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Select item 111094831.

K48- and K63-linked ubiquitin chain interactome reveals branch- and length-specific ubiquitin interactors

Anita Waltho, Oliver Popp, Christopher Lenz, Lukas Pluska, Mahil Lambert, Volker Dötsch, Philipp Mertins, Thomas Sommer

Life Sci Alliance. 2024 Aug; 7(8): e202402740. Published online 2024 May 21. doi: 10.26508/lsa.202402740

PMCID:: PMC11109483

Abstract Article PDF–2.9M

Select item 104838612.

Systematic analysis of RNASET2 gene as a potential prognostic and immunological biomarker in clear cell renal cell carcinoma

Yifu Liu, Zhicheng Zhang, Ping Xi, Ru Chen, Xiaofeng Cheng, Ji Liu, Qiqi Zhu, Yechen Nie, Ting Sun, Binbin Gong, Siyuan Wang

BMC Cancer. 2023; 23: 837. Published online 2023 Sep 7. doi: 10.1186/s12885-023-11356-6

PMCID:: PMC10483861

Abstract Article PDF–8.5M

Select item 100683293.

HIF2α‐induced upregulation of RNASET2 promotes triglyceride synthesis and enhances cell migration in clear cell renal cell carcinoma

Yanmei Quan, Jun Dai, Sian Zhou, Lingyi Zhao, Lixing Jin, Yijing Long, Siwei Liu, Yanqin Hu, Yue Liu, Juping Zhao, Zhide Ding

FEBS Open Bio. 2023 Apr; 13(4): 638–654. Published online 2023 Feb 12. doi: 10.1002/2211-5463.13570

PMCID:: PMC10068329

Abstract Article PDF–6.2M

Select item 97092814.

Diagnostic and therapeutic potential of RNASET2 in Crohn’s disease: Disease-risk polymorphism modulates allelic-imbalance in expression and circulating protein levels and recombinant-RNASET2 attenuates pro-inflammatory cytokine secretion

Eva Biener-Ramanujan, Florian Rosier, Simon G. Coetzee, Dermot D. P. McGovern, Dennis Hazelett, Stephan R. Targan, Rivkah Gonsky

Front Immunol. 2022; 13: 999155. Published online 2022 Nov 16. doi: 10.3389/fimmu.2022.999155

PMCID:: PMC9709281

Abstract Article PDF–4.0M

Select item 94091345.

Human RNASET2: A Highly Pleiotropic and Evolutionary Conserved Tumor Suppressor Gene Involved in the Control of Ovarian Cancer Pathogenesis

Antonino Bruno, Douglas M. Noonan, Roberto Valli, Giovanni Porta, Roberto Taramelli, Lorenzo Mortara, Francesco Acquati

Int J Mol Sci. 2022 Aug; 23(16): 9074. Published online 2022 Aug 13. doi: 10.3390/ijms23169074

PMCID:: PMC9409134

Abstract Article PDF–271K

Select item 83038976.

Hypoxia Enhances the Expression of RNASET2 in Human Monocyte-Derived Dendritic Cells: Role of PI3K/AKT Pathway

Sara Monaci, Federica Coppola, Gaia Giuntini, Rossella Roncoroni, Francesco Acquati, Silvano Sozzani, Fabio Carraro, Antonella Naldini

Int J Mol Sci. 2021 Jul; 22(14): 7564. Published online 2021 Jul 15. doi: 10.3390/ijms22147564

PMCID:: PMC8303897

Abstract Article PDF–1.9M

Select item 81650307.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 79948448.

FBXO6-mediated RNASET2 ubiquitination and degradation governs the development of ovarian cancer

Mei Ji, Zhao Zhao, Yue Li, Penglin Xu, Jia Shi, Zhe Li, Kaige Wang, Xiaotian Huang, Bin Liu

Cell Death Dis. 2021 Apr; 12(4): 317. Published online 2021 Mar 25. doi: 10.1038/s41419-021-03580-4

PMCID:: PMC7994844

Abstract Article PDF–2.4M

Select item 76060089.

