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Select item 109715461.

P53 and BCL-2 family proteins PUMA and NOXA define competitive fitness in pluripotent cell competition

Jose A. Valverde-Lopez, Lin Li-Bao, Rocío Sierra, Elisa Santos, Giovanna Giovinazzo, Covadonga Díaz-Díaz, Miguel Torres

PLoS Genet. 2024 Mar; 20(3): e1011193. Published online 2024 Mar 15. doi: 10.1371/journal.pgen.1011193

PMCID:: PMC10971546

Abstract Article PDF–5.1M

Select item 107882692.

Epigenetic repression of Cend1 by lysine-specific demethylase 1 is essential for murine heart development

Huahua Liu, Rui Zhou, Shanshan Li, Jinling Dong, Yuan Fang, Yuru Luo, Hongyu Su, Baochang Lai, Lingli Liang, Donghong Zhang, Yanmin Zhang, John Y-J. Shyy, Bin Zhou, Zuyi Yuan, Yidong Wang

iScience. 2024 Jan 19; 27(1): 108722. Published online 2023 Dec 13. doi: 10.1016/j.isci.2023.108722

PMCID:: PMC10788269

Abstract Article PDF–11M

Select item 104474333.

Deletion of ARGLU1 causes global defects in alternative splicing in vivo and mouse cortical malformations primarily via apoptosis

Fenyong Yao, Shisheng Huang, Jiahui Liu, Chunhua Tan, Mengqi Xu, Dengkui Wang, Maoqing Huang, Yiyao Zhu, Xingxu Huang, Shuijin He

Cell Death Dis. 2023 Aug; 14(8): 543. Published online 2023 Aug 23. doi: 10.1038/s41419-023-06071-w

PMCID:: PMC10447433

Abstract Article PDF–9.2M

Select item 99740954.

TP63 gain-of-function mutations cause premature ovarian insufficiency by inducing oocyte apoptosis

Chengzi Huang, Simin Zhao, Yajuan Yang, Ting Guo, Hanni Ke, Xin Mi, Yingying Qin, Zi-Jiang Chen, Shidou Zhao

J Clin Invest. 2023 Mar 1; 133(5): e162315. Published online 2023 Mar 1. doi: 10.1172/JCI162315

PMCID:: PMC9974095

Abstract Article PDF–3.1M

Select item 98887255.

Hepatic ribosomal protein S6 (Rps6) insufficiency results in failed bile duct development and loss of hepatocyte viability; a ribosomopathy-like phenotype that is partially p53-dependent

Sarah A. Comerford, Elizabeth A. Hinnant, Yidong Chen, Robert E. Hammer

PLoS Genet. 2023 Jan; 19(1): e1010595. Published online 2023 Jan 19. doi: 10.1371/journal.pgen.1010595

PMCID:: PMC9888725

Abstract Article PDF–6.9M

Select item 90912176.

Loss of TAF8 causes TFIID dysfunction and p53-mediated apoptotic neuronal cell death

Farrah El-Saafin, Maria I. Bergamasco, Yunshun Chen, Rose E. May, Prabagaran Esakky, Soroor Hediyeh-zadeh, Mathew Dixon, Stephen Wilcox, Melissa J. Davis, Andreas Strasser, Gordon K. Smyth, Tim Thomas, Anne K. Voss

Cell Death Differ. 2022 May; 29(5): 1013–1027. Published online 2022 Mar 31. doi: 10.1038/s41418-022-00982-5

PMCID:: PMC9091217

Abstract Article PDF–7.2M

Select item 88226207.

