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Select item 115322141.

FTO-mediated m ⁶A demethylation of ULK1 mRNA promotes autophagy and activation of hepatic stellate cells in liver fibrosis : FTO regulates HSC activation by targeting ULK1

Tingjuan Huang, Chunhong Zhang, Junjie Ren, Qizhi Shuai, Xiaonan Li, Xuewei Li, Jun Xie, Jun Xu

Acta Biochim Biophys Sin (Shanghai) 2024 Oct 25; 56(10): 1509–1520. Published online 2024 Aug 22. doi: 10.3724/abbs.2024098

PMCID:: PMC11532214

Abstract Article PDF–3.3M

Select item 113815322.

Protein phosphatase 4 maintains the survival of primordial follicles by regulating autophagy in oocytes

Ming-Zhe Dong, Ying-Chun Ouyang, Shi-Cai Gao, Lin-Jian Gu, Jia-Ni Guo, Si-Min Sun, Zhen-Bo Wang, Qing-Yuan Sun

Cell Death Dis. 2024 Sep; 15(9): 658. Published online 2024 Sep 8. doi: 10.1038/s41419-024-07051-4

PMCID:: PMC11381532

Abstract Article PDF–6.1M

Select item 113644353.

Inhibition of ULK1/2 and KRAS^G12C controls tumor growth in preclinical models of lung cancer

Phaedra C Ghazi, Kayla T O'Toole, Sanjana Srinivas Boggaram, Michael T Scherzer, Mark R Silvis, Yun Zhang, Madhumita Bogdan, Bryan D Smith, Guillermina Lozano, Daniel L Flynn, Eric L Snyder, Conan G Kinsey, Martin McMahon

eLife. 2024; 13: RP96992. Published online 2024 Aug 30. doi: 10.7554/eLife.96992

PMCID:: PMC11364435

Abstract Article PDF–5.1M

Select item 108874514.

mTOR Regulates Mineralocorticoid Receptor Transcriptional Activity by ULK1-Dependent and -Independent Mechanisms

Yusuf Ali, Celso E Gomez-Sanchez, Maria Plonczynski, Aniko Naray-Fejes-Toth, Geza Fejes-Toth, Elise P Gomez-Sanchez

Endocrinology. 2024 Apr; 165(4): bqae015. Published online 2024 Feb 7. doi: 10.1210/endocr/bqae015

PMCID:: PMC10887451

Abstract Article

Select item 108787895.

IL-4 activates ULK1/Atg9a/Rab9 in asthma, NLRP3 inflammasomes, and Golgi fragmentation by increasing autophagy flux and mitochondrial oxidative stress

Chang Xu, Yilan Song, Wanting Liu, Ruobai Liu, Qiaoyun Bai, Liangchang Li, Chongyang Wang, Guanghai Yan

Redox Biol. 2024 May; 71: 103090. Published online 2024 Feb 15. doi: 10.1016/j.redox.2024.103090

PMCID:: PMC10878789

Abstract Article PDF–20M

Select item 107792816.

Endurance Exercise Training Mitigates Diastolic Dysfunction in Diabetic Mice Independent of Phosphorylation of Ulk1 at S555

Yuntian Guan, Mei Zhang, Christie Lacy, Soham Shah, Frederick H. Epstein, Zhen Yan

Int J Mol Sci. 2024 Jan; 25(1): 633. Published online 2024 Jan 3. doi: 10.3390/ijms25010633

PMCID:: PMC10779281

Abstract Article PDF–2.9M

Select item 103508337.

Phosphorylation of phase‐separated p62 bodies by ULK1 activates a redox‐independent stress response

Ryo Ikeda, Daisuke Noshiro, Hideaki Morishita, Shuhei Takada, Shun Kageyama, Yuko Fujioka, Tomoko Funakoshi, Satoko Komatsu‐Hirota, Ritsuko Arai, Elena Ryzhii, Manabu Abe, Tomoaki Koga, Hozumi Motohashi, Mitsuyoshi Nakao, Kenji Sakimura, Arata Horii, Satoshi Waguri, Yoshinobu Ichimura, Nobuo N Noda, Masaaki Komatsu

EMBO J. 2023 Jul; 42(14): e113349. Published online 2023 Jun 12. doi: 10.15252/embj.2022113349

PMCID:: PMC10350833

Abstract Article PDF–4.4M

Select item 101447288.

Ulk1-dependent alternative mitophagy plays a protective role during pressure overload in the heart

Jihoon Nah, Akihiro Shirakabe, Risa Mukai, Peiyong Zhai, Eun Ah Sung, Andreas Ivessa, Wataru Mizushima, Yasuki Nakada, Toshiro Saito, Chengchen Hu, Yong Keun Jung, Junichi Sadoshima

Cardiovasc Res. 2022 Aug; 118(12): 2638–2651. Published online 2022 Jan 9. doi: 10.1093/cvr/cvac003

PMCID:: PMC10144728

Abstract Article PDF–2.0M

Select item 98919569.

