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Select item 116547381.

Overexpression of the LAT1 in primary human trophoblast cells increases the uptake of essential amino acids and activates mTOR signaling

Fredrick J Rosario, Johann Urschitz, Theresa L Powell, Thomas L Brown, Thomas Jansson

Clin Sci (Lond) Author manuscript; available in PMC 2024 Dec 18.

Published in final edited form as: Clin Sci (Lond). 2023 Nov 15; 137(21): 1651–1664. doi: 10.1042/CS20230490

PMCID:: PMC11654738

Abstract Article PDF–2.4M

Select item 114907122.

LAT1 supports mitotic progression through Golgi unlinking in an amino acid transport activity-independent manner

Sakura Yanagida, Ryuzaburo Yuki, Youhei Saito, Yuji Nakayama

J Biol Chem. 2024 Oct; 300(10): 107761. Published online 2024 Sep 11. doi: 10.1016/j.jbc.2024.107761

PMCID:: PMC11490712

Abstract Article PDF–2.9M

Select item 114140653.

TRIM35 triggers cardiac remodeling by regulating SLC7A5-mediated amino acid transport and mTORC1 activation in fibroblasts

Boshen Yang, Zhixiang Wang, Kaifan Niu, Taixi Li, Tingting Tong, Suiji Li, Liuhang Su, Yan Wang, Chengxing Shen, Xian Jin, Juan Song, Xia Lu

Cell Commun Signal. 2024; 22: 444. Published online 2024 Sep 20. doi: 10.1186/s12964-024-01826-0

PMCID:: PMC11414065

Abstract Article PDF–20M

Select item 113717174.

TP63 transcriptionally regulates SLC7A5 to suppress ferroptosis in head and neck squamous cell carcinoma

Zilong Chen, Haoxi Cai, Weiwei Ye, Junming Wu, Jing Liu, Yun Xie, Shiqiang Feng, Yuanpei Jin, Yunxia Lv, Hui Ye, Chengfu Cai, Gengming Cai

Front Immunol. 2024; 15: 1445472. Published online 2024 Aug 21. doi: 10.3389/fimmu.2024.1445472

PMCID:: PMC11371717

Abstract Article PDF–9.7M

Select item 113437655.

LAT1 expression in colorectal cancer cells is unresponsive to HIF-1/2α accumulation under experimental hypoxia

Ryuichi Ohgaki, Yuma Hirase, Minhui Xu, Hiroki Okanishi, Yoshikatsu Kanai

Sci Rep. 2024; 14: 19635. Published online 2024 Aug 23. doi: 10.1038/s41598-024-70603-3

PMCID:: PMC11343765

Abstract Article PDF–4.3M

Select item 112367336.

MRPL35 Induces Proliferation, Invasion, and Glutamine Metabolism in NSCLC Cells by Upregulating SLC7A5 Expression

Wei Hou, Juan Chen, Yaoyuan Wang

Clin Respir J. 2024 Jul; 18(7): e13799. Published online 2024 Jul 10. doi: 10.1111/crj.13799

PMCID:: PMC11236733

Abstract Article PDF–954K

Select item 112099357.

Antagonistic roles of canonical and alternative-RPA in disease-associated tandem CAG repeat instability

Terence Gall-Duncan, Jennifer Luo, Carla-Marie Jurkovic, Laura A. Fischer, Kyota Fujita, Amit L. Deshmukh, Rachel J. Harding, Stephanie Tran, Mustafa Mehkary, Vanessa Li, David E. Leib, Ran Chen, Hikari Tanaka, Amanda G. Mason, Dominique Lévesque, Mahreen Khan, Mortezaali Razzaghi, Tanya Prasolava, Stella Lanni, Nozomu Sato, Marie-Christine Caron, Gagan B. Panigrahi, Peixiang Wang, Rachel Lau, Arturo López Castel, Jean-Yves Masson, Lynette Tippett, Clinton Turner, Maria Spies, Albert R. La Spada, Eric I. Campos, Maurice A. Curtis, François-Michel Boisvert, Richard L.M. Faull, Beverly L. Davidson, Masayuki Nakamori, Hitoshi Okazawa, Marc S. Wold, Christopher E. Pearson

Cell. Author manuscript; available in PMC 2024 Oct 26.

