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Select item 116146891.

Single-cell m⁶A profiling in the mouse brain uncovers cell type-specific RNA methylomes and age-dependent differential methylation

Matthew Tegowski, Anna K. Prater, Christopher L. Holley, Kate D. Meyer

Nat Neurosci. Author manuscript; available in PMC 2024 Dec 4.

Published in final edited form as: Nat Neurosci. 2024 Dec; 27(12): 2512–2520. Published online 2024 Sep 24. doi: 10.1038/s41593-024-01768-3

PMCID:: PMC11614689

Abstract Article PDF–5.2M

Select item 114132352.

MFSD7C protects hemolysis-induced lung impairments by inhibiting ferroptosis

Huirui Wang, Xiaona You, Jingcheng Wang, Xinyi Chen, Yinghui Gao, Mengmeng Wang, Wenru Zhang, Jiaozhen Zhang, Yang Yu, Bo Han, Mei Qi, Xiaohui Liu, Hongxiang Lou, Ting Dong

Nat Commun. 2024; 15: 8226. Published online 2024 Sep 19. doi: 10.1038/s41467-024-52537-6

PMCID:: PMC11413235

Abstract Article PDF–3.6M

Select item 113418183.

Multiple endocrine defects in adult-onset Sprouty1/2/4 triple knockout mice

Gisela Altés, Anna Olomí, Aida Perramon-Güell, Sara Hernández, Anna Casanovas, Aurora Pérez, Juan Miguel Díaz-Tocados, José Manuel Valdivielso, Cristina Megino, Raúl Navaridas, Xavier Matias-Guiu, Ophir D. Klein, Joaquim Egea, Xavi Dolcet, Andrée Yeramian, Mario Encinas

Sci Rep. 2024; 14: 19479. Published online 2024 Aug 22. doi: 10.1038/s41598-024-70529-w

PMCID:: PMC11341818

Abstract Article PDF–2.8M

Select item 112636434.

The ATP-exporting channel Pannexin 1 promotes CD8⁺ T cell effector and memory responses

Trupti Vardam-Kaur, Alma Banuelos, Maria Gabaldon-Parish, Bruna Gois Macedo, Caio Loureiro Salgado, Kelsey Marie Wanhainen, Maggie Hanqi Zhou, Sarah van Dijk, Igor Santiago-Carvalho, Angad S. Beniwal, Chloe L. Leff, Changwei Peng, Nhan L. Tran, Stephen C. Jameson, Henrique Borges da Silva

iScience. 2024 Jul 19; 27(7): 110290. Published online 2024 Jun 17. doi: 10.1016/j.isci.2024.110290

PMCID:: PMC11263643

Abstract Article PDF–5.1M

Select item 112002725.

Nrg1 intracellular signaling regulates the development of interhemispheric callosal axons in mice

Ángela Rodríguez-Prieto, Isabel Mateos-White, Mar Aníbal-Martínez, Carmen Navarro-González, Cristina Gil-Sanz, Yaiza Domínguez-Canterla, Ana González-Manteiga, Verónica Del Buey Furió, Guillermina López-Bendito, Pietro Fazzari

Life Sci Alliance. 2024 Sep; 7(9): e202302250. Published online 2024 Jun 25. doi: 10.26508/lsa.202302250

PMCID:: PMC11200272

Abstract Article PDF–2.6M

Select item 111564126.

Malic enzyme 1 knockout has no deleterious phenotype and is favored in the male germline under standard laboratory conditions

Jonathan M. Alektiar, Mengrou Shan, Megan D. Radyk, Li Zhang, Christopher J. Halbrook, Lin Lin, Carlos Espinoza, Ivan F. Mier, Brooke L. Lavoie, Lucie Salvatore, Marina Pasca di Magliano, Lewis C. Cantley, Jacob L. Mueller, Costas A. Lyssiotis

PLoS One. 2024; 19(6): e0303577. Published online 2024 Jun 6. doi: 10.1371/journal.pone.0303577

PMCID:: PMC11156412

Abstract Article PDF–2.1M

Select item 111481227.

Conditional deficiency of Rho‐associated kinases disrupts endothelial cell junctions and impairs respiratory function in adult mice

Takahiro Akamine, Takeshi Terabayashi, Takako Sasaki, Riku Hayashi, Ichitaro Abe, Fumihiro Hirayama, Shin‐ichi Nureki, Masahito Ikawa, Haruhiko Miyata, Akinori Tokunaga, Takashi Kobayashi, Katsuhiro Hanada, Dean Thumkeo, Shuh Narumiya, Toshimasa Ishizaki

FEBS Open Bio. 2024 Jun; 14(6): 906–921. Published online 2024 Apr 11. doi: 10.1002/2211-5463.13802

PMCID:: PMC11148122

Abstract Article PDF–12M

Select item 110936128.

