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Select item 96058651.

Novel antigen-presenting cell imparts T_reg-dependent tolerance to gut microbiota

Blossom Akagbosu, Zakieh Tayyebi, Gayathri Shibu, Yoselin A. Paucar Iza, Deeksha Deep, Yollanda Franco Parisotto, Logan Fisher, H. Amalia Pasolli, Valentin Thevin, Rasa Elmentaite, Maximilian Knott, Saskia Hemmers, Lorenz Jahn, Christin Friedrich, Jacob Verter, Zhong-Min Wang, Marcel van den Brink, Georg Gasteiger, Thomas G. P. Grünewald, Julien C. Marie, Christina Leslie, Alexander Y. Rudensky, Chrysothemis C. Brown

Nature. 2022; 610(7933): 752–760. Published online 2022 Sep 7. doi: 10.1038/s41586-022-05309-5

PMCID:: PMC9605865

Abstract Article PDF–14M

Select item 94029932.

Thymic epithelial cells require lipid kinase Vps34 for CD4 but not CD8 T cell selection

J. Luke Postoak, Wenqiang Song, Guan Yang, Xingyi Guo, Shiyun Xiao, Cherie E. Saffold, Jianhua Zhang, Sebastian Joyce, Nancy R. Manley, Lan Wu, Luc Van Kaer

J Exp Med. 2022 Oct 3; 219(10): e20212554. Published online 2022 Aug 23. doi: 10.1084/jem.20212554

PMCID:: PMC9402993

Abstract Article PDF–6.9M

Select item 86743763.

MHC Class II presentation is affected by polymorphism in the H2-Ob gene and additional loci

Emily Cullum, Austin M. Graves, Vera L. Tarakanova, Lisa K. Denzin, Tatyana Golovkina

J Immunol. Author manuscript; available in PMC 2022 Jan 1.

Published in final edited form as: J Immunol. 2021 Jul 1; 207(1): 5–14. Published online 2021 Jun 16. doi: 10.4049/jimmunol.2100061

PMCID:: PMC8674376

Abstract Article PDF–1.1M

Select item 82390234.

Type II alveolar cell MHCII improves respiratory viral disease outcomes while exhibiting limited antigen presentation

Sushila A. Toulmin, Chaitali Bhadiadra, Andrew J. Paris, Jeffrey H. Lin, Jeremy Katzen, Maria C. Basil, Edward E. Morrisey, G. Scott Worthen, Laurence C. Eisenlohr

Nat Commun. 2021; 12: 3993. Published online 2021 Jun 28. doi: 10.1038/s41467-021-23619-6

PMCID:: PMC8239023

Abstract Article PDF–2.5M

Select item 75781065.

Strength of tonic T cell receptor signaling instructs T follicular helper fate decisions

Juliet M. Bartleson, Ashley A. Viehmann Milam, David L. Donermeyer, Stephen Horvath, Yu Xia, Takeshi Egawa, Paul M. Allen

Nat Immunol. Author manuscript; available in PMC 2021 Mar 28.

Published in final edited form as: Nat Immunol. 2020 Nov; 21(11): 1384–1396. Published online 2020 Sep 28. doi: 10.1038/s41590-020-0781-7

PMCID:: PMC7578106

Abstract Article PDF–1.2M

Select item 70659586.

Activation of Dendritic Cells Alters the Mechanism of MHC Class II Antigen Presentation to CD4 T Cells

Kyung-Jin Cho, Satoshi Ishido, Laurence C. Eisenlohr, Paul A. Roche

J Immunol. Author manuscript; available in PMC 2021 Mar 15.

Published in final edited form as: J Immunol. 2020 Mar 15; 204(6): 1621–1629. Published online 2020 Jan 29. doi: 10.4049/jimmunol.1901234

PMCID:: PMC7065958

Abstract Article PDF–1.2M

Select item 68148127.