Interferon-γ primes macrophages for pathogen ligand-induced killing via a caspase-8 and mitochondrial cell death pathway

Daniel S. Simpson, Jiyi Pang, Ashley Weir, Isabella Y. Kong, Melanie Fritsch, Maryam Rashidi, James P. Cooney, Kathryn C. Davidson, Mary Speir, Tirta M. Djajawi, Sebastian Hughes, Liana Mackiewicz, Merle Dayton, Holly Anderton, Marcel Doerflinger, Yexuan Deng, Allan Shuai Huang, Stephanie A. Conos, Hazel Tye, Seong H. Chow, Arfatur Rahman, Raymond S. Norton, Thomas Naderer, Sandra E. Nicholson, Gaetan Burgio, Si Ming Man, Joanna R. Groom, Marco J. Herold, Edwin D. Hawkins, Kate E. Lawlor, Andreas Strasser, John Silke, Marc Pellegrini, Hamid Kashkar, Rebecca Feltham, James E. Vince

Immunity. 2022 Mar 8; 55(3): 423–441.e9. Published online 2022 Feb 8. doi: 10.1016/j.immuni.2022.01.003

PMCID:: PMC8822620

Abstract Article PDF–6.5M

Select item 83191238.

A p53-dependent translational program directs tissue-selective phenotypes in a model of ribosomopathies

Gerald C. Tiu, Craig H. Kerr, Craig M. Forester, Pallavi S. Krishnarao, Hannah D. Rosenblatt, Nitin Raj, Travis C. Lantz, Olena Zhulyn, Margot E. Bowen, Leila Shokat, Laura D. Attardi, Davide Ruggero, Maria Barna

Dev Cell. Author manuscript; available in PMC 2022 Jul 26.

Published in final edited form as: Dev Cell. 2021 Jul 26; 56(14): 2089–2102.e11. Published online 2021 Jul 8. doi: 10.1016/j.devcel.2021.06.013

PMCID:: PMC8319123

Abstract Article PDF–2.5M

Select item 80586359.

RORγt limits the amount of the cytokine receptor γc through the prosurvival factor Bcl-x_L in developing thymocytes

Davinna L. Ligons, SuJin Hwang, Adam T. Waickman, Joo-Young Park, Megan A. Luckey, Jung-Hyun Park

Sci Signal. Author manuscript; available in PMC 2021 Apr 21.

Published in final edited form as: Sci Signal. 2018 Aug 28; 11(545): eaam8939. Published online 2018 Aug 28. doi: 10.1126/scisignal.aam8939

PMCID:: PMC8058635

Abstract Article PDF–1.5M

Select item 802656310.

Robust p53 stabilization is dispensable for its activation and tumor suppressor function

Ning Kon, Michael Churchill, Huan Li, Siddhartha Mukherjee, James J. Manfredi, Wei Gu

Cancer Res. Author manuscript; available in PMC 2021 Aug 15.

Published in final edited form as: Cancer Res. 2021 Feb 15; 81(4): 935–944. Published online 2020 Dec 15. doi: 10.1158/0008-5472.CAN-20-1804

PMCID:: PMC8026563

Abstract Article PDF–1.5M

Select item 794122411.

Nbs1‐mediated DNA damage repair pathway regulates haematopoietic stem cell development and embryonic haematopoiesis

Yu Chen, Jie Sun, Zhenyu Ju, Zhao‐Qi Wang, Tangliang Li

Cell Prolif. 2021 Mar; 54(3): e12972. Published online 2021 Feb 14. doi: 10.1111/cpr.12972

PMCID:: PMC7941224

Abstract Article PDF–1.3M

Select item 777826112.

Differential requirements for MDM2 E3 activity during embryogenesis and in adult mice

Timothy J. Humpton, Koji Nomura, Julia Weber, Helge M. Magnussen, Andreas K. Hock, Colin Nixon, Sandeep Dhayade, David Stevenson, Danny T. Huang, Douglas Strathdee, Karen Blyth, Karen H. Vousden

Genes Dev. 2021 Jan 1; 35(1-2): 117–132. doi: 10.1101/gad.341875.120

Correction in:: Genes Dev. 2021 Jul 1; 35(13-14): 1071.

PMCID:: PMC7778261

Abstract Article PDF–9.6M

Select item 772839413.

Runx2 is essential for the transdifferentiation of chondrocytes into osteoblasts

Xin Qin, Qing Jiang, Kenichi Nagano, Takeshi Moriishi, Toshihiro Miyazaki, Hisato Komori, Kosei Ito, Klaus von der Mark, Chiharu Sakane, Hitomi Kaneko, Toshihisa Komori

PLoS Genet. 2020 Nov; 16(11): e1009169. Published online 2020 Nov 30. doi: 10.1371/journal.pgen.1009169

PMCID:: PMC7728394

Abstract Article PDF–10M

Select item 724806914.