Published in final edited form as: Cell. 2023 Oct 26; 186(22): 4898–4919.e25. Published online 2023 Oct 11. doi: 10.1016/j.cell.2023.09.008

PMCID:: PMC11209935

Abstract Article PDF–3.0M

Select item 111600218.

Production and characterization of highly tumor‐specific rat monoclonal antibodies recognizing the extracellular domain of human l‐type amino‐acid transporter 1

Yoshiya Ohno, Kentaro Suda, Kazue Masuko, Hideki Yagi, Yoshiyuki Hashimoto, Takashi Masuko

Cancer Sci. 2008 May; 99(5): 1000–1007. Published online 2008 Feb 24. doi: 10.1111/j.1349-7006.2008.00770.x

PMCID:: PMC11160021

Abstract Article PDF–954K

Select item 111597669.

l‐type amino acid transporter 1 and CD98 expression in primary and metastatic sites of human neoplasms

Kyoichi Kaira, Noboru Oriuchi, Hisao Imai, Kimihiro Shimizu, Noriko Yanagitani, Noriaki Sunaga, Takeshi Hisada, Shigebumi Tanaka, Tamotsu Ishizuka, Yoshikatsu Kanai, Hitoshi Endou, Takashi Nakajima, Masatomo Mori

Cancer Sci. 2008 Dec; 99(12): 2380–2386. Published online 2008 Nov 19. doi: 10.1111/j.1349-7006.2008.00969.x

PMCID:: PMC11159766

Abstract Article PDF–364K

Select item 1115921410.

Prognostic significance of L‐type amino acid transporter 1 (LAT1) and 4F2 heavy chain (CD98) expression in early stage squamous cell carcinoma of the lung

Kyoichi Kaira, Noboru Oriuchi, Hisao Imai, Kimihiro Shimizu, Noriko Yanagitani, Noriaki Sunaga, Takeshi Hisada, Tamotsu Ishizuka, Yoshikatsu Kanai, Hitoshi Endou, Takashi Nakajima, Masatomo Mori

Cancer Sci. 2009 Feb; 100(2): 249–254. Published online 2008 Dec 5. doi: 10.1111/j.1349-7006.2008.01029.x

PMCID:: PMC11159214

Abstract Article PDF–323K

Select item 1099027711.

ER-export and ARFRP1/AP-1–dependent delivery of SARS-CoV-2 Envelope to lysosomes controls late stages of viral replication

Guy J. Pearson, Harriet V. Mears, Malgorzata Broncel, Ambrosius P. Snijders, David L. V. Bauer, Jeremy G. Carlton

Sci Adv. 2024 Apr 5; 10(14): eadl5012. Published online 2024 Apr 3. doi: 10.1126/sciadv.adl5012

PMCID:: PMC10990277

Abstract Article PDF–3.9M

Select item 1098222512.

Fat mass and obesity-associated protein (FTO) mediated m⁶A modification of circFAM192A promoted gastric cancer proliferation by suppressing SLC7A5 decay

Xi Wu, Yuan Fang, Yunru Gu, Haoyang Shen, Yangyue Xu, Tingting Xu, Run Shi, Duo Xu, Jingxin Zhang, Kai Leng, Yongqian Shu, Pei Ma

Mol Biomed. 2024 Dec; 5: 11. Published online 2024 Apr 1. doi: 10.1186/s43556-024-00172-4

PMCID:: PMC10982225

Abstract Article PDF–5.9M

Select item 1091686613.

Cooperative polarization of MCAM/CD146 and ERM family proteins in melanoma

Suzannah G. Miller, Maria Hoh, Christopher C. Ebmeier, Jian Wei Tay, Natalie G. Ahn

Mol Biol Cell. 2024 Mar 1; 35(3): ar31. Published online 2024 Jan 29. doi: 10.1091/mbc.E23-06-0255

PMCID:: PMC10916866

Abstract Article PDF–4.7M

Select item 1079990314.

Proteomic analysis of SARS-CoV-2 particles unveils a key role of G3BP proteins in viral assembly

Emilie Murigneux, Laurent Softic, Corentin Aubé, Carmen Grandi, Delphine Judith, Johanna Bruce, Morgane Le Gall, François Guillonneau, Alain Schmitt, Vincent Parissi, Clarisse Berlioz-Torrent, Laurent Meertens, Maike M. K. Hansen, Sarah Gallois-Montbrun

Nat Commun. 2024; 15: 640. Published online 2024 Jan 20. doi: 10.1038/s41467-024-44958-0

PMCID:: PMC10799903

Abstract Article PDF–25M

Select item 1064152415.