Activation of eIF4E‐binding‐protein‐1 rescues mTORC1‐induced sarcopenia by expanding lysosomal degradation capacity

Elisa M. Crombie, Seonyoung Kim, Stuart Adamson, Han Dong, Tzu‐Chiao Lu, Yiju Wu, Yajun Wu, Yotam Levy, Nolan Stimple, Wing Moon R. Lam, Hwee Weng D. Hey, Dominic J. Withers, Ao‐Lin Hsu, Boon Huat Bay, Julien Ochala, Shih‐Yin Tsai

J Cachexia Sarcopenia Muscle. 2023 Feb; 14(1): 198–213. Published online 2022 Nov 17. doi: 10.1002/jcsm.13121

PMCID:: PMC9891956

Abstract Article PDF–4.2M

Select item 985150110.

A role for BCL2L13 and autophagy in germline purifying selection of mtDNA

Laura S. Kremer, Lyuba V. Bozhilova, Diana Rubalcava-Gracia, Roberta Filograna, Mamta Upadhyay, Camilla Koolmeister, Patrick F. Chinnery, Nils-Göran Larsson

PLoS Genet. 2023 Jan; 19(1): e1010573. Published online 2023 Jan 6. doi: 10.1371/journal.pgen.1010573

PMCID:: PMC9851501

Abstract Article PDF–1.4M

Select item 970473711.

Autophagy protein ULK1 interacts with and regulates SARM1 during axonal injury

Harry M. C. Choi, Yun Li, Delwin Suraj, Ru-Ching Hsia, Chinmoy Sarkar, Junfang Wu, Marta M. Lipinski

Proc Natl Acad Sci U S A. 2022 Nov 22; 119(47): e2203824119. Published online 2022 Nov 14. doi: 10.1073/pnas.2203824119

PMCID:: PMC9704737

Abstract Article PDF–4.5M

Select item 946661412.

Perinatal versus adult loss of ULK1 and ULK2 distinctly influences cardiac autophagy and function

Matthew P. Harris, Quan J. Zhang, Cole T. Cochran, Jessica Ponce, Sean Alexander, Ana Kronemberger, Jordan D. Fuqua, Yuan Zhang, Ranan Fattal, Tyler Harper, Matthew L. Murry, Chad E. Grueter, E. Dale Abel, Vitor A. Lira

Autophagy. 2022; 18(9): 2161–2177. Published online 2022 Feb 1. doi: 10.1080/15548627.2021.2022289

PMCID:: PMC9466614

Abstract Article PDF–6.8M

Select item 928970913.

TRIM27 cooperates with STK38L to inhibit ULK1‐mediated autophagy and promote tumorigenesis

Yi Yang, Yifu Zhu, Shuai Zhou, Peipei Tang, Ran Xu, Yuwei Zhang, Dongping Wei, Jian Wen, Rick F Thorne, Xu Dong Zhang, Jun‐Lin Guan, Lianxin Liu, Mian Wu, Song Chen

EMBO J. 2022 Jul; 41(14): e109777. Published online 2022 Jun 7. doi: 10.15252/embj.2021109777

PMCID:: PMC9289709

Abstract Article PDF–2.3M

Select item 901569914.

The ATG5 interactome links clathrin-mediated vesicular trafficking with the autophagosome assembly machinery

Kiren Baines, Kazuaki Yoshioka, Yoh Takuwa, Jon D. Lane

Autophagy Rep. 2022; 1(1): 88–118. Published online 2022 Apr 7. doi: 10.1080/27694127.2022.2042054

PMCID:: PMC9015699

Abstract Article PDF–3.3M

Select item 901455915.

Functional genomic landscape of cancer-intrinsic evasion of killing by T cells

Keith A. Lawson, Cristovão M. Sousa, Xiaoyu Zhang, Eiru Kim, Rummy Akthar, Joseph J. Caumanns, Yuxi Yao, Nicholas Mikolajewicz, Catherine Ross, Kevin R. Brown, Abdelrahman Abou Zid, Zi Peng Fan, Shirley Hui, Jordan A. Krall, Donald M. Simons, Chloe J. Slater, Victor De Jesus, Lujia Tang, Richa Singh, Joshua E. Goldford, Sarah Martin, Qian Huang, Elizabeth A. Francis, Andrea Habsid, Ryan Climie, David Tieu, Jiarun Wei, Ren Li, Amy Hin Yan Tong, Michael Aregger, Katherine S. Chan, Hong Han, Xiaowei Wang, Patricia Mero, John H. Brumell, Antonio Finelli, Laurie Ailles, Gary Bader, Gromoslaw A. Smolen, Gillian A. Kingsbury, Traver Hart, Charles Kung, Jason Moffat

Nature. Author manuscript; available in PMC 2022 Apr 18.

Published in final edited form as: Nature. 2020 Oct; 586(7827): 120–126. Published online 2020 Sep 23. doi: 10.1038/s41586-020-2746-2