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Select item 111594031.

Roles of cyclooxygenase‐2 and microsomal prostaglandin E synthase‐1 expression and β‐catenin activation in gastric carcinogenesis in N‐methyl‐N‐nitrosourea‐treated K19‐C2mE transgenic mice

Shinji Takasu, Tetsuya Tsukamoto, Xue‐Yuan Cao, Takeshi Toyoda, Akihiro Hirata, Hisayo Ban, Masami Yamamoto, Hiroki Sakai, Tokuma Yanai, Toshiaki Masegi, Masanobu Oshima, Masae Tatematsu

Cancer Sci. 2008 Dec; 99(12): 2356–2364. Published online 2008 Nov 19. doi: 10.1111/j.1349-7006.2008.00983.x

PMCID:: PMC11159403

Abstract Article PDF–393K

Select item 111579402.

mPGES-1 Deletion Retards Renal Disease Progression but Exacerbates Anemia in Mice with Renal Mass Reduction

Zhanjun Jia, Haiping Wang, Tianxin Yang

Hypertension. Author manuscript; available in PMC 2024 Jun 7.

Published in final edited form as: Hypertension. 2012 Jan; 59(1): 122–128. Published online 2011 Nov 21. doi: 10.1161/HYPERTENSIONAHA.111.178897

PMCID:: PMC11157940

Abstract Article PDF–864K

Select item 107882693.

Epigenetic repression of Cend1 by lysine-specific demethylase 1 is essential for murine heart development

Huahua Liu, Rui Zhou, Shanshan Li, Jinling Dong, Yuan Fang, Yuru Luo, Hongyu Su, Baochang Lai, Lingli Liang, Donghong Zhang, Yanmin Zhang, John Y-J. Shyy, Bin Zhou, Zuyi Yuan, Yidong Wang

iScience. 2024 Jan 19; 27(1): 108722. Published online 2023 Dec 13. doi: 10.1016/j.isci.2023.108722

PMCID:: PMC10788269

Abstract Article PDF–11M

Select item 98754324.

Transient inhibition of microsomal prostaglandin E synthase-1 after status epilepticus blunts brain inflammation and is neuroprotective

Nelufar Yasmen, Madison N. Sluter, Lexiao Li, Ying Yu, Jianxiong Jiang

Mol Brain. 2023; 16: 14. Published online 2023 Jan 25. doi: 10.1186/s13041-023-01008-y

PMCID:: PMC9875432

Abstract Article PDF–5.7M

Select item 97925705.

Biosynthesis of prostaglandin 15dPGJ₂ -glutathione and 15dPGJ₂-cysteine conjugates in macrophages and mast cells via MGST3

Julia Steinmetz-Späh, Jianyang Liu, Rajkumar Singh, Maria Ekoff, Sanjaykumar Boddul, Xiao Tang, Filip Bergqvist, Helena Idborg, Pascal Heitel, Elin Rönnberg, Daniel Merk, Fredrik Wermeling, Jesper Z. Haeggström, Gunnar Nilsson, Dieter Steinhilber, Karin Larsson, Marina Korotkova, Per-Johan Jakobsson

J Lipid Res. 2022 Dec; 63(12): 100310. Published online 2022 Nov 9. doi: 10.1016/j.jlr.2022.100310

PMCID:: PMC9792570

Abstract Article PDF–2.4M

Select item 94639396.

The Role of mPGES-1 in Promoting Granulation Tissue Angiogenesis Through Regulatory T-cell Accumulation

TETSUYA HYODO, YOSHIYA ITO, KANAKO HOSONO, SATOSHI UEMATSU, SHIZUO AKIRA, MASATAKA MAJIMA, AKIRA TAKEDA, HIDEKI AMANO

In Vivo. 2022 Sep-Oct; 36(5): 2061–2073. Published online 2022 Sep 3. doi: 10.21873/invivo.12932

PMCID:: PMC9463939

Abstract Article PDF–11M

Select item 84919507.

Phagocytes produce prostaglandin E₂ in response to cytosolic Listeria monocytogenes

Courtney E. McDougal, Zachary T. Morrow, Tighe Christopher, Seonyoung Kim, Drake Carter, David M. Stevenson, Daniel Amador-Noguez, Mark J. Miller, John-Demian Sauer

PLoS Pathog. 2021 Sep; 17(9): e1009493. Published online 2021 Sep 23. doi: 10.1371/journal.ppat.1009493

PMCID:: PMC8491950

Abstract Article PDF–2.3M

Select item 82115408.

Fever During Localized Inflammation in Mice Is Elicited by a Humoral Pathway and Depends on Brain Endothelial Interleukin-1 and Interleukin-6 Signaling and Central EP₃ Receptors

Anna Eskilsson, Kiseko Shionoya, David Engblom, Anders Blomqvist

J Neurosci. 2021 Jun 16; 41(24): 5206–5218. doi: 10.1523/JNEUROSCI.0313-21.2021

PMCID:: PMC8211540

Abstract Article PDF–5.4M

Select item 81754519.

Leukotriene D₄ paradoxically limits LTC₄-driven platelet activation and lung immunopathology

Tao Liu, Nora A. Barrett, Jun Nagai, Juying Lai, Chunli Feng, Joshua A. Boyce

J Allergy Clin Immunol. Author manuscript; available in PMC 2022 Jul 1.

