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Select item 112834111.

Silencing of the DNA damage repair regulator PPP1R15A sensitizes acute myeloid leukemia cells to chemotherapy

Anthi Bouchla, Christina D. Sotiropoulou, Christopher Esteb, Theodoros Loupis, Sotirios G. Papageorgiou, Georgia G. Deliconstantinos, Maria Pagoni, Eleftheria Hatzimichael, Maria Dellatola, Smaragdi Kalomoiri, Elisavet Apostolidou, Christos K. Kontos, Thomas P. Thomopoulos, Theodoros Karantanos, Vasiliki Pappa

Ann Hematol. 2024; 103(8): 2853–2863. Published online 2024 Jun 6. doi: 10.1007/s00277-024-05785-x

PMCID:: PMC11283411

Abstract Article PDF–3.2M

Select item 110295702.

Growth arrest and DNA damage-inducible protein (GADD34) enhanced liver inflammation and tumorigenesis in a diethylnitrosamine (DEN)-treated murine model

Nana Chen, Naomi Nishio, Sachiko Ito, Yuriko Tanaka, Yang Sun, Ken-ichi Isobe

Cancer Immunol Immunother. 2015 Jun; 64(6): 777–789. Published online 2015 Apr 2. doi: 10.1007/s00262-015-1690-8

PMCID:: PMC11029570

Abstract Article PDF–9.4M

Select item 109642493.

The integrated stress response effector GADD34 is repurposed by neurons to promote stimulus-induced translation

Mauricio M. Oliveira, Muhaned Mohamed, Megan K. Elder, Keylin Banegas-Morales, Maggie Mamcarz, Emily H. Lu, Ela A.N. Golhan, Nishika Navrange, Snehajyoti Chatterjee, Ted Abel, Eric Klann

Cell Rep. Author manuscript; available in PMC 2024 Mar 26.

Published in final edited form as: Cell Rep. 2024 Feb 27; 43(2): 113670. Published online 2024 Jan 13. doi: 10.1016/j.celrep.2023.113670

PMCID:: PMC10964249

Abstract Article PDF–2.9M

Select item 101030924.

Translation Rescue by Targeting Ppp1r15a through Its Upstream Open Reading Frame in Sepsis-Induced Acute Kidney Injury in a Murine Model

Ashley Kidwell, Shiv Pratap Singh Yadav, Bernhard Maier, Amy Zollman, Kevin Ni, Arvin Halim, Danielle Janosevic, Jered Myslinski, Farooq Syed, Lifan Zeng, Alain Bopda Waffo, Kimihiko Banno, Xiaoling Xuei, Emma H. Doud, Pierre C. Dagher, Takashi Hato

J Am Soc Nephrol. 2023 Feb; 34(2): 220–240. Published online 2022 Oct 31. doi: 10.1681/ASN.2022060644

PMCID:: PMC10103092

Abstract Article

Select item 99682975.

Ssu72 phosphatase is essential for thermogenic adaptation by regulating cytosolic translation

Eun-Ji Park, Hyun-Soo Kim, Do-Hyoung Lee, Su-Min Kim, Joon-Sup Yoon, Ji-Min Lee, Se Jin Im, Ho Lee, Min-Woo Lee, Chang-Woo Lee

Nat Commun. 2023; 14: 1097. Published online 2023 Feb 25. doi: 10.1038/s41467-023-36836-y

PMCID:: PMC9968297

Abstract Article PDF–4.4M

Select item 96973756.

GADD34 Ablation Exacerbates Retinal Degeneration in P23H RHO Mice

Irina V. Saltykova, Assylbek Zhylkibayev, Oleg S. Gorbatyuk, Marina S. Gorbatyuk

Int J Mol Sci. 2022 Nov; 23(22): 13748. Published online 2022 Nov 9. doi: 10.3390/ijms232213748

PMCID:: PMC9697375

Abstract Article PDF–1.6M

Select item 89607747.

All-trans retinoic acid changes muscle fiber type via increasing GADD34 dependent on MAPK signal

Yuichiro Adachi, Masashi Masuda, Iori Sakakibara, Takayuki Uchida, Yuki Niida, Yuki Mori, Yuki Kamei, Yosuke Okumura, Hirokazu Ohminami, Kohta Ohnishi, Hisami Yamanaka-Okumura, Takeshi Nikawa, Yutaka Taketani

Life Sci Alliance. 2022 Jul; 5(7): e202101345. Published online 2022 Mar 22. doi: 10.26508/lsa.202101345

PMCID:: PMC8960774

Abstract Article PDF–2.7M

Select item 85665888.

Sensitization of the UPR by loss of PPP1R15A promotes fibrosis and senescence in IPF

Susan Monkley, Catherine Overed-Sayer, Helen Parfrey, Doris Rassl, Damian Crowther, Leire Escudero-Ibarz, Nicola Davis, Alan Carruthers, Richard Berks, Marisa Coetzee, Ewa Kolosionek, Maria Karlsson, Leia R. Griffin, Maryam Clausen, Graham Belfield, Cory M. Hogaboam, Lynne A. Murray

Sci Rep. 2021; 11: 21584. Published online 2021 Nov 3. doi: 10.1038/s41598-021-00769-7

PMCID:: PMC8566588

Abstract Article PDF–2.7M

Select item 79873409.

Prolonging the integrated stress response enhances CNS remyelination in an inflammatory environment

Yanan Chen, Rejani B Kunjamma, Molly Weiner, Jonah R Chan, Brian Popko

eLife. 2021; 10: e65469. Published online 2021 Mar 23. doi: 10.7554/eLife.65469

PMCID:: PMC7987340

Abstract Article PDF–5.8M

Select item 658842910.

