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Items: 1 to 20 of 70

1.
C5aR plus MEK inhibition durably targets the tumor milieu and reveals tumor cell phagocytosis
Melissa R Perrino, Niousha Ahmari, Ashley Hall, Mark Jackson, Youjin Na, Jay Pundavela, Sara Szabo, Trent M Woodruff, Eva Dombi, Mi-Ok Kim, Jörg Köhl, Jianqiang Wu, Nancy Ratner
Life Sci Alliance. 2024 May; 7(5): e202302229. Published online 2024 Mar 8. doi: 10.26508/lsa.202302229
PMCID:
PMC10923703
AbstractArticlePDF–3.2M
2.
Cell-intrinsic C5a synergizes with Dectin-1 in macrophages to mediate fungal killing
Xaria X. Li, Jenny N. Fung, Richard J. Clark, John D. Lee, Trent M. Woodruff
Proc Natl Acad Sci U S A. 2024 Jan 30; 121(5): e2314627121. Published online 2024 Jan 22. doi: 10.1073/pnas.2314627121
PMCID:
PMC10835034
AbstractArticlePDF–3.1M
3.
Improving radiotherapy in immunosuppressive microenvironments by targeting complement receptor C5aR1
Callum Beach, David MacLean, Dominika Majorova, Stavros Melemenidis, Dhanya K. Nambiar, Ryan K. Kim, Gabriel N. Valbuena, Silvia Guglietta, Carsten Krieg, Mahnaz Darvish-Damavandi, Tatsuya Suwa, Alistair Easton, Lily V.S. Hillson, Ashley K. McCulloch, Ross K. McMahon, Kathryn Pennel, Joanne Edwards, Sean M. O’Cathail, Campbell S. Roxburgh, Enric Domingo, Eui Jung Moon, Dadi Jiang, Yanyan Jiang, Qingyang Zhang, Albert C. Koong, Trent M. Woodruff, Edward E. Graves, Tim Maughan, Simon J.A. Buczacki, Manuel Stucki, Quynh-Thu Le, Simon J. Leedham, Amato J. Giaccia, Monica M. Olcina
J Clin Invest. 2023 Dec 1; 133(23): e168277. Published online 2023 Dec 1. doi: 10.1172/JCI168277
Correction in:
J Clin Invest. 2024 Aug 15; 134(16): e185067.
PMCID:
PMC10688992
AbstractArticlePDF–3.7M
4.
Anaphylatoxin C5a receptor signaling induces mitochondrial fusion and sensitizes Retina Pigment Epithelial Cells to oxidative stress
Masaaki Ishii, Bärbel Rohrer
Biochim Biophys Acta Gen Subj. Author manuscript; available in PMC 2024 Aug 1.
Published in final edited form as: Biochim Biophys Acta Gen Subj. 2023 Aug; 1867(8): 130374. Published online 2023 May 13. doi: 10.1016/j.bbagen.2023.130374
PMCID:
PMC10330548
AbstractArticlePDF–3.9M
5.
C5aR1 shapes a non-inflammatory tumor microenvironment and mediates immune evasion in gastric cancer
Honghong Shen, Xianhua Gu, Xinwei Li, Zheng Xiang, Rong Zhang, Fan Shi, Mingyue Tang, Huiyuan Li, Guangzheng Zhu, Fang Su, Zishu Wang
Biomol Biomed. 2023 Jun 1; 23(3): 392–404. Published online 2023 May 1. doi: 10.17305/bjbms.2022.8317
PMCID:
PMC10171445
AbstractArticlePDF–3.8M
6.
Ras-Related Protein Rab5a Regulates Complement C5a Receptor Trafficking, Chemotaxis, and Chemokine Secretion in Human Macrophages
Kai-Chen Wu, Nicholas D. Condon, Timothy A. Hill, Robert C. Reid, David P. Fairlie, Junxian Lim
J Innate Immun. 2023 Jan-Dec; 15(1): 468–484. Published online 2023 Mar 7. doi: 10.1159/000530012
PMCID:
PMC10105068
AbstractArticlePDF–2.2M
7.