The BCL-2 pathway preserves mammalian genome integrity by eliminating recombination-defective oocytes

Elias ElInati, Agata P. Zielinska, Afshan McCarthy, Nada Kubikova, Valdone Maciulyte, Shantha Mahadevaiah, Mahesh N. Sangrithi, Obah Ojarikre, Dagan Wells, Kathy K. Niakan, Melina Schuh, James M. A. Turner

Nat Commun. 2020; 11: 2598. Published online 2020 May 25. doi: 10.1038/s41467-020-16441-z

PMCID:: PMC7248069

Abstract Article PDF–4.7M

Select item 717107115.

NOXA-dependent contextual synthetic lethality of BCL-XL inhibition and “osmotic reprogramming” in colorectal cancer

Gertrud Knoll, Petra Riffelsberger, Danielle Raats, Onno Kranenburg, Martin Ehrenschwender

Cell Death Dis. 2020 Apr; 11(4): 257. Published online 2020 Apr 20. doi: 10.1038/s41419-020-2446-8

PMCID:: PMC7171071

Abstract Article PDF–2.4M

Select item 692772316.

Inactivation of Mdm2 restores apoptosis proficiency of cooperativity mutant p53 in vivo

Boris Klimovich, Thorsten Stiewe, Oleg Timofeev

Cell Cycle. 2020; 19(1): 109–123. Published online 2019 Nov 21. doi: 10.1080/15384101.2019.1693748

PMCID:: PMC6927723

Abstract Article PDF–3.9M

Select item 672600617.

Noxa Is a Critical Mediator of p53-Dependent Motor Neuron Death after Nerve Injury in Adult Mouse

Sumiko Kiryu-Seo, Teruhisa Hirayama, Ryuichi Kato, Hiroshi Kiyama

J Neurosci. 2005 Feb 9; 25(6): 1442–1447. doi: 10.1523/JNEUROSCI.4041-04.2005

PMCID:: PMC6726006

Abstract Article PDF–452K

Select item 667497018.

Bim and Noxa Are Candidates to Mediate the Deleterious Effect of the NF-κB Subunit RelA in Cerebral Ischemia

Ioana Inta, Stephan Paxian, Ira Maegele, Wen Zhang, Marina Pizzi, PierFranco Spano, Ilenia Sarnico, Sajjad Muhammad, Oliver Herrmann, Dragos Inta, Bernd Baumann, Hsiou-Chi Liou, Roland M. Schmid, Markus Schwaninger

J Neurosci. 2006 Dec 13; 26(50): 12896–12903. doi: 10.1523/JNEUROSCI.3670-06.2006

PMCID:: PMC6674970

Abstract Article PDF–433K

Select item 667394719.

BH3-Only Proapoptotic Bcl-2 Family Members Noxa and Puma Mediate Neural Precursor Cell Death

Rizwan S. Akhtar, Ying Geng, Barbara J. Klocke, Cecelia B. Latham, Andreas Villunger, Ewa M. Michalak, Andreas Strasser, Steven L. Carroll, Kevin A. Roth

J Neurosci. 2006 Jul 5; 26(27): 7257–7264. doi: 10.1523/JNEUROSCI.0196-06.2006

PMCID:: PMC6673947

Abstract Article PDF–499K

Select item 667327520.

Puma Is a Dominant Regulator of Oxidative Stress Induced Bax Activation and Neuronal Apoptosis

Diana Steckley, Meera Karajgikar, Lianne B. Dale, Ben Fuerth, Patrick Swan, Chris Drummond-Main, Michael O. Poulter, Stephen S. G. Ferguson, Andreas Strasser, Sean P. Cregan

J Neurosci. 2007 Nov 21; 27(47): 12989–12999. doi: 10.1523/JNEUROSCI.3400-07.2007

PMCID:: PMC6673275

Abstract Article PDF–561K

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