The UPR-PERK pathway is not a promising therapeutic target for mutant SOD1-induced ALS

Yulia Dzhashiashvili, Chase P. Monckton, Harini S. Shah, Rejani B. Kunjamma, Brian Popko

Neurobiol Dis. Author manuscript; available in PMC 2020 Jul 1.

Published in final edited form as: Neurobiol Dis. 2019 Jul; 127: 527–544. Published online 2019 Mar 26. doi: 10.1016/j.nbd.2019.03.024

PMCID:: PMC6588429

Abstract Article PDF–2.7M

Select item 653868411.

Delineating the role of eIF2α in retinal degeneration

Christopher R. Starr, Marina S. Gorbatyuk

Cell Death Dis. 2019 Jun; 10(6): 409. Published online 2019 May 28. doi: 10.1038/s41419-019-1641-y

PMCID:: PMC6538684

Abstract Article PDF–1.6M

Select item 639354112.

Inactivation of Ppp1r15a minimises weight gain and insulin resistance during caloric excess in female mice

Vruti Patel, Guillaume Bidault, Joseph E. Chambers, Stefania Carobbio, Angharad J. T. Everden, Concepción Garcés, Lucy E. Dalton, Fiona M. Gribble, Antonio Vidal-Puig, Stefan J. Marciniak

Sci Rep. 2019; 9: 2903. Published online 2019 Feb 27. doi: 10.1038/s41598-019-39562-y

PMCID:: PMC6393541

Abstract Article PDF–5.4M

Select item 610883513.

Target-Based Discovery of an Inhibitor of the Regulatory Phosphatase PPP1R15B

Agnieszka Krzyzosiak, Anna Sigurdardottir, Laura Luh, Marta Carrara, Indrajit Das, Kim Schneider, Anne Bertolotti

Cell. 2018 Aug 23; 174(5): 1216–1228.e19. doi: 10.1016/j.cell.2018.06.030

PMCID:: PMC6108835

Abstract Article

Select item 606350314.

The COPII cargo adapter SEC24C is essential for neuronal homeostasis

Bo Wang, Joung Hyuck Joo, Rebecca Mount, Brett J. W. Teubner, Alison Krenzer, Amber L. Ward, Viraj P. Ichhaporia, Elizabeth J. Adams, Rami Khoriaty, Samuel T. Peters, Shondra M. Pruett-Miller, Stanislav S. Zakharenko, David Ginsburg, Mondira Kundu

J Clin Invest. 2018 Aug 1; 128(8): 3319–3332. Published online 2018 Jun 25. doi: 10.1172/JCI98194

PMCID:: PMC6063503

Abstract Article PDF–26M

Select item 591245915.

Hairy and enhancer of split 1 (HES1) protects cells from endoplasmic reticulum stress–induced apoptosis through repression of GADD34

Ji Eun Lee, William Morrison, Julie Hollien

J Biol Chem. 2018 Apr 20; 293(16): 5947–5955. Published online 2018 Feb 28. doi: 10.1074/jbc.RA118.002124

PMCID:: PMC5912459

Abstract Article PDF–1.7M

Select item 576691416.

Chronic oxidative stress promotes GADD34-mediated phosphorylation of the TAR DNA-binding protein TDP-43, a modification linked to neurodegeneration

Catherine Wenhui Goh, Irene Chengjie Lee, Jeyapriya Rajameenakshi Sundaram, Simi Elizabeth George, Permeen Yusoff, Matthew Hayden Brush, Newman Siu Kwan Sze, Shirish Shenolikar

J Biol Chem. 2018 Jan 5; 293(1): 163–176. Published online 2017 Nov 6. doi: 10.1074/jbc.M117.814111

PMCID:: PMC5766914

Abstract Article PDF–2.5M

Select item 576284117.

Oxidative stress promotes SIRT1 recruitment to the GADD34/PP1α complex to activate its deacetylase function

Irene Chengjie Lee, Xue Yan Ho, Simi Elizabeth George, Catherine Wenhui Goh, Jeyapriya Rajameenakshi Sundaram, Karen Ka Lam Pang, Weiwei Luo, Permeen Yusoff, Newman Siu Kwan Sze, Shirish Shenolikar

Cell Death Differ. 2018 Feb; 25(2): 255–267. Published online 2017 Oct 6. doi: 10.1038/cdd.2017.152

PMCID:: PMC5762841

Abstract Article PDF–3.9M

Select item 565008918.

Activation of the Integrated Stress Response and Metabolic Dysfunction in a Murine Model of Sleep Apnea

Abdelnaby Khalyfa, Zhuanhong Qiao, Alex Gileles-Hillel, Ahamed A. Khalyfa, Mahzad Akbarpour, Brian Popko, David Gozal

Am J Respir Cell Mol Biol. 2017 Oct; 57(4): 477–486. doi: 10.1165/rcmb.2017-0057OC

PMCID:: PMC5650089

Abstract Article PDF–971K

Select item 535056719.

Protein synthesis inhibition and GADD34 control IFN‐β heterogeneous expression in response to dsRNA

Alexandre Dalet, Rafael J Argüello, Alexis Combes, Lionel Spinelli, Sebastien Jaeger, Mathieu Fallet, Thien‐Phong Vu Manh, Andreia Mendes, Jessica Perego, Marisa Reverendo, Voahirana Camosseto, Marc Dalod, Tobias Weil, Manuel A Santos, Evelina Gatti, Philippe Pierre

EMBO J. 2017 Mar 15; 36(6): 761–782. Published online 2017 Jan 18. doi: 10.15252/embj.201695000