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Items: 1 to 20 of 160

1.
A common mechanism for recruiting the Rrm3 and RTEL1 accessory helicases to the eukaryotic replisome
Ottavia Olson, Simone Pelliciari, Emma D Heron, Tom D Deegan
EMBO J. 2024 Sep; 43(18): 3846–3875. Published online 2024 Jul 22. doi: 10.1038/s44318-024-00168-4
PMCID:
PMC11405395
AbstractArticlePDF–3.3M
2.
Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein
Xiao Tang, Yang Liu, Jinhui Wang, Teng Long, Bobo Wing Yee Mok, Yan Huang, Ziqing Peng, Qinyu Jia, Chengxi Liu, Pui-Kin So, Sirius Pui-Kam Tse, Cheuk Hei NG, Shiyi Liu, Fei Sun, Shaojun Tang, Zhong-Ping Yao, Honglin Chen, Yusong Guo
J Biol Chem. 2024 Jun; 300(6): 107390. Published online 2024 May 21. doi: 10.1016/j.jbc.2024.107390
PMCID:
PMC11237930
AbstractArticlePDF–3.8M
3.
Antagonistic roles of canonical and alternative-RPA in disease-associated tandem CAG repeat instability
Terence Gall-Duncan, Jennifer Luo, Carla-Marie Jurkovic, Laura A. Fischer, Kyota Fujita, Amit L. Deshmukh, Rachel J. Harding, Stephanie Tran, Mustafa Mehkary, Vanessa Li, David E. Leib, Ran Chen, Hikari Tanaka, Amanda G. Mason, Dominique Lévesque, Mahreen Khan, Mortezaali Razzaghi, Tanya Prasolava, Stella Lanni, Nozomu Sato, Marie-Christine Caron, Gagan B. Panigrahi, Peixiang Wang, Rachel Lau, Arturo López Castel, Jean-Yves Masson, Lynette Tippett, Clinton Turner, Maria Spies, Albert R. La Spada, Eric I. Campos, Maurice A. Curtis, François-Michel Boisvert, Richard L.M. Faull, Beverly L. Davidson, Masayuki Nakamori, Hitoshi Okazawa, Marc S. Wold, Christopher E. Pearson
Cell. Author manuscript; available in PMC 2024 Oct 26.
Published in final edited form as: Cell. 2023 Oct 26; 186(22): 4898–4919.e25. Published online 2023 Oct 11. doi: 10.1016/j.cell.2023.09.008
PMCID:
PMC11209935
AbstractArticlePDF–3.0M
4.
DNA polymerase ε and δ variants drive mutagenesis in polypurine tracts in human tumors
Daria Ostroverkhova, Kathrin Tyryshkin, Annette K. Beach, Elizabeth A. Moore, Yosef Masoudi-Sobhanzadeh, Stephanie R. Barbari, Igor B. Rogozin, Konstantin V. Shaitan, Anna R. Panchenko, Polina V. Shcherbakova
Cell Rep. Author manuscript; available in PMC 2024 Feb 1.
Published in final edited form as: Cell Rep. 2024 Jan 23; 43(1): 113655. Published online 2024 Jan 13. doi: 10.1016/j.celrep.2023.113655
PMCID:
PMC10830898
AbstractArticlePDF–1.8M
5.
Exploring Co-occurring POLE Exonuclease and Non-exonuclease Domain Mutations and Their Impact on Tumor Mutagenicity
Shreya M. Shah, Elena V. Demidova, Salena Ringenbach, Bulat Faezov, Mark Andrake, Arjun Gandhi, Pilar Mur, Julen Viana-Errasti, Joanne Xiu, Jeffrey Swensen, Laura Valle, Roland L. Dunbrack, Jr, Michael J. Hall, Sanjeevani Arora
Cancer Res Commun. 2024 Jan; 4(1): 213–225. Published online 2024 Jan 26. doi: 10.1158/2767-9764.CRC-23-0312
Correction in:
Cancer Res Commun. 2024 May; 4(5): 1398.
PMCID:
PMC10812383
AbstractArticlePDF–4.4M
6.
