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Select item 109430201.

VHL suppresses autophagy and tumor growth through PHD1-dependent Beclin1 hydroxylation

Zheng Wang, Meisi Yan, Leiguang Ye, Qimin Zhou, Yuran Duan, Hongfei Jiang, Lei Wang, Yuan Ouyang, Huahe Zhang, Yuli Shen, Guimei Ji, Xiaohan Chen, Qi Tian, Liwei Xiao, Qingang Wu, Ying Meng, Guijun Liu, Leina Ma, Bo Lei, Zhimin Lu, Daqian Xu

EMBO J. 2024 Mar; 43(6): 931–955. Published online 2024 Feb 15. doi: 10.1038/s44318-024-00051-2

PMCID:: PMC10943020

Abstract Article PDF–7.2M

Select item 93485762.

Chr21 protein–protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer’s disease

Julia Viard, Yann Loe-Mie, Rachel Daudin, Malik Khelfaoui, Christine Plancon, Anne Boland, Francisco Tejedor, Richard L Huganir, Eunjoon Kim, Makoto Kinoshita, Guofa Liu, Volker Haucke, Thomas Moncion, Eugene Yu, Valérie Hindie, Henri Bléhaut, Clotilde Mircher, Yann Herault, Jean-François Deleuze, Jean-Christophe Rain, Michel Simonneau, Aude-Marie Lepagnol-Bestel

Life Sci Alliance. 2022 Dec; 5(12): e202101205. Published online 2022 Aug 1. doi: 10.26508/lsa.202101205

PMCID:: PMC9348576

Abstract Article PDF–3.0M

Select item 81650303.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 75418834.

Association of EGLN2 rs10680577 Polymorphism with the Risk and Clinicopathological Features of Patients with Prostate Cancer

Nahid Rahimi, Mahsa Azizi, Gholamreza Bahari, Behzad Narouie, Mohammad Hashemi

Asian Pac J Cancer Prev. 2020 May; 21(5): 1221–1226. doi: 10.31557/APJCP.2020.21.5.1221

PMCID:: PMC7541883

Abstract Article PDF–614K

Select item 73220675.

RIG-I regulates myeloid differentiation by promoting TRIM25-mediated ISGylation

Song-Fang Wu, Li Xia, Xiao-Dong Shi, Yu-Jun Dai, Wei-Na Zhang, Jun-Mei Zhao, Wu Zhang, Xiang-Qin Weng, Jing Lu, Huang-Ying Le, Sheng-ce Tao, Jiang Zhu, Zhu Chen, Yue-Ying Wang, Saijuan Chen

Proc Natl Acad Sci U S A. 2020 Jun 23; 117(25): 14395–14404. Published online 2020 Jun 8. doi: 10.1073/pnas.1918596117

PMCID:: PMC7322067

Abstract Article PDF–2.7M

Select item 68584556.

Prolyl hydroxylase substrate adenylosuccinate lyase is an oncogenic driver in triple negative breast cancer

Giada Zurlo, Xijuan Liu, Mamoru Takada, Cheng Fan, Jeremy M. Simon, Travis S. Ptacek, Javier Rodriguez, Alex von Kriegsheim, Juan Liu, Jason W. Locasale, Adam Robinson, Jing Zhang, Jessica M. Holler, Baek Kim, Marie Zikánová, Jörgen Bierau, Ling Xie, Xian Chen, Mingjie Li, Charles M. Perou, Qing Zhang

Nat Commun. 2019; 10: 5177. Published online 2019 Nov 15. doi: 10.1038/s41467-019-13168-4

PMCID:: PMC6858455

Abstract Article PDF–2.7M

Select item 67854347.

Association between an indel polymorphism within the distal promoter of EGLN2 and cancer risk: An updated meta‐analysis

Shulong Zhang, Kaihua Zhu, Zuoliang Zhang, Hui Wang, Xiaolong Wang

Mol Genet Genomic Med. 2019 Oct; 7(10): e00936. Published online 2019 Aug 15. doi: 10.1002/mgg3.936

PMCID:: PMC6785434

Abstract Article PDF–932K

Select item 67398668.

