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Items: 1 to 20 of 61

1.
4EBP2-regulated protein translation has a critical role in high-fat diet–induced insulin resistance in hepatocytes
Xiao Han, Fei Yang, Zhengyi Zhang, Zhanwu Hou, Qiong Sun, Tian Su, Weiqiang Lv, Zhen Wang, Chao Yuan, Guanfei Zhang, Xin Pi, Jiangang Long, Huadong Liu
J Biol Chem. 2023 Nov; 299(11): 105315. Published online 2023 Oct 4. doi: 10.1016/j.jbc.2023.105315
PMCID:
PMC10641227
AbstractArticlePDF–4.2M
2.
Loss of 4E-BPs prevents the hindlimb immobilization-induced decrease in protein synthesis in skeletal muscle
Gregory N. Kincheloe, Paul A. Roberson, Allyson L. Toro, Bruce A. Stanley, Anne E. Stanley, Leonard S. Jefferson, Michael D. Dennis, Scot R. Kimball
J Appl Physiol (1985) 2023 Jan 1; 134(1): 72–83. Published online 2022 Dec 1. doi: 10.1152/japplphysiol.00563.2022
PMCID:
PMC9799152
AbstractArticle
3.
Activation of Disulfide Redox Switch in REDD1 Promotes Oxidative Stress Under Hyperglycemic Conditions
William P. Miller, Congzhou M. Sha, Siddharth Sunilkumar, Allyson L. Toro, Ashley M. VanCleave, Scot R. Kimball, Nikolay V. Dokholyan, Michael D. Dennis
Diabetes. 2022 Dec; 71(12): 2764–2776. Published online 2022 Sep 28. doi: 10.2337/db22-0355
PMCID:
PMC9750946
AbstractArticlePDF–6.8M
4.
The zinc finger/RING domain protein Unkempt regulates cognitive flexibility
Elin Vinsland, Pranetha Baskaran, Simeon R. Mihaylov, Carl Hobbs, Hannah Wood, Ihssane Bouybayoune, Kriti Shah, Corinne Houart, Andrew R. Tee, Jernej Murn, Cathy Fernandes, Joseph M. Bateman
Sci Rep. 2021; 11: 16299. Published online 2021 Aug 11. doi: 10.1038/s41598-021-95286-y
PMCID:
PMC8357790
AbstractArticlePDF–2.4M
5.
A p53-dependent translational program directs tissue-selective phenotypes in a model of ribosomopathies
Gerald C. Tiu, Craig H. Kerr, Craig M. Forester, Pallavi S. Krishnarao, Hannah D. Rosenblatt, Nitin Raj, Travis C. Lantz, Olena Zhulyn, Margot E. Bowen, Leila Shokat, Laura D. Attardi, Davide Ruggero, Maria Barna
Dev Cell. Author manuscript; available in PMC 2022 Jul 26.
Published in final edited form as: Dev Cell. 2021 Jul 26; 56(14): 2089–2102.e11. Published online 2021 Jul 8. doi: 10.1016/j.devcel.2021.06.013
PMCID:
PMC8319123
AbstractArticlePDF–2.5M
6.
4E-BP2–dependent translation in parvalbumin neurons controls epileptic seizure threshold
Vijendra Sharma, Rapita Sood, Danning Lou, Tzu-Yu Hung, Maxime Lévesque, Yelin Han, Jeremy Y. Levett, Peng Wang, Shravan Murthy, Shannon Tansley, Siyan Wang, Nadeem Siddiqui, Soroush Tahmasebi, Kobi Rosenblum, Massimo Avoli, Jean-Claude Lacaille, Nahum Sonenberg, Arkady Khoutorsky
Proc Natl Acad Sci U S A. 2021 Apr 13; 118(15): e2025522118. Published online 2021 Apr 5. doi: 10.1073/pnas.2025522118
PMCID:
PMC8053921
AbstractArticlePDF–2.4M
7.
BraInMap elucidates the macromolecular connectivity landscape of mammalian brain
Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili
Cell Syst. Author manuscript; available in PMC 2021 Apr 22.
Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003
Correction in:
Cell Syst. 2020 Aug 26; 11(2): 208.
PMCID:
PMC7938770
AbstractArticlePDF–2.0M
8.