The P286R mutation of DNA polymerase ε activates cancer-cell-intrinsic immunity and suppresses endometrial tumorigenesis via the cGAS-STING pathway
Ming Tang, Shasha Yin, Hongliang Zeng, Ao Huang, Yujia Huang, Zhiyi Hu, Ab Rauf Shah, Shuyong Zhang, Haisen Li, Guofang Chen
Cell Death Dis. 2024 Jan; 15(1): 69. Published online 2024 Jan 18. doi: 10.1038/s41419-023-06418-3
PMCID:
PMC10796917
AbstractArticlePDF–9.8M
7.
Race, Prevalence of POLE and POLD1 Alterations, and Survival Among Patients With Endometrial Cancer
Shuhua Zheng, Eric D. Donnelly, Jonathan B. Strauss
JAMA Netw Open. 2024 Jan; 7(1): e2351906. Published online 2024 Jan 17. doi: 10.1001/jamanetworkopen.2023.51906
PMCID:
PMC10794941
AbstractArticle
8.
Cervical Cytology Preserves Histologically Detected Surface Epithelial Slackening, Unique to the POLE Mutation-subtype in Endometrial Cancer
IKUMI KITAZONO, TOSHIAKI AKAHANE, SEIYA YOKOYAMA, EMI KUBOTA, YUKARI NISHIDA-KIRITA, HIROTSUGU NOGUCHI, MIKI MURAKAMI, SHINTARO YANAZUME, HIROAKI KOBAYASHI, AKIHIDE TANIMOTO
In Vivo. 2024 Jan-Feb; 38(1): 321–333. Published online 2024 Jan 3. doi: 10.21873/invivo.13442
PMCID:
PMC10756481
AbstractArticlePDF–3.6M
9.
Rare germline variants in POLE and POLD1 encoding the catalytic subunits of DNA polymerases ε and δ in glioma families
Christine A. M. Weber, Nicole Krönke, Valery Volk, Bernd Auber, Alisa Förster, Detlef Trost, Robert Geffers, Majid Esmaeilzadeh, Michael Lalk, Arya Nabavi, Amir Samii, Joachim K. Krauss, Friedrich Feuerhake, Christian Hartmann, Bettina Wiese, Frank Brand, Ruthild G. Weber
Acta Neuropathol Commun. 2023; 11: 184. Published online 2023 Nov 21. doi: 10.1186/s40478-023-01689-5
PMCID:
PMC10664377
AbstractArticlePDF–10M
10.
Exploring the basis of heterogeneity of cancer aggressiveness among the mutated POLE variants
Janick Selves, Helena de Castro e Gloria, Anne-Cécile Brunac, Jenifer Saffi, Rosine Guimbaud, Pierre Brousset, Jean-Sébastien Hoffmann
Life Sci Alliance. 2024 Jan; 7(1): e202302290. Published online 2023 Oct 27. doi: 10.26508/lsa.202302290
PMCID:
PMC10610022
AbstractArticlePDF–1.2M
11.
C9orf72 protein quality control by UBR5‐mediated heterotypic ubiquitin chains
Julia Jülg, Dieter Edbauer, Christian Behrends
EMBO Rep. 2023 Aug; 24(8): e55895. Published online 2023 Jun 15. doi: 10.15252/embr.202255895
PMCID:
PMC10398660
AbstractArticlePDF–2.4M
12.
TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing
Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan
Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233
PMCID:
PMC10237422
AbstractArticlePDF–23M
13.
Functional Landscapes of POLE and POLD1 Mutations in Checkpoint Blockade-Dependent Anti-Tumor Immunity
Xiaoxiao Ma, Nadeem Riaz, Robert M. Samstein, Mark Lee, Vladimir Makarov, Cristina Valero, Diego Chowell, Fengshen Kuo, Douglas Hoen, Conall W.R. Fitzgerald, Hui Jiang, Jonathan Alektiar, Tyler J. Alban, Ivan Juric, Prerana Bangalore Parthasarathy, Yu Zhao, Erich Y. Sabio, Richa Verma, Raghvendra M. Srivastava, Lynda Vuong, Wei Yang, Xiao Zhang, Jingming Wang, Lawrence K. Chu, Stephen L. Wang, Daniel W. Kelly, Xin Pei, Jiapeng Chen, Rona Yaeger, Dmitriy Zamarin, Ahmet Zehir, Mithat Gönen, Luc GT Morris, Timothy A. Chan
Nat Genet. Author manuscript; available in PMC 2023 May 12.
