidic domain inhibits p53 DNA binding in vivo and regulates tumorigenesis
Qingling Huang, Lihong Chen, Leixiang Yang, Xiaoling Xie, Lin Gan, John L. Cleveland, Jiandong Chen
Proc Natl Acad Sci U S A. 2018 Apr 10; 115(15): E3368–E3377. Published online 2018 Mar 26. doi: 10.1073/pnas.1719090115
PMCID:
PMC5899450
AbstractArticlePDF–2.0M
20.
An EZH2-mediated epigenetic mechanism behind p53-dependent tissue sensitivity to DNA damage
Gamze Kuser-Abali, Lu Gong, Jiawei Yan, Qingqing Liu, Weiqi Zeng, Amanda Williamson, Chuan Bian Lim, Mary Ellen Molloy, John B. Little, Lei Huang, Zhi-Min Yuan
Proc Natl Acad Sci U S A. 2018 Mar 27; 115(13): 3452–3457. Published online 2018 Mar 14. doi: 10.1073/pnas.1719532115
PMCID:
PMC5879692
AbstractArticlePDF–2.1M

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