BCAR1 promotes proliferation and cell growth in lung adenocarcinoma via upregulation of POLR2A

Chun‐guo Mao, Sha‐sha Jiang, Cheng Shen, Tan Long, Hua Jin, Qun‐You Tan, Bo Deng

Thorac Cancer. 2020 Nov; 11(11): 3326–3336. Published online 2020 Oct 1. doi: 10.1111/1759-7714.13676

PMCID:: PMC7606008

Abstract Article PDF–2.5M

Select item 722508610.

Zebrafish disease model of human RNASET2-deficient cystic leukoencephalopathy displays abnormalities in early microglia

Thomas Weber, Lars Schlotawa, Roland Dosch, Noémie Hamilton, Jens Kaiser, Stina Schiller, Britta Wenske, Jutta Gärtner, Marco Henneke

Biol Open. 2020 May 15; 9(5): bio049239. Published online 2020 May 7. doi: 10.1242/bio.049239

PMCID:: PMC7225086

Abstract Article PDF–14M

Select item 711600511.

TLR8 is a sensor of RNase T2 degradation products

Wilhelm Greulich, Mirko Wagner, Moritz M. Gaidt, Che Stafford, Yiming Cheng, Andreas Linder, Thomas Carell, Veit Hornung

Cell. Author manuscript; available in PMC 2020 Nov 27.

Published in final edited form as: Cell. 2019 Nov 27; 179(6): 1264–1275.e13. doi: 10.1016/j.cell.2019.11.001

PMCID:: PMC7116005

Abstract Article PDF–2.0M

Select item 681721012.

RNASET2,GPR174, and PTPN22 gene polymorphisms are related to the risk of liver damage associated with the hyperthyroidism in patients with Graves’ disease

Qing Zhang, Shaozheng Liu, Yanxing Guan, Qingjie Chen, Qing Zhang, Xiang Min

J Clin Lab Anal. 2018 Feb; 32(2): e22258. Published online 2017 May 31. doi: 10.1002/jcla.22258

PMCID:: PMC6817210

Abstract Article PDF–452K

Select item 677813713.

The midbody interactome reveals unexpected roles for PP1 phosphatases in cytokinesis

Luisa Capalbo, Zuni I. Bassi, Marco Geymonat, Sofia Todesca, Liviu Copoiu, Anton J. Enright, Giuliano Callaini, Maria Giovanna Riparbelli, Lu Yu, Jyoti S. Choudhary, Enrico Ferrero, Sally Wheatley, Max E. Douglas, Masanori Mishima, Pier Paolo D’Avino

Nat Commun. 2019; 10: 4513. Published online 2019 Oct 4. doi: 10.1038/s41467-019-12507-9

PMCID:: PMC6778137

Abstract Article PDF–7.8M

Select item 631414014.

Regulation of mitochondrion-associated cytosolic ribosomes by mammalian mitochondrial ribonuclease T2 (RNASET2)

Jinliang Huang, Peipei Liu, Geng Wang

J Biol Chem. 2018 Dec 21; 293(51): 19633–19644. Published online 2018 Nov 1. doi: 10.1074/jbc.RA118.005433

PMCID:: PMC6314140

Abstract Article PDF–3.7M

Select item 567858115.

RNA-binding activity of TRIM25 is mediated by its PRY/SPRY domain and is required for ubiquitination

Nila Roy Choudhury, Gregory Heikel, Maryia Trubitsyna, Peter Kubik, Jakub Stanislaw Nowak, Shaun Webb, Sander Granneman, Christos Spanos, Juri Rappsilber, Alfredo Castello, Gracjan Michlewski

BMC Biol. 2017; 15: 105. Published online 2017 Nov 8. doi: 10.1186/s12915-017-0444-9

PMCID:: PMC5678581

Abstract Article PDF–3.2M

Select item 563674916.