Published in final edited form as: J Allergy Clin Immunol. 2021 Jul; 148(1): 195–208.e5. Published online 2020 Dec 4. doi: 10.1016/j.jaci.2020.10.041

PMCID:: PMC8175451

Abstract Article PDF–2.6M

Select item 751988710.

Mechanistic definition of the cardiovascular mPGES-1/COX-2/ADMA axis

Nicholas S Kirkby, Joan Raouf, Blerina Ahmetaj-Shala, Bin Liu, Sarah I Mazi, Matthew L Edin, Mark Geoffrey Chambers, Marina Korotkova, Xiaomeng Wang, Walter Wahli, Darryl C Zeldin, Rolf Nüsing, Yingbi Zhou, Per-Johan Jakobsson, Jane A Mitchell

Cardiovasc Res. 2020 Oct 1; 116(12): 1972–1980. Published online 2019 Nov 5. doi: 10.1093/cvr/cvz290

PMCID:: PMC7519887

Abstract Article PDF–928K

Select item 722574211.

Contribution of Prostaglandin Transporter OATP2A1/SLCO2A1 to Placenta-to-Maternal Hormone Signaling and Labor Induction

Mai Inagaki, Tomohiro Nishimura, Takeo Nakanishi, Hiroaki Shimada, Saki Noguchi, Shin-ichi Akanuma, Masanori Tachikawa, Ken-ichi Hosoya, Ikumi Tamai, Emi Nakashima, Masatoshi Tomi

iScience. 2020 May 22; 23(5): 101098. Published online 2020 Apr 27. doi: 10.1016/j.isci.2020.101098

PMCID:: PMC7225742

Abstract Article PDF–3.9M

Select item 714202112.

PTGES/PGE₂ signaling links immunosuppression and lung metastasis in Gprc5a-knockout mouse model

Tong Wang, Bo Jing, Dongliang Xu, Yueling Liao, Hongyong Song, Beibei Sun, Wenzheng Guo, Jianhua Xu, Kaimi Li, Min Hu, Shuli Liu, Jing Ling, Yanbin Kuang, Tuo Zhang, Siwei Zhang, Feng Yao, Binhua P. Zhou, Jiong Deng

Oncogene. 2020; 39(15): 3179–3194. Published online 2020 Feb 14. doi: 10.1038/s41388-020-1207-6

PMCID:: PMC7142021

Abstract Article PDF–5.7M

Select item 708412013.

Cyp2c44 regulates prostaglandin synthesis, lymphangiogenesis, and metastasis in a mouse model of breast cancer

Rushendhiran Kesavan, Timo Frömel, Sven Zukunft, Hebatullah Laban, Alexandra Geyer, Zumer Naeem, Juliana Heidler, Ilka Wittig, Eiman Elwakeel, Bernhard Brüne, Andreas Weigert, Rüdiger Popp, Ingrid Fleming

Proc Natl Acad Sci U S A. 2020 Mar 17; 117(11): 5923–5930. Published online 2020 Mar 2. doi: 10.1073/pnas.1921381117

PMCID:: PMC7084120

Abstract Article PDF–2.0M

Select item 689406114.

Inhibition of human microsomal PGE2 synthase-1 reduces seizure-induced increases of P-glycoprotein expression and activity at the blood-brain barrier

Emma L. B. Soldner, Anika M. S. Hartz, Shin-Ichi Akanuma, Anton Pekcec, Henri Doods, Richard J. Kryscio, Ken-Ichi Hosoya, Björn Bauer

FASEB J. 2019 Dec; 33(12): 13966–13981. Published online 2019 Oct 22. doi: 10.1096/fj.201901460RR

PMCID:: PMC6894061

Abstract Article

Select item 666609315.

Inducible Prostaglandin E₂ Synthesis Interacts in a Temporally Supplementary Sequence with Constitutive Prostaglandin-Synthesizing Enzymes in Creating the Hypothalamic–Pituitary–Adrenal Axis Response to Immune Challenge

Louise Elander, Linda Engström, Johan Ruud, Ludmila Mackerlova, Per-Johan Jakobsson, David Engblom, Camilla Nilsberth, Anders Blomqvist

J Neurosci. 2009 Feb 4; 29(5): 1404–1413. doi: 10.1523/JNEUROSCI.5247-08.2009

PMCID:: PMC6666093

Abstract Article PDF–570K

Select item 654070316.

Myeloid Cell mPges-1 Deletion Attenuates Mortality Without Affecting Remodeling After Acute Myocardial Infarction in Mice

Lihong Chen, Guangrui Yang, Tingting Jiang, Soon Yew Tang, Tao Wang, Qing Wan, Miao Wang, Garret A. FitzGerald

J Pharmacol Exp Ther. 2019 Jul; 370(1): 18–24. Published online 2019 Jul. doi: 10.1124/jpet.118.256057

PMCID:: PMC6540703

Abstract Article PDF–801K

Select item 647887317.

The cyclooxygenase-1/mPGES-1/endothelial prostaglandin EP4 receptor pathway constrains myocardial ischemia-reperfusion injury

Liyuan Zhu, Chuansheng Xu, Xingyu Huo, Huifeng Hao, Qing Wan, Hong Chen, Xu Zhang, Richard M. Breyer, Yu Huang, Xuetao Cao, De-Pei Liu, Garret A. FitzGerald, Miao Wang

Nat Commun. 2019; 10: 1888. Published online 2019 Apr 23. doi: 10.1038/s41467-019-09492-4