Excess glucocorticoids inhibit murine bone turnover via modulating the immunometabolism of the skeletal microenvironment

Xu Li, Tongzhou Liang, Bingyang Dai, Liang Chang, Yuan Zhang, Shiwen Hu, Jiaxin Guo, Shunxiang Xu, Lizhen Zheng, Hao Yao, Hong Lian, Yu Nie, Ye Li, Xuan He, Zhi Yao, Wenxue Tong, Xinluan Wang, Dick Ho Kiu Chow, Jiankun Xu, Ling Qin

J Clin Invest. 2024 May 15; 134(10): e166795. Published online 2024 Mar 21. doi: 10.1172/JCI166795

PMCID:: PMC11093612

Abstract Article PDF–27M

Select item 110812249.

ΔNp63 regulates Sfrp1 expression to direct salivary gland branching morphogenesis

Theresa Wrynn, Sangwon Min, Erich Horeth, Jason Osinski, Satrajit Sinha, Rose-Anne Romano

PLoS One. 2024; 19(5): e0301082. Published online 2024 May 9. doi: 10.1371/journal.pone.0301082

PMCID:: PMC11081224

Abstract Article PDF–7.0M

Select item 1102288610.

Viable mutations of mouse midnolin suppress B cell malignancies

Xue Zhong, Nagesh Peddada, James J. Moresco, Jianhui Wang, Yiao Jiang, Jonathan J. Rios, Eva Marie Y. Moresco, Jin Huk Choi, Bruce Beutler

J Exp Med. 2024 Jun 3; 221(6): e20232132. Published online 2024 Apr 16. doi: 10.1084/jem.20232132

PMCID:: PMC11022886

Abstract Article PDF–7.7M

Select item 1099452911.

Temporal manipulation of the Scn1a gene reveals its essential role in adult brain function

Claudia Di Berardino, Martina Mainardi, Simone Brusco, Elena Benvenuto, Vania Broccoli, Gaia Colasante

Brain. 2024 Apr; 147(4): 1216–1230. Published online 2023 Oct 10. doi: 10.1093/brain/awad350

PMCID:: PMC10994529

Abstract Article PDF–1.0M

Select item 1097275012.

Resilient anatomy and local plasticity of naive and stress haematopoiesis

Qingqing Wu, Jizhou Zhang, Sumit Kumar, Siyu Shen, Morgan Kincaid, Courtney B. Johnson, Yanan Sophia Zhang, Raphaël Turcotte, Clemens Alt, Kyoko Ito, Shelli Homan, Bryan E. Sherman, Tzu-Yu Shao, Anastasiya Slaughter, Benjamin Weinhaus, Baobao Song, Marie Dominique Filippi, H. Leighton Grimes, Charles P. Lin, Keisuke Ito, Sing Sing Way, J. Matthew Kofron, Daniel Lucas

Nature. 2024; 627(8005): 839–846. Published online 2024 Mar 20. doi: 10.1038/s41586-024-07186-6

PMCID:: PMC10972750

Abstract Article PDF–146M

Select item 1094957613.

Cre-LoxP and tamoxifen-induced deletion of ovarian quiescin sulfhydryl oxidase 2 showed disruption of ovulatory activity in mice

Shih-Yun Chen, Tse-En Wang, Wei-Yun Lee, Ya-Yi Yang, Hong-Chun Lai, Fuko Matsuda, Haruhiko Kosek, You-Tzung Chen, Sheng-Hsiang Li, Pei-Shiue Tsai

J Ovarian Res. 2024; 17: 66. Published online 2024 Mar 19. doi: 10.1186/s13048-024-01388-2

PMCID:: PMC10949576

Abstract Article PDF–6.8M

Select item 1094364614.

Differential depletion of GluN2A induces heterogeneous schizophrenia-related phenotypes in mice

Yi Lu, Longyu Mu, Justin Elstrott, Chaoying Fu, Cailu Sun, Tonghui Su, Xiaofan Ma, Jia Yan, Hong Jiang, Jesse E. Hanson, Yang Geng, Yelin Chen

eBioMedicine. 2024 Apr; 102: 105045. Published online 2024 Mar 11. doi: 10.1016/j.ebiom.2024.105045

PMCID:: PMC10943646

Abstract Article PDF–2.1M

Select item 1088106215.

