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Select item 110469741.

DEC1 is involved in circadian rhythm disruption-exacerbated pulmonary fibrosis

Shuai-Jun Chen, Fan Yu, Xiao Feng, Qian Li, Ye-Han Jiang, Li-Qin Zhao, Pei-Pei Cheng, Meng Wang, Lin-Jie Song, Li-Mei Liang, Xin-Liang He, Liang Xiong, Fei Xiang, Xiaorong Wang, Hong Ye, Wan-Li Ma

Cell Commun Signal. 2024; 22: 245. Published online 2024 Apr 26. doi: 10.1186/s12964-024-01614-w

PMCID:: PMC11046974

Abstract Article PDF–24M

Select item 109177802.

BHLHE40/41 regulate microglia and peripheral macrophage responses associated with Alzheimer’s disease and other disorders of lipid-rich tissues

Anna Podleśny-Drabiniok, Gloriia Novikova, Yiyuan Liu, Josefine Dunst, Rose Temizer, Chiara Giannarelli, Samuele Marro, Taras Kreslavsky, Edoardo Marcora, Alison Mary Goate

Nat Commun. 2024; 15: 2058. Published online 2024 Mar 6. doi: 10.1038/s41467-024-46315-7

PMCID:: PMC10917780

Abstract Article PDF–4.5M

Select item 109042773.

The BHLHE40‒PPM1F‒AMPK pathway regulates energy metabolism and is associated with the aggressiveness of endometrial cancer

Kazuo Asanoma, Hiroshi Yagi, Ichiro Onoyama, Lin Cui, Emiko Hori, Minoru Kawakami, Shoji Maenohara, Kazuhisa Hachisuga, Hiroshi Tomonobe, Keisuke Kodama, Masafumi Yasunaga, Tatsuhiro Ohgami, Kaoru Okugawa, Hideaki Yahata, Hiroyuki Kitao, Kiyoko Kato

J Biol Chem. 2024 Mar; 300(3): 105695. Published online 2024 Jan 30. doi: 10.1016/j.jbc.2024.105695

PMCID:: PMC10904277

Abstract Article PDF–6.0M

Select item 105418904.

BHLHE40, a potential immune therapy target, regulated by FGD5-AS1/miR-15a-5p in pancreatic cancer

Wenxin Qi, Qian Liu, Wenjun Fu, Jiaming Shi, Minmin Shi, Songqi Duan, Zhe Li, Shaohua Song, Jiao Wang, Yihao Liu

Sci Rep. 2023; 13: 16400. Published online 2023 Sep 29. doi: 10.1038/s41598-023-43577-x

PMCID:: PMC10541890

Abstract Article PDF–9.1M

Select item 100864915.

Single-cell RNA-seq analysis reveals BHLHE40-driven pro-tumour neutrophils with hyperactivated glycolysis in pancreatic tumour microenvironment

Liwen Wang, Yihao Liu, Yuting Dai, Xiaomei Tang, Tong Yin, Chaofu Wang, Ting Wang, Lei Dong, Minmin Shi, Jiejie Qin, Meilin Xue, Yizhi Cao, Jia Liu, Pengyi Liu, Jinyan Huang, Chenlei Wen, Jun Zhang, Zhiwei Xu, Fan Bai, Xiaxing Deng, Chenghong Peng, Hao Chen, Lingxi Jiang, Saijuan Chen, Baiyong Shen

Gut. 2023 May; 72(5): 958–971. Published online 2022 Jun 10. doi: 10.1136/gutjnl-2021-326070

PMCID:: PMC10086491

Abstract Article PDF–13M

Select item 100644736.

High serum Bhlhe40 levels are associated with subclinical atherosclerosis in patients with type 2 diabetes mellitus: A cross-sectional study

Hui Xu, Qun-Yan Xiang, Shuang Li, You-Shuo Liu

Diab Vasc Dis Res. 2023 Mar-Apr; 20(2): 14791641231169246. Published online 2023 Mar 29. doi: 10.1177/14791641231169246

PMCID:: PMC10064473

Abstract Article PDF–596K

Select item 100259927.

