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Select item 108179391.

UBR5 promotes antiviral immunity by disengaging the transcriptional brake on RIG-I like receptors

Duomeng Yang, Tingting Geng, Andrew G. Harrison, Jason G. Cahoon, Jian Xing, Baihai Jiao, Mark Wang, Chao Cheng, Robert E. Hill, Huadong Wang, Anthony T. Vella, Gong Cheng, Yanlin Wang, Penghua Wang

Nat Commun. 2024; 15: 780. Published online 2024 Jan 26. doi: 10.1038/s41467-024-45141-1

PMCID:: PMC10817939

Abstract Article PDF–8.6M

Select item 94933942.

Quantitative interactome proteomics identifies a proteostasis network for GABA_A receptors

Ya-Juan Wang, Xiao-Jing Di, Ting-Wei Mu

J Biol Chem. 2022 Oct; 298(10): 102423. Published online 2022 Aug 27. doi: 10.1016/j.jbc.2022.102423

PMCID:: PMC9493394

Abstract Article PDF–2.6M

Select item 80575923.

Ubiquitin-protein ligase Ubr5 cooperates with hedgehog signalling to promote skeletal tissue homeostasis

David Mellis, Katherine A. Staines, Silvia Peluso, Ioanna Ch. Georgiou, Natalie Dora, Malgorzata Kubiak, Rob van’t Hof, Michela Grillo, Colin Farquharson, Elaine Kinsella, Anna Thornburn, Stuart H. Ralston, Donald M. Salter, Natalia A. Riobo-Del Galdo, Robert E. Hill, Mark Ditzel

PLoS Genet. 2021 Apr; 17(4): e1009275. Published online 2021 Apr 5. doi: 10.1371/journal.pgen.1009275

PMCID:: PMC8057592

Abstract Article PDF–5.5M

Select item 79689254.

TWIST1 and chromatin regulatory proteins interact to guide neural crest cell differentiation

Xiaochen Fan, V Pragathi Masamsetti, Jane QJ Sun, Kasper Engholm-Keller, Pierre Osteil, Joshua Studdert, Mark E Graham, Nicolas Fossat, Patrick PL Tam

eLife. 2021; 10: e62873. Published online 2021 Feb 8. doi: 10.7554/eLife.62873

PMCID:: PMC7968925

Abstract Article PDF–4.0M

Select item 79387705.

BraInMap elucidates the macromolecular connectivity landscape of mammalian brain

Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili

Cell Syst. Author manuscript; available in PMC 2021 Apr 22.

Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003

Correction in:: Cell Syst. 2020 Aug 26; 11(2): 208.

PMCID:: PMC7938770

Abstract Article PDF–2.0M

Select item 77227256.

Tumor derived UBR5 promotes ovarian cancer growth and metastasis through inducing immunosuppressive macrophages

Mei Song, Oladapo O. Yeku, Sarwish Rafiq, Terence Purdon, Xue Dong, Lijing Zhu, Tuo Zhang, Huan Wang, Ziqi Yu, Junhua Mai, Haifa Shen, Briana Nixon, Ming Li, Renier J. Brentjens, Xiaojing Ma

Nat Commun. 2020; 11: 6298. Published online 2020 Dec 8. doi: 10.1038/s41467-020-20140-0

PMCID:: PMC7722725

Abstract Article PDF–5.9M

Select item 76457137.

Promotion of somatic CAG repeat expansion by Fan1 knock-out in Huntington’s disease knock-in mice is blocked by Mlh1 knock-out

Jacob M Loupe, Ricardo Mouro Pinto, Kyung-Hee Kim, Tammy Gillis, Jayalakshmi S Mysore, Marissa A Andrew, Marina Kovalenko, Ryan Murtha, IhnSik Seong, James F Gusella, Seung Kwak, David Howland, Ramee Lee, Jong-Min Lee, Vanessa C Wheeler, Marcy E MacDonald

Hum Mol Genet. 2020 Sep 15; 29(18): 3044–3053. Published online 2020 Sep 2. doi: 10.1093/hmg/ddaa196

PMCID:: PMC7645713

Abstract Article PDF–952K

Select item 73659188.