Lack of activity of recombinant HIF prolyl hydroxylases (PHDs) on reported non-HIF substrates

Matthew E Cockman, Kerstin Lippl, Ya-Min Tian, Hamish B Pegg, William D Figg, Jnr, Martine I Abboud, Raphael Heilig, Roman Fischer, Johanna Myllyharju, Christopher J Schofield, Peter J Ratcliffe

eLife. 2019; 8: e46490. Published online 2019 Sep 10. doi: 10.7554/eLife.46490

PMCID:: PMC6739866

Abstract Article PDF–4.0M

Select item 67310749.

Targeted and Interactome Proteomics Revealed the Role of PHD2 in Regulating BRD4 Proline Hydroxylation

Luke Erber, Ang Luo, Yue Chen

Mol Cell Proteomics. 2019 Sep; 18(9): 1772–1781. Published online 2019 Jun 25. doi: 10.1074/mcp.RA119.001535

PMCID:: PMC6731074

Abstract Article PDF–1.4M

Select item 655759010.

EGLN2 DNA methylation and expression interact with HIF1A to affect survival of early-stage NSCLC

Ruyang Zhang, Linjing Lai, Jieyu He, Chao Chen, Dongfang You, Weiwei Duan, Xuesi Dong, Ying Zhu, Lijuan Lin, Sipeng Shen, Yichen Guo, Li Su, Andrea Shafer, Sebastian Moran, Thomas Fleischer, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, Yongyue Wei, Feng Chen, David C. Christiani

Epigenetics. 2019; 14(2): 118–129. Published online 2019 Jan 31. doi: 10.1080/15592294.2019.1573066

PMCID:: PMC6557590

Abstract Article PDF–2.4M

Select item 603180711.

Detection of a 4-bp Insertion/deletion Polymorphism within the Promoter of EGLN2 Using Mismatch PCR-RFLP and Its Association with Susceptibility to Breast Cancer

Mohammad Hashemi, Hiva Danesh, Fatemeh Bizhani, Hedieh Sattarifard, Seyed Mehdi Hashemi, Gholamreza Bahari

Asian Pac J Cancer Prev. 2018; 19(4): 923–926. doi: 10.22034/APJCP.2018.19.4.923

PMCID:: PMC6031807

Abstract Article PDF–317K

Select item 599210412.

Comparative Protein Interaction Network Analysis Identifies Shared and Distinct Functions for the Human ROCO Proteins

James E. Tomkins, Sybille Dihanich, Alexandra Beilina, Raffaele Ferrari, Nicolò Ilacqua, Mark R. Cookson, Patrick A. Lewis, Claudia Manzoni

Proteomics. 2018 May; 18(10): 1700444. Published online 2018 Apr 17. doi: 10.1002/pmic.201700444

PMCID:: PMC5992104

Abstract Article PDF–1.2M

Select item 583350013.

TCF7L2 positively regulates aerobic glycolysis via the EGLN2/HIF-1α axis and indicates prognosis in pancreatic cancer

Jinfeng Xiang, Qiangsheng Hu, Yi Qin, Shunrong Ji, Wenyan Xu, Wensheng Liu, Si Shi, Chen Liang, Jiang Liu, Qingcai Meng, Dingkong Liang, Quanxing Ni, Jin Xu, Bo Zhang, Xianjun Yu

Cell Death Dis. 2018 Mar; 9(3): 321. Published online 2018 Feb 23. doi: 10.1038/s41419-018-0367-6

PMCID:: PMC5833500

Abstract Article PDF–2.5M

Select item 567858114.