C5aR1 promotes the progression of colorectal cancer by EMT and activating Wnt/β-catenin pathway
Duo Xu, Meirong Li, Longyan Ran, Xiaochen Li, Xingwang Sun, Tao Yin
Clin Transl Oncol. 2023; 25(2): 440–446. Published online 2022 Oct 3. doi: 10.1007/s12094-022-02956-y
PMCID:
PMC9873742
AbstractArticlePDF–1.5M
8.
Molecular signatures of intrarenal complement receptors C3AR1 and C5AR1 correlate with renal outcome in human lupus nephritis
Désirée Tampe, Samy Hakroush, Björn Tampe
Lupus Sci Med. 2022; 9(1): e000831. Published online 2022 Dec 15. doi: 10.1136/lupus-2022-000831
PMCID:
PMC9756185
AbstractArticlePDF–1.2M
9.
Differential expression of C5aR1 and C5aR2 in innate and adaptive immune cells located in early skin lesions of bullous pemphigoid patients
Shirin Emtenani, Maike M. Holtsche, Richard Stahlkopf, Daniel L. Seiler, Timothy Burn, Huiqing Liu, Melissa Parker, Kaan Yilmaz, Hasan O. Dikmen, Markus Huber Lang, Christian D. Sadik, Christian M. Karsten, Nina van Beek, Ralf J. Ludwig, Jörg Köhl, Enno Schmidt
Front Immunol. 2022; 13: 942493. Published online 2022 Nov 18. doi: 10.3389/fimmu.2022.942493
PMCID:
PMC9716273
AbstractArticlePDF–5.3M
10.
Differential expression of immune-regulatory proteins C5AR1, CLEC4A and NLRP3 on peripheral blood mononuclear cells in early-stage non-small cell lung cancer patients
Nussara Pakvisal, Pornrat Kongkavitoon, Chirawadee Sathitruangsak, Nopporn Pornpattanarak, Piyaporn Boonsirikamchai, Pongsakorn Ouwongprayoon, Chatchawit Aporntewan, Poonchavist Chantranuwatana, Apiwat Mutirangura, Chanida Vinayanuwattikun
Sci Rep. 2022; 12: 18439. Published online 2022 Nov 2. doi: 10.1038/s41598-022-21891-0
PMCID:
PMC9630369
AbstractArticlePDF–1.4M
11.
Complement C5aR/LPS-induced BDNF and NGF modulation in human dental pulp stem cells
Muhammad Irfan, Ji Hyun Kim, Robert E. Druzinsky, Sriram Ravindran, Seung Chung
Sci Rep. 2022; 12: 2042. Published online 2022 Feb 7. doi: 10.1038/s41598-022-06110-0
PMCID:
PMC8821590
AbstractArticlePDF–2.7M
12.
C5a Complement Receptor Modulates Odontogenic Dental Pulp Stem Cell Differentiation Under Hypoxia
Ryan Pasiewicz, Yessenia Valverde, Raghuvaran Narayanan, Ji-Hyun Kim, Muhammad Irfan, Nam-Seob Lee, Anne George, Lyndon F Cooper, Satish B Alapati, Seung Chung
Connect Tissue Res. Author manuscript; available in PMC 2023 Jul 1.
Published in final edited form as: Connect Tissue Res. 2022 Jul; 63(4): 339–348. Published online 2021 May 24. doi: 10.1080/03008207.2021.1924696
PMCID:
PMC8611100
AbstractArticlePDF–1.1M
13.
C5aR1-positive neutrophils promote breast cancer glycolysis through WTAP-dependent m6A methylation of ENO1
Baochi Ou, Yuan Liu, Xiaowei Yang, Xiaojun Xu, Yunwen Yan, Jingjie Zhang
Cell Death Dis. 2021 Aug; 12(8): 737. Published online 2021 Jul 26. doi: 10.1038/s41419-021-04028-5
PMCID:
PMC8313695
AbstractArticlePDF–3.9M
14.
Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome
Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi
Cell. Author manuscript; available in PMC 2022 May 27.
Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011
PMCID:
PMC8165030
AbstractArticlePDF–2.2M
15.
C5a-C5aR1 Axis Activation Drives Envenomation Immunopathology by the Snake Naja annulifera
Felipe Silva de França, Isadora Maria Villas-Boas, Bruno Cogliati, Trent M. Woodruff, Edimara da Silva Reis, John D. Lambris, Denise V. Tambourgi
Front Immunol. 2021; 12: 652242. Published online 2021 Apr 15. doi: 10.3389/fimmu.2021.652242
PMCID:
PMC8082402
AbstractArticlePDF–3.7M
16.
C5aR inhibition of nonimmune cells suppresses inflammation and maintains epithelial integrity in SARS-CoV-2–infected primary human airway epithelia
Wilfried Posch, Jonathan Vosper, Asma Noureen, Viktoria Zaderer, Christina Witting, Giulia Bertacchi, Ronald Gstir, Przemyslaw A. Filipek, Günther K. Bonn, Lukas A. Huber, Rosa Bellmann-Weiler, Cornelia Lass-Flörl, Doris Wilflingseder
J Allergy Clin Immunol. 2021 Jun; 147(6): 2083–2097.e6. Published online 2021 Apr 20. doi: 10.1016/j.jaci.2021.03.038
PMCID:
PMC8056780
AbstractArticlePDF–7.1M
17.
Down-Regulation of C3aR/C5aR Inhibits Cell Proliferation and EMT in Hepatocellular Carcinoma
Bendong Chen, Wenyan Zhou, Chaofeng Tang, Genwang Wang, Peng Yuan, Yawen Zhang, Sah Chandra Bhushan, Jinlong Ma, Junzhi Leng
Technol Cancer Res Treat. 2020; 19: 1533033820970668. Published online 2020 Nov 11. doi: 10.1177/1533033820970668
PMCID:
PMC7672723
AbstractArticlePDF–3.1M
18.
The Complement C5a-C5aR1 GPCR Axis in COVID-19 Therapeutics
Trent M. Woodruff, Arun K. Shukla
Trends Immunol. 2020 Nov; 41(11): 965–967. Published online 2020 Sep 23. doi: 10.1016/j.it.2020.09.008
PMCID:
PMC7510552
AbstractArticlePDF–664K
19.
Pro- and anti-apoptotic dual functions of the C5a receptor: involvement of regulator of G protein signaling 3 and extracellular signal-regulated kinase
Hiroshi Nishiura, Hideo Nonaka, Ivette S Revollo, Umeko Semba, Ying Li, Yoshihiko Ota, Atsushi Irie, Kumiko Harada, John H Kehrl, Tetsuro Yamamoto
Lab Invest. Author manuscript; available in PMC 2020 Sep 21.
Published in final edited form as: Lab Invest. 2009 Jun; 89(6): 676–694. Published online 2009 Mar 30. doi: 10.1038/labinvest.2009.27
PMCID:
PMC7503222
AbstractArticlePDF–8.1M
20.
C5aR deficiency attenuates the breast cancer development via the p38/p21 axis
Jian Chen, Zi-han Sun, Li-ying Chen, Feng Xu, Yun-pei Zhao, Gui-qing Li, Ming Tang, You Li, Quan-you Zheng, Shu-feng Wang, Xin-hua Yang, Yu-zhang Wu, Gui-lian Xu
Aging (Albany NY) 2020 Jul 31; 12(14): 14285–14299. Published online 2020 Jul 15. doi: 10.18632/aging.103468
PMCID:
PMC7425439
AbstractArticlePDF–2.2M

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