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Select item 102374221.

TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing

Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan

Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233

PMCID:: PMC10237422

Abstract Article PDF–23M

Select item 91197362.

OpenCell: proteome-scale endogenous tagging enables the cartography of human cellular organization

Nathan H. Cho, Keith C. Cheveralls, Andreas-David Brunner, Kibeom Kim, André C. Michaelis, Preethi Raghavan, Hirofumi Kobayashi, Laura Savy, Jason Y. Li, Hera Canaj, James Y.S. Kim, Edna M. Stewart, Christian Gnann, Frank McCarthy, Joana P. Cabrera, Rachel M. Brunetti, Bryant B. Chhun, Greg Dingle, Marco Y. Hein, Bo Huang, Shalin B. Mehta, Jonathan S. Weissman, Rafael Gómez-Sjöberg, Daniel N. Itzhak, Loic A. Royer, Matthias Mann, Manuel D. Leonetti

Science. Author manuscript; available in PMC 2022 Sep 11.

Published in final edited form as: Science. 2022 Mar 11; 375(6585): eabi6983. Published online 2022 Mar 11. doi: 10.1126/science.abi6983

PMCID:: PMC9119736

Abstract Article PDF–3.3M

Select item 81650303.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 79928424.

TDP-43 proteinopathy alters the ribosome association of multiple mRNAs including the glypican Dally-like protein (Dlp)/GPC6

Erik M. Lehmkuhl, Suvithanandhini Loganathan, Eric Alsop, Alexander D. Blythe, Tina Kovalik, Nicholas P. Mortimore, Dianne Barrameda, Chuol Kueth, Randall J. Eck, Bhavani B. Siddegowda, Archi Joardar, Hannah Ball, Maria E. Macias, Robert Bowser, Kendall Van Keuren-Jensen, Daniela C. Zarnescu

Acta Neuropathol Commun. 2021; 9: 52. Published online 2021 Mar 24. doi: 10.1186/s40478-021-01148-z

PMCID:: PMC7992842

Abstract Article PDF–6.3M

Select item 79484525.

A conserved acetylation switch enables pharmacological control of tubby-like protein stability

Evan M. Kerek, Kevin H. Yoon, Shu Y. Luo, Jerry Chen, Robert Valencia, Olivier Julien, Andrew J. Waskiewicz, Basil P. Hubbard

J Biol Chem. 2021 Jan-Jun; 296: 100073. Published online 2020 Nov 23. doi: 10.1074/jbc.RA120.015839

PMCID:: PMC7948452

Abstract Article PDF–3.6M

Select item 74273276.

Kinase Interaction Network Expands Functional and Disease Roles of Human Kinases

Marija Buljan, Rodolfo Ciuffa, Audrey van Drogen, Anton Vichalkovski, Martin Mehnert, George Rosenberger, Sohyon Lee, Markku Varjosalo, Lucia Espona Pernas, Vincent Spegg, Berend Snijder, Ruedi Aebersold, Matthias Gstaiger

Mol Cell. 2020 Aug 6; 79(3): 504–520.e9. doi: 10.1016/j.molcel.2020.07.001

PMCID:: PMC7427327

Abstract Article

Select item 72956297.

Hedgehog signaling activation required for glypican-6-mediated regulation of invasion, migration, and epithelial–mesenchymal transition of gastric cancer cells

Chen Zeng, Ran Yan, Guanghua Yang, Sen Xiang, Fuli Zhao

Biosci Rep. 2020 Jun 26; 40(6): BSR20193181. Published online 2020 Jun 15. doi: 10.1042/BSR20193181

PMCID:: PMC7295629

Abstract Article PDF–1.2M

Select item 66251098.