RNA-binding activity of TRIM25 is mediated by its PRY/SPRY domain and is required for ubiquitination

Nila Roy Choudhury, Gregory Heikel, Maryia Trubitsyna, Peter Kubik, Jakub Stanislaw Nowak, Shaun Webb, Sander Granneman, Christos Spanos, Juri Rappsilber, Alfredo Castello, Gracjan Michlewski

BMC Biol. 2017; 15: 105. Published online 2017 Nov 8. doi: 10.1186/s12915-017-0444-9

PMCID:: PMC5678581

Abstract Article PDF–3.2M

Select item 551170515.

Tumor suppressor SPOP ubiquitinates and degrades EglN2 to compromise growth of prostate cancer cells

Linli Zhang, Shan Peng, Xiangpeng Dai, Wenjian Gan, Xin Nie, Wenyi Wei, Guoqing Hu, Jianping Guo

Cancer Lett. Author manuscript; available in PMC 2017 Jul 16.

Published in final edited form as: Cancer Lett. 2017 Apr 1; 390: 11–20. Published online 2017 Jan 13. doi: 10.1016/j.canlet.2017.01.003

PMCID:: PMC5511705

Abstract Article PDF–1.5M

Select item 538464716.

An ID2-dependent mechanism for VHL inactivation in cancer

Sang Bae Lee, Veronique Frattini, Mukesh Bansal, Angelica M. Castano, Dan Sherman, Keino Hutchinson, Jeffrey N. Bruce, Andrea Califano, Guangchao Liu, Timothy Cardozo, Antonio Iavarone, Anna Lasorella

Nature. Author manuscript; available in PMC 2017 Apr 7.

Published in final edited form as: Nature. 2016 Jan 14; 529(7585): 172–177. Published online 2016 Jan 6. doi: 10.1038/nature16475

PMCID:: PMC5384647

Abstract Article PDF–1.3M

Select item 535166917.

EglN2 contributes to triple negative breast tumorigenesis by functioning as a substrate for the FBW7 tumor suppressor

Mamoru Takada, Ming Zhuang, Hiroyuki Inuzuka, Jing Zhang, Giada Zurlo, Jinfang Zhang, Qing Zhang

Oncotarget. 2017 Jan 24; 8(4): 6787–6795. Published online 2016 Dec 27. doi: 10.18632/oncotarget.14290

PMCID:: PMC5351669

Abstract Article PDF–3.3M

Select item 503405718.

Tuning the Transcriptional Response to Hypoxia by Inhibiting Hypoxia-inducible Factor (HIF) Prolyl and Asparaginyl Hydroxylases

Mun Chiang Chan, Nicholas E. Ilott, Johannes Schödel, David Sims, Anthony Tumber, Kerstin Lippl, David R. Mole, Christopher W. Pugh, Peter J. Ratcliffe, Chris P. Ponting, Christopher J. Schofield

J Biol Chem. 2016 Sep 23; 291(39): 20661–20673. Published online 2016 Aug 8. doi: 10.1074/jbc.M116.749291

PMCID:: PMC5034057

Abstract Article PDF–2.8M

Select item 484160719.

High-throughput analyses of hnRNP H1 dissects its multi-functional aspect

Philip J. Uren, Emad Bahrami-Samani, Patricia Rosa de Araujo, Christine Vogel, Mei Qiao, Suzanne C. Burns, Andrew D. Smith, Luiz O. F. Penalva

RNA Biol. 2016 Apr; 13(4): 400–411. Published online 2016 Jan 13. doi: 10.1080/15476286.2015.1138030

PMCID:: PMC4841607

Abstract Article PDF–1.6M

Select item 482360120.

Role of prolyl hydroxylase domain proteins in the regulation of insulin secretion

Mei Huang, Sabina Paglialunga, Julia M.‐K. Wong, Monica Hoang, Renjitha Pillai, Jamie W. Joseph

Physiol Rep. 2016 Mar; 4(5): e12722. Published online 2016 Mar 20. doi: 10.14814/phy2.12722

PMCID:: PMC4823601

Abstract Article PDF–488K

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