Diabetes enhances translation of Cd40 mRNA in murine retinal Müller glia via a 4E-BP1/2–dependent mechanism
Sadie K. Dierschke, Allyson L. Toro, William P. Miller, Siddharth Sunilkumar, Michael D. Dennis
J Biol Chem. 2020 Jul 31; 295(31): 10831–10841. Published online 2020 May 31. doi: 10.1074/jbc.RA120.013711
PMCID:
PMC7397109
AbstractArticlePDF–1.8M
9.
Constitutive Interferon Attenuates RIPK1/3-Mediated Cytokine Translation
Hayley I. Muendlein, Joseph Sarhan, Beiyun C. Liu, Wilson M. Connolly, Stephen A. Schworer, Irina Smirnova, Amy Y. Tang, Vladimir Ilyukha, Jodie Pietruska, Soroush Tahmasebi, Nahum Sonenberg, Alexei Degterev, Alexander Poltorak
Cell Rep. Author manuscript; available in PMC 2020 Apr 25.
Published in final edited form as: Cell Rep. 2020 Jan 21; 30(3): 699–713.e4. doi: 10.1016/j.celrep.2019.12.073
PMCID:
PMC7183097
AbstractArticlePDF–2.7M
10.
Raptor-Mediated Proteasomal Degradation of Deamidated 4E-BP2 Regulates Postnatal Neuronal Translation and NF-κB Activity
Stella Kouloulia, Erik I. Hallin, Konstanze Simbriger, Inês S. Amorim, Gilliard Lach, Theoklitos Amvrosiadis, Kleanthi Chalkiadaki, Agniete Kampaite, Vinh Tai Truong, Mehdi Hooshmandi, Seyed Mehdi Jafarnejad, Paul Skehel, Petri Kursula, Arkady Khoutorsky, Christos G. Gkogkas
Cell Rep. 2019 Dec 10; 29(11): 3620–3635.e7. Published online 2019 Dec 10. doi: 10.1016/j.celrep.2019.11.023
PMCID:
PMC6915327
AbstractArticle
11.
Role of Translational Attenuation in Inherited Retinal Degeneration
Christopher R. Starr, Cyril N. A. Nyankerh, Xiaoping Qi, Yang Hu, Oleg S. Gorbatyuk, Nahum Sonenberg, Michael E. Boulton, Marina S. Gorbatyuk
Invest Ophthalmol Vis Sci. 2019 Nov; 60(14): 4849–4857. doi: 10.1167/iovs.19-27512
PMCID:
PMC6871337
AbstractArticlePDF–960K
12.
Inhibitory interneurons mediate autism-associated behaviors via 4E-BP2
Shane Wiebe, Anmol Nagpal, Vinh T. Truong, Jeehyun Park, Agnieszka Skalecka, Alexander J. He, Karine Gamache, Arkady Khoutorsky, Ilse Gantois, Nahum Sonenberg
Proc Natl Acad Sci U S A. 2019 Sep 3; 116(36): 18060–18067. Published online 2019 Aug 19. doi: 10.1073/pnas.1908126116
PMCID:
PMC6731681
AbstractArticlePDF–1.2M
13.
The Translation Repressor 4E-BP2 Is Critical for eIF4F Complex Formation, Synaptic Plasticity, and Memory in the Hippocampus
Jessica L. Banko, Francis Poulin, Lingfei Hou, Christine T. DeMaria, Nahum Sonenberg, Eric Klann
J Neurosci. 2005 Oct 19; 25(42): 9581–9590. doi: 10.1523/JNEUROSCI.2423-05.2005
PMCID:
PMC6725736
AbstractArticlePDF–653K
14.
Selective Regulation of GluA Subunit Synthesis and AMPA Receptor-Mediated Synaptic Function and Plasticity by the Translation Repressor 4E-BP2 in Hippocampal Pyramidal Cells
Israeli Ran, Christos G. Gkogkas, Cristina Vasuta, Maylis Tartas, Arkady Khoutorsky, Isabel Laplante, Armen Parsyan, Tatiana Nevarko, Nahum Sonenberg, Jean-Claude Lacaille
J Neurosci. 2013 Jan 30; 33(5): 1872–1886. doi: 10.1523/JNEUROSCI.3264-12.2013
PMCID:
PMC6619136
AbstractArticlePDF–1.6M
15.