Comparative proximity biotinylation implicates the small GTPase RAB18 in sterol mobilization and biosynthesis

Robert S. Kiss, Jarred Chicoine, Youssef Khalil, Robert Sladek, He Chen, Alessandro Pisaturo, Cyril Martin, Jessica D. Dale, Tegan A. Brudenell, Archith Kamath, Jeffrey Kyei-Boahen, Anouar Hafiane, Girija Daliah, Célia Alecki, Tayah S. Hopes, Martin Heier, Irene A. Aligianis, Jean-Jacques Lebrun, Julie Aspden, Emanuele Paci, Anja Kerksiek, Dieter Lütjohann, Peter Clayton, Jimi C. Wills, Alex von Kriegsheim, Tommy Nilsson, Eamonn Sheridan, Mark T. Handley

J Biol Chem. 2023 Nov; 299(11): 105295. Published online 2023 Sep 28. doi: 10.1016/j.jbc.2023.105295

PMCID:: PMC10641524

Abstract Article PDF–3.8M

Select item 1061767316.

The midnolin-proteasome pathway catches proteins for ubiquitination-independent degradation

Xin Gu, Christopher Nardone, Nolan Kamitaki, Aoyue Mao, Stephen J. Elledge, Michael E. Greenberg

Science. Author manuscript; available in PMC 2023 Oct 31.

Published in final edited form as: Science. 2023 Aug 25; 381(6660): eadh5021. Published online 2023 Aug 25. doi: 10.1126/science.adh5021

PMCID:: PMC10617673

Abstract Article PDF–3.6M

Select item 1050717717.

Targeting glutamine metabolic reprogramming of SLC7A5 enhances the efficacy of anti-PD-1 in triple-negative breast cancer

Renhong Huang, Han Wang, Jin Hong, Jiayi Wu, Ou Huang, Jianrong He, Weiguo Chen, Yafen Li, Xiaosong Chen, Kunwei Shen, Zheng Wang

Front Immunol. 2023; 14: 1251643. Published online 2023 Sep 4. doi: 10.3389/fimmu.2023.1251643

PMCID:: PMC10507177

Abstract Article PDF–35M

Select item 1039866018.

C9orf72 protein quality control by UBR5‐mediated heterotypic ubiquitin chains

Julia Jülg, Dieter Edbauer, Christian Behrends

EMBO Rep. 2023 Aug; 24(8): e55895. Published online 2023 Jun 15. doi: 10.15252/embr.202255895

PMCID:: PMC10398660

Abstract Article PDF–2.4M

Select item 1034596319.

A Multipronged Unbiased Strategy Guides the Development of an Anti-EGFR/EPHA2–Bispecific Antibody for Combination Cancer Therapy

Amr El Zawily, Frederick S. Vizeacoumar, Renuka Dahiya, Sara L. Banerjee, Kalpana K. Bhanumathy, Hussain Elhasasna, Glinton Hanover, Jessica C. Sharpe, Malkon G. Sanchez, Paul Greidanus, R. Greg Stacey, Kyung-Mee Moon, Ilya Alexandrov, Juha P. Himanen, Dimitar B. Nikolov, Humphrey Fonge, Aaron P. White, Leonard J. Foster, Bingcheng Wang, Behzad M. Toosi, Nicolas Bisson, Tajib A. Mirzabekov, Franco J. Vizeacoumar, Andrew Freywald

Clin Cancer Res. 2023 Jul 14; 29(14): 2686–2701. Published online 2023 Mar 28. doi: 10.1158/1078-0432.CCR-22-2535

PMCID:: PMC10345963

Abstract Article PDF–13M

Select item 1032325220.

Proximity labelling identifies pro-migratory endocytic recycling cargo and machinery of the Rab4 and Rab11 families

Beverley Wilson, Chloe Flett, Jakub Gemperle, Craig Lawless, Matthew Hartshorn, Eleanor Hinde, Tess Harrison, Megan Chastney, Sarah Taylor, Jennifer Allen, Jim C. Norman, Thomas Zacharchenko, Patrick T. Caswell

J Cell Sci. 2023 Jun 15; 136(12): jcs260468. Published online 2023 Jun 23. doi: 10.1242/jcs.260468

PMCID:: PMC10323252

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