Association of glypican‐6 polymorphisms with lumbar disk herniation risk in the Han Chinese population

Baoyang Hu, Wenhua Xing, Feng Li, Zhi Huang, Wenkai Zheng, Demin Ji, Fanglin Niu, Yong Zhu, Xuejun Yang

Mol Genet Genomic Med. 2019 Jul; 7(7): e00747. Published online 2019 May 20. doi: 10.1002/mgg3.747

PMCID:: PMC6625109

Abstract Article PDF–483K

Select item 65684039.

Glypican 6 is a putative biomarker for metastatic progression of cutaneous melanoma

Yuanyuan Li, Melissa Li, Igor Shats, Juno M. Krahn, Gordon P. Flake, David M. Umbach, Xiaoling Li, Leping Li

PLoS One. 2019; 14(6): e0218067. Published online 2019 Jun 14. doi: 10.1371/journal.pone.0218067

PMCID:: PMC6568403

Abstract Article PDF–1.0M

Select item 599939610.

The HIV-1 Tat protein recruits a ubiquitin ligase to reorganize the 7SK snRNP for transcriptional activation

Tyler B Faust, Yang Li, Curtis W Bacon, Gwendolyn M Jang, Amit Weiss, Bhargavi Jayaraman, Billy W Newton, Nevan J Krogan, Iván D'Orso, Alan D Frankel

eLife. 2018; 7: e31879. Published online 2018 May 30. doi: 10.7554/eLife.31879

PMCID:: PMC5999396

Abstract Article PDF–3.6M

Select item 583915811.

Quantitative mapping of RNA-mediated nuclear estrogen receptor β interactome in human breast cancer cells

Giorgio Giurato, Giovanni Nassa, Annamaria Salvati, Elena Alexandrova, Francesca Rizzo, Tuula A. Nyman, Alessandro Weisz, Roberta Tarallo

Sci Data. 2018; 5: 180031. Published online 2018 Mar 6. doi: 10.1038/sdata.2018.31

PMCID:: PMC5839158

Abstract Article PDF–1.9M

Select item 574065512.

EB1-binding–myomegalin protein complex promotes centrosomal microtubules functions

Habib Bouguenina, Danièle Salaun, Aurélie Mangon, Leslie Muller, Emilie Baudelet, Luc Camoin, Taro Tachibana, Sarah Cianférani, Stéphane Audebert, Pascal Verdier-Pinard, Ali Badache

Proc Natl Acad Sci U S A. 2017 Dec 12; 114(50): E10687–E10696. Published online 2017 Nov 21. doi: 10.1073/pnas.1705682114

PMCID:: PMC5740655

Abstract Article PDF–2.4M

Select item 570387813.

The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery

Ramesh Kumar, Román González-Prieto, Zhenyu Xiao, Matty Verlaan-de Vries, Alfred C. O. Vertegaal

Nat Commun. 2017; 8: 1809. Published online 2017 Nov 27. doi: 10.1038/s41467-017-01900-x

PMCID:: PMC5703878

Abstract Article PDF–3.7M

Select item 553161114.

Architecture of the human interactome defines protein communities and disease networks

Edward L. Huttlin, Raphael J. Bruckner, Joao A. Paulo, Joe R. Cannon, Lily Ting, Kurt Baltier, Greg Colby, Fana Gebreab, Melanie P. Gygi, Hannah Parzen, John Szpyt, Stanley Tam, Gabriela Zarraga, Laura Pontano-Vaites, Sharan Swarup, Anne E. White, Devin K. Schweppe, Ramin Rad, Brian K. Erickson, Robert A. Obar, K.G. Guruharsha, Kejie Li, Spyros Artavanis-Tsakonas, Steven P. Gygi, J. Wade Harper

Nature. Author manuscript; available in PMC 2017 Nov 17.

Published in final edited form as: Nature. 2017 May 25; 545(7655): 505–509. Published online 2017 May 17. doi: 10.1038/nature22366

PMCID:: PMC5531611

Abstract Article PDF–2.7M

Select item 539338615.