Balanced mTORC1 Activity in Oligodendrocytes Is Required for Accurate CNS Myelination
Frédéric Lebrun-Julien, Lea Bachmann, Camilla Norrmén, Martin Trötzmüller, Harald Köfeler, Markus A. Rüegg, Michael N. Hall, Ueli Suter
J Neurosci. 2014 Jun 18; 34(25): 8432–8448. doi: 10.1523/JNEUROSCI.1105-14.2014
PMCID:
PMC6608214
AbstractArticlePDF–6.0M
16.
4E‐BP1 and 4E‐BP2 double knockout mice are protected from aging‐associated sarcopenia
Olivier Le Bacquer, Kristell Combe, Véronique Patrac, Brian Ingram, Lydie Combaret, Dominique Dardevet, Christophe Montaurier, Jérôme Salles, Christophe Giraudet, Christelle Guillet, Nahum Sonenberg, Yves Boirie, Stéphane Walrand
J Cachexia Sarcopenia Muscle. 2019 Jun; 10(3): 696–709. Published online 2019 Mar 29. doi: 10.1002/jcsm.12412
PMCID:
PMC6596930
AbstractArticlePDF–1.0M
17.
Removing 4E-BP Enables Synapses to Refine without Postsynaptic Activity
Yumaine Chong, Natasha Saviuk, Brigitte Pie, Nathan Basisty, Ryan K. Quinn, Birgit Schilling, Nahum Sonenberg, Ellis Cooper, A. Pejmun Haghighi
Cell Rep. Author manuscript; available in PMC 2019 Apr 25.
Published in final edited form as: Cell Rep. 2018 Apr 3; 23(1): 11–22. doi: 10.1016/j.celrep.2018.03.040
PMCID:
PMC6483372
AbstractArticlePDF–1.7M
18.
O-GlcNAcylation alters the selection of mRNAs for translation and promotes 4E-BP1–dependent mitochondrial dysfunction in the retina
Sadie K. Dierschke, William P. Miller, John S. Favate, Premal Shah, Yuka Imamura Kawasawa, Anna C. Salzberg, Scot R. Kimball, Leonard S. Jefferson, Michael D. Dennis
J Biol Chem. 2019 Apr 5; 294(14): 5508–5520. Published online 2019 Feb 7. doi: 10.1074/jbc.RA119.007494
PMCID:
PMC6462503
AbstractArticlePDF–2.7M
19.
4E-BP1 is a tumor suppressor protein reactivated by mTOR inhibition in head and neck cancer
Zhiyong Wang, Xiaodong Feng, Alfredo A. Molinolo, Daniel Martin, Lynn Vitale-Cross, Nijiro Nohata, Mizuo Ando, Amy Wahba, Panomwat Amornphimoltham, Xingyu Wu, Mara Gilardi, Michael Allevato, Victoria Wu, Dana J. Steffen, Philip Tofilon, Nahum Sonenberg, Joseph Califano, Qianming Chen, Scott M. Lippman, J. Silvio Gutkind
Cancer Res. Author manuscript; available in PMC 2020 Apr 1.
Published in final edited form as: Cancer Res. 2019 Apr 1; 79(7): 1438–1450. Published online 2019 Mar 20. doi: 10.1158/0008-5472.CAN-18-1220
PMCID:
PMC6445709
AbstractArticlePDF–2.7M
20.
mTOR regulates metabolic adaptation of APCs in the lung and controls the outcome of allergic inflammation
Charles Sinclair, Gayathri Bommakanti, Luiz Gardinassi, Jens Loebbermann, Matthew Joseph Johnson, Paul Hakimpour, Thomas Hagan, Lydia Benitez, Andrei Todor, Deepa Machiah, Timothy Oriss, Anuradha Ray, Steven Bosinger, Rajesh Ravindran, Shuzhao Li, Bali Pulendran
Science. Author manuscript; available in PMC 2018 Sep 8.
Published in final edited form as: Science. 2017 Sep 8; 357(6355): 1014–1021. Published online 2017 Aug 10. doi: 10.1126/science.aaj2155
PMCID:
PMC5746055
AbstractArticlePDF–1.8M

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