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Select item 102374221.

TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing

Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan

Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233

PMCID:: PMC10237422

Abstract Article PDF–23M

Select item 100389922.

Calpain activity is negatively regulated by a KCTD7–Cullin-3 complex via non-degradative ubiquitination

Jaiprakash Sharma, Shalaka Mulherkar, Uan-I Chen, Yan Xiong, Lakshya Bajaj, Byoung-Kyu Cho, Young Ah Goo, Hon-Chiu Eastwood Leung, Kimberley F. Tolias, Marco Sardiello

Cell Discov. 2023; 9: 32. Published online 2023 Mar 24. doi: 10.1038/s41421-023-00533-3

PMCID:: PMC10038992

Abstract Article PDF–15M

Select item 90588363.

The involvement of Parkin-dependent mitophagy in the anti-cancer activity of Ginsenoside

Xin Sun, Yeting Hong, Yuhan Shu, Caixia Wu, Guiqin Ye, Hanxiao Chen, Hongying Zhou, Ruilan Gao, Jianbin Zhang

J Ginseng Res. 2022 Mar; 46(2): 266–274. Published online 2021 Jul 8. doi: 10.1016/j.jgr.2021.06.009

PMCID:: PMC9058836

Abstract Article PDF–2.9M

Select item 85887474.

The C2 domain of calpain 5 contributes to enzyme activation and membrane localization

Vimala Bondada, Jozsef Gal, Charles Mashburn, David W. Rodgers, Katherine E. Larochelle, Dorothy E. Croall, James W. Geddes

Biochim Biophys Acta Mol Cell Res. Author manuscript; available in PMC 2022 Jun 1.

Published in final edited form as: Biochim Biophys Acta Mol Cell Res. 2021 Jun; 1868(7): 119019. Published online 2021 Mar 31. doi: 10.1016/j.bbamcr.2021.119019

PMCID:: PMC8588747

Abstract Article PDF–2.3M

Select item 81650305.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 77360696.

Whole-Exome Sequencing of Patients with Posterior Segment Uveitis

Angela S. Li, Gabriel Velez, Benjamin Darbro, Marcus A. Toral, Jing Yang, Stephen H. Tsang, Polly J. Ferguson, James C. Folk, Alexander G. Bassuk, Vinit B. Mahajan

Am J Ophthalmol. Author manuscript; available in PMC 2022 Jan 1.

Published in final edited form as: Am J Ophthalmol. 2021 Jan; 221: 246–259. Published online 2020 Jul 21. doi: 10.1016/j.ajo.2020.07.021

PMCID:: PMC7736069

Abstract Article PDF–2.4M

Select item 74934297.

CAPN5 genetic inactivation phenotype supports therapeutic inhibition trials

Katherine J. Wert, Susanne F. Koch, Gabriel Velez, Chun-Wei Hsu, MaryAnn Mahajan, Alexander G. Bassuk, Stephen H. Tsang, Vinit B. Mahajan

Hum Mutat. Author manuscript; available in PMC 2020 Sep 16.

Published in final edited form as: Hum Mutat. 2019 Dec; 40(12): 2377–2392. Published online 2019 Aug 26. doi: 10.1002/humu.23894

PMCID:: PMC7493429

Abstract Article PDF–2.0M

Select item 70017648.

Structural Insights into the Unique Activation Mechanisms of a Non-classical Calpain and Its Disease-Causing Variants

Gabriel Velez, Young Joo Sun, Saif Khan, Jing Yang, Jonathan Herrmann, Teja Chemudupati, Robert E. MacLaren, Lokesh Gakhar, Soichi Wakatsuki, Alexander G. Bassuk, Vinit B. Mahajan

Cell Rep. Author manuscript; available in PMC 2020 Feb 5.

Published in final edited form as: Cell Rep. 2020 Jan 21; 30(3): 881–892.e5. doi: 10.1016/j.celrep.2019.12.077

PMCID:: PMC7001764

Abstract Article PDF–2.8M

Select item 65275839.

Proteomic insight into the pathogenesis of CAPN5-vitreoretinopathy

Gabriel Velez, Jing Yang, Angela S. Li, Stephen H. Tsang, Alexander G. Bassuk, Vinit B. Mahajan

Sci Rep. 2019; 9: 7608. Published online 2019 May 20. doi: 10.1038/s41598-019-44031-7

PMCID:: PMC6527583

Abstract Article PDF–3.3M

Select item 605442710.

Capn5 Expression in the Healthy and Regenerating Zebrafish Retina

Cagney E. Coomer, Ann C. Morris

Invest Ophthalmol Vis Sci. 2018 Jul; 59(8): 3643–3654. doi: 10.1167/iovs.18-24278

PMCID:: PMC6054427

Abstract Article PDF–1.7M

Select item 605324711.

Hepatitis C virus enters liver cells using the CD81 receptor complex proteins calpain-5 and CBLB

Janina Bruening, Lisa Lasswitz, Pia Banse, Sina Kahl, Carine Marinach, Florian W. Vondran, Lars Kaderali, Olivier Silvie, Thomas Pietschmann, Felix Meissner, Gisa Gerold

PLoS Pathog. 2018 Jul; 14(7): e1007111. Published online 2018 Jul 19. doi: 10.1371/journal.ppat.1007111

PMCID:: PMC6053247

Abstract Article PDF–8.7M

Select item 598317512.