Overcoming ABCB1-mediated multidrug resistance by transcription factor BHLHE40

Yongmei Yin, Yu Xin, Feng Zhang, Donghao An, Hui Fan, Mengyao Qin, Jinxin Xia, Tao Xi, Jing Xiong

Neoplasia. 2023 May; 39: 100891. Published online 2023 Mar 15. doi: 10.1016/j.neo.2023.100891

PMCID:: PMC10025992

Abstract Article PDF–4.3M

Select item 100118308.

Differentiated embryonic chondrocyte expressed gene-1 is a central signaling component in the development of collagen-induced rheumatoid arthritis

Yichen Wu, Haobin Wang, Ying Huo, Bingfang Yan, Hiroaki Honda, Wei Liu, Jian Yang

J Biol Chem. 2023 Mar; 299(3): 102982. Published online 2023 Feb 3. doi: 10.1016/j.jbc.2023.102982

PMCID:: PMC10011830

Abstract Article PDF–5.6M

Select item 99052019.

Long noncoding RNA SNHG1 alleviates high glucose-induced vascular smooth muscle cells calcification/senescence by post-transcriptionally regulating Bhlhe40 and autophagy via Atg10

Shuang Li, Yuqing Ni, Chen Li, Qunyan Xiang, Yan Zhao, Hui Xu, Wu Huang, Yanjiao Wang, Yi Wang, Junkun Zhan, Youshuo Liu

J Physiol Biochem. 2023; 79(1): 83–105. Published online 2022 Oct 4. doi: 10.1007/s13105-022-00924-2

PMCID:: PMC9905201

Abstract Article PDF–6.3M

Select item 934857610.

Chr21 protein–protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer’s disease

Julia Viard, Yann Loe-Mie, Rachel Daudin, Malik Khelfaoui, Christine Plancon, Anne Boland, Francisco Tejedor, Richard L Huganir, Eunjoon Kim, Makoto Kinoshita, Guofa Liu, Volker Haucke, Thomas Moncion, Eugene Yu, Valérie Hindie, Henri Bléhaut, Clotilde Mircher, Yann Herault, Jean-François Deleuze, Jean-Christophe Rain, Michel Simonneau, Aude-Marie Lepagnol-Bestel

Life Sci Alliance. 2022 Dec; 5(12): e202101205. Published online 2022 Aug 1. doi: 10.26508/lsa.202101205

PMCID:: PMC9348576

Abstract Article PDF–3.0M

Select item 927997911.

Upregulation of INHBA mediated by the transcription factor BHLHE40 promotes colon cancer cell proliferation and migration

Jianan Wang, Bo Li, Shaohui Yang, Chenyang Ma, Kaitai Liu, Xue Chen, Wei Cui

J Clin Lab Anal. 2022 Jul; 36(7): e24539. Published online 2022 Jun 11. doi: 10.1002/jcla.24539

PMCID:: PMC9279979

Abstract Article PDF–2.2M

Select item 895686412.

Differentiated embryonic chondrocyte expressed gene-1 (DEC1) enhances the development of colorectal cancer with an involvement of the STAT3 signaling

Enfang Shan, Ying Hao, Haobin Wang, Ziheng Zhang, Jingwan Hu, Guyu Wang, Wei Liu, Bingfang Yan, Honda Hiroaki, Jian Yang

Neoplasia. 2022 May; 27: 100783. Published online 2022 Mar 22. doi: 10.1016/j.neo.2022.100783

PMCID:: PMC8956864

Abstract Article PDF–4.6M

Select item 891705213.

REL and BHLHE40 variants are associated with IL-12 and IL-10 responses and tuberculosis risk

Javeed A. Shah, Alex J. Warr, Andrew D. Graustein, Aparajita Saha, Sarah J. Dunstan, Nguyen T.T. Thuong, Guy E. Thwaites, Maxine Caws, Phan V.K. Thai, Nguyen D. Bang, Tran T.H. Chau, Chiea Chuen Khor, Zheng Li, Martin Hibberd, Xuling Chang, Felicia K. Nguyen, Carlo A. Hernandez, Madison A. Jones, Christopher M. Sassetti, Katherine A. Fitzgerald, Munyaradzi Musvosvi, Anele Gela, Willem A. Hanekom, Mark Hatherill, Thomas J. Scriba, Thomas R. Hawn

J Immunol. Author manuscript; available in PMC 2023 Mar 15.