X-CHIME enables combinatorial, inducible, lineage-specific, and sequential knockout of genes in the immune system

Martin W. LaFleur, Ashlyn M. Lemmen, Ivy S.L. Streeter, Thao H. Nguyen, Lauren E. Milling, Nicole M. Derosia, Zachary M. Hoffman, Jacob E. Gillis, Qin Tjokrosurjo, Samuel C. Markson, Amy Y. Huang, Praju V. Anekal, Paula Montero Llopis, W. Nicholas Haining, John G. Doench, Arlene H. Sharpe

Nat Immunol. Author manuscript; available in PMC 2024 Jul 1.

Published in final edited form as: Nat Immunol. 2024 Jan; 25(1): 178–188. Published online 2023 Nov 27. doi: 10.1038/s41590-023-01689-6

PMCID:: PMC10881062

Abstract Article PDF–6.0M

Select item 1084175716.

TGFB1 Induces Fetal Reprogramming and Enhances Intestinal Regeneration

Lei Chen, Xia Qiu, Abigail Dupre, Oscar Pellon-Cardenas, Xiaojiao Fan, Xiaoting Xu, Prateeksha Rout, Katherine D. Walton, Joseph Burclaff, Ruolan Zhang, Wenxin Fang, Rachel Ofer, Alexandra Logerfo, Kiranmayi Vemuri, Sheila Bandyopadhyay, Jianming Wang, Gaetan Barbet, Yan Wang, Nan Gao, Ansu O. Perekatt, Wenwei Hu, Scott T. Magness, Jason R. Spence, Michael P. Verzi

Cell Stem Cell. Author manuscript; available in PMC 2024 Nov 2.

Published in final edited form as: Cell Stem Cell. 2023 Nov 2; 30(11): 1520–1537.e8. Published online 2023 Oct 20. doi: 10.1016/j.stem.2023.09.015

PMCID:: PMC10841757

Abstract Article PDF–4.4M

Select item 1082266917.

Reprogramming of tumor-associated macrophages via NEDD4-mediated CSF1R degradation by targeting USP18

Sayuri Miyauchi, Kei-ichiro Arimoto, Mengdan Liu, Yue Zhang, Dong-Er Zhang

Cell Rep. Author manuscript; available in PMC 2024 Jan 28.

Published in final edited form as: Cell Rep. 2023 Dec 26; 42(12): 113560. Published online 2023 Dec 13. doi: 10.1016/j.celrep.2023.113560

PMCID:: PMC10822669

Abstract Article PDF–2.5M

Select item 1080781518.

Endogenous retroviruses shape pluripotency specification in mouse embryos

Sergio de la Rosa, María del Mar Rigual, Pierfrancesco Vargiu, Sagrario Ortega, Nabil Djouder

Sci Adv. 2024 Jan 26; 10(4): eadk9394. Published online 2024 Jan 24. doi: 10.1126/sciadv.adk9394

PMCID:: PMC10807815

Abstract Article PDF–23M

Select item 1075026819.

Microenvironmental CXCL12 Deletion Enhances Flt3-ITD Acute Myeloid Leukemia Stem Cell Response to Therapy by Reducing p38 MAPK Signaling

Nicholas R. Anderson, Vipul Sheth, Hui Li, Mason W. Harris, Shaowei Qiu, David K. Crossman, Harish Kumar, Puneet Agarwal, Takashi Nagasawa, Andrew J. Paterson, Robert S. Welner, Ravi Bhatia

Leukemia. Author manuscript; available in PMC 2023 Dec 26.

Published in final edited form as: Leukemia. 2023 Mar; 37(3): 560–570. Published online 2022 Dec 22. doi: 10.1038/s41375-022-01798-5

PMCID:: PMC10750268

Abstract Article PDF–1.3M

Select item 1071615520.

Late gene therapy limits the restoration of retinal function in a mouse model of retinitis pigmentosa

Miranda L. Scalabrino, Mishek Thapa, Tian Wang, Alapakkam P. Sampath, Jeannie Chen, Greg D. Field

Nat Commun. 2023; 14: 8256. Published online 2023 Dec 12. doi: 10.1038/s41467-023-44063-8

PMCID:: PMC10716155

Abstract Article PDF–3.1M

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