A novel de novo CAPN5 mutation in a patient with inflammatory vitreoretinopathy, hearing loss, and developmental delay

Gabriel Velez, Alexander G. Bassuk, Kellie A. Schaefer, Brian Brooks, Lokesh Gakhar, MaryAnn Mahajan, Philip Kahn, Stephen H. Tsang, Polly J. Ferguson, Vinit B. Mahajan

Cold Spring Harb Mol Case Stud. 2018 Jun; 4(3): a002519. doi: 10.1101/mcs.a002519

PMCID:: PMC5983175

Abstract Article PDF–16M

Select item 583915813.

Quantitative mapping of RNA-mediated nuclear estrogen receptor β interactome in human breast cancer cells

Giorgio Giurato, Giovanni Nassa, Annamaria Salvati, Elena Alexandrova, Francesca Rizzo, Tuula A. Nyman, Alessandro Weisz, Roberta Tarallo

Sci Data. 2018; 5: 180031. Published online 2018 Mar 6. doi: 10.1038/sdata.2018.31

PMCID:: PMC5839158

Abstract Article PDF–1.9M

Select item 553161114.

Architecture of the human interactome defines protein communities and disease networks

Edward L. Huttlin, Raphael J. Bruckner, Joao A. Paulo, Joe R. Cannon, Lily Ting, Kurt Baltier, Greg Colby, Fana Gebreab, Melanie P. Gygi, Hannah Parzen, John Szpyt, Stanley Tam, Gabriela Zarraga, Laura Pontano-Vaites, Sharan Swarup, Anne E. White, Devin K. Schweppe, Ramin Rad, Brian K. Erickson, Robert A. Obar, K.G. Guruharsha, Kejie Li, Spyros Artavanis-Tsakonas, Steven P. Gygi, J. Wade Harper

Nature. Author manuscript; available in PMC 2017 Nov 17.

Published in final edited form as: Nature. 2017 May 25; 545(7655): 505–509. Published online 2017 May 17. doi: 10.1038/nature22366

PMCID:: PMC5531611

Abstract Article PDF–2.7M

Select item 526093915.

Gsk3β and Tomm20 are substrates of the SCFFbxo7/PARK15 ubiquitin ligase associated with Parkinson's disease

Felipe Roberti Teixeira, Suzanne J. Randle, Shachi P. Patel, Tycho E.T. Mevissen, Grasilda Zenkeviciute, Tie Koide, David Komander, Heike Laman

Biochem J. 2016 Oct 15; 473(20): 3563–3580. Prepublished online 2016 Aug 8. Published online 2016 Oct 11. doi: 10.1042/BCJ20160387

PMCID:: PMC5260939

Abstract Article PDF–1.1M

Select item 511809516.

Small-angle x-ray scattering of calpain-5 reveals a highly open conformation among calpains

Lokesh Gakhar, Alexander G. Bassuk, Gabriel Velez, Saif Khan, Jing Yang, Stephen H. Tsang, Vinit B. Mahajan

J Struct Biol. Author manuscript; available in PMC 2017 Dec 1.

Published in final edited form as: J Struct Biol. 2016 Dec; 196(3): 309–318. Published online 2016 Jul 27. doi: 10.1016/j.jsb.2016.07.017

PMCID:: PMC5118095

Abstract Article PDF–1.1M

Select item 486810217.

Calpain-5 Expression in the Retina Localizes to Photoreceptor Synapses

Kellie A. Schaefer, Marcus A. Toral, Gabriel Velez, Allison J. Cox, Sheila A. Baker, Nicholas C. Borcherding, Diana F. Colgan, Vimala Bondada, Charles B. Mashburn, Chen-Guang Yu, James W. Geddes, Stephen H. Tsang, Alexander G. Bassuk, Vinit B. Mahajan

Invest Ophthalmol Vis Sci. 2016 May; 57(6): 2509–2521. Published online 2016 May 6. doi: 10.1167/iovs.15-18680

PMCID:: PMC4868102

Abstract Article PDF–2.0M

Select item 451262818.

CAPN5 mutation in hereditary uveitis: the R243L mutation increases calpain catalytic activity and triggers intraocular inflammation in a mouse model

Katherine J. Wert, Alexander G. Bassuk, Wen-Hsuan Wu, Lokesh Gakhar, Diana Coglan, MaryAnn Mahajan, Shu Wu, Jing Yang, Chyuan-Sheng Lin, Stephen H. Tsang, Vinit B. Mahajan

Hum Mol Genet. 2015 Aug 15; 24(16): 4584–4598. Published online 2015 May 20. doi: 10.1093/hmg/ddv189

PMCID:: PMC4512628

Abstract Article PDF–1.7M

Select item 439191819.

Structural Modeling of a Novel CAPN5 Mutation that Causes Uveitis and Neovascular Retinal Detachment

Bassuk Alexander G., Yeh Steven, Wu Shu, Martin Daniel F., Tsang Stephen H., Gakhar Lokesh, Mahajan Vinit B.

PLoS One. 2015; 10(4): e0122352. Published online 2015 Apr 9. doi: 10.1371/journal.pone.0122352

PMCID:: PMC4391918

Abstract Article PDF–2.3M

Select item 416979620.

CAPN5 gene silencing by short hairpin RNA interference

Nnamdi G Nelson, Jessica M Skeie, Hakim Muradov, Hannah A Rowell, Seongjin Seo, Vinit B Mahajan

BMC Res Notes. 2014; 7: 642. Published online 2014 Sep 12. doi: 10.1186/1756-0500-7-642

PMCID:: PMC4169796

Abstract Article PDF–777K

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