UBR5 HECT domain mutations identified in mantle cell lymphoma control maturation of B cells

Samantha A. Swenson, Tyler J. Gilbreath, Heather Vahle, R. Willow Hynes-Smith, Jared H. Graham, Henry C.-H. Law, Catalina Amador, Nicholas T. Woods, Michael R. Green, Shannon M. Buckley

Blood. 2020 Jul 16; 136(3): 299–312. Prepublished online 2020 Apr 23. doi: 10.1182/blood.2019002102

PMCID:: PMC7365918

Abstract Article

Select item 72950339.

Ex vivo Quantitative Proteomic Analysis of Serotonin Transporter Interactome: Network Impact of the SERT Ala56 Coding Variant

Meagan A. Quinlan, Matthew J. Robson, Ran Ye, Kristie L. Rose, Kevin L. Schey, Randy D. Blakely

Front Mol Neurosci. 2020; 13: 89. Published online 2020 Jun 8. doi: 10.3389/fnmol.2020.00089

PMCID:: PMC7295033

Abstract Article PDF–2.7M

Select item 650708610.

MicroRNA-1224 Splicing CircularRNA-Filip1l in an Ago2-Dependent Manner Regulates Chronic Inflammatory Pain via Targeting Ubr5

Zhiqiang Pan, Guo-Fang Li, Meng-Lan Sun, Ling Xie, Di Liu, Qi Zhang, Xiao-Xiao Yang, Sunhui Xia, Xiaodan Liu, Huimin Zhou, Zhou-Ya Xue, Ming Zhang, Ling-Yun Hao, Li-Jiao Zhu, Jun-Li Cao

J Neurosci. 2019 Mar 13; 39(11): 2125–2143. doi: 10.1523/JNEUROSCI.1631-18.2018

PMCID:: PMC6507086

Abstract Article PDF–5.3M

Select item 564508211.

Spatio-temporal profile of postynaptic interactomes integrates components of complex brain disorders

Jing Li, Wangshu Zhang, Hui Yang, Daniel P. Howrigan, Brent Wilkinson, Tade Souaiaia, Oleg V. Evgrafov, Giulio Genovese, Veronica A. Clementel, Jennifer C. Tudor, Ted Abel, James A. Knowles, Benjamin M. Neale, Kai Wang, Fengzhu Sun, Marcelo P. Coba

Nat Neurosci. Author manuscript; available in PMC 2018 Aug 1.

Published in final edited form as: Nat Neurosci. 2017 Aug; 20(8): 1150–1161. Published online 2017 Jun 26. doi: 10.1038/nn.4594

PMCID:: PMC5645082

Abstract Article PDF–2.3M

Select item 550974012.

Synaptic GAP and GEF Complexes Cluster Proteins Essential for GTP Signaling

Brent Wilkinson, Jing Li, Marcelo P. Coba

Sci Rep. 2017; 7: 5272. Published online 2017 Jul 13. doi: 10.1038/s41598-017-05588-3

PMCID:: PMC5509740

Abstract Article PDF–4.6M

Select item 543464013.

Easi-CRISPR: a robust method for one-step generation of mice carrying conditional and insertion alleles using long ssDNA donors and CRISPR ribonucleoproteins

Rolen M. Quadros, Hiromi Miura, Donald W. Harms, Hisako Akatsuka, Takehito Sato, Tomomi Aida, Ronald Redder, Guy P. Richardson, Yutaka Inagaki, Daisuke Sakai, Shannon M. Buckley, Parthasarathy Seshacharyulu, Surinder K. Batra, Mark A. Behlke, Sarah A. Zeiner, Ashley M. Jacobi, Yayoi Izu, Wallace B. Thoreson, Lisa D. Urness, Suzanne L. Mansour, Masato Ohtsuka, Channabasavaiah B. Gurumurthy

Genome Biol. 2017; 18: 92. Published online 2017 May 17. doi: 10.1186/s13059-017-1220-4

PMCID:: PMC5434640

Abstract Article PDF–1.1M

Select item 538122614.

Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function

Tingting Zhang, Wei Du, Andrew F. Wilson, Satoshi H. Namekawa, Paul R. Andreassen, Amom Ruhikanta Meetei, Qishen Pang

Sci Rep. 2017; 7: 45626. Published online 2017 Apr 5. doi: 10.1038/srep45626

PMCID:: PMC5381226

Abstract Article PDF–1.4M

Select item 501612215.

Amyloid Precursor Protein (APP) May Act as a Substrate and a Recognition Unit for CRL4^CRBN and Stub1 E3 Ligases Facilitating Ubiquitination of Proteins Involved in Presynaptic Functions and Neurodegeneration

Dolores Del Prete, Richard C. Rice, Anjali M. Rajadhyaksha, Luciano D'Adamio

J Biol Chem. 2016 Aug 12; 291(33): 17209–17227. Published online 2016 Jun 20. doi: 10.1074/jbc.M116.733626

PMCID:: PMC5016122

Abstract Article PDF–1.8M

Select item 490751216.

Use of a Conditional Ubr5 Mutant Allele to Investigate the Role of an N-End Rule Ubiquitin-Protein Ligase in Hedgehog Signalling and Embryonic Limb Development

Elaine Kinsella, Natalie Dora, David Mellis, Laura Lettice, Paul Deveney, Robert Hill, Mark Ditzel

PLoS One. 2016; 11(6): e0157079. Published online 2016 Jun 14. doi: 10.1371/journal.pone.0157079

PMCID:: PMC4907512

Abstract Article PDF–27M

Select item 468613617.

Systematic Identification of Factors for Provirus Silencing in Embryonic Stem Cells

Bin Xia Yang, Chadi A. EL Farran, Hong Chao Guo, Tao Yu, Hai Tong Fang, Hao Fei Wang, Sharon Schlesinger, Yu Fen Samantha Seah, Germaine Yen Lin Goh, Suat Peng Neo, Yinghui Li, Matthew C. Lorincz, Vinay Tergaonkar, Tit-Meng Lim, Lingyi Chen, Jayantha Gunaratne, James J. Collins, Stephen P. Goff, George Q. Daley, Hu Li, Frederic A. Bard, Yuin-Han Loh

Cell. Author manuscript; available in PMC 2015 Dec 21.

Published in final edited form as: Cell. 2015 Sep 24; 163(1): 230–245. Published online 2015 Sep 10. doi: 10.1016/j.cell.2015.08.037

PMCID:: PMC4686136

Abstract Article PDF–1.2M

Select item 414303618.

UBR5-mediated ubiquitination of ATMIN is required for ionizing radiation-induced ATM signaling and function

Tianyi Zhang, Janet Cronshaw, Nnennaya Kanu, Ambrosius P. Snijders, Axel Behrens

Proc Natl Acad Sci U S A. 2014 Aug 19; 111(33): 12091–12096. Published online 2014 Aug 4. doi: 10.1073/pnas.1400230111

PMCID:: PMC4143036

Abstract Article PDF–1.4M

Select item 357241019.

A conditional knockout resource for the genome–wide study of mouse gene function

William C. Skarnes, Barry Rosen, Anthony P. West, Manousos Koutsourakis, Wendy Bushell, Vivek Iyer, Alejandro O. Mujica, Mark Thomas, Jennifer Harrow, Tony Cox, David Jackson, Jessica Severin, Patrick Biggs, Jun Fu, Michael Nefedov, Pieter J. de Jong, A. Francis Stewart, Allan Bradley

Nature. Author manuscript; available in PMC 2013 Feb 14.

Published in final edited form as: Nature. 2011 Jun 15; 474(7351): 337–342. Published online 2011 Jun 15. doi: 10.1038/nature10163

PMCID:: PMC3572410

Abstract Article PDF–1.1M

Select item 354631820.

An analysis and validation pipeline for large-scale RNAi-based screens

Michael Plank, Guang Hu, A. Sofia Silva, Shona H. Wood, Emily E. Hesketh, Georges Janssens, André Macedo, João Pedro de Magalhães, George M. Church

Sci Rep. 2013; 3: 1076. Published online 2013 Jan 16. doi: 10.1038/srep01076

PMCID:: PMC3546318

Abstract Article PDF–608K

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