Mammalian mitochondrial RNAs are degraded in the mitochondrial intermembrane space by RNASET2

Peipei Liu, Jinliang Huang, Qian Zheng, Leiming Xie, Xinping Lu, Jie Jin, Geng Wang

Protein Cell. 2017 Oct; 8(10): 735–749. Published online 2017 Jul 20. doi: 10.1007/s13238-017-0448-9

PMCID:: PMC5636749

Abstract Article PDF–2.0M

Select item 553161117.

Architecture of the human interactome defines protein communities and disease networks

Edward L. Huttlin, Raphael J. Bruckner, Joao A. Paulo, Joe R. Cannon, Lily Ting, Kurt Baltier, Greg Colby, Fana Gebreab, Melanie P. Gygi, Hannah Parzen, John Szpyt, Stanley Tam, Gabriela Zarraga, Laura Pontano-Vaites, Sharan Swarup, Anne E. White, Devin K. Schweppe, Ramin Rad, Brian K. Erickson, Robert A. Obar, K.G. Guruharsha, Kejie Li, Spyros Artavanis-Tsakonas, Steven P. Gygi, J. Wade Harper

Nature. Author manuscript; available in PMC 2017 Nov 17.

Published in final edited form as: Nature. 2017 May 25; 545(7655): 505–509. Published online 2017 May 17. doi: 10.1038/nature22366

PMCID:: PMC5531611

Abstract Article PDF–2.7M

Select item 548473318.

Association of RNASET2 Gene Polymorphisms with Decreased Expression and Clinical Characteristics of Severity in Crohn’s Disease

Rivkah Gonsky, Phillip Fleshner, Richard L. Deem, Eva Biener-Ramanujan, Dalin Li, Alka A. Potdar, Janine Bilsborough, Shaohong Yang, Dermot P.B. McGovern, Stephan R. Targan

Gastroenterology. Author manuscript; available in PMC 2018 Jul 1.

Published in final edited form as: Gastroenterology. 2017 Jul; 153(1): 219–232. Published online 2017 Apr 9. doi: 10.1053/j.gastro.2017.04.002

Correction in:: Gastroenterology. 2021 Nov 17

PMCID:: PMC5484733

Abstract Article PDF–1.0M

Select item 503652719.

Panorama of ancient metazoan macromolecular complexes

Cuihong Wan, Blake Borgeson, Sadhna Phanse, Fan Tu, Kevin Drew, Greg Clark, Xuejian Xiong, Olga Kagan, Julian Kwan, Alexandr Berzginov, Kyle Chessman, Swati Pal, Graham Cromar, Ophelia Papoulas, Zuyao Ni, Daniel R. Boutz, Snejana Stoilova, Pierre C. Havugimana, Xinghua Guo, Ramy H. Malty, Mihail Sarov, Jack Greenblatt, Mohan Babu, Brent Derry, Elisabeth Tillier, John B. Wallingford, John Parkinson, Edward M. Marcotte, Andrew Emili

Nature. Author manuscript; available in PMC 2016 Sep 26.

Published in final edited form as: Nature. 2015 Sep 17; 525(7569): 339–344. Published online 2015 Sep 7. doi: 10.1038/nature14877

PMCID:: PMC5036527

Abstract Article PDF–4.7M

Select item 461721120.

The BioPlex Network: A Systematic Exploration of the Human Interactome

Edward L. Huttlin, Lily Ting, Raphael J. Bruckner, Fana Gebreab, Melanie P. Gygi, John Szpyt, Stanley Tam, Gabriela Zarraga, Greg Colby, Kurt Baltier, Rui Dong, Virginia Guarani, Laura Pontano Vaites, Alban Ordureau, Ramin Rad, Brian K. Erickson, Martin Wühr, Joel Chick, Bo Zhai, Deepak Kolippakkam, Julian Mintseris, Robert A. Obar, Tim Harris, Spyros Artavanis-Tsakonas, Mathew E. Sowa, Pietro DeCamilli, Joao A. Paulo, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2016 Jul 16.

Published in final edited form as: Cell. 2015 Jul 16; 162(2): 425–440. doi: 10.1016/j.cell.2015.06.043

PMCID:: PMC4617211

Abstract Article PDF–2.2M

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