Dormant pathogenic CD4⁺ T cells are prevalent in the peripheral repertoire of healthy mice

Anna Cebula, Michal Kuczma, Edyta Szurek, Maciej Pietrzak, Natasha Savage, Wessam R. Elhefnawy, Grzegorz Rempala, Piotr Kraj, Leszek Ignatowicz

Nat Commun. 2019; 10: 4882. Published online 2019 Oct 25. doi: 10.1038/s41467-019-12820-3

PMCID:: PMC6814812

Abstract Article PDF–3.0M

Select item 55680928.

Neutralizing antibody responses to viral infections are linked to the non-classical MHC class II gene H2-Ob

Lisa K. Denzin, Aly Azeem Khan, Francesca Virdis, Jessica Wilks, Melissa Kane, Helen A. Beilinson, Stanislav Dikiy, Laure K. Case, Derry Roopenian, Michele Witkowski, Alexander V. Chervonsky, Tatyana V. Golovkina

Immunity. Author manuscript; available in PMC 2018 Aug 15.

Published in final edited form as: Immunity. 2017 Aug 15; 47(2): 310–322.e7. doi: 10.1016/j.immuni.2017.07.013

PMCID:: PMC5568092

Abstract Article PDF–3.5M

Select item 46642719.

The QTL within the H2 Complex Involved in the Control of Tuberculosis Infection in Mice Is the Classical Class II H2-Ab1 Gene

Nadezhda Logunova, Maria Korotetskaya, Vladimir Polshakov, Alexander Apt

PLoS Genet. 2015 Nov; 11(11): e1005672. Published online 2015 Nov 30. doi: 10.1371/journal.pgen.1005672

PMCID:: PMC4664271

Abstract Article PDF–8.4M

Select item 462998910.

Endogenous antigen processing drives the primary CD4⁺ T cell response to influenza

Michael A. Miller, Asha Purnima V. Ganesan, Nancy Luckashenak, Mark Mendonca, Laurence C. Eisenlohr

Nat Med. Author manuscript; available in PMC 2016 Apr 1.

Published in final edited form as: Nat Med. 2015 Oct; 21(10): 1216–1222. Published online 2015 Sep 28. doi: 10.1038/nm.3958

PMCID:: PMC4629989

Abstract Article PDF–998K

Select item 456765611.

Parasite Manipulation of the Invariant Chain and the Peptide Editor H2-DM Affects Major Histocompatibility Complex Class II Antigen Presentation during Toxoplasma gondii Infection

Louis-Philippe Leroux, Manami Nishi, Sandy El-Hage, Barbara A. Fox, David J. Bzik, Florence S. Dzierszinski

Infect Immun. 2015 Oct; 83(10): 3865–3880. Prepublished online 2015 Jul 20. Published online 2015 Sep 10. doi: 10.1128/IAI.00415-15

PMCID:: PMC4567656

Abstract Article PDF–4.5M

Select item 394414112.

Intrinsic CD4⁺ T cell sensitivity and response to pathogen are set and sustained by avidity for thymic and peripheral self-pMHC

Stephen P. Persaud, Chelsea R. Parker, Wan-Lin Lo, K. Scott Weber, Paul M. Allen

Nat Immunol. Author manuscript; available in PMC 2014 Sep 1.

Published in final edited form as: Nat Immunol. 2014 Mar; 15(3): 266–274. Published online 2014 Feb 2. doi: 10.1038/ni.2822

PMCID:: PMC3944141

Abstract Article PDF–1.2M

Select item 357241013.

A conditional knockout resource for the genome–wide study of mouse gene function

William C. Skarnes, Barry Rosen, Anthony P. West, Manousos Koutsourakis, Wendy Bushell, Vivek Iyer, Alejandro O. Mujica, Mark Thomas, Jennifer Harrow, Tony Cox, David Jackson, Jessica Severin, Patrick Biggs, Jun Fu, Michael Nefedov, Pieter J. de Jong, A. Francis Stewart, Allan Bradley

Nature. Author manuscript; available in PMC 2013 Feb 14.

Published in final edited form as: Nature. 2011 Jun 15; 474(7351): 337–342. Published online 2011 Jun 15. doi: 10.1038/nature10163