Published in final edited form as: Nat Genet. 2022 Jul; 54(7): 996–1012. Published online 2022 Jul 11. doi: 10.1038/s41588-022-01108-w
PMCID:
PMC10181095
AbstractArticlePDF–5.2M
14.
CLEC16A interacts with retromer and TRIM27, and its loss impairs endosomal trafficking and neurodevelopment
Daphne J. Smits, Jordy Dekker, Rachel Schot, Brahim Tabarki, Amal Alhashem, Jeroen A. A. Demmers, Dick H. W. Dekkers, Antonio Romito, Peter J. van der Spek, Tjakko J. van Ham, Aida M. Bertoli-Avella, Grazia M. S. Mancini
Hum Genet. 2023; 142(3): 379–397. Published online 2022 Dec 20. doi: 10.1007/s00439-022-02511-3
PMCID:
PMC9950183
AbstractArticlePDF–2.4M
15.
A whole genome CRISPR screen identifies AHR loss as a mechanism of resistance to a PARP7 inhibitor
Huadong Chen, Morgan E. Diolaiti, Patrick C. O’Leary, Ajda Rojc, Nevan J. Krogan, Minkyu Kim, Alan Ashworth
Mol Cancer Ther. Author manuscript; available in PMC 2023 Jan 5.
Published in final edited form as: Mol Cancer Ther. 2022 Jul 5; 21(7): 1076–1089. doi: 10.1158/1535-7163.MCT-21-0841
PMCID:
PMC9769698
AbstractArticlePDF–2.7M
16.
The iron-sulfur cluster is essential for DNA binding by human DNA polymerase ε
Alisa E. Lisova, Andrey G. Baranovskiy, Lucia M. Morstadt, Nigar D. Babayeva, Elena I. Stepchenkova, Tahir H. Tahirov
Sci Rep. 2022; 12: 17436. Published online 2022 Oct 19. doi: 10.1038/s41598-022-21550-4
PMCID:
PMC9581978
AbstractArticlePDF–1.6M
17.
ALS-linked loss of Cyclin-F function affects HSP90
Alexander Siebert, Vanessa Gattringer, Jochen H Weishaupt, Christian Behrends
Life Sci Alliance. 2022 Dec; 5(12): e202101359. Published online 2022 Sep 16. doi: 10.26508/lsa.202101359
PMCID:
PMC9481933
AbstractArticlePDF–3.5M
18.
The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis
Natalie Vaughan, Nico Scholz, Catherine Lindon, Julien D. F. Licchesi
Sci Rep. 2022; 12: 13160. Published online 2022 Aug 1. doi: 10.1038/s41598-022-16965-y
PMCID:
PMC9343455
AbstractArticlePDF–3.7M
19.
Scalable multiplex co-fractionation/mass spectrometry platform for accelerated protein interactome discovery
Pierre C. Havugimana, Raghuveera Kumar Goel, Sadhna Phanse, Ahmed Youssef, Dzmitry Padhorny, Sergei Kotelnikov, Dima Kozakov, Andrew Emili
Nat Commun. 2022; 13: 4043. Published online 2022 Jul 13. doi: 10.1038/s41467-022-31809-z
PMCID:
PMC9279285
AbstractArticlePDF–2.5M
20.
A dual-activity topoisomerase complex regulates mRNA translation and turnover
Shuaikun Su, Yutong Xue, Alexei Sharov, Yongqing Zhang, Seung Kyu Lee, Jennifer L Martindale, Wen Li, Wai Lim Ku, Keji Zhao, Supriyo De, Weiping Shen, Payel Sen, Myriam Gorospe, Dongyi Xu, Weidong Wang
Nucleic Acids Res. 2022 Jul 8; 50(12): 7013–7033. Published online 2022 Jun 24. doi: 10.1093/nar/gkac538
PMCID:
PMC9262614
AbstractArticlePDF–3.6M

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