Human Antiviral Protein IFIX Suppresses Viral Gene Expression during Herpes Simplex Virus 1 (HSV-1) Infection and Is Counteracted by Virus-induced Proteasomal Degradation

Marni S. Crow, Ileana M. Cristea

Mol Cell Proteomics. 2017 Apr; 16(4 Suppl 1): S200–S214. Published online 2017 Jan 11. doi: 10.1074/mcp.M116.064741

PMCID:: PMC5393386

Abstract Article PDF–2.6M

Select item 509804116.

TNIP2 is a Hub Protein in the NF-κB Network with Both Protein and RNA Mediated Interactions

Charles A. S. Banks, Gina Boanca, Zachary T. Lee, Cassandra G. Eubanks, Gaye L. Hattem, Allison Peak, Lauren E. Weems, Juliana J. Conkright, Laurence Florens, Michael P. Washburn

Mol Cell Proteomics. 2016 Nov; 15(11): 3435–3449. Published online 2016 Sep 8. doi: 10.1074/mcp.M116.060509

PMCID:: PMC5098041

Abstract Article PDF–2.1M

Select item 461721117.

The BioPlex Network: A Systematic Exploration of the Human Interactome

Edward L. Huttlin, Lily Ting, Raphael J. Bruckner, Fana Gebreab, Melanie P. Gygi, John Szpyt, Stanley Tam, Gabriela Zarraga, Greg Colby, Kurt Baltier, Rui Dong, Virginia Guarani, Laura Pontano Vaites, Alban Ordureau, Ramin Rad, Brian K. Erickson, Martin Wühr, Joel Chick, Bo Zhai, Deepak Kolippakkam, Julian Mintseris, Robert A. Obar, Tim Harris, Spyros Artavanis-Tsakonas, Mathew E. Sowa, Pietro DeCamilli, Joao A. Paulo, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2016 Jul 16.

Published in final edited form as: Cell. 2015 Jul 16; 162(2): 425–440. doi: 10.1016/j.cell.2015.06.043

PMCID:: PMC4617211

Abstract Article PDF–2.2M

Select item 458405118.

Overexpression of GPC6 and TMEM132D in Early Stage Ovarian Cancer Correlates with CD8+ T-Lymphocyte Infiltration and Increased Patient Survival

Athanasios Karapetsas, Antonis Giannakakis, Denarda Dangaj, Evripidis Lanitis, Spyridon Kynigopoulos, Maria Lambropoulou, Janos L. Tanyi, Alex Galanis, Stylianos Kakolyris, Gregorios Trypsianis, George Coukos, Raphael Sandaltzopoulos

Biomed Res Int. 2015; 2015: 712438. Published online 2015 Sep 13. doi: 10.1155/2015/712438

PMCID:: PMC4584051

Abstract Article PDF–2.1M

Select item 440234819.

Gene–Smoking Interactions Identify Several Novel Blood Pressure Loci in the Framingham Heart Study

Yun J. Sung, Lisa de las Fuentes, Karen L. Schwander, Jeannette Simino, Dabeeru C. Rao

Am J Hypertens. 2015 Mar; 28(3): 343–354. Published online 2014 Sep 3. doi: 10.1093/ajh/hpu149

PMCID:: PMC4402348

Abstract Article PDF–38M

Select item 433073620.

PTPσ functions as a presynaptic receptor for the glypican-4/LRRTM4 complex and is essential for excitatory synaptic transmission

Ji Seung Ko, Gopal Pramanik, Ji Won Um, Ji Seon Shim, Dongmin Lee, Kee Hun Kim, Gug-Young Chung, Giuseppe Condomitti, Ho Min Kim, Hyun Kim, Joris de Wit, Kang-Sik Park, Katsuhiko Tabuchi, Jaewon Ko

Proc Natl Acad Sci U S A. 2015 Feb 10; 112(6): 1874–1879. Published online 2015 Jan 26. doi: 10.1073/pnas.1410138112

PMCID:: PMC4330736

Abstract Article PDF–1.3M

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