Published in final edited form as: J Immunol. 2022 Mar 15; 208(6): 1352–1361. Published online 2022 Feb 25. doi: 10.4049/jimmunol.2100671

PMCID:: PMC8917052

Abstract Article PDF–917K

Select item 860245114.

Identification of proximal SUMO-dependent interactors using SUMO-ID

Orhi Barroso-Gomila, Fredrik Trulsson, Veronica Muratore, Iñigo Canosa, Laura Merino-Cacho, Ana Rosa Cortazar, Coralia Pérez, Mikel Azkargorta, Ibon Iloro, Arkaitz Carracedo, Ana M. Aransay, Felix Elortza, Ugo Mayor, Alfred C. O. Vertegaal, Rosa Barrio, James D. Sutherland

Nat Commun. 2021; 12: 6671. Published online 2021 Nov 18. doi: 10.1038/s41467-021-26807-6

PMCID:: PMC8602451

Abstract Article PDF–11M

Select item 850876415.

The Potential Roles of Dec1 and Dec2 in Periodontal Inflammation

Xingzhi Wang, Fuyuki Sato, Keiji Tanimoto, Niveda Rajeshwaran, Lakshmi Thangavelu, Makoto Makishima, Ujjal K. Bhawal

Int J Mol Sci. 2021 Oct; 22(19): 10349. Published online 2021 Sep 26. doi: 10.3390/ijms221910349

PMCID:: PMC8508764

Abstract Article PDF–747K

Select item 816503016.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 815996217.

Identification of BHLHE40 expression in peripheral blood mononuclear cells as a novel biomarker for diagnosis and prognosis of hepatocellular carcinoma

Pattapon Kunadirek, Chaiyaboot Ariyachet, Supachaya Sriphoosanaphan, Nutcha Pinjaroen, Pongserath Sirichindakul, Intawat Nookaew, Natthaya Chuaypen, Pisit Tangkijvanich

Sci Rep. 2021; 11: 11201. Published online 2021 May 27. doi: 10.1038/s41598-021-90515-w

PMCID:: PMC8159962

Abstract Article PDF–2.7M

Select item 810809318.

DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity

Rajat Gupta, Kumar Somyajit, Takeo Narita, Elina Maskey, Andre Stanlie, Magdalena Kremer, Dimitris Typas, Michael Lammers, Niels Mailand, Andre Nussenzweig, Jiri Lukas, Chunaram Choudhary

Cell. Author manuscript; available in PMC 2021 May 10.

Published in final edited form as: Cell. 2018 May 3; 173(4): 972–988.e23. Published online 2018 Apr 12. doi: 10.1016/j.cell.2018.03.050

PMCID:: PMC8108093

Abstract Article PDF–3.5M

Select item 800904819.

Impact of cytosine methylation on DNA binding specificities of human transcription factors

Yimeng Yin, Ekaterina Morgunova, Arttu Jolma, Eevi Kaasinen, Biswajyoti Sahu, Syed Khund-Sayeed, Pratyush K. Das, Teemu Kivioja, Kashyap Dave, Fan Zhong, Kazuhiro R. Nitta, Minna Taipale, Alexander Popov, Paul A. Ginno, Silvia Domcke, Jian Yan, Dirk Schübeler, Charles Vinson, Jussi Taipale

Science. Author manuscript; available in PMC 2021 Mar 30.

Published in final edited form as: Science. 2017 May 5; 356(6337): eaaj2239. doi: 10.1126/science.aaj2239

PMCID:: PMC8009048

Abstract Article PDF–2.6M

Select item 768695720.

TFEB Transcriptional Responses Reveal Negative Feedback by BHLHE40 and BHLHE41

Kimberly L. Carey, Geraldine L.C. Paulus, Lingfei Wang, Dale R. Balce, Jessica W. Luo, Phil Bergman, Ianina C. Ferder, Lingjia Kong, Nicole Renaud, Shantanu Singh, Maria Kost-Alimova, Beat Nyfeler, Kara G. Lassen, Herbert W. Virgin, Ramnik J. Xavier

Cell Rep. Author manuscript; available in PMC 2020 Nov 25.

Published in final edited form as: Cell Rep. 2020 Nov 10; 33(6): 108371. doi: 10.1016/j.celrep.2020.108371

PMCID:: PMC7686957

Abstract Article PDF–1.6M

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